Trends in Proportions of Respiratory Syncytial Virus Infections Among Reported Respiratory Tract Infection Cases in Children Aged 0 to 5 Years in Western Pacific and Southeast Asia Regions: A Systematic Review and Meta-Analysis

IF 4.2 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-02-08 DOI:10.1111/irv.70077

Sangshin Park, Hyelan Lee, Jung Yoon Park, Sujin Choi, Hyun Jung Kim, Lorenzo Bertizzolo, Young Hwa Lee, Young June Choe

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引用次数: 0

Abstract

Background

Respiratory syncytial virus (RSV) is an important cause of bronchiolitis and pneumonia in children globally. This study aimed to incorporate new data to update estimates of RSV burden in children through 5 years of age in Western Pacific and Southeast Asia Regions.

Methods

A systematic review and meta-analysis were conducted to examine the proportion of RSV among cases of respiratory tract infection (RTI) in children in Western Pacific and Southeast Asia Regions using random effects models. Studies were eligible if they met the following inclusion criteria: (1) observational studies such as cohort and cross-sectional studies; (2) studies on humans; (3) studies on patients with RTI or influenza-like illness (ILI); (4) studies reporting incidence or proportion of RSV infection among respiratory related illness; and (5) studies on children aged 5 years or less.

Findings

A total of 4403 studies were identified from an initial search. After screening titles, abstracts, and full-text review, a total of 173 studies that met predefined eligibility criteria were included in the analysis. The overall proportion of RSV infections among all ARTIs was 18.7% (95% CI: 16.0%–21.5%), whereas the proportion of RSV infections among LRTIs was 28.7% (95% CI: 2.6%–30.3%) in children in Western Pacific and Southeast Asia Regions between 1970 and 2020. The proportion of RSV infections peaked in the 1980s at 33.4% (95% CI: 19.8%–48.5%), having increased from 10.6% (95% CI: 2.9%–22.2%) in the 1970s. It then showed a decreasing trend, with 28.9% (95% CI: 18.8%–40.3%) in the 1990s, 24.5% (95% CI: 22.3%–26.8%) in the 2000s, and 20.1% (95% CI: 17.8%–22.5%) in the 2010s. By country, Myanmar (50.0%; 95% CI, 47.5%–52.4%) and New Zealand (45.3%; 95% CI, 37.1%–53.7%) had the highest proportion during the overall time period, followed by Bhutan (45.2%; 95% CI, 36.4%–54.3%), Lao PDR (41.0%; 95% CI, 36.2%–46.0%), and Vietnam (35.5%; 95% CI, 19.3%–53.6%).

Interpretation

Substantial RSV-associated disease burden occurs in children in Western Pacific and Southeast Asia Regions. Our findings provide new and important evidence of the need for RSV prevention in Western Pacific and Southeast Asia countries. They could inform future preventive policy.

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西太平洋和东南亚地区0 - 5岁儿童呼吸道感染病例中呼吸道合胞病毒感染比例的趋势：系统回顾和荟萃分析

呼吸道合胞病毒（RSV）是全球儿童毛细支气管炎和肺炎的重要病因。本研究旨在纳入新的数据，以更新西太平洋和东南亚区域5岁以下儿童呼吸道合胞病毒负担的估计数。方法采用随机效应模型，对西太平洋和东南亚地区儿童呼吸道感染（RTI）病例中RSV的比例进行系统评价和meta分析。符合以下入选标准的研究：(1)观察性研究，如队列研究和横断面研究；(2)人体研究；(3)呼吸道感染或流感样疾病（ILI）患者的研究；(4)报告呼吸道相关疾病中RSV感染发生率或比例的研究；(5) 5岁以下儿童的研究。从最初的搜索中，总共确定了4403项研究。在筛选标题、摘要和全文审查后，总共有173项研究符合预定的资格标准被纳入分析。1970年至2020年，西太平洋和东南亚地区儿童中，所有急性呼吸道感染中RSV感染的总比例为18.7% (95% CI: 16.0%-21.5%)，而下呼吸道感染中RSV感染的比例为28.7% （95% CI: 2.6%-30.3%）。RSV感染比例在20世纪80年代达到峰值，为33.4% (95% CI: 19.8%-48.5%)，从20世纪70年代的10.6% （95% CI: 2.9%-22.2%）上升。随后呈下降趋势，1990年代为28.9% (95% CI: 18.8%-40.3%)， 2000年代为24.5% (95% CI: 22.3%-26.8%)， 2010年代为20.1% （95% CI: 17.8%-22.5%）。按国家划分，缅甸（50.0%）；95% CI, 47.5%-52.4%)和新西兰(45.3%；95% CI, 37.1%-53.7%)在整个时间段内的比例最高，其次是不丹(45.2%；95% CI, 36.4%-54.3%)，老挝人民民主共和国(41.0%；95% CI, 36.2%-46.0%)和越南(35.5%；95% ci, 19.3%-53.6%)。西太平洋和东南亚地区儿童中存在大量与rsv相关的疾病负担。我们的发现为西太平洋和东南亚国家需要预防RSV提供了新的重要证据。它们可以为未来的预防政策提供信息。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.