Influenza and Other Respiratory Viruses最新文献

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Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023–January 2024 2023 年 9 月至 2024 年 1 月期间,Nirsevimab 对法国儿科重症监护病房住院呼吸道合胞病毒支气管炎病例的疗效。
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-06-05 DOI: 10.1111/irv.13311
Juliette Paireau, Cécile Durand, Sylvain Raimbault, Joséphine Cazaubon, Guillaume Mortamet, Delphine Viriot, Christophe Milesi, Elise Daudens-Vaysse, Dominique Ploin, Sabrina Tessier, Noémie Vanel, Jean-Loup Chappert, Karine Levieux, Ronan Ollivier, Jamel Daoudi, Bruno Coignard, Stéphane Leteurtre, Isabelle Parent-du-Châtelet, Sophie Vaux
{"title":"Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023–January 2024","authors":"Juliette Paireau,&nbsp;Cécile Durand,&nbsp;Sylvain Raimbault,&nbsp;Joséphine Cazaubon,&nbsp;Guillaume Mortamet,&nbsp;Delphine Viriot,&nbsp;Christophe Milesi,&nbsp;Elise Daudens-Vaysse,&nbsp;Dominique Ploin,&nbsp;Sabrina Tessier,&nbsp;Noémie Vanel,&nbsp;Jean-Loup Chappert,&nbsp;Karine Levieux,&nbsp;Ronan Ollivier,&nbsp;Jamel Daoudi,&nbsp;Bruno Coignard,&nbsp;Stéphane Leteurtre,&nbsp;Isabelle Parent-du-Châtelet,&nbsp;Sophie Vaux","doi":"10.1111/irv.13311","DOIUrl":"10.1111/irv.13311","url":null,"abstract":"<p>In September 2023, France was one of the first countries that started a national immunisation campaign with nirsevimab, a new monoclonal antibody against respiratory syncytial virus (RSV). Using data from a network of paediatric intensive care units (PICUs), we aimed to estimate nirsevimab effectiveness against severe cases of RSV bronchiolitis in France. We conducted a case–control study based on the test-negative design and included 288 infants reported by 20 PICUs. We estimated nirsevimab effectiveness at 75.9% (48.5–88.7) in the main analysis and 80.6% (61.6–90.3) and 80.4% (61.7–89.9) in two sensitivity analyses. These real-world estimates confirmed the efficacy observed in clinical studies.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High SARS-CoV-2 Exposure in Rural Southern Mozambique After Four Waves of COVID-19: Community-Based Seroepidemiological Surveys 莫桑比克南部农村地区在四次 COVID-19 之后的 SARS-CoV-2 高暴露率:基于社区的血清流行病学调查
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-06-05 DOI: 10.1111/irv.13332
Áuria de Jesus, Rita Ernesto, Arsénia J. Massinga, Felizarda Nhacolo, Khátia Munguambe, Alcido Timana, Arsénio Nhacolo, Augusto Messa Jr., Sérgio Massora, Valdemiro Escola, Sónia Enosse, Rufino Gunjamo, Carlos Funzamo, Jason M. Mwenda, Joseph Okeibunor, Alberto Garcia-Basteiro, Caterina Guinovart, Alfredo Mayor, Inácio Mandomando
{"title":"High SARS-CoV-2 Exposure in Rural Southern Mozambique After Four Waves of COVID-19: Community-Based Seroepidemiological Surveys","authors":"Áuria de Jesus,&nbsp;Rita Ernesto,&nbsp;Arsénia J. Massinga,&nbsp;Felizarda Nhacolo,&nbsp;Khátia Munguambe,&nbsp;Alcido Timana,&nbsp;Arsénio Nhacolo,&nbsp;Augusto Messa Jr.,&nbsp;Sérgio Massora,&nbsp;Valdemiro Escola,&nbsp;Sónia Enosse,&nbsp;Rufino Gunjamo,&nbsp;Carlos Funzamo,&nbsp;Jason M. Mwenda,&nbsp;Joseph Okeibunor,&nbsp;Alberto Garcia-Basteiro,&nbsp;Caterina Guinovart,&nbsp;Alfredo Mayor,&nbsp;Inácio Mandomando","doi":"10.1111/irv.13332","DOIUrl":"https://doi.org/10.1111/irv.13332","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mozambique was one of many African countries with limited testing capacity for SARS-CoV-2. Serosurveys, an alternative to estimate the real exposure to understand the epidemiology and transmission dynamics, have been scarce in Mozambique. Herein, we aimed to estimate the age-specific seroprevalence of SARS-CoV-2 in the general population of the Manhiça District, at four time points, for evaluating dynamics of exposure and the impact of vaccination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted four community-based seroepidemiological surveys separated by 3 months between May 2021 and June 2022 to assess the prevalence of SARS-CoV-2 antibodies. An age-stratified (0–19, 20–39, 40–59, and ≥ 60 years) sample of 4810 individuals was randomly selected from demographic surveillance database, and their blood samples were analyzed using WANTAI SARS-CoV-2 IgG + IgM ELISA. Nasopharyngeal swabs from a subsample of 2209 participants were also assessed for active infection by RT-qPCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SARS-CoV-2 seroprevalence increased from 27.6% in the first survey (May 2021) to 63.6%, 91.2%, and 91.1% in the second (October 2021), third (January 2022), and fourth (May 2022) surveys, respectively. Seroprevalence in individuals &lt; 18 years, who were not eligible for vaccination, increased from 23.1% in the first survey to 87.1% in the fourth. The prevalence of active infection was below 10.1% in all surveys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A high seroprevalence to SARS-CoV-2 was observed in the study population, including individuals not eligible for vaccination at that time, particularly after circulation of the highly transmissible Delta variant. These data are important to inform decision making on the vaccination strategies in the context of pandemic slowdown in Mozambique.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141251427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2 Seroprevalence Trends in the Netherlands in the Variant of Concern Era: Input for Future Response 荷兰在关注变异体时代的 SARS-CoV-2 血清流行趋势:为未来应对措施提供参考
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-06-04 DOI: 10.1111/irv.13312
Eric R. A. Vos, Cheyenne C. E. van Hagen, Denise Wong, Gaby Smits, Marjan Kuijer, Alienke J. Wijmenga-Monsuur, Joanna Kaczorowska, Robert S. van Binnendijk, Fiona R. M. van der Klis, Gerco den Hartog, Hester E. de Melker
{"title":"SARS-CoV-2 Seroprevalence Trends in the Netherlands in the Variant of Concern Era: Input for Future Response","authors":"Eric R. A. Vos,&nbsp;Cheyenne C. E. van Hagen,&nbsp;Denise Wong,&nbsp;Gaby Smits,&nbsp;Marjan Kuijer,&nbsp;Alienke J. Wijmenga-Monsuur,&nbsp;Joanna Kaczorowska,&nbsp;Robert S. van Binnendijk,&nbsp;Fiona R. M. van der Klis,&nbsp;Gerco den Hartog,&nbsp;Hester E. de Melker","doi":"10.1111/irv.13312","DOIUrl":"https://doi.org/10.1111/irv.13312","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To inform future response planning we aimed to assess SARS-CoV-2 trends in infection- and/or vaccine-induced immunity, including breakthrough infections, among (sub)groups, professions and regions in the Dutch population during the Variant of Concern (VOC)-era.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective population-based cohort, randomly selected participants (<i>n</i> = 9985) aged 1–92 years (recruited early-2020) donated home-collected fingerstick-blood samples at six timepoints in 2021/2022, covering waves dominated by Alpha, Delta, and multiple Omicron (sub-)variants. IgG antibody assessment against Spike-S1 and Nucleoprotein was combined with vaccination- and testing data to estimate infection-induced (inf) and total (infection- and vaccination-induced) seroprevalence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nationwide inf-seroprevalence rose modestly from 12% (95% CI 11–13) since Alpha to 26% (95% CI 24–28) amidst Delta, while total seroprevalence increased rapidly to 87% (95% CI 85–88), particularly in elderly and those with comorbidities (i.e., vulnerable groups). Interestingly, highest infection rates were noticeable among low/middle educated elderly, non-Western, those in contact professions, adolescents and young adults, and in low-vaccination coverage regions. Following Omicron emergence, inf-seroprevalence elevated sharply to 62% (95% CI 59–65) and further to 86% (95% CI 83–90) in late-2022, with frequent breakthrough infections and decreasing seroprevalence dissimilarities between most groups. Whereas &gt; 90% of &lt; 60-year-olds had been infected at least once, 30% of vaccinated vulnerable individuals had still not acquired hybrid immunity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Groups identified to have been infected disproportionally during the acute phase of the pandemic require specific attention in evaluation of control measures and future response planning worldwide. Furthermore, ongoing tailored vaccination efforts and (sero-)monitoring of vulnerable groups may remain important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141251371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups 非洲人、高加索人和亚洲人清除 SARS-CoV-2 的时间
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-06-04 DOI: 10.1111/irv.13238
Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya
{"title":"Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups","authors":"Louis Sides Ndjengue Nson,&nbsp;Daniella Ndombi Delpo Dede,&nbsp;Fabrice Lotola Mougeni,&nbsp;Natacha Bouassa,&nbsp;Basma Bennjakhoukh,&nbsp;Alexandra Luthi,&nbsp;Anselme Voubou,&nbsp;Juliette Atatama,&nbsp;Raymond Tat Pambou,&nbsp;Guy Dieudonné Mvogo,&nbsp;Victorien Sah,&nbsp;Bertin Atangana,&nbsp;Amandine Mveang Nzoghe,&nbsp;Anicet Christel Maloupazoa Siawaya,&nbsp;Paulin N. Essone,&nbsp;Pélagie Mougola Bissiengou,&nbsp;Bénédicte Ndeboko,&nbsp;Joel Fleury Djoba Siawaya","doi":"10.1111/irv.13238","DOIUrl":"https://doi.org/10.1111/irv.13238","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (<i>p</i> &lt; 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test <i>p</i> &lt; 0.0001 and <i>p</i> &lt; 0.05, respectively). On average, viral clearance occurred within 9.5 days during the second semester (higher rate of vaccination and SARS-CoV-2 exposition), whereas it took 13.6 days during the first semester (lower rate of vaccination and SARS-CoV-2 exposition) (Mann–Whitney <i>t</i>-test <i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, ethnicity and spatiotemporal changes including SARS-CoV-2 exposition and immunization affect SARS-CoV-2 clearance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141251368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Novel Influenza Viruses Through Community and Healthcare Testing: Implications for Surveillance Efforts in the United States 通过社区和医疗保健检测发现新型流感病毒:对美国监测工作的影响》。
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-26 DOI: 10.1111/irv.13315
Sinead E. Morris, Matthew Gilmer, Ryan Threlkel, Lynnette Brammer, Alicia P. Budd, A. Danielle Iuliano, Carrie Reed, Matthew Biggerstaff
{"title":"Detection of Novel Influenza Viruses Through Community and Healthcare Testing: Implications for Surveillance Efforts in the United States","authors":"Sinead E. Morris,&nbsp;Matthew Gilmer,&nbsp;Ryan Threlkel,&nbsp;Lynnette Brammer,&nbsp;Alicia P. Budd,&nbsp;A. Danielle Iuliano,&nbsp;Carrie Reed,&nbsp;Matthew Biggerstaff","doi":"10.1111/irv.13315","DOIUrl":"10.1111/irv.13315","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Novel influenza viruses pose a potential pandemic risk, and rapid detection of infections in humans is critical to characterizing the virus and facilitating the implementation of public health response measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We use a probabilistic framework to estimate the likelihood that novel influenza virus cases would be detected through testing in different community and healthcare settings (urgent care, emergency department, hospital, and intensive care unit [ICU]) while at low frequencies in the United States. Parameters were informed by data on seasonal influenza virus activity and existing testing practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In a baseline scenario reflecting the presence of 100 novel virus infections with similar severity to seasonal influenza viruses, the median probability of detecting at least one infection per month was highest in urgent care settings (72%) and when community testing was conducted at random among the general population (77%). However, urgent care testing was over 15 times more efficient (estimated as the number of cases detected per 100,000 tests) due to the larger number of tests required for community testing. In scenarios that assumed increased clinical severity of novel virus infection, median detection probabilities increased across all healthcare settings, particularly in hospitals and ICUs (up to 100%) where testing also became more efficient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggest that novel influenza virus circulation is likely to be detected through existing healthcare surveillance, with the most efficient testing setting impacted by the disease severity profile. These analyses can help inform future testing strategies to maximize the likelihood of novel influenza detection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019 流感保护性抗体的血清流行率与流感发病率的降低:2014年至2019年年度重复横断面研究》。
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-26 DOI: 10.1111/irv.13307
Raquel Guiomar, Susana Pereira da Silva, Inês Costa, Patricia Conde, Paula Cristóvão, Ana Paula Rodrigues, Aida Fernandes, Ana Paula Dias, Ana Rita Couto, Angélica Ramos, Carina Moita, Carina Rodrigues, Fátima Vale, Filomena Caldeira, Jácome Bruges Armas, João Pereira-Vaz, José Alves, Ludivina Freitas, Luis Martins, Luís Milho, Luisa Mota-Vieira, Lurdes Lopes, Margarida Freitas, Maria Ana Pessanha, Maria Correia, Maria Helena Marques, Maria João Cardoso, Maria João Peres, Mário Cunha, Patricia Amantegui, Paula Mota, Paulo Lopes, Paulo Pereira, Regina Viseu, Rita Cabral, Rita Côrte-Real, Sofia Almeida, Vânia Soares, Kamal Mansinho, Olav Hungnes, Baltazar Nunes
{"title":"Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019","authors":"Raquel Guiomar,&nbsp;Susana Pereira da Silva,&nbsp;Inês Costa,&nbsp;Patricia Conde,&nbsp;Paula Cristóvão,&nbsp;Ana Paula Rodrigues,&nbsp;Aida Fernandes,&nbsp;Ana Paula Dias,&nbsp;Ana Rita Couto,&nbsp;Angélica Ramos,&nbsp;Carina Moita,&nbsp;Carina Rodrigues,&nbsp;Fátima Vale,&nbsp;Filomena Caldeira,&nbsp;Jácome Bruges Armas,&nbsp;João Pereira-Vaz,&nbsp;José Alves,&nbsp;Ludivina Freitas,&nbsp;Luis Martins,&nbsp;Luís Milho,&nbsp;Luisa Mota-Vieira,&nbsp;Lurdes Lopes,&nbsp;Margarida Freitas,&nbsp;Maria Ana Pessanha,&nbsp;Maria Correia,&nbsp;Maria Helena Marques,&nbsp;Maria João Cardoso,&nbsp;Maria João Peres,&nbsp;Mário Cunha,&nbsp;Patricia Amantegui,&nbsp;Paula Mota,&nbsp;Paulo Lopes,&nbsp;Paulo Pereira,&nbsp;Regina Viseu,&nbsp;Rita Cabral,&nbsp;Rita Côrte-Real,&nbsp;Sofia Almeida,&nbsp;Vânia Soares,&nbsp;Kamal Mansinho,&nbsp;Olav Hungnes,&nbsp;Baltazar Nunes","doi":"10.1111/irv.13307","DOIUrl":"10.1111/irv.13307","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an annual repeated cross-sectional seroepidemiological survey, during June–August, from 2014 to 2019, in Portugal. A total of 4326 sera from all age groups, sex, and regions was tested by hemagglutination inhibition assay. Seroprevalence and geometric mean titers (GMT) of protective antibodies against influenza were assessed by age group, sex, and vaccine status (65+ years old). The association between summer annual seroprevalence and the difference of influenza incidence rates between one season and the previous one was measured by Pearson correlation coefficient (<i>r</i>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences in seroprevalence of protective antibodies against influenza were observed in the population. Higher seroprevalence and GMT for A(H1N1)pdm09 and A(H3N2) were observed in children (5–14); influenza B seroprevalence in adults 65+ was 1.6–4.4 times than in children (0–4). Vaccinated participants (65+) showed significant higher seroprevalence/GMT for influenza. A strong negative and significant correlation was found between seroprevalence and ILI incidence rate for A(H1N1)pdm09 in children between 5 and 14 (<i>r</i> = −0.84; 95% CI, −0.98 to −0.07); a weak negative correlation was observed for A(H3N2) and B/Yamagata (<i>r</i> ≤ −0.1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study provides new insight into the anti-influenza antibodies seroprevalence measured in summer on the ILI incidence rate in the next season and the need for adjusted preventive health care measures to prevent influenza infection and transmission.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom 英国 2023/2024 年流感季节初级和二级护理中流感疫苗的临时有效性。
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-21 DOI: 10.1111/irv.13284
Heather Whitaker, Beth Findlay, Jana Zitha, Rosalind Goudie, Katie Hassell, Josie Evans, Panoraia Kalapotharakou, Utkarsh Agrawal, Beatrix Kele, Mark Hamilton, Catherine Moore, Rachel Byford, Julia Stowe, Chris Robertson, Anastasia Couzens, Gavin Jamie, Katja Hoschler, Kathleen Pheasant, Elizabeth Button, Catherine Quinot, Tim Jones, Sneha Anand, Conall Watson, Nick Andrews, Simon de Lusignan, Maria Zambon, Christopher Williams, Simon Cottrell, Kimberly Marsh, Jim McMenamin, Jamie Lopez Bernal
{"title":"Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom","authors":"Heather Whitaker,&nbsp;Beth Findlay,&nbsp;Jana Zitha,&nbsp;Rosalind Goudie,&nbsp;Katie Hassell,&nbsp;Josie Evans,&nbsp;Panoraia Kalapotharakou,&nbsp;Utkarsh Agrawal,&nbsp;Beatrix Kele,&nbsp;Mark Hamilton,&nbsp;Catherine Moore,&nbsp;Rachel Byford,&nbsp;Julia Stowe,&nbsp;Chris Robertson,&nbsp;Anastasia Couzens,&nbsp;Gavin Jamie,&nbsp;Katja Hoschler,&nbsp;Kathleen Pheasant,&nbsp;Elizabeth Button,&nbsp;Catherine Quinot,&nbsp;Tim Jones,&nbsp;Sneha Anand,&nbsp;Conall Watson,&nbsp;Nick Andrews,&nbsp;Simon de Lusignan,&nbsp;Maria Zambon,&nbsp;Christopher Williams,&nbsp;Simon Cottrell,&nbsp;Kimberly Marsh,&nbsp;Jim McMenamin,&nbsp;Jamie Lopez Bernal","doi":"10.1111/irv.13284","DOIUrl":"10.1111/irv.13284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We report 2023/2024 season interim influenza vaccine effectiveness for three studies, namely, primary care in Great Britain, hospital settings in Scotland and hospital settings in England.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A test negative design was used to estimate vaccine effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Estimated vaccine effectiveness against all influenzas ranged from 63% (95% confidence interval 46 to 75%) to 65% (41 to 79%) among children aged 2–17, from 36% (20 to 49%) to 55% (43 to 65%) among adults 18–64 and from 40% (29 to 50%) to 55% (32 to 70%) among adults aged 65 and over.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>During a period of co-circulation of influenza A(H1N1)pdm09 and A(H3N2) in the United Kingdom, evidence for effectiveness of the influenza vaccine in both children and adults was found.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avian Influenza Virus (H5N1) Was Not Detected Among Dairy Cattle and Farm Workers in Pakistan 巴基斯坦奶牛和农场工人中未检测到禽流感病毒 (H5N1)
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-17 DOI: 10.1111/irv.13317
Aftab Ahmed, Samia Saqlain, Arslan Rasool, Shaban Muhammad, Sajid Umar
{"title":"Avian Influenza Virus (H5N1) Was Not Detected Among Dairy Cattle and Farm Workers in Pakistan","authors":"Aftab Ahmed,&nbsp;Samia Saqlain,&nbsp;Arslan Rasool,&nbsp;Shaban Muhammad,&nbsp;Sajid Umar","doi":"10.1111/irv.13317","DOIUrl":"https://doi.org/10.1111/irv.13317","url":null,"abstract":"<p>Influenza A virus (IAV) is a zoonotic pathogen that poses a significant challenge to avian and public health [<span>1</span>]. Migratory waterfowl, such as ducks and geese, are the main reservoir of IAVs and spread IAVs to other domestic birds and animals. Cross-species transmission of IAV is generally rare, but it can occur, particularly if there are mutations in the virus's genetic code that allow it to attach to receptors in a new host or if a reassortment event occurs when two different influenza viruses infect the same host simultaneously and exchange genetic material. The Avian Influenza A(H5N1) virus, commonly known as “bird flu,” remains primarily a virus that affects birds, but it has on occasion infected humans. A relatively low number of sporadic human infections with A(H5N1) has been reported over the years. A total of 26 sporadic human cases from January 2022 through April 2024 [<span>2</span>] from eight countries indicates ongoing transmission from birds to humans. These cases highlight the potential for this virus to cause severe illness and death in humans. On rare occasions, A(H5N1) has crossed over to some nonavian species especially when there has been close contact with infected birds [<span>3-5</span>]. Cattle, like other mammalian species, are generally susceptible to specific types of IAV and Influenza D virus. Typically, A(H5N1) is not a common infection in cattle. Surprisingly, numerous sporadic cases of A(H5N1) have been reported recently from dairy cattle in multiple states of the United States [<span>5, 6</span>]. The emerging bovine H5N1 virus is novel to the cattle industry. Unlike other mammals, H5N1 grows in the udder of the dairy cows and does not seem to cause respiratory disease in cattle. Bovine H5N1 virus has undergone a specific adaptation in an enzyme called polymerase allowing better replication inside cow udder. A dairy farm worker with conjunctivitis was also confirmed positive highlighting fresh concerns of bovine H5N1 virus to human health [<span>5, 6</span>]. The dairy worker might have encountered this virus during the milking process or through hand-to-eye contact. Further genetic changes within polymerase enzyme or other genome segments of bovine H5N1 virus could allow for faster adaptation and may even support cattle-to-cattle or cattle to human transmission [<span>5, 6</span>]. Together, these reports highlight that H5N1 has potential to evolve and become a serious threat to human health. There is no data bovine H5N1 virus from Pakistan. Therefore, this study was designed to monitor the prevalence of IAVs and potential spillover of novel H5N1 among cattle and farm workers in Punjab province of Pakistan. Human subject research was approved by Institutional Review Board (IRB) at Duke Kunshan University, China (2024SU040).</p><p>As part of the Influenza D virus surveillance study, we collected nasal washes (<i>n =</i> 117) and nasal swab samples (<i>n =</i> 376) from farm workers and dairy cattle","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Detection of Influenza Virus Before and During the COVID-19 Pandemic in Cameroon 在喀麦隆 COVID-19 大流行之前和期间检测流感病毒
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-17 DOI: 10.1111/irv.13313
Gwladys Chavely Monamele, Desmon Toutou Tsafack, Chanceline Ndongo Bilounga, Mohamadou Njankouo Ripa, Christian Nsangou Yogne, Hermann Landry Munshili Njifon, Felix Nkom, Ubald Tamoufe, Linda Esso, Fancioli Koro Koro, Ronald Perraut, Richard Njouom
{"title":"The Detection of Influenza Virus Before and During the COVID-19 Pandemic in Cameroon","authors":"Gwladys Chavely Monamele,&nbsp;Desmon Toutou Tsafack,&nbsp;Chanceline Ndongo Bilounga,&nbsp;Mohamadou Njankouo Ripa,&nbsp;Christian Nsangou Yogne,&nbsp;Hermann Landry Munshili Njifon,&nbsp;Felix Nkom,&nbsp;Ubald Tamoufe,&nbsp;Linda Esso,&nbsp;Fancioli Koro Koro,&nbsp;Ronald Perraut,&nbsp;Richard Njouom","doi":"10.1111/irv.13313","DOIUrl":"https://doi.org/10.1111/irv.13313","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are both respiratory viruses with similar clinical manifestations and modes of transmission. This study describes influenza data before and during the coronavirus disease pandemic (COVID-19) in Cameroon and SARS-CoV-2 data during the pandemic period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study ran from 2017 to 2022, and data were divided into two periods: before (2017–2019) and during (2020–2022) the COVID-19 pandemic. Nasopharyngeal samples collected from persons with respiratory illness were tested for influenza using the Centers for Disease Control and Prevention (CDC) typing and subtyping assays. During the COVID-19 pandemic, the respiratory specimens were simultaneously tested for SARS-CoV-2 using the <i>DaAn</i> gene protocol or the Abbott real-time SARS-CoV-2 assay. The WHO average curve method was used to compare influenza virus seasonality before and during the pandemic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 6246 samples were tested. Influenza virus detection rates were significantly higher in the pre-pandemic period compared to the pandemic period (30.8% vs. 15.5%; <i>p</i> &lt; 0.001). Meanwhile, the SARS-CoV-2 detection rate was 2.5%. A change in the seasonality of influenza viruses was observed from a bi-annual peak before the pandemic to no clear seasonal pattern during the pandemic. The age groups 2–4 and 5–14 years were significantly associated with higher influenza positivity rates in both pre-pandemic and pandemic periods. For SARS-CoV-2, all age groups above 15 years were the most affected population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The COVID-19 pandemic had a significant impact on the seasonal influenza by changing the seasonality of the virus and reducing its detection rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015–2021 2015-2021 年蒙古乌兰巴托儿童呼吸道合胞病毒和流感感染情况
IF 4.4 4区 医学
Influenza and Other Respiratory Viruses Pub Date : 2024-05-16 DOI: 10.1111/irv.13303
Lien Anh Ha Do, Naranzul Tsedenbal, Chimidregzen Khishigmunkh, Bazarkhuu Tserendulam, Lkhagvadorj Altanbumba, Dashtseren Luvsantseren, Munkhchuluun Ulziibayar, Bujinlkham Suuri, Dorj Narangerel, Bilegtsaikhan Tsolmon, Sodbayar Demberelsuren, Casey L Pell, Sam Manna, Catherine Satzke, Cattram Nguyen, Tuya Mungun, Claire von Mollendorf, Darmaa Badarch, Kim Mulholland
{"title":"Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015–2021","authors":"Lien Anh Ha Do,&nbsp;Naranzul Tsedenbal,&nbsp;Chimidregzen Khishigmunkh,&nbsp;Bazarkhuu Tserendulam,&nbsp;Lkhagvadorj Altanbumba,&nbsp;Dashtseren Luvsantseren,&nbsp;Munkhchuluun Ulziibayar,&nbsp;Bujinlkham Suuri,&nbsp;Dorj Narangerel,&nbsp;Bilegtsaikhan Tsolmon,&nbsp;Sodbayar Demberelsuren,&nbsp;Casey L Pell,&nbsp;Sam Manna,&nbsp;Catherine Satzke,&nbsp;Cattram Nguyen,&nbsp;Tuya Mungun,&nbsp;Claire von Mollendorf,&nbsp;Darmaa Badarch,&nbsp;Kim Mulholland","doi":"10.1111/irv.13303","DOIUrl":"https://doi.org/10.1111/irv.13303","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Data available for RSV and influenza infections among children &lt; 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged &lt; 2 years with arterial O<sub>2</sub> saturation &lt; 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for <i>S. pneumoniae</i> (<i>S.p</i>.) by qPCR and for serotypes by culture and DNA microarray.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2–6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, <i>p</i>-value Fisher's exact = 0.001). <i>S.p</i>. carriage was detected in 1073/2281 (47.0%) patients. Among <i>S.p</i>. carriage cases, 363/1073 (33.8%) had <i>S.p</i>. and RSV codetection, and 82/1073 (7.6%) had <i>S.p</i>. and influenza codetection. <i>S.p</i>. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and <i>S.p</i>. was not associated with increased severity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140953008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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