Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya
{"title":"非洲人、高加索人和亚洲人清除 SARS-CoV-2 的时间","authors":"Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya","doi":"10.1111/irv.13238","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (<i>p</i> < 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test <i>p</i> < 0.0001 and <i>p</i> < 0.05, respectively). On average, viral clearance occurred within 9.5 days during the second semester (higher rate of vaccination and SARS-CoV-2 exposition), whereas it took 13.6 days during the first semester (lower rate of vaccination and SARS-CoV-2 exposition) (Mann–Whitney <i>t</i>-test <i>p</i> < 0.0001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In conclusion, ethnicity and spatiotemporal changes including SARS-CoV-2 exposition and immunization affect SARS-CoV-2 clearance.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13238","citationCount":"0","resultStr":"{\"title\":\"Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups\",\"authors\":\"Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya\",\"doi\":\"10.1111/irv.13238\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (<i>p</i> < 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test <i>p</i> < 0.0001 and <i>p</i> < 0.05, respectively). 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Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups
Background
COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.
Methods
To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.
Results
The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (p < 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test p < 0.0001 and p < 0.05, respectively). On average, viral clearance occurred within 9.5 days during the second semester (higher rate of vaccination and SARS-CoV-2 exposition), whereas it took 13.6 days during the first semester (lower rate of vaccination and SARS-CoV-2 exposition) (Mann–Whitney t-test p < 0.0001).
Conclusion
In conclusion, ethnicity and spatiotemporal changes including SARS-CoV-2 exposition and immunization affect SARS-CoV-2 clearance.
期刊介绍：
Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases.
Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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