SARS-CoV-2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2024-06-06 DOI:10.1111/irv.13333

Tamara Dörr, Sabine Güsewell, Alexia Cusini, Angela Brucher, Stephan Goppel, Fabian Grässli, Elsbeth Betschon, J. Carsten Möller, Manuela Ortner, Markus Ruetti, Reto Stocker, Danielle Vuichard-Gysin, Ulrike Besold, Lorenz Risch, Matthias von Kietzell, Matthias Schlegel, Stefan P. Kuster, Christian R. Kahlert, Philipp Kohler, for the SURPRISE (SURveillance of infectious diseases among health Professionals In SwitzErland) Study Group

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引用次数: 0

Abstract

Background

There is debate about the causes of the recent birth rate decline in high-income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS-CoV-2 vaccination and infection with involuntary childlessness.

Methods

Females in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS-CoV-2-infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti-nucleocapsid and anti-spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS-CoV-2-vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020.

Results

Of 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19/26) were vaccinated compared to 86.0% (664/772) without involuntary childlessness (p = 0.73). SARS-CoV-2 infection was reported by 76.9% (20/26) compared to 72.4% (559/772) of controls (p = 0.64). Neither SARS-CoV-2 vaccination (aOR 0.91 per dose, 95%CI 0.67–1.26) nor infection (aOR per infection 1.05, 95%CI 0.62–1.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results.

Conclusions

Among female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre-pandemic data. No association between involuntary childlessness and SARS-CoV-2 vaccination or infection was found.

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SARS-CoV-2 疫苗接种与女性医护人员非自愿无子女无关：一项多中心队列研究

背景：关于近期全球高收入国家出生率下降的原因存在争议。在疫情流行期间，由于担心对生殖健康的影响，人们对接种疫苗犹豫不决。我们调查了 SARS-CoV-2 疫苗接种和感染与非自愿无子女的关系：方法：自 2020 年 8 月起，我们对医疗保健工作者（HCW）多中心前瞻性队列中的育龄女性进行了跟踪调查。方法：自 2020 年 8 月起，对医护人员（HCW）中处于生育年龄的女性进行前瞻性多中心队列随访，获取并定期更新有关基线健康、SARS-CoV-2 感染和疫苗接种的数据，并重复采集血清样本，筛查抗核头状病毒抗体和抗尖峰抗体。2023 年 10 月，参与者表示非自愿无子女，并在大流行期间发病，而那些表示在大流行之前发病的人则被排除在外。通过单变量和多变量分析，研究了非自愿生育与 SARS-CoV-2 疫苗接种和感染的关系。还进行了敏感性分析，将报告非自愿无子女者与 2020 年以来生育子女者进行了比较：在 798 名参与者中，有 26 人（3.2%）报告自大流行后开始非自愿无子女。在非自愿无子女的妇女中，73.1%（19/26）已接种疫苗，而非自愿无子女妇女的接种率为 86.0%（664/772）（p = 0.73）。报告感染 SARS-CoV-2 的比例为 76.9%（20/26），而对照组为 72.4%（559/772）（p = 0.64）。接种 SARS-CoV-2 疫苗（每剂 aOR 0.91，95%CI 0.67-1.26）或感染（每感染 aOR 1.05，95%CI 0.62-1.71）均与非自愿无子女无关。敏感性分析证实了这些结果：结论：在育龄女性人机工程人员中，3.2%的人表示非自愿无子女，这与疫前的数据相当。非自愿生育与 SARS-CoV-2 疫苗接种或感染之间没有关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.