Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2024-06-04 DOI:10.1111/irv.13238

Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya

{"title":"Time to SARS-CoV-2 clearance in African, Caucasian, and Asian ethnic groups","authors":"Louis Sides Ndjengue Nson, Daniella Ndombi Delpo Dede, Fabrice Lotola Mougeni, Natacha Bouassa, Basma Bennjakhoukh, Alexandra Luthi, Anselme Voubou, Juliette Atatama, Raymond Tat Pambou, Guy Dieudonné Mvogo, Victorien Sah, Bertin Atangana, Amandine Mveang Nzoghe, Anicet Christel Maloupazoa Siawaya, Paulin N. Essone, Pélagie Mougola Bissiengou, Bénédicte Ndeboko, Joel Fleury Djoba Siawaya","doi":"10.1111/irv.13238","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (<i>p</i> < 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test <i>p</i> < 0.0001 and <i>p</i> < 0.05, respectively). On average, viral clearance occurred within 9.5 days during the second semester (higher rate of vaccination and SARS-CoV-2 exposition), whereas it took 13.6 days during the first semester (lower rate of vaccination and SARS-CoV-2 exposition) (Mann–Whitney <i>t</i>-test <i>p</i> < 0.0001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In conclusion, ethnicity and spatiotemporal changes including SARS-CoV-2 exposition and immunization affect SARS-CoV-2 clearance.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"18 6","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13238","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Influenza and Other Respiratory Viruses","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/irv.13238","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

COVID-19 may become a seasonal disease. SARS-CoV-2 active circulation coupled with vaccination efforts has undoubtedly modified the virus dynamic. It is therefore important investigate SARS-CoV-2 dynamic in different groups of population following the course of spatiotemporal variance and immunization.

Methods

To investigate SARS-CoV-2 clearance in different ethnic groups and the impact of immunization, we recruited 777 SARS-CoV-2-positive patients (570 Africans, 156 Caucasians, and 51 Asians). Participants were followed and regularly tested for 2 months until they had two negative tests.

Results

The vaccination rate was 64.6%. African individuals were less symptomatic (2%), Caucasians (41%) and Asians (36.6%). On average, viral clearance occurred after 10.5 days. Viral load at diagnosis was inversely correlated with viral clearance (p < 0.0001). The time of SARS-CoV-2 clearance was higher in Africans and Caucasians than in Asians (Dunn's test p < 0.0001 and p < 0.05, respectively). On average, viral clearance occurred within 9.5 days during the second semester (higher rate of vaccination and SARS-CoV-2 exposition), whereas it took 13.6 days during the first semester (lower rate of vaccination and SARS-CoV-2 exposition) (Mann–Whitney t-test p < 0.0001).

Conclusion

In conclusion, ethnicity and spatiotemporal changes including SARS-CoV-2 exposition and immunization affect SARS-CoV-2 clearance.

Abstract Image

查看原文本刊更多论文

非洲人、高加索人和亚洲人清除 SARS-CoV-2 的时间

背景 COVID-19 可能成为一种季节性疾病。SARS-CoV-2 的活跃循环和疫苗接种工作无疑改变了病毒的动态。因此，随着时空变化和免疫接种的进行，调查不同人群中 SARS-CoV-2 的动态非常重要。方法为了调查不同种族群体的 SARS-CoV-2 清除情况以及免疫接种的影响，我们招募了 777 名 SARS-CoV-2 阳性患者（570 名非洲人、156 名白种人和 51 名亚洲人）。我们对参与者进行了为期 2 个月的跟踪和定期检测，直到检测结果两次呈阴性为止。结果疫苗接种率为 64.6%。非洲人（2%）、白种人（41%）和亚洲人（36.6%）的症状较轻。病毒平均在 10.5 天后清除。诊断时的病毒载量与病毒清除率成反比（p < 0.0001）。非洲人和白种人的 SARS-CoV-2 清除时间高于亚洲人（邓恩检验 p < 0.0001 和 p < 0.05）。第二学期（疫苗接种率和 SARS-CoV-2 暴露率较高）平均在 9.5 天内清除病毒，而第一学期（疫苗接种率和 SARS-CoV-2 暴露率较低）则需要 13.6 天（Mann-Whitney t 检验 p < 0.0001）。结论总之，种族和时空变化（包括 SARS-CoV-2 暴露和免疫接种）会影响 SARS-CoV-2 清除率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.