Innovation in Aging最新文献

{"title":"The Association Between Social Isolation and Incident Dementia Among Older Adults: Evidence From National Health and Aging Trend Study.","authors":"Yong Yang, Yu Jiang","doi":"10.1093/geroni/igae093","DOIUrl":"https://doi.org/10.1093/geroni/igae093","url":null,"abstract":"<p><strong>Background and objectives: </strong>Older adults are vulnerable to social isolation, making it crucial to understand its impact on dementia risk. Yet, existing evidence lacks consistency, with studies using varied measures of social isolation and overlooking potential confounders. We aim to investigate the associations between social isolation and dementia risk among older adults, hypothesizing that this association may diminish after adjusting for confounding factors.</p><p><strong>Research design and methods: </strong>We used 2 977 community-dwelling older adults who had no dementia in 2015 from National Health and Aging Trends. Group-based trajectory modeling was used to analyze the trajectories of social isolation, depression, and anxiety from 2011 to 2015. Cox proportional hazards regression models were then employed to estimate the association between social isolation trajectories and incident dementia from 2015 to 2022, adjusting for demographic variables, depression, anxiety, self-rated health, smoking status, and cardiovascular disease-related variables.</p><p><strong>Results: </strong>Three social isolation trajectories were identified: minimal, moderate, and high levels of social isolation. During a mean follow-up of 3.6 years, 19.0% of participants were diagnosed with dementia. When only demographics were adjusted, individuals in the moderate social isolation group were 22% less likely to develop dementia compared to those with high social isolation. This association between social isolation and incident dementia became nonsignificant after further adjustment for depression, anxiety, and health indicators.</p><p><strong>Discussion and implications: </strong>The association between social isolation and dementia risk may be mediated by factors such as depression and other health indicators.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Social Interaction Intervention on Cognitive Functions Among Older Adults Without Dementia: A Systematic Review and Meta-Analysis.","authors":"Chi-Chuan Wei, Min-Jia Hsieh, Yi-Fang Chuang","doi":"10.1093/geroni/igae084","DOIUrl":"https://doi.org/10.1093/geroni/igae084","url":null,"abstract":"<p><strong>Background and objectives: </strong>Previous systemic reviews, predominantly including observational studies, have shown that participation in social activities is a protective factor against cognitive decline. However, this association is subject to potential reverse causality, creating a knowledge gap in our understanding of the effect of social interaction interventions on cognitive function. Therefore, this study aims to conduct a systematic review and meta-analysis of randomized controlled trials to examine the effects of social interaction interventions on cognitive decline among older adults without dementia.</p><p><strong>Research design and methods: </strong>This systematic review, registered in PROSPERO (CRD42022367828), systematically searched 6 databases from inception to May 6, 2022, to identify relevant articles on the effects of activities with social interaction components on cognitive function in community-dwelling older adults without dementia aged above 60. Two independent reviewers conducted study selection, data extraction, and bias assessment, with RevMan5.3 used for meta-analysis. Subgroup analysis was conducted to assess variation in intervention effects among subgroups.</p><p><strong>Results: </strong>We included 11 studies for qualitative analysis and 8 studies for the meta-analysis. The results showed that social interaction intervention had a significant effect on executive function (standardized mean difference [SMD] = 1.60; 95% CI, 0.50 to 2.70; <i>p</i> = .004), but not attention and memory. The subgroup analysis showed a greater cognitive benefit for healthy older adults, but not those with mild cognitive impairment. Moreover, in-person social interaction positively affected global cognition, whereas online interaction did not.</p><p><strong>Discussion and implications: </strong>Social interaction interventions have a limited impact on cognitive function in older adults without dementia but showed potential effects on executive function. This finding offers insights for implementing social intervention in the community.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Prevalence and Risk Factor Profile of Olfactory Impairment and Its Impact on Patient Health Indicators and Economic Outcomes in Community-Dwelling Older Asian Adults.","authors":"Ryan E K Man, Chiew Meng Johnny Wong, Preeti Gupta, Eva K Fenwick, Amudha Aravindhan, Neville Wei Yang Teo, Tze Choong Charn, Ciaran Forde, Ecosse L Lamoureux","doi":"10.1093/geroni/igae088","DOIUrl":"https://doi.org/10.1093/geroni/igae088","url":null,"abstract":"<p><strong>Background and objectives: </strong>There is a paucity of data on the prevalence, risk factors, and impact of olfactory impairment (OI) on key health indicators and economic outcomes in Asian populations. We aimed to address these gaps in a population of community-dwelling older adults.</p><p><strong>Research design and methods: </strong>We included 2 101 participants (mean age ± standard deviation [<i>SD</i>]: 72.9 ± 8.1 years; 55.1% women) from the baseline assessment of the Population Health and Eye Disease Profile in Elderly Singaporeans (PIONEER) study (2017-2022). Any OI was based on a score of <11 on the 16-item identification segment of the Sniffin' Sticks test battery; subcategorized into hyposmia (score 9-10) and anosmia (score ≤8). Sociodemographic, clinical, and lifestyle risk determinants, health indicators (health-related quality of life, depressive symptoms, daily caloric intake, frailty, and cognitive impairment), and economic outcomes (healthcare expenditure, productivity loss) were assessed via standardized clinical testing and validated questionnaires. Multivariable logistic and linear regression models were utilized to explore the risk factor profile of OI across its severity spectrum and its impact on health indicators and economic outcomes.</p><p><strong>Results: </strong>The census-adjusted prevalence of any OI, hyposmia, and anosmia were 34.0%, 20.5%, and 13.5%, respectively. Older age and male gender were associated with increased likelihood of hyposmia and anosmia, while the presence of diabetes and >4 days/week alcohol consumption were associated with increased odds of having anosmia only (all <i>p</i> < .05). Both hyposmia and anosmia were also associated with more than twofold increased odds of having CI.</p><p><strong>Discussion and implications: </strong>Over a third of our community-dwelling older Singaporean population had OI, with 1-in-10 experiencing total olfaction loss. Those with OI had more than double the odds of having CI, regardless of its severity. Our results suggest the importance of community-based programs aimed at detecting and delaying the progression of OI in high-risk individuals.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Care Network Characteristics in Older Adults' Relocation to Residential Care Settings.","authors":"Natasha Nemmers, Wenhua Lai, Sophia Tsuker, Srabani Haldar, Vicki A Freedman, Amanda N Leggett","doi":"10.1093/geroni/igae087","DOIUrl":"https://doi.org/10.1093/geroni/igae087","url":null,"abstract":"<p><strong>Background and objectives: </strong>When older adults face increasing care needs or limited support, remaining safely and comfortably at home becomes challenging. Extant research has primarily concentrated on characteristics of the older adult or their primary caregiver on nursing home admission. This study examines the risk of older adults transitioning to residential care (e.g., assisted living, nursing home), focusing on the influence of their care network or involvement of multiple helpers.</p><p><strong>Research design and methods: </strong>Using the National Health and Aging Trends Study, we conducted competing risk regression models that account for mortality, following 7,085 initially community-dwelling older adults across Rounds 1-9 (2011-2019). We assessed network composition, size, shared tasks, and the number of in-network specialists or generalists while controlling for individual sociodemographic and health factors.</p><p><strong>Results: </strong>Individuals with care networks that shared medical tasks had the highest risk of moving to a residential care setting, followed by those sharing household tasks. Conversely, shared mobility or self-care and transportation responsibilities were associated with lower risks. Having more generalists, but not specialists, increased the risk. Larger networks were associated with heightened risk, although having close family members like a spouse was protective.</p><p><strong>Discussion and implications: </strong>The findings underscore that care network characteristics are critical to older adults' ability to age in place. Specifically, older adults with larger networks, lacking a spouse or child, and providing complex care are at greater risk for relocating. Understanding care networks can guide interventions related to care network coordination and resource allocation to help avoid or postpone a residential care move.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifty Years of NIA Research: A New Journal's Perspective.","authors":"Steven M Albert, Karen J Jung, Jennifer Tehan Stanley","doi":"10.1093/geroni/igae091","DOIUrl":"https://doi.org/10.1093/geroni/igae091","url":null,"abstract":"","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Problems Among Flemish and Dutch Nursing Home Residents Assessed by Nondental Caregivers Using the Novel Oral Health Section for Inclusion in interRAI.","authors":"Emilie Schoebrechts, Johanna de Almeida Mello, Patricia A I Vandenbulcke, Ellen E Palmers, Hein P J van Hout, Jan De Lepeleire, Anja Declercq, Dominique Declerck, Joke Duyck","doi":"10.1093/geroni/igae090","DOIUrl":"10.1093/geroni/igae090","url":null,"abstract":"<p><strong>Background and objectives: </strong>Oral health of older adults in nursing homes is poor, which can negatively affect general health and well-being. Most oral health problems are preventable with good oral hygiene and regular dental check-ups. Caregivers can help improve residents' oral health through regular oral health assessments. The interRAI instrument used in Long-Term Care Facilities to evaluate older adults' health and well-being, has the potential to integrate oral care into general care planning. The recently optimized Oral Health Section for inclusion in the interRAI instruments (OHS-interRAI) enables nondental caregivers to identify residents requiring help with oral hygiene and/or a dental referral. This study reports the first data obtained using the OHS-interRAI, describing the oral health situation of older adults in Flemish and Dutch nursing homes.</p><p><strong>Research design and methods: </strong>In this cross-sectional study, interRAI Long-Term Care Facilities data, including OHS-interRAI data, were collected from October 2020 to January 2023 and analyzed from 417 and 795 persons aged 65 years or older in Flemish and Dutch nursing homes, respectively.</p><p><strong>Results: </strong>Most common oral health problems were poor oral hygiene and compromised teeth. Differences in oral health were found between Flemish and Dutch residents. Flemish residents had significantly more problems with chewing, dry mouth, oral and denture hygiene, and tongue condition than their Dutch counterparts. They also had a higher need for help with oral hygiene (19.4% vs 14.0%), and a dental referral (36.8% vs 20.9%). Older adults in Flemish nursing homes (20.3%) had significantly fewer dental check-ups than those in Dutch nursing homes (73.5%).</p><p><strong>Discussion and implications: </strong>The use of the OHS-interRAI by nondental caregivers identified at least one-third of the residents requiring help with oral hygiene and/or a dental referral. By means of trigger algorithms (Collaborative Action Points), the OHS-interRAI enables the integration of oral care into general care planning.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeking Dental Healthcare in the Context of COVID-19 Pandemic: A Study Examining the Health Belief Model.","authors":"Aviv Goldstein, Shlomo Matalon, Na'ama Fridenberg, Hagay Slutzky","doi":"10.1093/geroni/igae089","DOIUrl":"https://doi.org/10.1093/geroni/igae089","url":null,"abstract":"<p><strong>Background and objectives: </strong>The main purpose of the study was to examine the factors influencing older adults' seeking dental care, in the context of coronavirus disease 2019 (COVID-19) pandemic, based on the Health Belief Model (HBM).</p><p><strong>Research design and methods: </strong>Phone interviews were conducted using a structured questionnaire, among 200 older adults aged 65 and above, who are members of the Israeli largest sick fund Clalit Health Services, that were sampled through a systematic random sample. The data were collected between January 2022 and March 2022 and during September 2022.</p><p><strong>Results: </strong>Our findings indicate that since the outbreak of COVID-19 in Israel, 61.5% and 55% of the participants reported visiting a dentist and a dental hygienist, respectively, and about a fifth of the participants have foregone care at both. Seeking dental care was associated with an increase in perceived threat, benefits, willingness to seek care, and with a decrease in perceived barriers. The HBM was found to be a suitable framework for illuminating older adults' dental behavior, which explains 43% of the variance.</p><p><strong>Discussion and implications: </strong>The results of the study provided first-hand findings regarding seeking dental care during the COVID-19 pandemic. These findings emphasize the importance of providing dental services with clear recommendations about dental care and appropriate protective equipment, even under conditions of health concern, to enhance oral health services utilization.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Evidence of Healthier Aging: Positive Cohort Effects on Verbal Fluency.","authors":"Fernando Massa, Alejandra Marroig, Joe Rodgers, Scott M Hoffer, Graciela Muniz-Terrera","doi":"10.1093/geroni/igae082","DOIUrl":"https://doi.org/10.1093/geroni/igae082","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cross-sectional studies have shown improvements in cognition in later-born cohorts. However, it remains unclear whether these cohort effects extend beyond cognitive levels and are also detectable in the rate of age-related cognitive decline. Additionally, evidence is scarce on the presence and consistency of cohort effects throughout different segments of the distribution of cognitive trajectories.</p><p><strong>Research design and methods: </strong>This study evaluates the existence and variability of cohort effects across the entire distribution of aging-related trajectories of verbal fluency. With this purpose, we develop sex and education-adjusted longitudinal norms of verbal fluency using data from 9 waves of the English Longitudinal Study of Aging (ELSA) by fitting quantile mixed models. The effect of age was modeled using splines to assess birth cohort effects, after grouping individuals in 5-year groups from 1920 to 1950 according to their age at study entry. To test for possible cohort effects across the 10th, 50th, and 90th quantiles, the coefficients associated with the splines were allowed to vary among cohorts.</p><p><strong>Results: </strong>Our results suggest that, consistently across longitudinal quantiles, decline in verbal fluency across age is less pronounced for later-born individuals (<i>p</i> < .001), supporting the hypothesis of cohort effects. Additionally, we also found that quantiles of verbal fluency at any age are shifted upwards in later-born cohorts compared to those in earlier-born cohorts.</p><p><strong>Discussion and implications: </strong>These results enhance our understanding of cognitive decline in older adults by demonstrating that cohort effects on cognition are observable both cross-sectionally and longitudinally, affecting the entire range of verbal fluency trajectories.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The High Prevalence and Complexity of Over-the-Counter Medication Misuse in Older Adults.","authors":"Jason S Chladek, Aaron M Gilson, Jamie A Stone, Maria E Berbakov, Taylor L Watterson, Elin C Lehnbom, Emily L Hoffins, Katherine A Hemesath, Jukrin Moon, Lauren L Welch, Denise L Walbrandt Pigarelli, Edward C Portillo, Stephanie M Resendiz, Shiying Mai, Michelle A Chui","doi":"10.1093/geroni/igae083","DOIUrl":"10.1093/geroni/igae083","url":null,"abstract":"<p><strong>Background and objectives: </strong>Older adults (≥65 years) are the largest consumers of over-the-counter (OTC) medications and exceptionally vulnerable to the risks of these medications, including adverse drug events (ADEs). However, little is known about how older adults select and use OTCs. This is the first multisite study designed to prospectively quantify the type and intended use of OTCs selected by older adults in community pharmacies where products are purchased.</p><p><strong>Research design and methods: </strong>Older adults (<i>n</i> = 144) were recruited from 10 community pharmacies from a Midwestern health system. Participants were given hypothetical symptoms and asked to select one or more OTCs for self-treatment. They were asked to report how they would use the products at symptom onset and when symptoms persisted or worsened. They also reported their current medication list and health conditions. Participants' OTC selections were evaluated for 4 types of misuse: drug-age, drug-drug, drug-disease, and drug-label.</p><p><strong>Results: </strong>Of the 144 participants, 114 (79%) demonstrated at least one type of misuse when describing how they would use their OTC selections at symptom onset. Drug-drug and drug-label misuse had the highest prevalence. Overall, 26 (18%) and 28 (19%) participants showed only drug-drug or drug-label misuse, respectively. Notably, 55 (38%) of participants demonstrated misuse in 2 or more misuse categories. Misuse potential was exacerbated when participants described treating persistent or worsening symptoms.</p><p><strong>Discussion and implications: </strong>The results highlight the high prevalence and complexity of OTC misuse in older adults and the need for additional work to improve OTC safety.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Isolation and Healthcare Utilization in Older Adults Living With Dementia and Mild Cognitive Impairment in the United States.","authors":"Mairead M Bartley, Jennifer L St Sauver, Darrell R Schroeder, Nandita Khera, Joan M Griffin","doi":"10.1093/geroni/igae081","DOIUrl":"10.1093/geroni/igae081","url":null,"abstract":"<p><strong>Background and objectives: </strong>Social isolation is commonly experienced by older people and is associated with adverse health outcomes. Little is known about the influence of social isolation on the risk of acute care utilization among people living with mild cognitive impairment (MCI) or dementia. Our objective was to investigate the impact of social isolation on the risk of death, hospitalization, and emergency department (ED) use among people living with MCI or dementia who are followed in our Community Internal Medicine practice at Mayo Clinic, Rochester, Minnesota.</p><p><strong>Research design and methods: </strong>We included people living with MCI or dementia, 55 years and older, who had a clinic visit between June 1, 2019, and June 30, 2021, and who had completed questions about social connections. The risk of death, hospitalization, and ED use was examined by levels of social connection (socially isolated, moderately isolated, moderately integrated, or socially integrated).</p><p><strong>Results: </strong>Of 2,320 people included (1,010 with MCI and 1,310 with dementia), 455 (19.6%) were classified as socially isolated and 591 (25.5%) were moderately isolated. Compared with those who were socially integrated, people who were socially isolated were at higher risk of death, hospitalization, and ED visits (<i>p</i> < .001).</p><p><strong>Discussion and implications: </strong>Social isolation is associated with an increased risk of acute health care utilization and death in people living with MCI or dementia. Interventions to address social isolation in this population are needed.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}