Raquel Guiomar, Susana Pereira da Silva, Inês Costa, Patricia Conde, Paula Cristóvão, Ana Paula Rodrigues, Aida Fernandes, Ana Paula Dias, Ana Rita Couto, Angélica Ramos, Carina Moita, Carina Rodrigues, Fátima Vale, Filomena Caldeira, Jácome Bruges Armas, João Pereira-Vaz, José Alves, Ludivina Freitas, Luis Martins, Luís Milho, Luisa Mota-Vieira, Lurdes Lopes, Margarida Freitas, Maria Ana Pessanha, Maria Correia, Maria Helena Marques, Maria João Cardoso, Maria João Peres, Mário Cunha, Patricia Amantegui, Paula Mota, Paulo Lopes, Paulo Pereira, Regina Viseu, Rita Cabral, Rita Côrte-Real, Sofia Almeida, Vânia Soares, Kamal Mansinho, Olav Hungnes, Baltazar Nunes
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We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We conducted an annual repeated cross-sectional seroepidemiological survey, during June–August, from 2014 to 2019, in Portugal. A total of 4326 sera from all age groups, sex, and regions was tested by hemagglutination inhibition assay. Seroprevalence and geometric mean titers (GMT) of protective antibodies against influenza were assessed by age group, sex, and vaccine status (65+ years old). The association between summer annual seroprevalence and the difference of influenza incidence rates between one season and the previous one was measured by Pearson correlation coefficient (<i>r</i>).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Significant differences in seroprevalence of protective antibodies against influenza were observed in the population. Higher seroprevalence and GMT for A(H1N1)pdm09 and A(H3N2) were observed in children (5–14); influenza B seroprevalence in adults 65+ was 1.6–4.4 times than in children (0–4). Vaccinated participants (65+) showed significant higher seroprevalence/GMT for influenza. A strong negative and significant correlation was found between seroprevalence and ILI incidence rate for A(H1N1)pdm09 in children between 5 and 14 (<i>r</i> = −0.84; 95% CI, −0.98 to −0.07); a weak negative correlation was observed for A(H3N2) and B/Yamagata (<i>r</i> ≤ −0.1).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The study provides new insight into the anti-influenza antibodies seroprevalence measured in summer on the ILI incidence rate in the next season and the need for adjusted preventive health care measures to prevent influenza infection and transmission.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"18 5","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13307","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019\",\"authors\":\"Raquel Guiomar, Susana Pereira da Silva, Inês Costa, Patricia Conde, Paula Cristóvão, Ana Paula Rodrigues, Aida Fernandes, Ana Paula Dias, Ana Rita Couto, Angélica Ramos, Carina Moita, Carina Rodrigues, Fátima Vale, Filomena Caldeira, Jácome Bruges Armas, João Pereira-Vaz, José Alves, Ludivina Freitas, Luis Martins, Luís Milho, Luisa Mota-Vieira, Lurdes Lopes, Margarida Freitas, Maria Ana Pessanha, Maria Correia, Maria Helena Marques, Maria João Cardoso, Maria João Peres, Mário Cunha, Patricia Amantegui, Paula Mota, Paulo Lopes, Paulo Pereira, Regina Viseu, Rita Cabral, Rita Côrte-Real, Sofia Almeida, Vânia Soares, Kamal Mansinho, Olav Hungnes, Baltazar Nunes\",\"doi\":\"10.1111/irv.13307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. 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Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019
Background
Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate.
Methods
We conducted an annual repeated cross-sectional seroepidemiological survey, during June–August, from 2014 to 2019, in Portugal. A total of 4326 sera from all age groups, sex, and regions was tested by hemagglutination inhibition assay. Seroprevalence and geometric mean titers (GMT) of protective antibodies against influenza were assessed by age group, sex, and vaccine status (65+ years old). The association between summer annual seroprevalence and the difference of influenza incidence rates between one season and the previous one was measured by Pearson correlation coefficient (r).
Results
Significant differences in seroprevalence of protective antibodies against influenza were observed in the population. Higher seroprevalence and GMT for A(H1N1)pdm09 and A(H3N2) were observed in children (5–14); influenza B seroprevalence in adults 65+ was 1.6–4.4 times than in children (0–4). Vaccinated participants (65+) showed significant higher seroprevalence/GMT for influenza. A strong negative and significant correlation was found between seroprevalence and ILI incidence rate for A(H1N1)pdm09 in children between 5 and 14 (r = −0.84; 95% CI, −0.98 to −0.07); a weak negative correlation was observed for A(H3N2) and B/Yamagata (r ≤ −0.1).
Conclusions
The study provides new insight into the anti-influenza antibodies seroprevalence measured in summer on the ILI incidence rate in the next season and the need for adjusted preventive health care measures to prevent influenza infection and transmission.
期刊介绍：
Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases.
Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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