Debbie Ten Cate, Marieke Schuurmans, Lisette Schoonhoven, R. Ettema
{"title":"FROM MISFIT TO FIT: THE IMPACT OF NURSING PRACTICE ON COMPLEX NURSING INTERVENTION DEVELOPMENT","authors":"Debbie Ten Cate, Marieke Schuurmans, Lisette Schoonhoven, R. Ettema","doi":"10.1093/geroni/igad104.2461","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2461","url":null,"abstract":"Abstract Nurses have a key role in providing nutritional care to older adults to prevent and treat malnutrition, and stimulate health and well-being. However, evidence for nursing activities regarding nutritional care is often lacking. Therefore, intervention development is necessary. From earlier studies, an evidence-based nutritional intervention carried out by nurses appeared the best solution. The aim of this study was to outline the steps taken to develop a complex nursing intervention to prevent and treat malnutrition in older adults and the challenges faced during this stage. Following the phase of intervention development of the Medical Research Council (MRC) Framework, a systematic review, a questionnaire survey, semi-structured interviews, focus groups and participant observation were carried out. The purpose was to gather information about current nursing practice and context, the needs of future users and providers, and gain insight into the problem. The studies showed that nurses had moderate knowledge of (mal)nutrition. They gave nutritional care low prioritization during daily nursing activities. These results provided insight that the intended nursing nutritional intervention would most likely lead to a misfit with the context. To fit the intervention properly into nursing practice, it was decided to develop an educational intervention targeting nurses instead of a nutritional intervention carried out by nurses. Building proofs in context leads to challenges but is essential to prevent a misfit between complex nursing interventions and nursing practice. As an element of rigorous intervention development following systematic steps, it increases the chance of successful implementation.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138986514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DIVERSE ENVIRONMENTAL CONTEXTS AND LINKS TO LATER-LIFE WELL-BEING","authors":"Noah Webster, Markus Schafer","doi":"10.1093/geroni/igad104.0170","DOIUrl":"https://doi.org/10.1093/geroni/igad104.0170","url":null,"abstract":"Abstract The places older adults spend time have profound impacts on their well-being. As new sources of data and methods become available it is imperative to refine work in this area to guide development of interventions with the precision necessary to address persistent disparities in well-being. This symposium brings together four complementary papers that focus on diverse environmental contexts and well-being using multiple methodological approaches. Perzynski, Berg, and Dalton discuss the potential of Digital Twin Neighborhoods, i.e., digital replicas of real communities, to address health inequalities. They present findings from engagement sessions with community members about priorities, preferences, and concerns with regard to use of digital twins. Sol, Clarke and Zahodne link data from the Detroit-area Michigan Cognitive Aging Project with data from the National Neighborhood Data Archive to examine the association between neighborhood disadvantage and cognitive reserve. They show how this association differs between Black and White participants. Cho, Dunkle, and Smith use data from the Health and Retirement Study (HRS) to examine the association between later life relocation and contact frequency with adult children. They illustrate the importance of proximity and mode of contact in this association. Morris and colleagues also use HRS data to examine the extent to which stressors operating at multiple levels (interpersonal, community, and society) explain racial disparities in memory. They show these contexts together explain 11% of the racial disparity in baseline memory. These papers will be discussed by Markus Schafer who will provide an outlook for future research in this area.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138991730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PHYSICAL CAPACITY AS MARKER FOR RATE OF AGING IN MID LIFE","authors":"Roy Tzemah-Shahar, M. Agmon","doi":"10.1093/geroni/igad104.0913","DOIUrl":"https://doi.org/10.1093/geroni/igad104.0913","url":null,"abstract":"Abstract Biological age captures the heterogeneity of aging by providing an estimation for rate of aging. As an alternative to the widely investigated laboratory biomarkers of aging, behavioral functional markers of physical capacity may offer a feasible alternative for identifying individuals at risk for negative aging trajectory. We aimed to examine the associations of different functional tests both together and as a composite score of physical capacity with rate of aging. We conducted a cross-sectional study, with midlife adults (age ~45) reporting being able to perform leisure physical exercise. Biological age was estimated using the Klemera-Doubal method and a set of physiological biomarkers; rate of aging, ∆Age, was defined as the difference between age and estimated biological age. Physical capacity was measured using a testing battery of 15 functional tests linked with six physical capacity domains. 116 participants completed the testing battery. For women, better results in terms of strength, flexibility, cardiorespiratory fitness, and balance tests were negatively correlated with ∆Age (r=0.38-0.29, p<0.05); for men, beyond these tests, agility was also negatively correlated with ∆Age (r=0.27-0.59, p<0.05). A sex-standardized composite score of physical capacity was negatively associated with ∆Age after controlling for chronological age, smoking, and education (r=-0.437, p=0.007; r=-0.491, p<0.001 for women and men respectively). The suggested physical capacity battery offers a functional assessment for ∆Age. Higher physical capacity metrics correlate with smaller ∆Age, corresponding with younger biological age. Measuring physical capacity may help to assess aging trajectory and offer a suitable behavioral intervention goal.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138991830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grant Denham, Saeed S. Alahmari, Aiden Anderson, Krystal Sanchez, Dominick Dag, Lawrence Hall, Dmitry Goldgof, Peter Mouton
{"title":"COMPARISON OF STEREOLOGY METHODS FOR ASSESSING AGE-RELATED EFFECTS ON IMMUNOSTAINED BRAIN CELLS","authors":"Grant Denham, Saeed S. Alahmari, Aiden Anderson, Krystal Sanchez, Dominick Dag, Lawrence Hall, Dmitry Goldgof, Peter Mouton","doi":"10.1093/geroni/igad104.2232","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2232","url":null,"abstract":"Abstract The primary benefit of stereology methods is quantification of well-stained biological objects in tissue sections with the ability to adjust sampling intensity to achieve desired levels of precision. The advent of hand-crafted algorithms and artificial intelligence-based deep learning (DL) provides an opportunity for more standardized collection of stereology data with enhanced efficiency and higher reproducibility compared to state-of-the-art manual stereology. We contrasted and compared the performance of four manual, semi-automatic, and fully automatic approaches for generating data for total number of Neu-N immunostained neurons in neocortex (NCTX) in the mouse brain. The gold standard for these studies was manual counts using the state-of-the-art optical fractionator method on 3-D reconstructed serial z-axis image stacks through a known tissue volume (disector stacks). To allow for direct methodological comparisons on the same images, disector stacks were automatically converted into extended depth of field (EDF) images in which all neurons in the disector stack were imaged at each cell’s maximal plane of focus. Total number of Neu-N neurons on the same EDF images were counted by a fully automatic hand-crafted method [automatic segmentation algorithm (ASA)] and a semi-automatic method [ASA counts manually corrected for false positives and negatives]. All comparison counts were done using unbiased frames and counting rules with total counts of NeuN-immunostained neurons by the optical fractionator method. The results were comparable across methods with wide variations in throughput efficiency and inter-rater agreement. These results are discussed with respect to applications to experimental studies of brain aging, neuroinflammation and neurodegenerative disease.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"OLDER WOMEN ENTREPRENEURS ARE DRIVEN BY WANT RATHER THAN NEED","authors":"L. Choi-allum","doi":"10.1093/geroni/igad104.1920","DOIUrl":"https://doi.org/10.1093/geroni/igad104.1920","url":null,"abstract":"Abstract During the COVID-19 pandemic, women ages 50+ pursued their dream of starting a business. This study contacted 278 women ages 50-plus by phone and online, examining the drivers and barriers of women entrepreneurs. Over a quarter (27%) of women said they always wanted to start a business, and 19% said they did it to follow their passion; another 17% were pursuing additional income, and 11% wanted flexible work options. Age, and perhaps the value of experience, has been an advantage in business ownership. Women entrepreneurs age 50-plus were less likely to have faced financial challenges since starting their business, with over two in five (45%) avoiding such challenges, compared to 29% of women entrepreneurs in their 40s. Nearly seven in 10 women (69%) surveyed poured their personal savings into their start-up. In addition, two in three agree that they face unique challenges in trying to access capital for their business that are different from men. Despite these challenges, most women were optimistic about their entrepreneurial path. The majority of women (97%) agreed that they made the right decision in starting their business – with about two in five (39%) saying their business is doing better than expected compared to when they first started. Respondents say they need resources on marketing, recruiting and hiring staff, and financing. And over two in five say they have not taken any type of training. Increasing awareness of business supports, funding sources, and training opportunities will help women as they grow their business.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carol Ma, Angela Y M Leung, Denise Chua, Wai Choo Teo, Laura Bee Gek Tay, Wai Chong Ng
{"title":"INTRINSIC CAPACITY OF OLDER ADULTS IN SINGAPORE USING WHO INTEGRATED CARE FOR OLDER PEOPLE (ICOPE) FRAMEWORK","authors":"Carol Ma, Angela Y M Leung, Denise Chua, Wai Choo Teo, Laura Bee Gek Tay, Wai Chong Ng","doi":"10.1093/geroni/igad104.2875","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2875","url":null,"abstract":"Abstract The World Health Organization (WHO) proposed the Integrated Care for Older People (ICOPE) approach to guide health systems in better supporting the intrinsic capacity and functional ability of older adults to enable healthy aging (Briggs et al., 2018; de Carvalho et al., 2019). This approach is aligned with Singapore’s Healthier SG initiative, which aims to build a good healthcare system that promotes better health and quality of life for everyone. Recent studies have shown that older adults experience intrinsic capacity decline in various countries, including Singapore, highlighting the importance of targeted interventions to maintain functionality and quality of life in old age (Beard et al., 2019; Liu et al., 2021; Tay et al., 2022). In this cross-sectional study, 367 participants were assessed by 43 ICOPE assessors, of whom 77.4% (n=284) had impairments in intrinsic capacity. The three most prevalent intrinsic capacity impairments were visual impairment (42%), hearing loss (33.5%), and cognitive decline (31.3%), followed by limited mobility (24.3%), malnutrition (16.1%), and depressive symptoms (16.1%). Furthermore, 22.6% of participants were unaware of any elderly care services available in the community, and 8.2% did not know where to seek help in case of problems. These findings emphasize the need for ICOPE assessments at the community level to promote early detection of intrinsic capacity impairments and interventions. More discussion of the care pathway, together with health professionals, older adults, and caregivers, should be the next step to offer diagnostic assessment and guide self-management of intrinsic capacity impairment for among older adults.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Severance, Linda Edelman, Barbara Gordon, S. Luk-Jones, Jacqueline Telonidis, Jennifer Morgan
{"title":"GERIATRIC WORKFORCE ENHANCEMENT PROGRAMS AS AAA AGE-FRIENDLY INITIATIVES PARTNER","authors":"J. Severance, Linda Edelman, Barbara Gordon, S. Luk-Jones, Jacqueline Telonidis, Jennifer Morgan","doi":"10.1093/geroni/igad104.2067","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2067","url":null,"abstract":"Abstract The Health Resources and Services Administration funded 48 Geriatric Workforce Enhancement Programs (GWEPs) to partner with community-based organizations in addressing gaps in health care for older adults, promoting Age-Friendly ecosystems, and addressing social determinants of health. This paper discusses three GWEPs collaborative projects with Area Agencies on Aging (AAAs) that deliver community-based programs . The University of Utah’s GWEP, a rural AAA, the Alzheimer’s Association, and the Utah Department of Veterans and Military Affairs provided a hybrid Dementia Caregiver Conference to six counties, reaching 65 in-person attendees and 10 senior centers online. Attendees agreed the content met their educational needs, would positively influence care, and was motivation to form a caregiver coalition. The University of Louisville Trager Institute (Trager), AAA, and Kentucky Coalition for Healthy Communities provided focused regional training and sharing of community resources utilizing the Project ECHO training model for 11 AAA regions, reaching 412 home and community-based services professionals. The University of North Texas Health Science Center, AAA, and emergency management services expanded evidence-based programs in falls prevention, medication safety, and dementia caregiving, serving an additional 23 urban postal codes, rural counties, and over 1,900 individuals. These examples utilize unique community relationships and partnership strategies to identify local needs, maximize older adult and family caregiver engagement, measure outcomes, and achieve GWEP goals to educate diverse, underserved and rural communities.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PREPARING STUDENTS FOR A MULTIGENERATIONAL WORKFORCE: PERSPECTIVES FROM OLDER WORKERS AND RETIREES","authors":"Allyson Graf, Katherina A. Nikzad-Terhune","doi":"10.1093/geroni/igad104.0471","DOIUrl":"https://doi.org/10.1093/geroni/igad104.0471","url":null,"abstract":"Abstract Workforce diversity can be a major asset for personal, interpersonal, and economic development. Age diversity is prevalent with five generations currently represented in the workforce. Intergenerational tension is common, however, largely fueled by stereotypes centered on age and generation that can infiltrate all workplace processes. Working from the Age-Friendly University framework, our aim was to gather qualitative data to inform the development of a training program for college students, pairing information on age-related bias with opportunities for meaningful intergenerational exchange to mimic workplace interactions. We hosted three community-based focus groups with adults ranging from 60-69 years of age who were either currently employed or recently retired (N = 10) to discuss their intergenerational interactions in the workplace. Participants had an average of 41.06 years of work experience and worked across multiple industries, most commonly administrative work, food services, government, and healthcare. The most common theme reported was the dismissal of participants’ work experience by their younger colleagues, which some equated to a lack of respect due to their age, and others painted as a breakdown in communication. Technology was highlighted as exasperating intergenerational tensions. Participants also reported that younger colleagues often approached them for general life advice, which helped to reduce tensions. The willingness to see the value of older adults’ wisdom in general, but not specific to the work at hand, has implications for the content and structure of future career-readiness training programs. Recommendations for enhancing positive intergenerational exchanges and reducing generational tensions within the workplace will be discussed.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Taani, Yura Lee, Julie Ellis, Chi Cho, Ammar Hammouri
{"title":"SOCIAL PARTICIPATION, LONELINESS, AND CIRCADIAN RHYTHMS OF MIDDLE-AGED AND OLDER ADULTS IN TAIWAN","authors":"M. Taani, Yura Lee, Julie Ellis, Chi Cho, Ammar Hammouri","doi":"10.1093/geroni/igad104.2735","DOIUrl":"https://doi.org/10.1093/geroni/igad104.2735","url":null,"abstract":"Abstract Loneliness among middle-aged and older adults is a growing public health concern in the aging society. While social participation is known as a protective factor against loneliness, not all older adults enjoy social participation. The purpose of this study is to investigate the social participation and loneliness characteristics in communities and their association with the demographic data, health-related variables, objective sleep parameters and rest-activity circadian rhythms with a sample of 242 Taiwan community-dwelling middle-aged and older adults aged 45 to 89 years. Loneliness and social participation levels were grouped in different clusters via Two-Step Cluster Analysis. Subsequently, Chi-square test and ANOVA were performed to identify the differences between clusters with relevant variables. Results showed that five social participation-loneliness clusters were grouped: Average(40.1%), Active-Lonely(3.8%), Not Active-Lonely(13.1%),Active -Not Lonely(5.9%),Not Active -Not Lonely(37.1%). Age, employment status, property management, self-perceived health, depression, life satisfaction and relative amplitude were related to clusters. The Active-Not Lonely cluster was older, had a higher retirement percentage, and higher life satisfaction. Compared with the Not Active-Lonely cluster, the Not Active -Not Lonely cluster had more power to manage their property, felt healthier and less depressive. The Active-Lonely cluster had a high percentage of unemployment and felt unhealthier. The Not Active-Lonely cluster had the lowest relative amplitude, which meant they had weaker rest-activity circadian rhythms. Objective sleep parameters were no difference between each cluster. These findings provide the potential benefits of developing appropriate social care programs to reduce loneliness for middle-aged and older adults via objective data.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138989010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COGNITIVE BEHAVIORAL AND VIRTUAL REALITY TREATMENTS FOR INSOMNIA (CBTI AND IVR): OFF-LABEL IMPACT ON COGNITION","authors":"Christina McCrae, Melanie Stearns, Ashley Curtis","doi":"10.1093/geroni/igad104.1205","DOIUrl":"https://doi.org/10.1093/geroni/igad104.1205","url":null,"abstract":"Abstract Chronic insomnia (CI) is common in mid-to-late life and associated with hyperarousal and impaired cognition and mood. CBTi improves sleep and may also improve cognition, arousal and mood but evidence for these latter outcomes is limited. We examined these outcomes across 3 studies with different delivery platforms (telehealth, digital, VR), dosages (2 sessions, 4 sessions), and (primarily) mid-to-older CI populations (fibromyalgia, dementia caregivers). Study 1 compared 8-week CBTi vs sleep hygiene in women with fibromyalgia (n=43, Mage=44.45). Study 2 piloted 4-session web-based CBTi in caregivers (n=5, Mage=62.40). Study 3 piloted 4-session iVR (n=18, Mage=36.45). Participants completed 2-week daily diaries pre/post treatment (sleep onset latency-SOL; wake after sleep onset-WASO; total sleep time-TST) and Insomnia Severity Index-ISI. Other measures included: study 1(arousal/heart rate variability-RMSDNN), studies 1 and 3(Wisconsin Card Sort Test-WCST, Stroop), study 2(Cognitive Failures Questionnaire-CFQ, Beck Depression Inventory-BDI-II, Perceived Stress Scale). Group x time interactions (study 1) and within-group pre/post differences were examined. CBTi improved sleep across studies (ps<.05). Study 1 found and study 3 trended toward improved cognitive flexibility (WCST %perseverative errors-t(14)=2.65, p=.019 and t(10)=1.76, p=.055, respectively). Study 1 found improved attention and processing speed [Stroop reaction time(RT)-congruent trials-t(14)=2.59, p=.023], inhibition (Stroop RT-incongruent trials-t(14)=2.43, p=.031), and arousal [increased RMSDNN; F(1,41)=4.87, p=.03]. Study 2 found improved subjective cognition-CFQ (t(4)=2.44, p=.04), arousal-RMSDNN (t(4)=2.09, p=.05), and depression-BDI-II (t(4)=2.89, p=.02). CBTi improved sleep, cognition, arousal and mood in mid-to-older CI populations. Research using randomization, active controls, and follow-ups is needed to delineate temporality and explore sleep’s mechanistic contribution to cognition and other “off-label” outcomes.","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138989076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}