{"title":"Development of an Integrated Gamma-Ultrasound (γ -US) Probe Detector and Multiplexed Readout for Simultaneous γ -US Detection","authors":"Muhammad Nasir Ullah;Muhammad Waqar;Yuseung Park;Gyeong Beom Kim;Kyungseok Choi;Seungjoo Jang;Chanyoung Kim;Qifa Zhou;Hojong Choi;Jung-Yeol Yeom","doi":"10.1109/TUFFC.2025.3612985","DOIUrl":"10.1109/TUFFC.2025.3612985","url":null,"abstract":"This article presents the first fully integrated, highly compact single-element integrated gammaultrasound (<inline-formula> <tex-math>$gamma $ </tex-math></inline-formula>-US) probe for simultaneous molecular and anatomical imaging. The probe integrates a PZT-5A ultrasound (US) transducer with a Ce:GAGG scintillator and silicon photomultiplier (SiPM), enabling dual-modality detection along the same line-of-sight (LOS). The tungsten-epoxy composite serves dual roles as both the US backing layer and <inline-formula> <tex-math>$gamma $ </tex-math></inline-formula> collimator, making it innovative and significantly reduces size and complexity. Furthermore, a single-channel frequency-based multiplexed circuit enables real-time dual-modality data acquisition (DAQ). The <inline-formula> <tex-math>$gamma $ </tex-math></inline-formula> part of the probe achieves 17.3% energy resolution (FWHM at 122 keV), 80.0 cps/MBq sensitivity, and 2.69 mm spatial resolution at 1 cm distance in air. The US component provides a 36.0% fractional bandwidth (FBW), 5.95 dB signal-to-noise ratio (SNR), 1.32 mm axial resolution, and 4.90 mm lateral resolution at 5 cm depth in water. Finally, a fused B-mode image of a breast phantom validates the probe's imaging capability. This integrated probe design offers a compact, cost-effective solution for handheld medical diagnostics and nondestructive testing (NDT), with minimal performance trade-offs compared to standalone systems.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1509-1521"},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuanyang Guo;Qiandong Sun;Yang Xie;Jean-Gabriel Minonzio;Kailiang Xu;Dean Ta
{"title":"Brain-Wide Transcranial Ultrasound Localization Microscopy of the Nonhuman Primate","authors":"Yuanyang Guo;Qiandong Sun;Yang Xie;Jean-Gabriel Minonzio;Kailiang Xu;Dean Ta","doi":"10.1109/TUFFC.2025.3611501","DOIUrl":"10.1109/TUFFC.2025.3611501","url":null,"abstract":"Transcranial ultrasound localization microscopy (t-ULM) faces significant challenges for broader clinical and research applications, particularly in addressing image quality degradation caused by the skull. Research on nonhuman primate (NHP) models, with their human-like cranial characteristics, offers crucial insights for technical innovations and neuroscience applications of t-ULM. In this study, we developed a systematic pipeline for t-ULM of NHP, incorporating low-frequency diverging wave emission, phase aberration correction, and microbubble (MB) detection equalization. We also explored the contrast agent strategies and imaging plane selection. We achieved an optimal spatial resolution of 93 <inline-formula> <tex-math>$mu $ </tex-math></inline-formula>m in the coronal section and 105 <inline-formula> <tex-math>$mu $ </tex-math></inline-formula>m in the sagittal section at an emission frequency of 2.23 MHz, while both maintaining 5–8-cm penetration depth and 6-cm lateral field of view. We also obtained the hemodynamic mapping with a wide dynamic range up to 40 cm/s at a 1000-Hz compounded frame rate. This work validates the feasibility of t-ULM in the NHP and provides important tools and references for further neuroscience applications of t-ULM.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1448-1461"},"PeriodicalIF":3.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tzu-Hsuan Hsu;Lezli Matto;Joshua Campbell;Jack Kramer;Zhi-Qiang Lee;Ian Anderson;Kaicheung Chow;Mark S. Goorsky;Ming-Huang Li;Ruochen Lu
{"title":"Toward mmWave Surface Acoustic Wave Resonators in Lithium Niobate on Silicon Carbide","authors":"Tzu-Hsuan Hsu;Lezli Matto;Joshua Campbell;Jack Kramer;Zhi-Qiang Lee;Ian Anderson;Kaicheung Chow;Mark S. Goorsky;Ming-Huang Li;Ruochen Lu","doi":"10.1109/TUFFC.2025.3611298","DOIUrl":"10.1109/TUFFC.2025.3611298","url":null,"abstract":"Recent advancements in next-generation wireless systems have expanded the need for radio frequency front-ends (RFFEs) toward the millimeter-wave (mmWave) range. This work introduces two methods targeting the efficient design of solidly mounted surface acoustic wave (SAW) resonator architectures based on lithium niobate on silicon carbide (LN-on-SiC) heteroacoustic waveguides for mmWave applications. The first method uses a longitudinal SAW (L-SAW) mode in X-cut LN to achieve a high phase velocity of 6500 m/s and a figure of merit (FoM) of 6.53 at 22.42 GHz, enabled by strong acoustic confinement and careful wavelength scaling. The second method presents a novel electrode-guided shear horizontal SAW (EG SH-SAW) mode in Y-cut LN, leveraging electrode design to confine higher order SH modes and mitigate internal stress cancellation. The fabricated EG SH-SAW resonator achieves operation at 23.5 GHz with a coupling coefficient k2 of 1.6% and an FoM of 4.16. Both methods demonstrate resonators successfully scaled toward mmWave range with high Q-factors and open the potential for future solidly mounted frequency-scalable, high-performance acoustic devices in mmWave bands.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1522-1532"},"PeriodicalIF":3.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keith A. Wear;Christopher R. Fury;Andre V. Alvarenga
{"title":"Spatial Resolution Limits for Needle Hydrophones From 0.5 to 20 MHz With Implications for Transcranial Ultrasound","authors":"Keith A. Wear;Christopher R. Fury;Andre V. Alvarenga","doi":"10.1109/TUFFC.2025.3610361","DOIUrl":"10.1109/TUFFC.2025.3610361","url":null,"abstract":"Hydrophone spatial resolution and spatial averaging effects are determined by the frequencydependent effective sensitive element diameter deff(f) rather than the geometrical sensitive element diameter dg. The objective of this work was to quantify average deff(f) for needle hydrophones as a function of dg and f. Estimates of effective radii aeff(f) = deff(f)/2 were inferred from directivity measurements from 0.5 to 20 MHz on 16 needle hydrophones with dg = 2ag ranging from 75 to 1000 μm (139 hydrophone/frequency combinations). Effective sensitive element diameter deff(f) exceeded dg by over 100% when λ > 4dg (where λ is the wavelength). For kag > 0.75 (where k = 2π/λ), deff(f) was consistent with the “rigid piston” (RP) theory, reinforcing a previous report from our laboratories. However, for kag < 0.75, deff(f) showed noticeable deviations from RP theory and fell between predictions from RP theory and predictions for an unbaffled (UB) circular piston. Examples: 1) for a needle hydrophone with dg = 75 μm at 1 MHz (kag = 0.16), the data imply that average deff = 505 μm, and 2) for a needle hydrophone with dg = 400 μm at 500 kHz (common parameters for human transcranial neuromodulation; kag = 0.42), the data imply that average deff = 1215 μm.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1489-1496"},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11165490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darcy M. Dunn-Lawless;Abigail C. Collins;Constantin C. Coussios;Michael D. Gray
{"title":"Acoustically Transparent Sample Containers for Quantitative Cavitation Imaging","authors":"Darcy M. Dunn-Lawless;Abigail C. Collins;Constantin C. Coussios;Michael D. Gray","doi":"10.1109/TUFFC.2025.3609832","DOIUrl":"10.1109/TUFFC.2025.3609832","url":null,"abstract":"Passive acoustic mapping (PAM) is a powerful and widely used method of imaging cavitation activity. However, the presence of a container around a cavitating sample in experiments performed in vitro can introduce significant aberrations into recorded cavitation noise and resulting PAM images. These artifacts may lead to energy being incorrectly estimated or mapped to the wrong place, preventing accurate correlation between cavitation and bioeffects. In this work, we quantify these acoustic effects for six common types of sample containers using an acoustic reciprocity experiment, then use the results to inform the design of a new container with improved acoustic transparency. Existing vessels were found to introduce up to 13-dB broadband insertion loss and change the location and spread of energy in PAM images by up to 1 mm and 25%, respectively. The new container caused up to 1.4-dB insertion loss (the lowest of any container tested) and introduced no significant phase aberration, source location error, or change in energy spread to the PAM images. Testing the new container with real cavitation noise produced very similar insertion loss figures of up to 1.6 dB. These results highlight deficiencies in existing sample containers for the purposes of quantifying cavitation activity with PAM, which is increasingly desired as cavitation matures as a therapy. The guidelines for acoustic transparency developed here may assist researchers in avoiding container aberrations and enable accurate measurement of cavitation energy in future studies.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1476-1488"},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11164665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Grounding DINO-US-SAM: Text-Prompted Multiorgan Segmentation in Ultrasound With LoRA-Tuned Vision–Language Models","authors":"Hamza Rasaee;Taha Koleilat;Hassan Rivaz","doi":"10.1109/TUFFC.2025.3605285","DOIUrl":"10.1109/TUFFC.2025.3605285","url":null,"abstract":"Accurate and generalizable object segmentation in ultrasound imaging remains a significant challenge due to anatomical variability, diverse imaging protocols, and limited annotated data. In this study, we propose a prompt-driven vision–language model (VLM) that integrates grounding DINO with SAM2 to enable object segmentation across multiple ultrasound organs. A total of 18 public ultrasound datasets, encompassing the breast, thyroid, liver, prostate, kidney, and paraspinal muscle, were utilized. These datasets were divided into 15 for fine-tuning and validation of grounding DINO using low-rank adaptation (LoRA) to the ultrasound domain, and three were held out entirely for testing to evaluate performance in unseen distributions. Comprehensive experiments demonstrate that our approach outperforms state-of-the-art (SOTA) segmentation methods, including UniverSeg, MedSAM, MedCLIP-segment anything model (SAM), BiomedParse, and SAMUS on most seen datasets while maintaining strong performance on unseen datasets without additional fine-tuning. These results underscore the promise of VLMs in scalable and robust ultrasound image analysis, reducing dependence on large, organ-specific annotated datasets. We will publish our code on code.sonography.ai after acceptance.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 10","pages":"1414-1425"},"PeriodicalIF":3.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Angerer;J. Lu;J. Welsch;M. Lu;C. Luo;W. Plunet;E. Cretu;W. Tetzlaff;R. Rohling
{"title":"A Polymer-Based CMUT Probe for Imaging the Spinal Cord in Rats","authors":"M. Angerer;J. Lu;J. Welsch;M. Lu;C. Luo;W. Plunet;E. Cretu;W. Tetzlaff;R. Rohling","doi":"10.1109/TUFFC.2025.3605440","DOIUrl":"10.1109/TUFFC.2025.3605440","url":null,"abstract":"The ability of ultrasound imaging to deliver real-time visualization of tissue structures and surgical instruments can provide essential benefits in guiding medical interventions. In spinal cord injury research, small animal models are commonly used, but their size restricts the applicability of many standard ultrasound systems. Capacitive micromachined ultrasonic transducers (CMUTs) offer advantages over traditional piezoelectric transducers, including a smaller form factor, high design flexibility, and improved acoustic performance. CMUT structures made of polymers (polyCMUTs) can be produced cost-effectively and quickly, while potentially offering flexible, biocompatible transducers for next-generation ultrasound systems. This study introduces the first polyCMUT probe designed for imaging spinal cords in rats. A compact 11 MHz, 64 channel probe with a <inline-formula> <tex-math>$12.9times 6.5$ </tex-math></inline-formula> mm small tip was developed through a three-stage fabrication process, combining in-house manufactured polyCMUT arrays with electronics, integrated in a research imaging system. Performance evaluation included electrical impedance measurements, acoustic characterization, and in vitro and ex-vivo imaging. Quality analysis validated the stability of the fabrication process, demonstrating high yield and minimal variability, with a standard deviation in resonance frequency of less than 1%. The probe successfully visualized key anatomical structures like the central canal as well as real-time imaging of needle insertion into tissue. However, distinguishing between gray and white matter remained challenging due to limitations in frequency and bandwidth. This study demonstrates the potential of the polyCMUT technology for developing tailored ultrasound solutions. Future work will focus on optimizing high-frequency performance and advancing toward in vivo applications to provide meaningful tools in spinal cord injury research and therapeutic interventions.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 11","pages":"1437-1447"},"PeriodicalIF":3.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control Publication Information","authors":"","doi":"10.1109/TUFFC.2025.3597498","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3597498","url":null,"abstract":"","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 9","pages":"C2-C2"},"PeriodicalIF":3.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11144926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast-Enhanced Structured Illumination Ultrasound Imaging (CE-SIU)","authors":"Xiaoyu Qian;Jiabin Zhang;Yu Xia;Dongdong Liang;Jue Zhang","doi":"10.1109/TUFFC.2025.3603281","DOIUrl":"10.1109/TUFFC.2025.3603281","url":null,"abstract":"Super-resolution ultrasound (SRUS) technology based on contrast agents has shown great potential in in vivo microvascular blood flow imaging and has become a hot topic in the industry in recent years. SRUS represented by ultrasound localization microscopy (ULM) eliminates the point spread function (PSF) caused by diffraction by localizing sparse microbubbles in the image, and then constructs a super-resolution blood flow structure map through long-term image accumulation. It is worth mentioning that almost all current super-resolution strategies, including ULM, adopt postimage processing strategies. In optics, in addition to postimage processing super-resolution techniques, the design of the illumination light field is also a popular super-resolution imaging method. This inspired us to design the acoustic field to achieve a super-resolution blood flow imaging strategy based on structured acoustic field illumination. In this article, we propose a new structured acoustic field illumination design method, which achieves 2-D structured acoustic field design by improving the acoustic field calculation of Gerchberg–Saxton algorithm (GSA) based on Talbot effect. At the same time, we have designed a corresponding structured acoustic field reconstruction strategy that can adaptively reconstruct any structured illumination method, and the reconstructed image frame rate is comparable to that of multiangle plane wave. Combined with image postprocessing methods, we have obtained contrast-enhanced structured illumination ultrasound (CE-SIU), which reduces the full width at half maximum (FWHM) of the microbubble PSF, breaking through the lateral resolution limit of contrast-enhanced imaging. The super-resolution strategy based on acoustic field design proposed in this study provides new insights and perspectives for the development of the overall technical route of SRUS.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 10","pages":"1401-1413"},"PeriodicalIF":3.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junhao Wang;Jiao Xia;Aocheng Bao;Chong Yang;Jinghan Gan;Lei Zhao;Bowen Sheng;Wei Wang;Yipeng Lu
{"title":"Surface Condition Sensing With Broadband and Highly Directional PMUT Array","authors":"Junhao Wang;Jiao Xia;Aocheng Bao;Chong Yang;Jinghan Gan;Lei Zhao;Bowen Sheng;Wei Wang;Yipeng Lu","doi":"10.1109/TUFFC.2025.3601660","DOIUrl":"10.1109/TUFFC.2025.3601660","url":null,"abstract":"Ultrasound propagation attenuation coefficient detection is a widely used technique for distinguishing different media types. Multifrequency ultrasound detection provides comprehensive information but requires ultrasonic transducers with a broad bandwidth. This study presents a piezoelectric micromachined ultrasonic transducer (PMUT) array that integrates multiple frequency elements with optimized spacing to achieve the fusion of multiple vibration modes, resulting in a −6 dB emission fractional bandwidth of 230% and pulse-echo fractional bandwidth up to 146%. This ultrawide bandwidth facilitates accurate pulse-echo signal reception across a broad frequency range while minimizing signal overlap caused by ringdown effects. Moreover, optimizing the PMUT array size relative to wavelength achieved a highly directional 5° acoustic beam, ensuring effective penetration through high attenuation or multilayered structures. Experimental results indicate that attenuation coefficients in ice and liquid correlate with their material composition and structural properties. These findings highlight the significant potential of the PMUT array for identifying and analyzing surface media, with promising applications in power supply systems, transportation, industrial production, and so on.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 10","pages":"1324-1335"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}