Influenza and Other Respiratory Viruses最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148089638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148078883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting Report: Fourth Correlates of Protection for Next Generation Influenza Vaccines","authors":"Alina Tscherne,&nbsp;Rebecca Jane Cox,&nbsp;Florian Krammer,&nbsp;Anders Bonnevie","doi":"10.1111/irv.70258","DOIUrl":"10.1111/irv.70258","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This report summarizes the discussions and conclusions from the fourth “Correlates of Protection for Next Generation Influenza Vaccines” meeting, which took place in Vienna, Austria, from October 15, 2025, to October 17, 2025.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Discussions on influenza virus correlates of protection built on prior meetings, with particular emphasis on challenges introduced by novel vaccine platforms and evolving regulatory expectations. Although established immune markers such as hemagglutination inhibiting (HI) antibodies remain central to influenza vaccine evaluation, this year's discussions highlighted the continued uncertainty and challenges around their generalizability across platforms, populations, and age groups. Regulatory perspectives emphasized the need for strong biological and clinical justification linking immune markers to protection. Overall, the meeting highlighted the importance of continued collaboration among academia, industry, and regulatory agencies to advance the identification and validation of correlates of protection, in alignment with priorities outlined in the 2025 influenza research and development road map for influenza vaccines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating COVID-19 Transmission in a Series of Cases and Contacts in Three Municipalities of Colombia: Insights From the WHO First Few X Protocol, August 2020–January 2021","authors":"Damaris Heredia,&nbsp;May Bibiana Osorio,&nbsp;Carolina Figueroa,&nbsp;Susanne Ardila,&nbsp;Dayner Vacca,&nbsp;Magdalena Santos,&nbsp;Daniel Velandia,&nbsp;Marcela Mercado,&nbsp;Maritza González,&nbsp;Franklyn Prieto,&nbsp;Ingrid Garcia,&nbsp;Ángel Rodriguez","doi":"10.1111/irv.70132","DOIUrl":"10.1111/irv.70132","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As part of the framework of preparedness and response to influenza viruses with pandemic potential, the World Health Organization (WHO) has developed a protocol for the characterization of a series of first cases and contacts of an agent with pandemic potential (FFX). At the end of 2019, PAHO/WHO invited Colombia to be among the pilot countries for implementing this protocol. It was conducted by the National Institute of Health of Colombia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The WHO generic protocol was reviewed and adapted to Colombia. In its implementation, a series of 99 cases of COVID-19 and 360 total contacts (159 positive contacts) were evaluated between August 2020 and January 2021 in three municipalities of Colombia. Surveys were conducted, along with RT-PCR and antibody titer tests. Sociodemographic, clinical, and virological transmission conditions were analyzed to calculate the main epidemiological indicators of viral transmission using measures of central tendency and absolute and relative frequencies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 258 cases were confirmed to be positive for COVID-19 for a secondary attack rate of 43%. The most common symptoms were cough, fever, headache, and odynophagia. The percentage of symptomatic contacts, clinical attack rate, incubation period, and serial interval were 34%, 16.2%, 4.6 days, and 4.7 days, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The significant rate of infection and incubation periods among contacts was similar to those reported worldwide. The implementation of the WHO FFX protocol in a novel context allowed the country to test its capacity to implement global studies to determine early public health interventions. The study faced limitations due to the selection bias towards severe cases and challenges in case recruitment and contact tracing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence About the Paper \"Effectiveness of High-Dose Influenza Vaccine Against Hospitalisations in Older Adults (FLUNITY-HD): An Individual Level Pooled Analysis\" by Niklas Dyrby Johansen et al., https://doi.org/10.1016/S0140-6736(25)01742-8.","authors":"Miloš Jeseňák, David Řezáč, Laura Colombo","doi":"10.1111/irv.70255","DOIUrl":"10.1111/irv.70255","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":"e70255"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postinfection Pig and Ferret Antisera Show Similar Antigenic Profiles for Human Influenza A(H1N1pdm09) Viruses.","authors":"Ruth Harvey, Tiphaine Cayol, Basudev Paudyal, Alice Lilley, Christine Carr, Catherine Hatton, Emily Briggs, Rodney S Daniels, Samuel Richardson, Thomas P Peacock, Nicola Lewis, Ian Brown, John W McCauley, Elma Tchilian","doi":"10.1111/irv.70261","DOIUrl":"10.1111/irv.70261","url":null,"abstract":"<p><strong>Background: </strong>Monitoring antigenic drift in human influenza A viruses is essential for vaccine strain selection and ensuring protection against circulating strains. Antigenic drift is traditionally assessed using ferret antisera, which provide monospecific responses and human vaccinee sera, which reflect exposure to multiple antigens. In this study, we evaluated the pig as an alternative source of antisera to study antigenic drift compared with immune responses in ferrets and humans. We included seasonal influenza A(H1N1pdm09) human viruses that had shown different antigenic characteristics when using ferret or human antisera.</p><p><strong>Methods: </strong>Pairs of pigs were inoculated with six human A(H1N1)pdm09 viruses circulating between 2019 and 2023, a period of marked antigenic drift. Pig and ferret antisera raised against these six reference viruses were analysed by haemagglutination inhibition (HI) and virus neutralisation (VN), and homologous and heterologous titre differences were used to assess antigenic reactivity profiles among the viruses between species.</p><p><strong>Results: </strong>Pigs were successfully infected with all strains, shedding virus and producing antibody responses, confirming their susceptibility to human influenza A viruses. Antigenic reactivity of pig antisera was qualitatively comparable to ferret antisera in both HI and VN assays, although maximum homologous antibody titres were significantly higher in ferrets (on average 16-fold for HI and from around 12- to 210-fold for VN). The antisera raised against viruses in circulation in 2019 and before, exemplified by A/Guangdong-Maonan/SWL1536/2019, clade 5a.1, were clearly differentiated by both ferret and pig antisera from those in clade 5a.2 and its derivatives that became predominant.</p><p><strong>Conclusions: </strong>Ferrets and pigs showed comparable responses and both distinguished clade 5a.1 from clade 5a.2. However, neither model recognised antigenically drifted variants from 2019 to 2022, including subclades 5a.2-C, 5a.2a-C.1/C.1.9 and 5a.2a.1-C.1.1/D, which were distinguishable using human postvaccination antisera.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":"e70261"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity and Cost of Respiratory Syncytial Virus Versus Influenza in Hospitalized Adults in Spain.","authors":"Elisa Correcher-Martínez, Cintia Muñoz-Quiles, Mónica López-Lacort, Ainara Mira-Iglesias, María Díaz-López, Beatriz Mengual-Chuliá, F Xavier López-Labrador, Javier Díez-Domingo, Alejandro Orrico-Sánchez","doi":"10.1111/irv.70254","DOIUrl":"10.1111/irv.70254","url":null,"abstract":"<p><strong>Background: </strong>Respiratory syncytial virus (RSV) can lead to severe outcomes, particularly in older and vulnerable adults, yet it remains underdiagnosed due to limited testing. This study compared the severity and costs of laboratory-confirmed RSV versus influenza hospitalizations.</p><p><strong>Methods: </strong>We performed a retrospective analysis using data from the Valencia Hospital Network for the Study of Infectious Diseases (VAHNSI), covering up to 46% of the Valencia Region's population. Hospitalized influenza-like illness (ILI) cases in individuals aged ≥ 65 years across six seasons (2014/15-2019/20) were included. RSV and influenza were identified by multiplex RT-PCR. Outcomes assessed included mechanical ventilation (MV), hospital length of stay (LOS), in-hospital death, 30-day post-discharge death, and hospitalization costs. Logistic and log-normal regression models were used to compare severity and cost outcomes between RSV and influenza, adjusting for age, sex, comorbidities, and influenza vaccination status. Odds ratios (ORs) and mean ratios (MRs) with 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>Of 1954 hospitalizations, 429 (22%) were due to RSV and 1525 (78%) to influenza. RSV cases showed higher MV use (9.26% vs. 4.15%; adjusted OR 2.43 [95% CI: 1.61-3.67]) and longer LOS (7.7 vs. 6.8 days; adjusted MR 1.10 [95% CI: 1.02-1.19]). Mortality outcomes were similar. RSV hospitalizations incurred 6% higher mean costs (€3907 vs. €3806).</p><p><strong>Conclusions: </strong>RSV hospitalizations in older adults were less frequent but more severe and costly than influenza, with comparable mortality. These findings highlight the importance of RSV prevention and support the development of targeted vaccination programs for the elderly.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 4","pages":"e70254"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}