Innovation in Aging最新文献_第10页

PHYSICAL CAPACITY AS MARKER FOR RATE OF AGING IN MID LIFE 体能是中年衰老速度的标志

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.0913

Roy Tzemah-Shahar, M. Agmon

{"title":"PHYSICAL CAPACITY AS MARKER FOR RATE OF AGING IN MID LIFE","authors":"Roy Tzemah-Shahar, M. Agmon","doi":"10.1093/geroni/igad104.0913","DOIUrl":"https://doi.org/10.1093/geroni/igad104.0913","url":null,"abstract":"Abstract Biological age captures the heterogeneity of aging by providing an estimation for rate of aging. As an alternative to the widely investigated laboratory biomarkers of aging, behavioral functional markers of physical capacity may offer a feasible alternative for identifying individuals at risk for negative aging trajectory. We aimed to examine the associations of different functional tests both together and as a composite score of physical capacity with rate of aging. We conducted a cross-sectional study, with midlife adults (age ~45) reporting being able to perform leisure physical exercise. Biological age was estimated using the Klemera-Doubal method and a set of physiological biomarkers; rate of aging, ∆Age, was defined as the difference between age and estimated biological age. Physical capacity was measured using a testing battery of 15 functional tests linked with six physical capacity domains. 116 participants completed the testing battery. For women, better results in terms of strength, flexibility, cardiorespiratory fitness, and balance tests were negatively correlated with ∆Age (r=0.38-0.29, p<0.05); for men, beyond these tests, agility was also negatively correlated with ∆Age (r=0.27-0.59, p<0.05). A sex-standardized composite score of physical capacity was negatively associated with ∆Age after controlling for chronological age, smoking, and education (r=-0.437, p=0.007; r=-0.491, p<0.001 for women and men respectively). The suggested physical capacity battery offers a functional assessment for ∆Age. Higher physical capacity metrics correlate with smaller ∆Age, corresponding with younger biological age. Measuring physical capacity may help to assess aging trajectory and offer a suitable behavioral intervention goal.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"228 ","pages":"274 - 275"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138991830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF STEREOLOGY METHODS FOR ASSESSING AGE-RELATED EFFECTS ON IMMUNOSTAINED BRAIN CELLS 比较立体学方法，评估年龄对免疫染色脑细胞的影响

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.2232

Grant Denham, Saeed S. Alahmari, Aiden Anderson, Krystal Sanchez, Dominick Dag, Lawrence Hall, Dmitry Goldgof, Peter Mouton

{"title":"COMPARISON OF STEREOLOGY METHODS FOR ASSESSING AGE-RELATED EFFECTS ON IMMUNOSTAINED BRAIN CELLS","authors":"Grant Denham, Saeed S. Alahmari, Aiden Anderson, Krystal Sanchez, Dominick Dag, Lawrence Hall, Dmitry Goldgof, Peter Mouton","doi":"10.1093/geroni/igad104.2232","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2232","url":null,"abstract":"Abstract The primary benefit of stereology methods is quantification of well-stained biological objects in tissue sections with the ability to adjust sampling intensity to achieve desired levels of precision. The advent of hand-crafted algorithms and artificial intelligence-based deep learning (DL) provides an opportunity for more standardized collection of stereology data with enhanced efficiency and higher reproducibility compared to state-of-the-art manual stereology. We contrasted and compared the performance of four manual, semi-automatic, and fully automatic approaches for generating data for total number of Neu-N immunostained neurons in neocortex (NCTX) in the mouse brain. The gold standard for these studies was manual counts using the state-of-the-art optical fractionator method on 3-D reconstructed serial z-axis image stacks through a known tissue volume (disector stacks). To allow for direct methodological comparisons on the same images, disector stacks were automatically converted into extended depth of field (EDF) images in which all neurons in the disector stack were imaged at each cell’s maximal plane of focus. Total number of Neu-N neurons on the same EDF images were counted by a fully automatic hand-crafted method [automatic segmentation algorithm (ASA)] and a semi-automatic method [ASA counts manually corrected for false positives and negatives]. All comparison counts were done using unbiased frames and counting rules with total counts of NeuN-immunostained neurons by the optical fractionator method. The results were comparable across methods with wide variations in throughput efficiency and inter-rater agreement. These results are discussed with respect to applications to experimental studies of brain aging, neuroinflammation and neurodegenerative disease.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"184 ","pages":"687 - 687"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OLDER WOMEN ENTREPRENEURS ARE DRIVEN BY WANT RATHER THAN NEED 老年女企业家的动力来自需求而非需要

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.1920

L. Choi-allum

{"title":"OLDER WOMEN ENTREPRENEURS ARE DRIVEN BY WANT RATHER THAN NEED","authors":"L. Choi-allum","doi":"10.1093/geroni/igad104.1920","DOIUrl":"https://doi.org/10.1093/geroni/igad104.1920","url":null,"abstract":"Abstract During the COVID-19 pandemic, women ages 50+ pursued their dream of starting a business. This study contacted 278 women ages 50-plus by phone and online, examining the drivers and barriers of women entrepreneurs. Over a quarter (27%) of women said they always wanted to start a business, and 19% said they did it to follow their passion; another 17% were pursuing additional income, and 11% wanted flexible work options. Age, and perhaps the value of experience, has been an advantage in business ownership. Women entrepreneurs age 50-plus were less likely to have faced financial challenges since starting their business, with over two in five (45%) avoiding such challenges, compared to 29% of women entrepreneurs in their 40s. Nearly seven in 10 women (69%) surveyed poured their personal savings into their start-up. In addition, two in three agree that they face unique challenges in trying to access capital for their business that are different from men. Despite these challenges, most women were optimistic about their entrepreneurial path. The majority of women (97%) agreed that they made the right decision in starting their business – with about two in five (39%) saying their business is doing better than expected compared to when they first started. Respondents say they need resources on marketing, recruiting and hiring staff, and financing. And over two in five say they have not taken any type of training. Increasing awareness of business supports, funding sources, and training opportunities will help women as they grow their business.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"174 ","pages":"586 - 587"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INTRINSIC CAPACITY OF OLDER ADULTS IN SINGAPORE USING WHO INTEGRATED CARE FOR OLDER PEOPLE (ICOPE) FRAMEWORK 利用老年人综合护理（ICOPE）框架研究新加坡老年人的内在能力

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.2875

Carol Ma, Angela Y M Leung, Denise Chua, Wai Choo Teo, Laura Bee Gek Tay, Wai Chong Ng

{"title":"INTRINSIC CAPACITY OF OLDER ADULTS IN SINGAPORE USING WHO INTEGRATED CARE FOR OLDER PEOPLE (ICOPE) FRAMEWORK","authors":"Carol Ma, Angela Y M Leung, Denise Chua, Wai Choo Teo, Laura Bee Gek Tay, Wai Chong Ng","doi":"10.1093/geroni/igad104.2875","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2875","url":null,"abstract":"Abstract The World Health Organization (WHO) proposed the Integrated Care for Older People (ICOPE) approach to guide health systems in better supporting the intrinsic capacity and functional ability of older adults to enable healthy aging (Briggs et al., 2018; de Carvalho et al., 2019). This approach is aligned with Singapore’s Healthier SG initiative, which aims to build a good healthcare system that promotes better health and quality of life for everyone. Recent studies have shown that older adults experience intrinsic capacity decline in various countries, including Singapore, highlighting the importance of targeted interventions to maintain functionality and quality of life in old age (Beard et al., 2019; Liu et al., 2021; Tay et al., 2022). In this cross-sectional study, 367 participants were assessed by 43 ICOPE assessors, of whom 77.4% (n=284) had impairments in intrinsic capacity. The three most prevalent intrinsic capacity impairments were visual impairment (42%), hearing loss (33.5%), and cognitive decline (31.3%), followed by limited mobility (24.3%), malnutrition (16.1%), and depressive symptoms (16.1%). Furthermore, 22.6% of participants were unaware of any elderly care services available in the community, and 8.2% did not know where to seek help in case of problems. These findings emphasize the need for ICOPE assessments at the community level to promote early detection of intrinsic capacity impairments and interventions. More discussion of the care pathway, together with health professionals, older adults, and caregivers, should be the next step to offer diagnostic assessment and guide self-management of intrinsic capacity impairment for among older adults.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"58 12","pages":"893 - 894"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAREER SELF-MANAGEMENT OF LATE LIFE WORK 晚年工作的职业自我管理

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.1105

Laura K. M. Donorfio

引用次数: 0

ON THE FRONTLINES: TRAINING A DEMENTIA CAREGIVING WORKFORCE IN CALIFORNIA 在前线：培训加州痴呆症护理人员队伍

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.3507

Brittney Pond, Corinne Eldridge, Mel Neri, Matthew Beld, Leslie Ross, Suzanna Martinez, Brooke Hollister, J. Yeh

{"title":"ON THE FRONTLINES: TRAINING A DEMENTIA CAREGIVING WORKFORCE IN CALIFORNIA","authors":"Brittney Pond, Corinne Eldridge, Mel Neri, Matthew Beld, Leslie Ross, Suzanna Martinez, Brooke Hollister, J. Yeh","doi":"10.1093/geroni/igad104.3507","DOIUrl":"https://doi.org/10.1093/geroni/igad104.3507","url":null,"abstract":"Abstract Direct care workers who provide in-home care – such as caregivers hired by consumers of California’s Medicaid-funded In-Home Supportive Services (IHSS) program – are well positioned to observe changes in their consumer’s cognition, health, or behaviors. This proximity to consumers better allows for reporting to healthcare partners, which may reduce risk of emergency department visits, hospitalizations, and other adverse outcomes that are disproportionately high among people living with Alzheimer’s disease and related dementias (ADRD). Despite their vital role in supporting people living with ADRD, IHSS caregivers receive minimal formal training for their unique position. To address this training gap, the IHSS+ ADRD Training Project is a five-year effort funded by the California Department of Public Health to train 720 IHSS caregivers in Alameda and Los Angeles counties, with classes in English, Spanish, Cantonese, and Mandarin. To date, 582 IHSS caregivers have been trained. Using a pre-posttest design, our preliminary findings indicate statistically significant increases in dementia knowledge and self-efficacy that could bolster caregiver’s skills. These results also reveal that IHSS caregivers value training opportunities to better support their consumers. Correlations between caregiver training outcomes and healthcare utilization patterns of their consumers were further examined by evaluating administrative data before and after the training. The results need to be further understood in the context of COVID-19 and the ADRD illness trajectory. Implications include expanding long-term funding for multi-week training programs, which aligns with the California Master Plan for Aging’s goal to support and create one million high-quality caregiving jobs by 2030.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"752 ","pages":"1092 - 1092"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE CRUCIAL ROLE OF LEPTIN IN MEDIATING VISCERAL ADIPOSITY-ASSOCIATED AGING PROCESS 瘦素在内脏脂肪相关衰老过程中的关键作用

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.1748

Shangang Zhao

{"title":"THE CRUCIAL ROLE OF LEPTIN IN MEDIATING VISCERAL ADIPOSITY-ASSOCIATED AGING PROCESS","authors":"Shangang Zhao","doi":"10.1093/geroni/igad104.1748","DOIUrl":"https://doi.org/10.1093/geroni/igad104.1748","url":null,"abstract":"Abstract Visceral adiposity is a hallmark of aging and an important contributor to reduced healthspan and lifespan. The factors that mediate the detrimental effects of aging-associated visceral adiposity are poorly identified. Here, we have shown that hyperleptinemia, induced by a leptin transgenic cassette in adipose tissue, accelerates diet-induced obesity and glucose intolerance. In addition, hyperleptinemia promotes adipose tissue inflammation. Chronic culture of stromal vascular fraction (SVF) with leptin reduces the capacity of differentiation and increases inflammation. Moreover, chronic hyperleptinemia in fat depots accelerates the development senescent cells to establish a senescent-associated secretory phenotype (SASP), including increased local inflammation. This result indicates hyperleptinemia may be a “unidentified” driver for cellular senescence. Moreover, deletion of leptin in visceral fat depots significantly reduces visceral adiposity and senescent-associated secretory phenotype (SASP). These results highlight the crucial role of leptin in establishing SASP and targeting leptin may be a novel approach to alleviate aging-associated metabolic syndromes.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"723 ","pages":"533 - 533"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLINICAL VERSUS SUBJECTIVE PREDICTORS OF DISTRESS AND HEALTH SATISFACTION AND THE MODERATING ROLE OF PERCEIVED CONTROL 困扰和健康满意度的临床与主观预测因素以及感知控制的调节作用

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.2532

G. Seçkin

{"title":"CLINICAL VERSUS SUBJECTIVE PREDICTORS OF DISTRESS AND HEALTH SATISFACTION AND THE MODERATING ROLE OF PERCEIVED CONTROL","authors":"G. Seçkin","doi":"10.1093/geroni/igad104.2532","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2532","url":null,"abstract":"Abstract Coping with cancer in old age and a general decline in physical health may result in a lack of control over health. Cancer diagnosis tends to be associated with fear, uncertainty, and loss. It also challenges one’s assumptions about the sense of the self and bodily image. This paper explores health perceptions (distress with somatic symptoms, treatment side effects, and satisfaction with health status) in a sample (N=350) of older individuals who reported being treated with cancer (M age=50.23, S.D. =10.91). Three models of hierarchical multiple regressions were performed to estimate the impact of sociodemographic, medical, and psychosocial variables and perceived control over health on subjective health indicators. The results indicated that lower income was associated with greater distress with physical symptoms (Slope = -.12; B= -.17, p =.002), older age was associated with less distress with cancer treatment side effects (Slope = -.01; B= -.12, p =.019) and gender (female) were negatively associated with satisfaction with health status (Slope = -.36; B= -.15, p =.002). Even though the higher stage of cancer was a significant covariate for greater distress with somatic symptoms (Slope = .12; B= .17, p =.001), it was not a significant covariate for distress with treatment side effects and satisfaction with health status. Perceived control over health significantly moderated the association between research covariates and satisfaction with health. These findings suggest that assessing differential aspects of self-rated health may provide health professionals with important information to supplement their diagnosis to understand the patient’s illness experience better.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"431 ","pages":"784 - 784"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LEVERAGING A BEHEMOTH: TRANSLATING VA FAMILY CAREGIVER RESEARCH TO POLICY AND PRACTICE 利用庞然大物：将瓦努阿图家庭照顾者研究转化为政策和实践

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.0825

Ranak Trivedi

引用次数: 0

MORE ADULT AMERICANS ARE AT NUTRITIONAL RISK SINCE THE COVID-19 PANDEMIC 自科维德-19 大流行以来，更多的美国成年人面临营养风险

IF 7 3区医学

Innovation in Aging Pub Date : 2023-12-01 DOI: 10.1093/geroni/igad104.2265

L. Monroe-Lord, A. Ardekani, Cassidy Whitman

{"title":"MORE ADULT AMERICANS ARE AT NUTRITIONAL RISK SINCE THE COVID-19 PANDEMIC","authors":"L. Monroe-Lord, A. Ardekani, Cassidy Whitman","doi":"10.1093/geroni/igad104.2265","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2265","url":null,"abstract":"Abstract The nutritional status of individuals has changed since COVID-19 pandemic due to disruptions in social, economic, and psychological factors. This study determines how nutritional status has changed since COVID-19 among American adults. The second aim is to examine which age range group was at a higher risk of nutritional status due to the pandemic. The study design was cross-sectional, with 10,035 participants aged 40-100 who answered a survey distributed by Qualtrics. Nutritional status was measured twice before and since the COVID-19 pandemic by the Dietary Screening Tool (DST). The total DST score was calculated for each participant, which categorized them into three different groups, including “at risk,” “possible risk,” and “not at risk.” The results revealed that the mean DST score before the pandemic was 56.04 (IQR: 48.00–65.00); this score significantly decreased since COVID-19 to 55.54 (IQR: 47.00–64.00) (p <.001). Of those participants who were not at risk before COVID-19, 28.5% became either at risk or at possible risk since COVID-19. Of those participants who were at possible risk before COVID-19, 21% are now at risk since COVID-19. Almost 60% of the younger group (40-60) were at risk before COVID-19 compared to 54.8% of participants aged 61-80 and 45.8% of older participants (81-100). These percentages increased by about 2% since COVID-19 among all three age groups. As a good nutritional status reduce the risk of severe illness, these findings can help policymakers to develop heath-protecting behavior sessions against future pandemics to manage crises.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"32 ","pages":"698 - 698"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0