Influenza and Other Respiratory Viruses最新文献

{"title":"Host Species Contribution to the Spatiotemporal Dynamics of the 2024–2025 H5N1 Epidemic in Italy","authors":"Enrico Savegnago,&nbsp;Lara Cavicchio,&nbsp;Marta Dianati,&nbsp;Angela Salomoni,&nbsp;Bianca Zecchin,&nbsp;Alessandro Sartori,&nbsp;Edoardo Giussani,&nbsp;Ana Moreno,&nbsp;Gianpiero Zamperin,&nbsp;Elisa Palumbo,&nbsp;Alessia Schivo,&nbsp;Annalisa Salviato,&nbsp;Silvia Ormelli,&nbsp;Maria Varotto,&nbsp;Calogero Terregino,&nbsp;Isabella Monne,&nbsp;Alice Fusaro","doi":"10.1111/irv.70279","DOIUrl":"10.1111/irv.70279","url":null,"abstract":"<p>This study uses a phylodynamic approach to investigate host species contribution in the spatiotemporal dynamics of the highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b identified during the 2024–2025 epidemic in Italy. Our findings revealed the key role of swans in the initial virus incursions, the central role of synanthropic bird species as the bridge hosts at the wild-domestic interface, and provided evidence of sustained circulation in both wild and domestic birds of viruses carrying mammalian-adaptive mutations. Overall, our results highlight a complex, multi-host transmission dynamic at the wildlife–domestic interface and underscore the value of a One Health, genomics-informed surveillance approach, explicitly including synanthropic species, to reconstruct transmission pathways and refine control strategies.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70279","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Respiratory Viral Codetections on RSV Disease Burden in Young Children in Primary Care","authors":"Levi Duijst,&nbsp;Valérie Sankatsing,&nbsp;Caterina Rizzo,&nbsp;Francesco Baglivo,&nbsp;Elizabeth Button,&nbsp;Marta Carballal Mariño,&nbsp;María Garcés Sánchez,&nbsp;Christine Hagemann,&nbsp;Simon de Lusignan,&nbsp;Oliver Martyn,&nbsp;Marc Raes,&nbsp;Daan Van Brusselen,&nbsp;Joanne Wildenbeest,&nbsp;Sarah Hak,&nbsp;Foekje Stelma,&nbsp;Jojanneke van Summeren,&nbsp;RSV ComNet network","doi":"10.1111/irv.70272","DOIUrl":"https://doi.org/10.1111/irv.70272","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Young children with respiratory syncytial virus (RSV) often have viral coinfections. This study assessed the impact of respiratory viral codetections on RSV disease burden in children &lt; 5 years and whether this varies by specific codetected viruses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective analyses were performed using data from the RSV ComNet study prior to implementation of passive immunisation. Children &lt; 5 years with acute respiratory infection (ARI) were eligible for testing for RSV and other viruses (multiplex real-time Polymerase Chain Reaction). Primary care physicians completed a short report on day 1, and parents completed follow-up questionnaires (digital or by phone) on days 14 and 30. Disease burden was measured by healthcare resource utilisation, clinical course, and parental work absence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 2637 children tested, 822 (31%) were RSV-positive, of which 585 (52%) had completed day 1 data. There were 378 (65%) children with RSV monoinfection and 207 (35%) with RSV codetection. Rhinovirus/enterovirus was most frequently codetected (60%). Healthcare resource utilisation, clinical course, and parental work absence did not significantly differ between children with RSV codetection and RSV monoinfection. Hospitalisation rate was 7% (CI: 5%–10%) versus 8% (CI: 5%–13%) and mean duration of illness 11 (CI: 10.6–11.9) versus 12 days (CI: 11.4–13.4), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RSV-infections with viral codetections were generally not associated with increased healthcare resource utilisation, symptomatology, or parental work absence in children in primary care, suggesting that viral codetection alongside RSV disease does not impose a greater burden on patients or society. Further research is needed to determine whether specific RSV codetected viruses differentially impact disease burden.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Surveillance of SARS-CoV-2 in Senegal (2020–2024): Variant Turnover, Omicron Introductions, and Interregional Spread","authors":"Ndeye Awa Ndiaye,&nbsp;Safiétou Sankhe,&nbsp;Mamadou Malado Jallow,&nbsp;Mouhamed Kane,&nbsp;Khadidiatou Ndour,&nbsp;Amadou Diallo,&nbsp;Maimouna Mbanne,&nbsp;Ndeye Marième Top,&nbsp;Seynabou Mbaye Ba Souna Diop,&nbsp;Madeleine Dieng,&nbsp;Issa Gnasse,&nbsp;Debora Goudiaby,&nbsp;Cheikh Talla,&nbsp;Mamadou Aliou Barry,&nbsp;Oumar Faye,&nbsp;Ousmane Faye,&nbsp;Cheikh Loucoubar,&nbsp;Amadou Alpha Sall,&nbsp;Gamou Fall,&nbsp;Marie Henriette Dior Ndione,&nbsp;Moussa Moïse Diagne,&nbsp;Ndongo Dia","doi":"10.1111/irv.70273","DOIUrl":"10.1111/irv.70273","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Genomic surveillance is central to tracking SARS-CoV-2 evolution, variant replacement, and transmission dynamics. In Senegal, the Institut Pasteur de Dakar generated one of the largest national longitudinal SARS-CoV-2 genomic datasets, offering a unique view of viral spread from the first pandemic wave to the post-Omicron period.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to reconstruct SARS-CoV-2 evolution and dissemination in Senegal from March 2020 to September 2024, assess variant and Omicron sublineage dynamics, infer introduction and interregional spread patterns, and describe the national mutational landscape.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Material and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 4820 SARS-CoV-2 genomes generated by the Institut Pasteur de Dakar were analyzed. Lineage assignment, temporal and regional distribution, time-scaled phylogenetics, discrete phylogeographic reconstruction, and mutation profiling were used to assess variant turnover, international seeding, intranational dissemination, and genomic diversification.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Ancestral A/B lineages predominated in 2020 before replacement by Alpha and Beta in early 2021, followed by Delta in mid-2021, which coincided with the highest case burden. From late 2021, Omicron became dominant, with rapid turnover of BA.1/BA.2, BA.4/BA.5, BQ.1.1, XBB, and BA.2.86, while later waves were smaller. Dakar contributed 64.7% of genomes and emerged as the main hub for inferred introductions and interregional spread, with Kaolack and Diourbel as secondary hubs. Major Omicron sublineages resulted from multiple introductions, mainly from Africa and Europe, with BA.1/BA.2 seeded from a broader range of continents than later lineages. Mutation profiling showed strong enrichment in Spike, with recurrent changes in ORF1a/ORF1b and nucleocapsid.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Discussion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The findings reveal repeated variant replacement, shifting international seeding routes, and a hub-and-spoke pattern of national dissemination centered on Dakar. Declining later waves may reflect increasing hybrid population immunity, although interpretation remains influenced by heterogeneous sequencing intensity.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study provides an integrated national picture of SARS-CoV-2 ev","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148224761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Syncytial Virus Transmission in Closed Community Settings That Include Children: A Systematic Review and Meta-Analysis","authors":"Gemma L. Saravanos,&nbsp;Mari Takashima,&nbsp;Asmaa El-Heneidy,&nbsp;Catherine King,&nbsp;Miroslava Ross,&nbsp;Anita Williams,&nbsp;Robert S. Ware,&nbsp;Philip N. Britton","doi":"10.1111/irv.70270","DOIUrl":"10.1111/irv.70270","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Respiratory syncytial virus (RSV) is a leading cause of severe respiratory infections in children and is predominantly acquired and spread in community settings such as households and early childhood education centres. This review aims to synthesise the available evidence on RSV transmission in closed community settings that include children, with a focus on secondary attack rates (SAR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review informed by Cochrane guidelines. We searched Ovid Medline, Ovid Embase Classic and Embase, Ovid Global Health, Cochrane Library, Web of Science, and Scopus from inception to March 2025. Grey literature was searched through Google Scholar and relevant websites. We included articles reporting primary data on RSV SAR or other attack rates in closed community settings that included children aged under 18 years. Two reviewers independently screened articles, extracted data, and assessed study quality using a modified Newcastle–Ottawa Scale. Random-effects meta-analysis was performed for SAR and attack rates. Subgroup analyses explored outcomes by study design, study setting and participant age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 38 articles were eligible and reported data from 30 unique study populations from 1956 to 2023 spanning 12 countries. Study settings included households (<i>n</i> = 19), early childhood education and care (<i>n</i> = 6) and residential care (<i>n</i> = 5). Pooled household SAR was 23.8% (95% CI: 16.5–30.0%) across all ages and 26.8% (95% CI: 15.5–38.2%) for children aged less than 5 years. Pooled outbreak attack rate among children in early childhood education and residential care was 59.2% (95% CI: 31.7–86.8%). There was substantial heterogeneity of methods, reporting and outcomes across studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Risk of RSV transmission in closed community settings that include children is substantial, yet current evidence is limited. Well-designed transmission studies, particularly in early childhood education and care settings, are needed to support disease prevention and control, and to optimise population-level modelling.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148224757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparable Neutralizing Antibody Responses Following JN.1 and KP.2-Based COVID-19 Vaccination Suggest Limited Added Value of Minor Strain Updates: A Multicentre Immunogenicity Study","authors":"Lena Pracher,&nbsp;Mastura Wahedi,&nbsp;Anselm Jorda,&nbsp;Michelle M. Fukumitsu,&nbsp;Marlene Prager,&nbsp;Dragan Copic,&nbsp;Jasmin Zessner-Spitzenberg,&nbsp;Edith Lackner,&nbsp;Theresa Pecho,&nbsp;Katie Sharff,&nbsp;Justin Iampietro,&nbsp;Joshua Nealon,&nbsp;William B. Messer,&nbsp;Markus Zeitlinger,&nbsp;Marcel E. Curlin","doi":"10.1111/irv.70268","DOIUrl":"10.1111/irv.70268","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>COVID-19 vaccines are periodically updated to address SARS-CoV-2 evolution. Whether minor antigen changes provide immunological or even clinical benefit remains unclear. This study compared neutralizing antibody responses following vaccination with the JN.1-based or KP.2-based 2024/25 Pfizer-BioNTech mRNA vaccine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adults aged 18–64 years who received the JN.1 vaccine in Austria, or the KP.2 vaccine in the United States were enrolled. A single blood sample was obtained within 120 days post-vaccination. Pseudovirus neutralization assays against SARS-CoV-2 variants XBB.1.5, JN.1, KP.2, KP3.1.1, XEC and LP.8.1 were performed. Geometric mean titre (GMT) ratios were analysed using t-tests and multivariable regression adjusted for age, sex, vaccination intervals, and prior infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 191 participants (78 JN.1, 113 KP.2), GMTs (95% CI) for XBB.1.5 variant were higher in the JN.1 cohort (3498 [2535–4826]) than in the KP.2 cohort (1901 [1386–2607]), GMT ratio 1.84 (1.16–2.92). For the JN.1 variant, GMTs were 1122 (819–1538) in the JN.1 cohort and 695 (510–948) in the KP.2 cohort (GMT ratio: 1.61 [1.03–2.54]). GMTs for other variants did not differ significantly. After adjustment, only the XBB.1.5 difference remained significant (<i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Comparable neutralizing responses across JN.1 lineage variants suggest that annual COVID-19 strain updates targeting variants with small differences within the same antigenic cluster may have limited impact on vaccine-induced protection. These findings may inform future public health policy and regulatory decision-making for COVID-19 vaccines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Effectiveness of Influenza Vaccines in Italy in the 2024/2025 Season: A Nationwide, Test-Negative Design Study Based on Surveillance Records”","authors":"","doi":"10.1111/irv.70275","DOIUrl":"10.1111/irv.70275","url":null,"abstract":"<p>\u0000 <span>Cifo, D.</span>, <span>Mateo-Urdiales, A.</span>, <span>Puzelli, S.</span>, <span>Facchini, M.</span>, <span>Piacentini, S.</span>, <span>Giombini, E.</span>, <span>Bellini, B.</span>, <span>Fabiani, M.</span>, <span>Pezzotti, P.</span>, <span>Stefanelli, P.</span>, <span>Palamara, A.</span>, <span>Bella, A.</span> and the RespiVirNet network (<span>2026</span>), <span>Effectiveness of Influenza Vaccines in Italy in the 2024/2025 Season: A Nationwide, Test-Negative Design Study Based on Surveillance Records</span>. <i>Influenza Other Respi Viruses</i>, <span>20</span>: e70252, https://doi.org/10.1111/irv.70252.\u0000 </p><p>We apologize for this error.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148091054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148086365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148084500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148078993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}