Innovation in Aging最新文献

{"title":"Simulation modeling of neighborhood-level differences in life course health outcomes: a proof of concept.","authors":"Jarrod E Dalton, Paul R Gunsalus, Adam T Perzynski, Lyla Mourany, Elizabeth R Pfoh, Madeleine M Blazel, Douglas D Gunzler, Kathryn A Martinez, Glen B Taksler","doi":"10.1093/geroni/igag026","DOIUrl":"10.1093/geroni/igag026","url":null,"abstract":"<p><strong>Background and objectives: </strong>Adults in low-resource neighborhoods face greater burden of preventable diseases than the general population. Methodologies to measure the impact of population-level efforts to reduce neighborhood-level disparities in health outcomes are lacking. We introduce a simulation modeling approach for incident disease and mortality risk over the life course and apply the model to assess the impact of a hypothetical population health initiative to reduce neighborhood-level disparities.</p><p><strong>Research design and methods: </strong>Using electronic health records, we constructed a probabilistic dynamic systems model that simulated the life course of each patient in a large primary care population, taking into account specific relationships by sex and Area Deprivation Index (ADI) quintile. The model predicted long-term incidence of 10 chronic conditions and all-cause mortality.</p><p><strong>Results: </strong>The model was reliable, with strong discrimination (C-statistic for 10-year mortality: 0.871) and calibration. Predicted median life expectancy was nearly a decade lower for patients ages 40-45 who resided in the highest (ADI quintile 5) vs the lowest (quintile 1) deprivation neighborhoods (difference [95% CI]; women, 8.6 [8.2, 9.0] years; men, 10.0 [9.6, 10.3]. A hypothetical initiative to reduce the number of smokers by 10% had minimal effect on disparities in life expectancy when implemented in the general patient population (women, -0.4 years; men, -0.2), but meaningfully narrowed disparities when focused on high-deprivation neighborhoods (women, -0.8 years; men, -0.6).</p><p><strong>Discussion and implications: </strong>In a broad patient population, it was feasible to measure socioeconomic disparities in health outcomes and life expectancy and evaluate interventions to improve health equity.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 5","pages":"igag026"},"PeriodicalIF":6.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal relationship between pain and depressive symptoms in later life: the buffering effects of social and physical activities among older Koreans.","authors":"Eunsol Song, Jinho Kim","doi":"10.1093/geroni/igag037","DOIUrl":"10.1093/geroni/igag037","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study examined the longitudinal relationship between pain intensity and depressive symptoms among older adults and assessed the buffering effects of social and physical activities. In addition, it explored whether these buffering effects vary by gender and educational attainment.</p><p><strong>Research design and methods: </strong>Using 8 waves (2006-2020) of the Korean Longitudinal Study of Aging, we analyzed a sample of 7,238 older adults aged 65 years and older. Longitudinal fixed-effects models were employed to assess how within-person changes in pain intensity were associated with within-person changes in depressive symptoms. Interaction terms were included to test the buffering effects of informal and formal social activity, as well as physical activity. Stratified analyses were conducted to explore potential heterogeneity by educational attainment and gender.</p><p><strong>Results: </strong>The fixed-effects models indicated that increases in pain intensity were significantly associated with higher levels of depressive symptoms. Interaction analyses revealed that this positive association was moderated by informal social activity, formal social activity, and physical activity. Specifically, older adults with higher levels of social or physical activity exhibited a weaker association between pain and depressive symptoms than those with lower levels of engagement. No clear differences in moderating effects were observed by education or gender.</p><p><strong>Discussion and implications: </strong>These findings highlight that social and physical activities act as key protective factors against the adverse psychological consequences of pain among older adults. Integrative interventions that promote sustained social engagement and physical activity may help mitigate depression risk in this population.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 5","pages":"igag037"},"PeriodicalIF":6.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance care planning by proxy for residential aged care facility residents: results of a pilot interventional study.","authors":"Laura Jones, Eve Rubli Truchard, Anca-Cristina Sterie, Yaëlle Rhyner, Elisabeth Iorio, Ralf J Jox","doi":"10.1093/geroni/igag033","DOIUrl":"10.1093/geroni/igag033","url":null,"abstract":"<p><strong>Background and objectives: </strong>Advance care planning (ACP) allows people with decision-making capacity (DMC) to stipulate their wishes for medical treatment if they lose this capacity. However, many lose DMC before expressing their treatment wishes. Supplementary ACP models, conducted with health care proxies (HCPs), could promote care that is as coherent as possible with the presumed wishes of people who have lost medical DMC. This study pilot-tested an ACP-by proxy (ACP-bp) intervention with HCPs of residential aged care facility (RACF) residents lacking medical DMC to examine the acceptability and feasibility of the intervention.</p><p><strong>Research design and methods: </strong>21 HCPs of 20 RACF residents participated in this multi-method evaluation of a single-arm intervention pilot study. Proxy decisional conflict and facilitator (RACF health professionals) self-efficacy were measured pre- and post-intervention. Semi-structured interviews were conducted with HCPs and facilitators. Interviews were audio-recorded, transcribed verbatim, and analyzed thematically.</p><p><strong>Results: </strong>The intervention significantly reduced proxy decisional conflict. Feasibility was threatened by health professional, proxy, and physician time, and RACF health professional turnover. Proxies and facilitators indicated that ACP-bp promoted in-depth discussions of residents' lives, thereby improving health professionals' knowledge and connection with residents, as well as proxy confidence. It promoted communication and cooperation between proxies and health professionals and provided clear documentation in case of emergency.</p><p><strong>Discussion and implications: </strong>The intervention was acceptable for all participants. Future research should focus on the most efficient models for implementing ACP-bp and establish their validity in promoting care that is coherent with patient wishes through a cluster randomized control study.</p><p><strong>Clinical trial registration number: </strong>NCT04779684.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 6","pages":"igag033"},"PeriodicalIF":6.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in temperature and life-space mobility among older adults: a pilot study using mobile health technology.","authors":"Annabel X Tan, Sylvie Dobrota Lai, Vishnu Ravi, J David Rhodes, Suzanne E Judd, Michelle C Odden","doi":"10.1093/geroni/igag027","DOIUrl":"10.1093/geroni/igag027","url":null,"abstract":"<p><strong>Background and objectives: </strong>Extreme outdoor temperatures are known barriers to physical activity and may constrain life-space mobility, the geographic footprint of where people live, work, and recreate, and an important indicator of health and independence among older adults. We conducted a pilot study to evaluate the feasibility of a mobile health (mHealth) app designed to objectively capture life-space and to demonstrate its utility through a downstream analysis of ambient temperature and life-space mobility.</p><p><strong>Research design and methods: </strong>Using data collected via an iPhone app from 82 participants in an ongoing cohort study (June 2023-January 2024), we used linear mixed-effects models to examine associations between daily average temperature and 3 objective life-space measures: ellipse area, maximum distance traveled, and total distance traveled. Models were stratified by season and adjusted for relative humidity and sociodemographic covariates.</p><p><strong>Results: </strong>The app successfully captured high-resolution longitudinal mobility data over 2 weeks per participant. There was a significant negative nonlinear association between higher daily average temperature and life-space in the summer. With the peak life-space ellipse area observed at 28.8 °C, for every degree Celsius greater than 28.8 °C, we found a statistically significant decrease in ellipse area by 2.97 km² (95% CI: -5.45, -0.51; <i>p </i>= .02). Findings were similar for the outcomes of maximum and total distances traveled.</p><p><strong>Discussion and implications: </strong>This study demonstrates that mHealth technology is a feasible tool for assessing life-space mobility in older adults. Higher temperatures are associated with lower life-space metrics, highlighting the potential of app-derived metrics as digital biomarkers for mobility research.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 5","pages":"igag027"},"PeriodicalIF":6.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do home modifications reduce caregiver burden? A cross-sectional analysis of factors associated with caregiver burden and resilience in Hong Kong.","authors":"Tarani Chandola, Patrick Rouxel, Vivian W Q Lou, Simon Ng, Vera Mun Yu Tang, Tom Chun Wai Tsoi, Wenyi Lin, Jianchao Quan, Wai Sze Chan, Peiyi Lu, Xingnan Yi","doi":"10.1093/geroni/igag029","DOIUrl":"10.1093/geroni/igag029","url":null,"abstract":"<p><strong>Background and objectives: </strong>The impact of modifiable housing factors on the mental health of caregivers of older adults and people with disabilities is often underestimated. This study examines the role of housing modifications in influencing caregiver burden and resilience in Hong Kong.</p><p><strong>Research design and methods: </strong>Data from a population-based survey of 2,960 caregivers of older adults (aged 60 and older) and younger individuals with disabilities (under 60) were analyzed. Modifications to the care recipients' homes-classified as any, wheelchair-accessible, stair/chairlift, or other modifications-and the proportion of homes modified within each building or estate were assessed. Quantile regression models of the Caregiver Burden Inventory and the Connor-Davidson Resilience Scale were used to estimate the association between home modifications and caregiver burden and resilience.</p><p><strong>Results: </strong>Caregivers living with their care recipients in buildings or estates where all homes had been modified reported approximately 0.3 standard deviations lower burden (at the 90th quantile) and 0.23 standard deviations higher resilience (at the 80th quantile) than those in non-modified buildings or estates. Similar associations were observed between modifications of individual care recipients' homes and caregiver burden, although not for resilience.</p><p><strong>Discussion and implications: </strong>There is some evidence that home modifications are associated with reduced caregiver burden and increased caregiver resilience, particularly when measured at the building or estate level. Enhancing the housing quality of older adults and people with disabilities may improve not only their well-being, but also that of their caregivers.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 8","pages":"igag029"},"PeriodicalIF":6.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of an acute medical teleconsultation model for nursing home residents.","authors":"Chong Yau Ong, Russell Yi Qian Koh, Angus Jun Jie Ng, Jean Mui Hua Lee","doi":"10.1093/geroni/igag031","DOIUrl":"10.1093/geroni/igag031","url":null,"abstract":"<p><strong>Background and objectives: </strong>Emergency department (ED) transfers and unplanned hospital admissions of nursing home residents are common and costly. This study evaluated the cost-effectiveness of a hospital-managed acute medical teleconsultation service (EAGLEcareACT) in reducing ED transfers and hospital admissions among nursing home residents in Singapore. Currently, the teleconsultation service is provided free of charge to nursing home residents.</p><p><strong>Research design and methods: </strong>A decision-tree model compared the EAGLEcareACT pathway with usual care from the healthcare institution's perspective. Clinical outcomes were obtained from service data (2022 to 2023). Both deterministic and probabilistic sensitivity analyses (PSA) were performed. Cost-effectiveness was further assessed using net monetary benefit (NMB) under Singapore willingness-to-pay thresholds.</p><p><strong>Results: </strong>The base-case analysis showed that EAGLEcareACT was cost-saving, with an incremental cost savings of 444.04 Singapore Dollars per unplanned hospital admission avoided, when compared with usual care. The PSA showed the model was both less costly and more effective. The NMB remained positive across all plausible Quality-Adjusted Life Year assumptions, with 97% probability being cost-effective.</p><p><strong>Discussion and implications: </strong>The acute medical teleconsultation service model, as a cost-saving and cost-effective in avoiding ED transfers and unplanned hospital admissions among nursing home residents, demonstrated potential for scalability.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 6","pages":"igag031"},"PeriodicalIF":6.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults' views of passive smartphone monitoring for dementia risk: a multi-method analysis.","authors":"Katherine Hackett, Heather Wurtz, Carolyn W Zhu, Maria Loizos, Frandys Berroa, Hillary Ramos Espinoza, Alex Federman, Mary Sano","doi":"10.1093/geroni/igag034","DOIUrl":"10.1093/geroni/igag034","url":null,"abstract":"<p><strong>Background and objectives: </strong>Functional difficulties are hallmark signs of incident cognitive decline and progression to dementia but are challenging to measure in clinics. Passive smartphone monitoring enables continuous tracking of everyday behaviors and may improve the status quo of dementia risk assessment, but acceptability is understudied. This study evaluated older adults' attitudes toward personal smartphone monitoring for dementia risk and identified barriers and facilitators to acceptability.</p><p><strong>Methods: </strong>Seventeen older adults completed a semi-structured interview followed by a Likert-scale rating to measure acceptability. Transcripts were analyzed using hybrid inductive-deductive thematic analysis. Exploratory correlations examined associations between acceptability ratings and participant features.</p><p><strong>Results: </strong>Participants identified unique benefits of smartphone monitoring, including enhanced scope of measurement, greater ecological validity and personalization, and improved accessibility. Potential disadvantages were confounding variables that threaten validity and concerns about privacy/data security. Preferences for clinical implementation that may improve acceptability included extended monitoring options, assurances of privacy safeguards, control over data, and continued face-to-face interactions with one's medical team. Most participants (13/17) were likely or extremely likely to participate in future smartphone monitoring research; higher likelihood was associated with lower depression (<i>r</i> = -.49, <i>p</i> = .046) and White vs non-White race (<i>U </i>= 57.50, n1 = 10, n2 = 7 <i>p</i> = .025, <i>r</i> = .57).</p><p><strong>Discussion and implications: </strong>Findings offer insights to enhance the acceptability of smartphone monitoring, including transparent review of procedures, privacy safeguards, and existing evidence. Outstanding requirements for clinical implementation include streamlining results to minimize physician burden and accounting for confounders that threaten data integrity. Our small, research-savvy cohort necessitates follow-up in other settings.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 6","pages":"igag034"},"PeriodicalIF":6.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital technology use among age-friendly community initiatives in the United States.","authors":"Emily A Greenfield, Natalie E Pope, Rebecca Martin, Uri Amir-Koren, Tawfiq Ammari","doi":"10.1093/geroni/igag025","DOIUrl":"10.1093/geroni/igag025","url":null,"abstract":"<p><strong>Background and objectives: </strong>Although studies have established the importance of various types of resources for age-friendly community (AFC) initiatives, there has been little research on digital technologies. This study explored the extent of, and contexts for, digital technology use among AFC initiatives in the United States.</p><p><strong>Research design and methods: </strong>This concurrent mixed-methods study used data from AARP's 2024 Survey of the National Network of Age-Friendly States and Communities (NAFSC) (<i>N </i>= 200) alongside qualitative interviews with 13 communities that reported in the survey relatively high levels or novel types of digital technology use.</p><p><strong>Results: </strong>Over 90% of survey respondents indicated using at least one technology, the most common being online survey platforms (65%), social media (64%), cloud-based video conferencing (57%), organizational websites (56%), and collaborative file sharing (54%). Initiatives later into the NAFSC program cycle, led by nonprofits or higher education, and with more sources of support, reported using a greater variety of tools. The qualitative analysis identified human capital, alongside the digital infrastructure and financial capital of collaborating organizations, as conditions for technology use and access. Shifting initiative circumstances, as well as perceptions of older adults' digital capacities and preferences, also influenced technology use.</p><p><strong>Discussion and implications: </strong>Our findings support digital capital as a central component of the development and implementation of AFC initiatives in the context of organizational, network, and community conditions. We discuss how findings can guide future research to enhance the strategic use of technology toward greater AFC impact.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 10","pages":"igag025"},"PeriodicalIF":6.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"healthy dyad\" bias in veteran-caregiver dyadic research: a methodological caution.","authors":"Alisa Bedrov, Erin D Bouldin, Roxana E Delgado, Mary Jo Pugh","doi":"10.1093/geroni/igag028","DOIUrl":"10.1093/geroni/igag028","url":null,"abstract":"","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 5","pages":"igag028"},"PeriodicalIF":6.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and sarcopenia in aged care: the mediating role of fatigability.","authors":"Tzu-Pei Yeh, Yen-Kuang Lin, Fang-Lin Kuo, Pi-Ju Liu, Dorothy Bai, I-Hui Chen","doi":"10.1093/geroni/igag023","DOIUrl":"10.1093/geroni/igag023","url":null,"abstract":"<p><strong>Background and objectives: </strong>Sarcopenia prevalence is higher in aged care facilities than in community settings, yet mechanistic pathways remain poorly understood. Although loneliness-sarcopenia associations are established, no studies have examined mediating mechanisms in institutional settings. We examined whether physical and mental fatigability mediate the loneliness-sarcopenia relationship in aged care residents.</p><p><strong>Methods: </strong>This cross-sectional study included 205 older adults (<i>M</i> _age = 80.5 ± 8.1 years; 52.2% male) from 6 aged care facilities in Taipei. Sarcopenia was assessed using the Asian Working Group for Sarcopenia 2019 criteria. Loneliness was measured via the UCLA Loneliness Scale and perceived fatigability via the validated Traditional Chinese Pittsburgh Fatigability Scale. Causal mediation analysis examined direct and indirect pathways, adjusting for demographic, health, and psychosocial confounders.</p><p><strong>Results: </strong>The sarcopenia prevalence was 58.0%. Physical fatigability significantly mediated the loneliness-sarcopenia association (odds ratio = 1.0, 95% confidence interval: 1.0-1.1), accounting for 15.0% of the total effect. The strongest mediation was for physical performance (44.2%). Substantial interaction effects between loneliness and both physical (74.7%) and mental fatigability (80.5%) suggested synergistic influences on sarcopenia risk.</p><p><strong>Discussion and implications: </strong>Physical fatigability represents a novel, modifiable mediating pathway between loneliness and sarcopenia in aged care, with particularly strong effects on functional mobility. The substantial interaction effects support the use of combined interventions that address both psychosocial and physiological factors. Dual screening for loneliness and fatigability could identify high-risk residents, addressing the 15.0% mediation pathway. These findings inform integrated care approaches that could transform sarcopenia prevention in institutional settings. Replication in community-dwelling populations is warranted.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"10 6","pages":"igag023"},"PeriodicalIF":6.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}