Clinical Outcomes of Coronavirus Disease 2019 in People Living With Human Immunodeficiency Virus in South Korea: A Nationwide Population-Based Cohort Study

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES
Jeong Yeon Kim, Yujin Jeong, Hyonggin An, Jin Woong Suh, Jang Wook Sohn, Young Kyung Yoon
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Abstract

Background

We aimed to compare the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) in people living with human immunodeficiency virus (HIV) (PLWH) with those in people living without HIV (PLWoH).

Methods

This nationwide descriptive epidemiological study was conducted in South Korea between January 2020 and February 2022. The National Health Insurance claim data, comprising the data of the entire Korean population, were collected through the Health Insurance Review and Assessment Service.

Results

Among 3,653,808 individuals who were diagnosed with COVID-19, 1311 (0.04%) were PLWH. All PLWH received antiretroviral therapy, and 26.47% had more than one underlying disease other than HIV infection. The overall in-hospital mortality rates of PLWH and PLWoH were 0.76% and 0.25%, respectively (P = 0.002). According to the Cox proportional hazard model, no significant difference was observed in the in-hospital mortality rate (hazard ratio [HR]: 1.80, 95% confidence interval [CI]: 0.70–4.67) between the PLWH and PLWoH. However, progression to severe or critical COVID-19 was more common in PLWH (HR: 2.70, 95% CI: 1.37–5.33). In PLWH diagnosed with COVID-19, a multivariable Cox regression analysis found old age (≥ 60 years) (HR: 6.9, 95% CI: 2.57–18.56) and diabetes mellitus (HR: 5.13, 95% CI: 2.02–13.00) as the independent risk factors for severe or critical COVID-19.

Conclusions

PLWH had a significantly higher risk of developing severe or critical COVID-19 compared with PLWoH. Our findings suggest the need for implementing tailored strategies to decrease the impact of COVID-19 on PLWH.

Abstract Image

韩国 2019 年人类免疫缺陷病毒感染者冠状病毒疾病的临床结果:基于全国人口的队列研究》(Nationalwide Population-Based Cohort Study)。
背景:我们旨在比较人类免疫缺陷病毒(HIV)感染者(PLWH)与非HIV感染者(PLWoH)中冠状病毒病2019(COVID-19)的流行病学和临床特征:这项全国性的描述性流行病学研究于 2020 年 1 月至 2022 年 2 月在韩国进行。通过健康保险审查和评估服务收集了国民健康保险索赔数据,其中包括韩国全体人口的数据:在 3,653,808 名确诊感染 COVID-19 的患者中,有 1311 人(0.04%)是 PLWH。所有 PLWH 都接受了抗逆转录病毒治疗,26.47% 的 PLWH 除感染 HIV 外还患有一种以上的基础疾病。PLWH 和 PLWoH 的总体院内死亡率分别为 0.76% 和 0.25%(P = 0.002)。根据 Cox 比例危险模型,PLWH 和 PLWoH 的院内死亡率无明显差异(危险比 [HR]:1.80,95% 置信区间 [CI]:0.70-4.67)。然而,在 PLWH 中,进展为严重或危重 COVID-19 的情况更为常见(HR:2.70,95% 置信区间 [CI]:1.37-5.33)。在确诊为 COVID-19 的 PLWH 中,多变量 Cox 回归分析发现,高龄(≥ 60 岁)(HR:6.9,95% CI:2.57-18.56)和糖尿病(HR:5.13,95% CI:2.02-13.00)是重度或危重 COVID-19 的独立风险因素:结论:与 PLWoH 相比,PLWH 感染严重或危重 COVID-19 的风险明显更高。我们的研究结果表明,有必要实施有针对性的策略来降低 COVID-19 对 PLWH 的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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