Influenza and Other Respiratory Viruses最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148078993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148073075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148073076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148071563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148066451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulation of Influenza and Other Respiratory Viruses in Tunisia, 2022-2023 Season.","authors":"Bouslah Zoubeir, Bouguerra Hind, Dhaouadi Sonia, Abid Salma, Whitehouse Erin Rachel, El Ghord Hakim, Yazidi Rihab, Ben Mrad Nacef, Miraoui Amal, Bougharriou Ichrak, Ennouri Emna, Ben Slimen Najla, Guebsi Nour El Houda, Toumi Radhouane, Bouabid Leila, Ben Hamida Chokri, Merhabane Takoua, Boussarsar Mohamed, Ben Jemaa Mounir, Menif Khaled, Ben Khelil Jalila, Ben Alaya Nissaf, Ben Salah Afif, Laouini Dhafer, Zureick Kinda, Boutiba-Ben Boubaker Ilhem","doi":"10.1111/irv.70199","DOIUrl":"10.1111/irv.70199","url":null,"abstract":"<p><strong>Introduction: </strong>Influenza sentinel surveillance has been ongoing in Tunisia since 1999. We describe the epidemiology of respiratory viruses during 2022-2023, the first season to include testing for other respiratory viruses, such as respiratory syncytial virus (RSV).</p><p><strong>Methods: </strong>We analyzed weekly surveillance data from severe acute respiratory infection (SARI) inpatients and influenza-like illness outpatients from 11 hospitals and 85 clinics in Tunisia. Nasopharyngeal specimens and demographic, clinical, and vaccination data were collected. Specimens were tested by rRT-PCR for influenza, SARS-CoV-2, RSV, and 18 other respiratory viruses. Descriptive statistics were used to summarize case characteristics; group differences were assessed using chi-squared or Fisher's exact tests.</p><p><strong>Results: </strong>2038 specimens were collected from unique patients; 1231 (60.4%) were positive for ≥ 1 respiratory virus and 200 (16.2%) were positive for ≥ 2 viruses. Influenza was the most detected (n = 445; 21.8%), followed by rhinovirus (n = 301, 14.8%), RSV (n = 255, 12.5%), and SARS-CoV-2 (n = 125, 6.1%). Among SARI cases, infections with influenza and SARS-CoV-2 were more common in adults ≥ 50 years (61.8% and 71.4%, respectively), while children < 2 years had higher RSV prevalence (83.0%, adjusted p-value = 0.004). 4.9% of patients received a recent influenza vaccine.</p><p><strong>Conclusion: </strong>The burden of respiratory viruses varied by age, with RSV being more prevalent among younger children and SARS-CoV-2 and influenza being more prevalent among older adults. Ongoing sentinel surveillance is essential to monitor priority respiratory pathogens, particularly those with available public health interventions, such as vaccination, to enable timely action and reduce disease burden.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":"e70199"},"PeriodicalIF":3.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanded Genomic Surveillance and Seasonal Comparisons of Human Respiratory Syncytial Virus Infections in Minnesota, USA, 2023-2025.","authors":"Daniel Evans, Henry Kunerth, Erica Mumm, Matthew Plumb, Laura Bohnker-Voels, Sarah Bistodeau, Scott A Cunningham, Jordan Davis, Karen Martin, Kathryn Como-Sabetti, Sarah Namugenyi, Xiong Wang, Ruth Lynfield, Anna Strain, Sara Vetter","doi":"10.1111/irv.70257","DOIUrl":"10.1111/irv.70257","url":null,"abstract":"<p><strong>Background: </strong>Human respiratory syncytial virus (HRSV) imposes a substantial burden in the United States. The use of whole-genome sequencing (WGS) for public health surveillance of HRSV lags that for other viral pathogens. The objective of this study was to expand the scope and depth of WGS-based surveillance of HRSV in Minnesota, USA.</p><p><strong>Methods: </strong>HRSV-positive specimens collected from outpatients and inpatients from July 2023 to April 2025 were submitted to the Minnesota Public Health Laboratory for WGS. Genomes were sequenced using a tiled amplicon approach, characterized by lineage, phylogenetically compared to those from prior surveillance, and searched for mutations reported to affect monoclonal antibody susceptibility or fusion (F) protein function. Data from surveillance of HRSV-associated hospitalizations were incorporated for epidemiological analysis.</p><p><strong>Results: </strong>Continuing WGS through 2025 generated 2975 HRSV genomes. Compared to those from 2023 to 2024, genomes from the 2024-2025 season were collected from greater proportions of patients with HRSV-associated hospitalizations, of older age, and from a broader geographical distribution. Subgroups A and B both exhibited significant differences in total genetic diversity by season (p < 0.001). Twenty subclades and lineage A.D.5.4 were not observed during the 2024-2025 season. F protein mutations were identified at 15 amino acid positions of epidemiological concern, of which 11 emerged homoplastically. Genomes from 39 hospitalized patients carried at least one of these mutations.</p><p><strong>Conclusions: </strong>Continuing WGS-based HRSV surveillance across multiple respiratory seasons yielded valuable insights into the emergence and evolution of viral lineages and the prevalence of mutations of concern among outpatient and inpatient infections.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":"e70257"},"PeriodicalIF":3.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Syncytial Virus Hospitalizations Among Adults in Thailand: A Nationwide Retrospective Observational Study (RSV-HAT).","authors":"Kanrutai Jarottammarat, Kanokkarn Pinyopornpanish, Chadakan Yan, Bussakorn Mahakkanukrauh, Otavio Cintra, Adriana Guzman-Holst, Phichayut Phinyo, Wipa Reechaipichitkul","doi":"10.1111/irv.70263","DOIUrl":"10.1111/irv.70263","url":null,"abstract":"<p><strong>Background: </strong>Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults, especially older individuals, yet data on burden in Thailand are limited. This study aimed to describe clinical characteristics and mortality risk factors of RSV-related hospitalizations in Thai adults.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using Thailand's national hospital database, including adults aged ≥ 18 years hospitalized with RSV-associated ARIs between June 2016 and September 2024, identified using ICD-10 codes J12.1, J20.5, J21.0, and B97.4. Demographics, case fatality ratio, and healthcare resource utilization were assessed. Multivariable logistic regression identified predictors of in-hospital mortality, and Kaplan-Meier analysis estimated 60-day overall survival by age and comorbidity status.</p><p><strong>Results: </strong>Among 1595 RSV-related hospitalizations, the mean age was 66.5 years; 72.0% were aged ≥60 years and 78.4% had ≥ 1 comorbidity, most commonly hypertension, diabetes, chronic respiratory disease, and chronic heart disease. The median length of stay (LOS) was 7 days, 17.3% required oxygen therapy, and 8.2% received invasive mechanical ventilation (IMV). The in-hospital mortality was 9.53%. Mortality was independently associated with age ≥ 75 years (mOR 1.83, p = 0.019), LOS ≥ 7 days (1.95, p = 0.001), IMV (2.94, p < 0.001), pneumonia (4.10, p < 0.001), and acute myocardial infarction (3.05, p = 0.005). The 60-day survival rate was 88.2%, declining to 84.0% in patients aged ≥ 75 years (p < 0.001) and 87.1% in those with comorbidities versus 92.2% in those without (p = 0.013).</p><p><strong>Conclusions: </strong>RSV causes substantial morbidity and mortality in Thai adults, especially those aged ≥ 75 years and with chronic comorbidities, underscoring the need for strengthened RSV surveillance and prevention strategies.</p><p><strong>Trial registration: </strong>Thai Clinical Trials Registry: TCTR20250929005.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":"e70263"},"PeriodicalIF":3.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Respiratory Syncytial Virus Infection Among Patients Aged Less Than 2 Years: A Retrospective Study From an Italian Southern Region in Years 2018-2023.","authors":"Giuseppe Di Martino, Pamela Di Giovanni, Federica Vaccaro, Francesca Romana Cascavilla, Carla Di Marzio, Livia Tognaccini, Edoardo Trebbi, Teresa Aita, Ferdinando Romano, Tommaso Staniscia","doi":"10.1111/irv.70224","DOIUrl":"10.1111/irv.70224","url":null,"abstract":"<p><strong>Introduction: </strong>Respiratory syncytial virus (RSV) is one of the most common viruses infecting nearly all children worldwide within the first 2 years of life, requiring hospitalization for over 80% of cases in infants under the age of 1. The aim of this study was to evaluate the epidemiological impact of RSV infections on hospital admissions among patients aged less than 2 years in the Abruzzo region, Italy. In addition, the analysis on patients aged less than 1 year and the evaluation of direct costs related to RSV admissions were also performed.</p><p><strong>Methods: </strong>A retrospective observational study was performed in Abruzzo, a Southern Italian region. Data related to hospitalizations were extracted from the hospital discharge record (HDRs) of the Abruzzo region, considering all hospitalizations registered from 2018 to 2023. HDRs from patients younger than 2 years of age and diagnosed with RSV were extracted. Hospitalizations were stratified by calendar year and seasonal cycle. In addition, the analysis of costs generated by each admission was performed.</p><p><strong>Results: </strong>Totally, 1899 hospitalizations for RSV (98.43 admissions/1000 inhabitants aged under 2 years of age) were recorded in the Abruzzo region during the study period. The median length of stay of all the considered hospitalizations was 5 days (IQR 5-5). The year with the highest number of hospitalizations was 2023. The incident rate among patients under 2 years of age rose from 17.42 to 19.39 in 2023 in A2 over 1000 inhabitants. About costs, the total expenditure for hospitalizations strongly increased from €579,047.29 in 2018 to €1,060,018.94 in 2023.</p><p><strong>Conclusions: </strong>This study highlights the heavy burden of RSV on hospital admissions among patients aged under 2 years in a region of Southern Italy. These results are in line with previously published research, leading to the necessity of the introduction of effective preventive measures.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":"e70224"},"PeriodicalIF":3.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and Cardiac Dysfunction in Hospitalized Patients With Influenza: The FluHeart Study.","authors":"Kristoffer Grundtvig Skaarup, Filip Soeskov Davidovski, Emil Durukan, Ema Rastoder, Maria Dons, Morten Sengeløv, Bernadette Rasborg, Katrine Feldballe Bernholm, Julie Inge-Marie Helene Borchsenius, Lene Nielsen, Jens-Ulrik Stæhr Jensen, Tor Biering-Sørensen","doi":"10.1111/irv.70266","DOIUrl":"10.1111/irv.70266","url":null,"abstract":"<p><strong>Background: </strong>Influenza virus infection can lead to acute cardiovascular events, but the relationship between influenza-induced inflammation and cardiac dysfunction remains unclear. This study evaluated whether the severity of inflammation was associated with cardiac impairment, as assessed by echocardiography, in hospitalized patients with influenza.</p><p><strong>Methods: </strong>In this prospective cohort study conducted in Denmark across three influenza seasons (2021-2022, 2022-2023, and 2023-2024), consecutive hospitalized patients with laboratory-confirmed influenza underwent protocolized echocardiography. Associations between C-reactive protein (CRP) levels and measures of cardiac function were assessed using multivariable models.</p><p><strong>Results: </strong>Among 241 patients (median age, 73.2 years; IQR, 58.3-82.8; 53% female), 54% had left ventricular (LV) systolic dysfunction (ejection fraction < 50% or global longitudinal strain < 16%), 15% had signs of elevated LV filling pressure (E/e' ≥ 14), 29% had right ventricular (RV) systolic dysfunction (tricuspid annular plane systolic excursion [TAPSE] < 1.7 cm or RV free wall strain < 20%), and 31% had pulmonary hypertension (RV systolic pressure [RVSP] > 40 mmHg). CRP showed a significant nonlinear association with E/e', RVSP, and TAPSE. E/e' and TAPSE worsened with higher CRP up to 100 mg/L, plateauing thereafter, whereas RVSP worsened at CRP levels > 100 mg/L.</p><p><strong>Conclusions: </strong>Cardiac dysfunction was observed in more than half of all examined hospitalized patients with influenza. Higher levels of inflammation were independently associated with elevated LV filling pressure, pulmonary hypertension, and RV dysfunction, supporting a potential link between influenza infection and cardiac impairment.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"20 5","pages":"e70266"},"PeriodicalIF":3.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}