Influenza and Other Respiratory Viruses最新文献

{"title":"Shifts in Respiratory Virus Epidemiology on Reunion Island From 2017 to 2023: Impact of COVID-19 Pandemic and Non-Pharmaceutical Interventions","authors":"Nicolas M'nemosyme,&nbsp;Etienne Frumence,&nbsp;Laurent Souply,&nbsp;Diana Heaugwane,&nbsp;Nicolas Traversier,&nbsp;Alizé Mercier,&nbsp;Jamel Daoudi,&nbsp;Jean-Sébastien Casalegno,&nbsp;Martine Valette,&nbsp;Marie-Pierre Moiton,&nbsp;Rodolphe Manaquin,&nbsp;Etienne Darieux,&nbsp;Raphaëlle Sarton,&nbsp;Anaïs Grimal,&nbsp;Fabian Thouillot,&nbsp;Xavier Deparis,&nbsp;Bruno Lina,&nbsp;Marie-Christine Jaffar-Bandjee","doi":"10.1111/irv.70075","DOIUrl":"https://doi.org/10.1111/irv.70075","url":null,"abstract":"<p>The emergence of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in late December 2019 in Wuhan, China, has had a profound impact worldwide [<span>1, 2</span>]. Reunion Island, situated in the southwest of the Indian Ocean and spanning 2500 km² as a French overseas department, is inhabited by around 885,700 people, primarily residing along the coastal areas. On this island, the first case of COVID-19 was reported on March 11, 2020, at the University Hospital Center (UHC) of La Reunion, in a group of travelers returning from a cruise [<span>3</span>]. Given the lack of available treatments to combat the infection during that period, the government implemented a comprehensive array of public health measures on Reunion Island, similar to those in metropolitan France, in an effort to control the spread of the virus. These measures, referred to as non-pharmaceutical interventions (NPIs), included a strict lockdown period and the closure of all schools and childcare centers on the island from March 17, 2020, to May 11, 2020. Subsequently, in August 2020, control measures were formally introduced on the island, encompassing social distancing and mandatory mask-wearing in public. Starting in July 2020, several SARS-CoV-2 screening campaigns were launched across all cities on the island, aiming to test all travelers entering and leaving the island, as well as all hospital admissions.</p><p>These NPIs were implemented both to reduce the transmission of the virus and to prevent the healthcare system from exceeding its capacity of intensive care beds [<span>4</span>]. Thanks to these measures, Reunion Island registered only 9037 cases and 42 deaths during the initial year of the COVID-19 pandemic, managing to remain relatively unscathed [<span>5</span>]. The vaccination campaign began on January 15, 2021, and in the subsequent months, a range of new NPIs, including lockdowns and curfews, were introduced. Nevertheless, the island encountered numerous successive waves of infection caused by different variants of SARS-CoV-2 (such as Beta, Delta, and Omicron variants) [<span>6</span>]. This led to over 82,796 reported cases in 2021 and a surge to more than 420,850 cases in 2022, according to regional public health authority statistics [<span>6, 7</span>]. The year 2023, on the other hand, was a year of low SARS-CoV-2 circulation on the island [<span>8</span>].</p><p>It has been reported that the combination of SARS-CoV-2 circulation and NPIs across the world has had a significant impact on the circulation of other respiratory viruses [<span>9-14</span>]. Notably, a global decline in influenza cases and a shift in the seasonal transmission pattern of respiratory syncytial virus (RSV) were evident worldwide. In mainland France, no influenza outbreaks were reported for the 2020–2021 season following the implementation of NPIs, while the RSV bronchiolitis outbreak in children was delayed ","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess All-Cause Mortality by Age and Gender During the COVID-19 Pandemic in the Federation of Bosnia and Herzegovina, Bosnia and Herzegovina: 2020–2022","authors":"Šeila Cilović-Lagarija,&nbsp;Johanna Thea Mølgaard Rantzau,&nbsp;Siniša Skočibušić,&nbsp;Sanjin Musa,&nbsp;Armin Sprečo,&nbsp;Amna Isaković,&nbsp;Mirza Palo,&nbsp;Faris Dizdar,&nbsp;Hidajeta Čolović,&nbsp;Veronica Ivey Sawin,&nbsp;Jens Nielsen,&nbsp;Pernille Jorgensen","doi":"10.1111/irv.70086","DOIUrl":"https://doi.org/10.1111/irv.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>COVID-19 has had a profound impact on global mortality and morbidity, yet only a fraction of deaths was confirmed and reported. We estimated all-cause excess mortality from 1 January 2020 to 31 December 2022 in the Federation of Bosnia and Herzegovina (FBiH) to assess the true magnitude of the pandemic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data for this analysis was sourced from the FBiH mortality register and supplemented with population statistics and official COVID-19 death counts (i.e., cases where COVID-19 was registered as the cause of death). Using a Poisson model, all-cause excess number of deaths and rates per 100,000 person-years, adjusted for registration delays and stratified by age and gender, were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FBiH experienced three periods of excess all-cause mortality throughout the first 3 years of the pandemic, with a total of 12,000 excess deaths, highest among adults 45–74 years and males. No excess mortality was observed in children &lt;15 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The true mortality impact of COVID-19 in FBiH was substantially higher than the reported deaths, including among younger adults. Strengthening civil registration and vital statistics, including establishment of all-cause mortality surveillance, is essential for improved monitoring of future pandemics and other important public health events. A detailed review of the direct and indirect effects of COVID-19 on mortality should be conducted to identify areas that require more resources, improve health provision and inform mitigation efforts in future pandemics to save lives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Assessing the Impact of Non-Pharmaceutical Interventions During the COVID-19 Pandemic on RSV Seasonality in Europe”","authors":"","doi":"10.1111/irv.70087","DOIUrl":"https://doi.org/10.1111/irv.70087","url":null,"abstract":"<p>\u0000 <span>Heemskerk, S.</span>, <span>Baliatsas, C.</span>, <span>Stelma, F.</span>, <span>Nair, H.</span>, <span>Paget, J.</span>, &amp; <span>Spreeuwenberg, P.</span> <span>Assessing the Impact of Non-Pharmaceutical Interventions During the COVID-19 Pandemic on RSV Seasonality in Europe</span>. <i>Influenza and Other Respiratory Viruses.</i> <span>2025</span>; <span>19</span>(<span>1</span>), e70066.\u0000 </p><p>We apologize for this error.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Impact of Variants, Epidemiological Trends, and Comorbidities on Hospitalization Rates of Unvaccinated Children in Brazil: A Retrospective Study (2020–2022)”","authors":"","doi":"10.1111/irv.70084","DOIUrl":"https://doi.org/10.1111/irv.70084","url":null,"abstract":"<p>\u0000 <span>Conte, D.D.</span>, <span>Watanabe, R.A.S.</span>, <span>Chaves, A.P.C.</span>, <span>Alberto-Lei, F.</span>, <span>Perosa, A.H.S.</span>, <span>Barbosa, G.</span> and <span>Bellei, N.</span> (<span>2024</span>), <span>Impact of Variants, Epidemiological Trends, and Comorbidities on Hospitalization Rates of Unvaccinated Children in Brazil: A Retrospective Study (2020–2022)</span>. <i>Influenza Other Respi Viruses</i>, <span>18</span>: e70011, https://doi.org/10.1111/irv.70011.\u0000 </p><p>In the article, the funding information was incomplete.</p><p>The funding details read:</p><p>This study was supported by FINEP/UFMG/REITORIA/PRPQ (29334)</p><p>The funding details should read:</p><p>This study was supported by FINEP/UFMG/EDITORIAL/PRPQ (29334) and São Paulo State Research Support Foundation (2023/07391-7).</p><p>The online version of the article has been corrected.</p><p>We apologize for this error.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The Respiratory Syncytial Virus Prefusion F Protein Vaccine Attenuates the Severity of RSV-Associated Disease in Breakthrough Infections in Adults ≥60 Years of Age”","authors":"","doi":"10.1111/irv.70088","DOIUrl":"https://doi.org/10.1111/irv.70088","url":null,"abstract":"<p>\u0000 <span>Curran, D</span>, <span>Matthews, S</span>, <span>Cabrera, ES</span>, et al., <span>The Respiratory Syncytial Virus Prefusion F Protein Vaccine Attenuates the Severity of Respiratory Syncytial Virus-Associated Disease in Breakthrough Infections in Adults ≥60 Years of Age</span>. <i>Influenza Other Respi Viruses.</i> <span>2024</span>; <span>18</span>(<span>2</span>):e13236.\u0000 </p><p>In the article, there were errors in the affiliations of Laura Helman and John H. Powers III. Their correct affiliations are shown below.</p><p>Desmond Curran ¹ |Sean Matthews ²|Eliazar Sabater Cabrera ¹ |Silvia Narejos Pérez ³|Lina Pérez Breva ⁴|Mika Rämet ⁵|Laura Helman ⁶|Dae Won Park ⁷|Tino F. Schwarz ⁸|Isabel Maria Galan Melendez ⁹|Axel Schaefer ¹⁰|Nathalie Roy ¹¹|Brigitte Stephan ¹²|Daniel Molnar ¹ |Lusine Kostanyan ¹ |John H. Powers III ¹³|Veronica Hulstrøm ¹|Members of the AReSVi-006 Study Group</p><p>¹GSK, Wavre, Belgium</p><p>² Freelance c/o GSK, Wavre, Belgium</p><p>³ CAP Centelles, Barcelona, Spain</p><p>⁴ Vaccine Research, FISABIO-Public Health, Valencia, Spain</p><p>⁵ Finnish Vaccine Research, Tampere, Finland</p><p>⁶ MOC Research, Mishawaka, Indiana, USA</p><p>⁷ Korea University Ansan Hospital, Ansan, Republic of Korea</p><p>⁸ Institute of Laboratory Medicine and Vaccination Centre, Klinikum Würzburg Mitte, Würzburg, Germany</p><p>⁹ Hospital Universitario Fundacion Alcorcon, Madrid, Spain</p><p>¹⁰ Medizentrum Essen Borbeck, Essen, Germany</p><p>¹¹ Medicor Research, Greater Sudbury, Canada</p><p>¹² SGS proDERM, Schenefeld, Germany</p><p>¹³ Department of Clinical Medicine, George Washington University School of Medicine &amp; Health Sciences, Washington, District of Columbia, USA</p><p>We apologize for this error.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Respiratory Viruses Other Than SARS-CoV-2 in a Large Hospital Laboratory in Rome, Italy, During the Seasons 2016–2017 to 2022–2023","authors":"Flora Marzia Liotti,&nbsp;Simona Marchetti,&nbsp;Sara D'Onghia,&nbsp;Maurizio Sanguinetti,&nbsp;Rosaria Santangelo,&nbsp;Brunella Posteraro","doi":"10.1111/irv.70079","DOIUrl":"https://doi.org/10.1111/irv.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>Respiratory viruses are major contributors to morbidity and mortality worldwide, with their circulation influenced by seasonal patterns and pandemic-related interventions. This study analyzed detection trends of non-SARS-CoV-2 respiratory viruses in a large Italian hospital over a 7-year period, focusing on variations across COVID-19–related periods and patient age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed multiplex PCR-based laboratory results of 8836 nasopharyngeal samples collected between September 2016 and August 2023. Viral detection rates were stratified by season, COVID-19–related periods (pre-pandemic, pandemic, post-pandemic), and age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 8836 nasopharyngeal samples analyzed, 2795 (31.6%) tested positive for at least one respiratory virus. Rhinovirus/enterovirus (RV/EV) was the most frequently detected virus (37.6%), followed by influenza A virus (IAV, 17.9%) and respiratory syncytial virus (RSV, 17.2%). The 2020–2021 season had the lowest positivity rate (<i>p</i> &lt; 0.001), with marked declines in IAV and RSV detections, likely because of COVID-19 mitigation measures. Conversely, detections of RV/EV and human coronaviruses increased. Postpandemic data suggested a return to prepandemic patterns, though overall positivity rates remained altered. Age-stratified analysis revealed RSV predominance in infants (<i>p</i> &lt; 0.001), emphasizing its clinical relevance in pediatric populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings highlight the dynamic nature of respiratory virus epidemiology and the persistent impact of the COVID-19 pandemic on viral circulation. Continuous surveillance and adaptive public health strategies are essential for managing future outbreaks and mitigating the burden of respiratory viral infections.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Analysis of Human Respiratory Syncytial Virus Group B Strains Isolated in Kenya Before and During the Emergence of Pandemic Influenza A/H1N1","authors":"Julia Wangui,&nbsp;George Gachara,&nbsp;Victor Mobegi,&nbsp;Charles Agoti,&nbsp;James Otieno,&nbsp;Silvanos Opanda,&nbsp;Benjamin Opot,&nbsp;Joseph N. Ngeranwa,&nbsp;Regina Njeru,&nbsp;Wallace Bulimo","doi":"10.1111/irv.70082","DOIUrl":"https://doi.org/10.1111/irv.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We conducted a retrospective study to explore molecular insights into human respiratory syncytial virus (HRSV) group B strains among patients attending outpatient clinics at government medical facilities both prior and during the onset of Influenza A/H1N1/2009 pandemic outbreak.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We screened 2300 nasopharyngeal swabs using multiplex real time reverse transcriptase polymerase chain reaction. We amplified a segment of the first and second hypervariable regions, as well as the conserved portion of the third domain of the G-gene using HRSV-B specific primers, sequenced by Sanger di-deoxy chain termination method and thereafter analyzed the sequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We characterized the circulating strains into three known genotypes: SAB4 (1.4%), BA7 (1.4%), and multiple variants of BA9 (97.2%). The majority of BA9 viruses were uniquely Kenyan with only 4% aligning with BA9 lineages found elsewhere. The mean evolutionary rate of the HRSV-B was estimated to be 3.08 × 10⁻³ substitutions per site per year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings indicate that the circulating HRSV-B viruses in Kenya underwent a slower evolution during the period of 2007–2010. Additionally, our findings reveal the existence of a unique lineage as well as new variants that have not been reported elsewhere to date.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Characteristics of Hospitalized Influenza Patients: An Interim Analysis From the FluHeart Study","authors":"Kristoffer Grundtvig Skaarup,&nbsp;Filip Soeskov Davidovski,&nbsp;Emil Durukan,&nbsp;Daniel Modin,&nbsp;Mats Christian Højbjerg Lassen,&nbsp;Maria Dons,&nbsp;Anne Marie Reimer Jensen,&nbsp;Niklas Dyrby Johansen,&nbsp;Morten Sengeløv,&nbsp;Frederikke Vyff,&nbsp;Nino Emanuel Landler,&nbsp;Gorm Boje Jensen,&nbsp;Anne Bjerg Nielsen,&nbsp;Jacob Christensen,&nbsp;Raphael Hauser,&nbsp;Peter Schnohr,&nbsp;Rasmus Møgelvang,&nbsp;Lene Nielsen,&nbsp;Jens-Ulrik Stæhr Jensen,&nbsp;Tor Biering-Sørensen","doi":"10.1111/irv.70067","DOIUrl":"https://doi.org/10.1111/irv.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza infection on cardiac structure and function as assessed by echocardiography during hospitalization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study included hospitalized influenza patients of the 2021–2022 influenza season. Participants underwent echocardiography using a prespecified protocol. Participants were successfully matched 1:1:1 on age, sex, and heart failure status with controls from the general population and controls hospitalized with COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This interim analysis involved 108 participants (36 influenza patients, 36 general population controls, and 36 COVID-19 patients). Mean age was 72 ± 18 years and 58% were male. Median time from admission to echocardiography was 1 day (IQI: 1:1) for influenza patients. The prevalence of left ventricular (LV) dysfunction was 75%, and right ventricular (RV) dysfunction was observed in 20% of influenza patients. N-terminal pro-brain natriuretic peptide levels were elevated ≥ 300 pg/mL in 62%, and 19% exhibited myocardial injury with elevated high-sensitivity troponin I levels. RV tricuspid annular plane systolic excursion and LV early diastolic peak mitral inflow to early diastolic tissue velocity were significantly worse in influenza patients compared to general population controls. Echocardiographic measures did not significantly differ between patients hospitalized with influenza and COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this interim analysis of the FluHeart study, both RV and LV function measures were significantly impaired in hospitalized influenza patients compared with matched general population controls. The extent of impairment resembled that observed in hospitalized COVID-19 patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Influenza Epidemiology Before and After the COVID-19 Pandemic in Argentina (2018–2019 vs. 2022–2023)","authors":"Angela Gentile,&nbsp;María del Valle Juárez,&nbsp;Gabriela Ensinck,&nbsp;Oscar Lopez,&nbsp;Pablo Melonari,&nbsp;Tatiana Fernández,&nbsp;Andrés Gioiosa,&nbsp;Gustavo Lazarte,&nbsp;Silvina Lobertti,&nbsp;María Florencia Lucion,&nbsp;Natalia Pejito,&nbsp;Camila Racana,&nbsp;Leandro López,&nbsp;Gabriela Gregorio","doi":"10.1111/irv.70078","DOIUrl":"https://doi.org/10.1111/irv.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The COVID-19 pandemic altered the epidemiology of respiratory viruses other than SARS-CoV-2. This study investigated the clinical-epidemiological pattern of hospitalized pediatric patients with acute lower respiratory tract infections (ALRI) and influenza in Argentina, comparing prepandemic and postpandemic periods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This multicenter, cross-sectional study included patients under 18 years old admitted for ALRIs in five tertiary centers of Argentina before (2018 and 2019) and after (2022 and 2023) COVID-19. Changes in viral detection rates, seasonality, and case fatality rate (CFR), along with epidemiological and clinical characteristics, were analyzed. Indirect immunofluorescence assay (IFA) or RT-PCR was used for virological diagnosis pre-pandemic, and only RT-PCR in post-pandemic. Epi Info 7 and SPSS 15.0 was used for data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 5838 cases of ALRI were included (mean age: 9.5 months; IQR: 4–22 months); 96.6% were tested for viral detection, and 66.4% were positive (3877 cases). Respiratory syncytial virus (RSV) was the most prevalent. Influenza showed typical winter seasonality in 2018, 2019, and 2023. However, 2022 exhibited a bimodal pattern: late summer and spring, with co-circulation of influenza A and B in the second peak. CFR varied by viral diagnosis; influenza showed the highest CFR, all deaths related to influenza A. Among 354 influenza cases, 81% were &lt; 5 years old, 53% were male, 63% had comorbidities, and 14.1% required intensive care. Mean of influenza vaccine coverage (6–24 months) was 21.4%. In both periods, patients with influenza were more likely to have pneumonia. Additionally, in the postpandemic period, malnourishment or being 3 years of age or older was also associated with a higher likelihood of influenza infection compared with infection with other respiratory viruses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Influenza primarily affected children under 5 years old. Postpandemic cases involved older individuals, and increased circulation of influenza A H3N2 was observed. Vaccination coverage was notably low. Influenza returned to its usual seasonal pattern in 2023.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Registry-Based Surveillance of Severe Acute Respiratory Infections in Norway During 2021–2024","authors":"Elina Seppälä,&nbsp;Håkon Bøås,&nbsp;Jesper Dahl,&nbsp;Jeanette Stålcrantz,&nbsp;Melanie Stecher,&nbsp;Ragnhild Tønnessen,&nbsp;Gunnar Øyvind Isaksson Rø,&nbsp;Hilde Kløvstad,&nbsp;Trine Hessevik Paulsen","doi":"10.1111/irv.70080","DOIUrl":"https://doi.org/10.1111/irv.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In 2021, the Norwegian Institute of Public Health established temporary registry-based surveillance of severe acute respiratory infections (SARI). We aimed to describe the surveillance system and evaluate selected attributes to inform the establishment of a permanent SARI surveillance system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>SARI cases were defined using ICD-10 discharge codes from national health and administrative registries, including codes for acute upper or lower respiratory infection (URI and LRI), COVID-19, acute respiratory distress syndrome, pertussis or otitis media. Data from polymerase chain reaction (PCR) analyses were available for 10 respiratory pathogens including SARS-CoV-2, influenza virus and respiratory syncytial virus (RSV). We included data from 28 September 2020 to 31 March 2024 and calculated the following parameters: the proportion of cases tested for SARS-CoV-2, influenza virus and/or RSV; time between admission and registration of a SARI-related ICD-10 code; and proportion of cases with URI, LRI and COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 214,730 SARI cases, of whom 82%, 73% and 53% were tested for SARS-CoV-2, influenza virus and RSV. Case peaks were predominantly driven by one or a combination of these pathogens. Median time between admission and a registered SARI diagnostic code was 5 (lower–upper quartile 3–10) days. Nowcasting and alternative case definitions for SARI with COVID-19, influenza and RSV improved the timeliness. The ICD-10 codes for LRIs and COVID-19 captured only ~55% of the cases in the age group of 0–29 years compared to the routine case definition, where URIs were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Registry-based SARI surveillance provides timely data for handling epidemics of respiratory infections in Norway. We recommend establishing a permanent SARI surveillance system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}