Modifiable Risk Factors for Alzheimer's Disease and Related Dementias Among Middle Eastern and North African Immigrants to the United States.

IF 4.9 3区医学 Q1 GERIATRICS & GERONTOLOGY

Innovation in Aging Pub Date : 2024-02-29 eCollection Date: 2024-01-01 DOI:10.1093/geroni/igae025

Tiffany B Kindratt, Laura B Zahodne, Kristine J Ajrouch, Florence J Dallo

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引用次数: 0

Abstract

Background and objectives: Modifiable risk factors across the life course play a role in the development of Alzheimer's disease and related dementias (ADRD). Studies have identified racial and ethnic disparities in ADRD risk factors. Few studies have explored the epidemiology of ADRD risk among Middle Eastern and North African (MENA) Americans, largely due to their classification as White in US national health surveys. Our aim was to estimate ADRD risk factors among MENA immigrants compared to US- and foreign-born non-Hispanic White adults.

Research design and methods: We linked cross-sectional 2000-2017 National Health Interview Survey and 2001-2018 Medical Expenditure Panel Survey data (N = 108 695; age ≥ 18 years). Modifiable risk factors for ADRD that were evaluated (yes or no) included less than ninth grade education, hearing loss, traumatic brain injury, hypertension, alcohol use, obesity, smoking, depressive symptoms, marital status, physical inactivity, and diabetes. Bivariate analysis and multivariable logistic regression were conducted. Regression models were adjusted by age and sex.

Results: Compared to US-born White adults, MENA immigrants had higher odds of reporting less than 9th grade education (OR = 1.93; 95% CI = 1.17-3.21) and psychological health concerns (OR = 1.28; 95% CI = 1.06-1.56). Compared to foreign-born White adults, MENA immigrants had higher odds of diabetes (OR = 1.48; 95% CI = 1.06-2.08) and psychological health concerns (OR = 1.24; 95% CI = 1.01-1.54).

Discussion and implications: The findings provide the first comprehensive look at potentially modifiable risk factors for ADRD among MENA immigrants based on a life course model. Without a racial/ethnic identifier for MENA individuals on a national level, ADRD risk factors among US-born MENA adults and MENA immigrants cannot be examined. More research is needed to explore these risk factors by life stage (early, midlife, and late) to further determine ADRD risk and prevention strategies for MENA Americans.

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美国中东和北非移民中阿尔茨海默病及相关痴呆症的可改变风险因素。

背景和目的：在整个生命过程中，可改变的风险因素在阿尔茨海默病和相关痴呆症（ADRD）的发展中起着一定的作用。研究发现，在 ADRD 风险因素方面存在种族和民族差异。很少有研究探讨中东和北非（MENA）裔美国人的 ADRD 风险流行病学，这主要是因为他们在美国全国健康调查中被归类为白人。我们的目的是估算中东和北非移民与在美国和外国出生的非西班牙裔白人成年人相比的 ADRD 风险因素：我们将 2000-2017 年全国健康访谈调查和 2001-2018 年医疗支出小组调查的横截面数据（N = 108 695；年龄≥ 18 岁）联系起来。评估的 ADRD 可改变风险因素（是或否）包括：教育程度低于九年级、听力损失、脑外伤、高血压、饮酒、肥胖、吸烟、抑郁症状、婚姻状况、缺乏运动和糖尿病。我们进行了二元分析和多变量逻辑回归。回归模型根据年龄和性别进行了调整：与在美国出生的白人成年人相比，中东和北非移民报告受教育程度低于 9 年级（OR = 1.93；95% CI = 1.17-3.21）和心理健康问题（OR = 1.28；95% CI = 1.06-1.56）的几率更高。与外国出生的白人成年人相比，中东和北非移民患糖尿病（OR = 1.48；95% CI = 1.06-2.08）和心理健康问题（OR = 1.24；95% CI = 1.01-1.54）的几率更高：这些研究结果首次基于生命过程模型，对中东和北非地区移民中可改变的潜在ADRD风险因素进行了全面研究。由于没有全国范围内的中东和北非个人的种族/族裔标识符，因此无法研究在美国出生的中东和北非成年人和中东和北非移民的 ADRD 风险因素。需要开展更多研究，按生命阶段（早年、中年和晚年）探讨这些风险因素，以进一步确定美国中东和北非人的 ADRD 风险和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Innovation in Aging GERIATRICS & GERONTOLOGY-

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Innovation in Aging, an interdisciplinary Open Access journal of the Gerontological Society of America (GSA), is dedicated to publishing innovative, conceptually robust, and methodologically rigorous research focused on aging and the life course. The journal aims to present studies with the potential to significantly enhance the health, functionality, and overall well-being of older adults by translating scientific insights into practical applications. Research published in the journal spans a variety of settings, including community, clinical, and laboratory contexts, with a clear emphasis on issues that are directly pertinent to aging and the dynamics of life over time. The content of the journal mirrors the diverse research interests of GSA members and encompasses a range of study types. These include the validation of new conceptual or theoretical models, assessments of factors impacting the health and well-being of older adults, evaluations of interventions and policies, the implementation of groundbreaking research methodologies, interdisciplinary research that adapts concepts and methods from other fields to aging studies, and the use of modeling and simulations to understand factors and processes influencing aging outcomes. The journal welcomes contributions from scholars across various disciplines, such as technology, engineering, architecture, economics, business, law, political science, public policy, education, public health, social and psychological sciences, biomedical and health sciences, and the humanities and arts, reflecting a holistic approach to advancing knowledge in gerontology.