Innovation in Aging最新文献

{"title":"Navigating Challenges and Opportunities in Community-Based Interventions for Promoting Active Aging: A Systematic Review of the Roles of Technology.","authors":"Fangyuan Chang, Gubing Wang, Zhenyu Gu","doi":"10.1093/geroni/igae077","DOIUrl":"10.1093/geroni/igae077","url":null,"abstract":"<p><strong>Background and objectives: </strong>Researchers from different fields are increasingly interested in incorporating technology into community-based interventions that promote active aging. Yet, there lacks a comprehensive understanding of technology roles, posing challenges for designers seeking to maximize the intended impacts of such interventions. This systematic review aims to fill the gap by examining existing community-based interventions that integrate digital technologies to promote active aging.</p><p><strong>Research design and methods: </strong>Thirteen studies were screened, with a total of 14 interventions examined, following the PRISMA Guideline.</p><p><strong>Results: </strong>The challenges in designing and operating community-based interventions, the roles of technology in the interventions, and the caveats of utilizing technology during the process were identified. The review emphasizes the importance of overcoming challenges in community-based interventions and leveraging technology to enhance the intended impacts.</p><p><strong>Discussion and implications: </strong>The findings underscore the need to understand technology's nuanced roles in community-based interventions for active aging. The article provides a starting point for accumulating knowledge and practice in utilizing technology to navigate the challenges and opportunities encountered in such interventions. It also sheds light on a notable gap: the lack of innovative and strategic approaches that harness digital interventions appropriately in community-based interventions. This emphasizes a crucial requirement for guidelines to assist designers, policymakers, and community staff in integrating technology appropriately into community-based interventions or implementing interventions that incorporate digital technologies at the community level.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Based Sit-to-Stand Analysis for Mobility Assessment in Middle Age.","authors":"Roee Hayek, Itai Gutman, Guy Baranes, Yaniv Nudelman, Shmuel Springer","doi":"10.1093/geroni/igae079","DOIUrl":"10.1093/geroni/igae079","url":null,"abstract":"<p><strong>Background and objectives: </strong>Mobility can decline in middle age and growing evidence highlights the importance of assessing mobility at this stage of life. Smartphone-based accelerometry during sit-to-stand has been shown to identify mobility impairments, but its utility in detecting subtle mobility deterioration in middle age has not been tested. This study aimed to examine whether smartphone-based accelerometry data measured during sit-to-stand tests performed on a regular chair and a cushioned sofa could be useful for detecting subtle changes in mobility in middle age.</p><p><strong>Research design and methods: </strong>Twenty-three young (25.0 ± 2.5 years), 25 middle-aged (52.0 ± 5.2 years), and 17 older adults (70.0 ± 4.1 years) performed the 5-times sit-to-stand test on both a standard chair and a sofa. A smartphone attached to the participants' lower back was used to measure lower-limb muscle power, maximal vertical velocity (MVV) during rising, the duration of the total task and the subphase of transition from sitting to standing (SiToSt), and repetition variability using the dynamic time warping method.</p><p><strong>Results: </strong>Middle-aged adults had reduced lower-limb muscle power compared to young adults (5.25 ± 1.08 vs 6.19 ± 1.38 W/kg, <i>p</i> = .034), being more pronounced on the sofa (6.23 ± 1.61 vs 8.08 ± 2.17 W/kg, <i>p</i> = .004). Differences between middle-aged and young adults in terms of MVV (<i>p</i> = .011) and SiToSt duration (<i>p</i> = .038) were only detected on the sofa, and the middle-aged adults showed less variability compared to the older adults on the chair (<i>p</i> = .018). There was no difference in total task duration between the middle-aged group and the young or older adults in either condition.</p><p><strong>Discussion and implications: </strong>Most common tests are limited in their ability to detect early mobility deterioration in midlife due to a ceiling effect. Our results, which show the potential of smartphone-based sit-to-stand assessment in detecting subtle mobility decline in midlife, could serve as a screening tool for this purpose.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Polysocial Approach in Exploring Racial and Ethnic Differences in Dementia and Cognitive Decline Among U.S. Older Adults: Health and Retirement Study.","authors":"Yongjing Ping, Michelle C Odden, Xi Chen, Matthew Prina, Hanzhang Xu, Hao Xiang, Chenkai Wu","doi":"10.1093/geroni/igae078","DOIUrl":"https://doi.org/10.1093/geroni/igae078","url":null,"abstract":"<p><strong>Background and objectives: </strong>The racial or ethnic disparity in the burden of dementia exists among older adults in the United States, whereas gaps remain in understanding the synergic effect of multiple social determinants of health on diminishing this disparity. We aim to build a polysocial score for dementia and investigate the racial or ethnic difference in dementia risk among older persons with different polysocial score categories.</p><p><strong>Research design and methods: </strong>In this prospective cohort study, we utilized longitudinal data from the Health and Retirement Study in the United States recruiting 6 945 participants aged ≥65 years who had data on 24 social determinants of health in 2006/2008. The dementia status of participants was measured by a modified version of the Telephone Interview of Cognitive Status. The stepwise Cox regression was applied to select social determinants of health associated with incident dementia to construct a polysocial score. The multivariable Poisson model and linear mixed model were utilized to investigate the associations between polysocial score and incident dementia and cognitive decline, respectively.</p><p><strong>Results: </strong>Eight social determinants of health were used to build the polysocial score. Non-Hispanic Black older participants had a higher incidence rate (incidence rate difference [IRD] = 22.7; 95% confident interval [95% CI] = 12.7-32.8) than non-Hispanic White older adults in the low polysocial score, while this difference was substantially attenuated in the high polysocial score category (IRD = 0.5; 95% CI = -6.4 to -7.5). The cognitive decline of non-Hispanic older Black adults with high polysocial score was 84.6% slower (averaged cognitive decline: non-Hispanic White: -2.4 [95% CI = -2.5 to -2.3] vs non-Hispanic Black: -1.3 [95% CI = -1.9 to -0.8]) than that of non-Hispanic older White persons.</p><p><strong>Discussion and implications: </strong>These findings may help comprehensively understand and address racial and ethnic disparities in dementia risk and may be integrated into existing dementia prevention programs to provide targeted interventions for community-dwelling older adults with differentiated social disadvantages.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Asymmetric Spillover Effects of Retirement on Disability: Evidence From China.","authors":"Anying Bai, Zhuang Hao, Huihui Cheng, Simiao Chen, Yu Jiang","doi":"10.1093/geroni/igae074","DOIUrl":"10.1093/geroni/igae074","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recent research has explored the spillover effects of retirement on spousal well-being, yet limited attention has been given to the short-term impact on spousal disability. This study explored the asymmetric spillover impact of retirement on spouses' disability severity among a national cohort of urban residents in China.</p><p><strong>Research design and methods: </strong>Utilizing 4 waves of data (2011-2018) from the China Health and Retirement Longitudinal Survey, we employ a nonparametric regression discontinuity design to estimate the short-term effect of retirement on spousal disability severity. Disability is assessed based on their ability to perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Furthermore, we conduct heterogeneity analysis stratified by factors such as the husband's retirement status, health conditions, lifestyle behaviors, and the wife's educational level. Additionally, we explore potential mechanisms including changes in health behaviors, emotions, and disease diagnoses.</p><p><strong>Results: </strong>Our findings indicate that wives' retirement has a significant favorable short-term effect on husbands' ADL scores, with a magnitude of -0.644 points (-9.78% relative to baseline). A significant beneficial effect of wives' retirement on the prevalence of husbands' difficulty in dressing, bathing, and eating was observed with substantial magnitudes of 0.075, 0.201, and 0.051 points, respectively. Various heterogeneity analyses and sensitivity tests confirmed the robustness of our results. The positive spillover effect of wives' retirement likely results from reduced negative emotions in husbands. In contrast, husbands' retirement does not affect the prevalence of ADL/IADL disability in their wives.</p><p><strong>Discussion and implications: </strong>Underscoring the gender asymmetry in the effects of spousal retirement on disability, this study emphasizes the need for tailored policies considering men's and women's distinct disability experiences.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being Under-Benefited and Perceived Stress in the Relationship Between Aging Parents and Adult Children: The Moderating Role of Empathy.","authors":"Da Jiang, Zewen Huang, Chi-Kin John Lee","doi":"10.1093/geroni/igae075","DOIUrl":"10.1093/geroni/igae075","url":null,"abstract":"<p><strong>Background and objectives: </strong>Previous studies examining the relationship between being under-benefited and stress among aging parents and their adult children have yielded mixed findings. Few studies have examined whether this positive association can be alleviated by state-level or trait-level factors. Given the positive effects of empathy on interpersonal exchanges, we tested the moderating role of empathy on the relationship between being under-benefited and perceived stress among aging parents and adult children in this 14-day diary study.</p><p><strong>Research design and methods: </strong>A sample of 99 pairs of parents (<i>M</i> _age = 50.01 years, <i>SD</i> _age = 4.53 years; 79.8% female) and children (<i>M</i> _age = 22.38, <i>SD</i> _age = 3.49; 85.9% female) were recruited reported their level of being under-benefited in the exchange with their parent/child, perceived stress, and empathy as an affective state on a daily basis for 14 consecutive days, after completing a pretest which measured their trait empathy and demographic information.</p><p><strong>Results: </strong>For both parents and children, the positive under-benefited-stress association was only significant when they reported lower affective empathy on a daily basis. The association between the level of being under-benefited and stress was negative when children reported greater affective empathy on a daily basis. Children reported more perceived stress on the days their parents reported a greater level of being under-benefited. Such association was only significant in children with lower trait empathy. The negative association between children's being under-benefited and parents' perceived stress was only significant in parents with higher trait empathy.</p><p><strong>Discussion and implications: </strong>These findings highlight the importance of empathy as a daily affect and a trait in the relationship between daily exchanges and mental health in the intergenerational contexts between aging parents and adult children.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Somatosensory Games on Heart Rate Variability and Sleep-Related Biomarkers in Menopausal Women With Poor Sleep Quality.","authors":"Yi-Yuan Lin, Yi-Hung Liao, Hua Ting, Kunanya Masodsai, Chi Chen","doi":"10.1093/geroni/igae072","DOIUrl":"10.1093/geroni/igae072","url":null,"abstract":"<p><strong>Background and objectives: </strong>The aim of this study was to investigate the effects of 12-week somatosensory games on heart rate variability and sleep-related biomarkers in middle-aged women with poor sleep quality.</p><p><strong>Research design and methods: </strong>Twenty-nine women with poor sleep quality were recruited as participants randomly assigned into ring fit adventure exergame group (RFA, <i>n</i> = 15) and control group (CON, <i>n</i> = 14). The RFA group received ring fit adventure exergame for 60 min each time, 2 times a week, for 12 weeks. The CON group was not allowed to participate in intervention activities during the study period. Heart rate variability, sleep quality, cortisol, serotonin, and high-sensitive C-reactive protein were measured before and after the 12-week intervention.</p><p><strong>Results: </strong>The Pittsburgh Sleep Quality Index total score in the RFA group was significantly lower compared with the CON group. The value of the standard deviation of normal NN intervals and the root mean square of the successive RR Differences were significantly increased in the RFA group, when compared with the CON group. The change in the logarithm of high frequency (log HF) was significantly higher and change in the logarithm of low frequency to high frequency ratio (log LF/HF) was significantly lower in the RFA group, when compared to the CON group. The change level of serotonin in the RFA group was significantly higher compared with the CON group.</p><p><strong>Discussion and implications: </strong>The results suggest that somatosensory games might improve sleep quality, increase serotonin level, and decrease sympathetic nerve activities in middle-aged women with poor sleep quality.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional Care Poverty Among East Asian and Nordic Older Adults.","authors":"Yueh-Ching Chou, Jiby Mathew Puthenparambil, Teppo Kröger, Christy Pu","doi":"10.1093/geroni/igae076","DOIUrl":"10.1093/geroni/igae076","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study uses the care poverty framework, focusing on both individuals and structures. In this context, structures are represented by 2 welfare states: Taiwan, an East Asian welfare system and Finland, a Nordic welfare state. This study explores multidimensional care poverty rates and examines 3 realms of individual factors (health status, sociodemographic factors, and care support availability) among older adults in these long-term care (LTC) models.</p><p><strong>Research design and methods: </strong>We analyzed data from the 2019 Taiwan Longitudinal Study on Ageing Survey and the 2020 Daily Life and Care in Old Age Survey in Finland to compare the rates and factors of care poverty in these 2 culturally and structurally different countries.</p><p><strong>Results: </strong>Our analysis revealed different rates of care poverty in personal, practical, and socioemotional care needs in the 2 countries. Under a familistic welfare regime, Taiwanese older adults had higher personal care poverty rates than their Finnish counterparts. Those living alone faced more personal and practical care poverty. Conversely, Finnish older adults, under the Nordic welfare model, experienced more practical and socioemotional care poverty. Those with high care needs and disadvantaged social status and support were more likely to experience personal and practical care poverty. Socioemotional care poverty varied with the availability of support and health status in both countries.</p><p><strong>Discussion and implications: </strong>The study highlights the impact of 2 LTC policies and cultures on older adults' multidimensional care poverty, identifying disadvantaged older adults under different welfare-transforming LTC models. Taiwan's budget-constrained LTC policies and high family reliance contrast with Finland's inadequate attention to the practical and socioemotional needs of its aging population. This study suggests that holistic LTC policies are needed in both countries to improve the well-being of older adults with limited support and health issues.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Employment Transitions and Health Outcomes in Later Life: Evidence from China","authors":"Ting Hu, Yu-Chih Chen, Cal J. Halvorsen","doi":"10.1093/geroni/igae073","DOIUrl":"https://doi.org/10.1093/geroni/igae073","url":null,"abstract":"\u0000 \u0000 \u0000 Self-employment is a vital alternative to waged employment for older workers. Recent research has shown that employment transitions frequently occur when individuals approach retirement. However, evidence of how older people’s health changes when they switch between self- and waged employment is lacking, particularly outside Western contexts. To address this research gap, we explored the health impact of employment transitions for the older working population in China by hukou (urban or rural household registration status), region, and education.\u0000 \u0000 \u0000 \u0000 We employed fixed effect models to examine the impact of employment transitions on cognitive, mental, and physical health and life satisfaction drawing on data from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study (N=4,606). Given China’s unique context, we analyzed the results of agricultural and non-agricultural work separately.\u0000 \u0000 \u0000 \u0000 Individuals transitioning into or remaining in self-employment had lower self-rated health and life satisfaction than those remaining in waged employment. There was no significant difference in cognitive functioning or depressive symptoms. Additionally, those who transitioned from self-employment into waged employment rated their health worse than those who remained in waged employment. The health impacts were more apparent for agricultural than non-agricultural self-employment, particularly for older workers living in urban regions with rural hukou and lower education levels.\u0000 \u0000 \u0000 \u0000 Most older Chinese transitioning into or staying self-employed are or were pushed into self-employment due to their low human capital and socioeconomic status, which affects their subsequent health. Pension reform and policies supporting older adults to stay in the workforce could help close the economic and health gaps between rural and urban older adults.\u0000","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Employment Transitions and Health Outcomes in Later Life: Evidence from China","authors":"Ting Hu, Yu-Chih Chen, Cal J. Halvorsen","doi":"10.1093/geroni/igae073","DOIUrl":"https://doi.org/10.1093/geroni/igae073","url":null,"abstract":"\u0000 \u0000 \u0000 Self-employment is a vital alternative to waged employment for older workers. Recent research has shown that employment transitions frequently occur when individuals approach retirement. However, evidence of how older people’s health changes when they switch between self- and waged employment is lacking, particularly outside Western contexts. To address this research gap, we explored the health impact of employment transitions for the older working population in China by hukou (urban or rural household registration status), region, and education.\u0000 \u0000 \u0000 \u0000 We employed fixed effect models to examine the impact of employment transitions on cognitive, mental, and physical health and life satisfaction drawing on data from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study (N=4,606). Given China’s unique context, we analyzed the results of agricultural and non-agricultural work separately.\u0000 \u0000 \u0000 \u0000 Individuals transitioning into or remaining in self-employment had lower self-rated health and life satisfaction than those remaining in waged employment. There was no significant difference in cognitive functioning or depressive symptoms. Additionally, those who transitioned from self-employment into waged employment rated their health worse than those who remained in waged employment. The health impacts were more apparent for agricultural than non-agricultural self-employment, particularly for older workers living in urban regions with rural hukou and lower education levels.\u0000 \u0000 \u0000 \u0000 Most older Chinese transitioning into or staying self-employed are or were pushed into self-employment due to their low human capital and socioeconomic status, which affects their subsequent health. Pension reform and policies supporting older adults to stay in the workforce could help close the economic and health gaps between rural and urban older adults.\u0000","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life","authors":"F. Lin, Jiefeng Luo, Yiqun Zhu, H. Liang, Dianwu Li, Duoduo Han, Qinyu Chang, Pinhua Pan, Yan Zhang","doi":"10.1093/geroni/igae070","DOIUrl":"https://doi.org/10.1093/geroni/igae070","url":null,"abstract":"\u0000 \u0000 \u0000 Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent.\u0000 \u0000 \u0000 \u0000 We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank. The early life factors (e.g., maternal smoking, breastfeeding, birth weight, and comparative body size and height to peers at age 10) were measured. The regression coefficients (β) and 95% confidence interval (CI) were applied to assess the link of the early life factors and TL in adulthood. Flexible parametric survival models incorporated age to calculate the relationship between early life factors and life expectancy.\u0000 \u0000 \u0000 \u0000 Exposure to maternal smoking, lack of breastfeeding, low birth weight, and shorter height compared to peers at age 10 were identified to be associated with shorter TL in middle and older age according to the large population-based study with 197,504 participants. Individuals who experienced more than three adverse early life factors had the shortest TL in middle and late life (β = −0.053; 95% CI, −0.069 to −0.038; p < 0.0001), as well as an average of 0.54 years of life loss at the age of 45 and 0.49 years of life loss at the age of 60, compared to those who were not exposed to any early life risk factors.\u0000 \u0000 \u0000 \u0000 Early life factors including maternal smoking, non-breastfed, low birth weight, and shorter height compared to peers at age 10 were associated with shorter TL in later life. In addition, an increased number of the aforementioned factors was associated with a greater likelihood of shorter TL in adulthood, as well as a reduced life expectancy.\u0000","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}