IEEE transactions on ultrasonics, ferroelectrics, and frequency control最新文献_第2页

Spatially Variant Ultrasound Image Restoration with Product Convolution. 基于积卷积的空间变异超声图像恢复。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-30 DOI: 10.1109/TUFFC.2025.3584533

Arthur Floquet, Emmanuel Soubies, Duong-Hung Pham, Denis Kouame

引用次数: 0

In Vivo Ultrasound Dynamic Coronary Blood Flow Imaging through Adaptive Frame Selection Method. 基于自适应帧选择方法的体内超声动态冠状动脉血流成像。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-25 DOI: 10.1109/TUFFC.2025.3582154

Deng-Yan Zhuang, Hsin Huang, Wei-Ting Chang, Chih-Chung Huang

{"title":"In Vivo Ultrasound Dynamic Coronary Blood Flow Imaging through Adaptive Frame Selection Method.","authors":"Deng-Yan Zhuang, Hsin Huang, Wei-Ting Chang, Chih-Chung Huang","doi":"10.1109/TUFFC.2025.3582154","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3582154","url":null,"abstract":"Use of ultrasound for coronary imaging in commercial echocardiography remains challenging because of the small nature of coronary vasculature and the myocardium's intricate motion. Several super-resolution imaging techniques have been applied for coronary imaging; however, most only measure the coronary flow during the diastolic phase and have a long data acquisition time. To address these problems, this study proposes an adaptive frame selection approach for coronary vasculature imaging. In this approach, similar frames within cardiac cycles are selected using the sum of absolute difference (SAD) algorithm, and the coronary vasculature blood flow is calculated without using electrocardiographic gating data. Experiments were performed in mouse hearts through high-frequency ultrafast ultrasound imaging. After similar frames were selected from several cardiac cycles (one to five cycles), a singular value decomposition filter was applied to extract blood flow signals and obtain a dynamic coronary vasculature image, the accuracy of which was confirmed by measuring Doppler sonograms from the left coronary artery and arterioles. The conventional method (without SAD), in which only blood flow in the diastolic phase is calculated, was also conducted to enable a comparison in terms of measured vessel size and signal-to-noise ratio. The signal-to-noise ratio for the proposed approach were found to be 20.74 ± 1.62 dB, under the best parameter settings. The proposed approach was successfully verified in the small animal model and has potential for use in human dynamic coronary artery imaging.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation, Design and characterization of a Large Divergent Element Sparse Array (LDESA) for 3D Ultrasound Imaging. 用于三维超声成像的大发散元稀疏阵列（LDESA）的仿真、设计和表征。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-25 DOI: 10.1109/TUFFC.2025.3583178

Jean-Baptiste Jacquet, Jean-Luc Guey, Pierre Kauffmann, Mohamed Tamraoui, Emmanuel Roux, Barbara Nicolas, Etienne Coffy, Herve Liebgott

{"title":"Simulation, Design and characterization of a Large Divergent Element Sparse Array (LDESA) for 3D Ultrasound Imaging.","authors":"Jean-Baptiste Jacquet, Jean-Luc Guey, Pierre Kauffmann, Mohamed Tamraoui, Emmanuel Roux, Barbara Nicolas, Etienne Coffy, Herve Liebgott","doi":"10.1109/TUFFC.2025.3583178","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3583178","url":null,"abstract":"Sparse arrays address the complexity of manufacturing large 2D arrays. However, they usually suffer from a low signal-to-noise ratio (SNR) due to their small element size. The Large Divergent Element (LDE) technology overcomes this limitation by simultaneously having a large emitting area and a large angular aperture. The aim of this work is to demonstrate the feasibility of imaging in B-mode using the Large Divergent Element Sparse Array (LDESA), that is, increasing the sparse array SNR without noteworthy impact contrast. The paper provides the simulation, the design and an experimental characterization of a 1 MHz LDESA. Simulations are performed using the Angular Impulse Response based Ultrasound Simulation (AIRUS), providing coupled image-transducer optimizations of LDESA designs. Probe parameters, including probe diameter, layout, LDE size and electroacoustic response, are optimized to maximize the contrast ratio. The final layout is a 100 mm diameter Fermat spiral covered by 256 LDEs. Each LDE is 3.5mmwide in diameter and experimentally reaches an angular aperture of 75° at -6 dB in echo. The transmit focused beam is 1° wide and steerable up to 60° with an amplitude loss of only 10 dB. The array exhibits a 2.2 mm lateral resolution and a 1.8 mm axial resolution in a wire experiment.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedside Ultrasound Vector Doppler Imaging System with GPU Processing and Deep Learning. 床边超声矢量多普勒成像系统与GPU处理和深度学习。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-24 DOI: 10.1109/TUFFC.2025.3582773

Hassan Nahas, Billy Y S Yiu, Adrian J Y Chee, Takuro Ishii, Alfred C H Yu

{"title":"Bedside Ultrasound Vector Doppler Imaging System with GPU Processing and Deep Learning.","authors":"Hassan Nahas, Billy Y S Yiu, Adrian J Y Chee, Takuro Ishii, Alfred C H Yu","doi":"10.1109/TUFFC.2025.3582773","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3582773","url":null,"abstract":"Recent innovations in vector flow imaging promise to bring the modality closer to clinical application and allow for more comprehensive high-frame-rate vascular assessments. One such innovation is plane-wave multi-angle vector Doppler, where pulsed Doppler principles from multiple steering angles are used to realize vector flow imaging at frame rates upward of 1,000 frames per second (fps). Currently, vector Doppler is limited by the presence of aliasing artifacts that have prevented its reliable realization at the bedside. In this work, we present a new aliasing-resistant vector Doppler imaging system that can be deployed at the bedside using a programmable ultrasound core, graphics processing unit (GPU) processing, and deep learning principles. The framework supports two operational modes: 1) live imaging at 17 fps where vector flow imaging serves to guide image view navigation in blood vessels with complex dynamics; 2) on-demand replay mode where flow data acquired at high frame rates of over 1,000 fps is depicted as a slow-motion playback at 60 fps using an aliasing-resistant vector projectile visualization. Using our new system, aliasing-free vector flow cineloops were successfully obtained in a stenosis phantom experiment and in human bifurcation imaging scans. This system represents a major engineering advance towards the clinical adoption of vector flow imaging.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Supervised Optimization of RF Data Coherence for Improving Breast Reflection UCT Reconstruction. 改进乳房反射UCT重建的射频数据相干性自监督优化。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-23 DOI: 10.1109/TUFFC.2025.3581915

Lei He, Zhaohui Liu, Yuxin Cai, Qiude Zhang, Liang Zhou, Jing Yuan, Yang Xu, Mingyue Ding, Ming Yuchi, Wu Qiu

{"title":"Self-Supervised Optimization of RF Data Coherence for Improving Breast Reflection UCT Reconstruction.","authors":"Lei He, Zhaohui Liu, Yuxin Cai, Qiude Zhang, Liang Zhou, Jing Yuan, Yang Xu, Mingyue Ding, Ming Yuchi, Wu Qiu","doi":"10.1109/TUFFC.2025.3581915","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3581915","url":null,"abstract":"Reflection Ultrasound Computed Tomography (UCT) is gaining prominence as an essential instrument for breast cancer screening. However, reflection UCT quality is often compromised by the variability in sound speed across breast tissue. Traditionally, reflection UCT utilizes the Delay and Sum (DAS) algorithm, where the Time of Flight significantly affects the coherence of the reflected radio frequency (RF) data, based on an oversimplified assumption of uniform sound speed. This study introduces three meticulously engineered modules that leverage the spatial correlation of receiving arrays to improve the coherence of RF data and enable more effective summation. These modules include the self-supervised blind RF data segment block (BSegB) and the state-space model-based strong reflection prediction block (SSM-SRP), followed by a polarity-based adaptive replacing refinement (PARR) strategy to suppress sidelobe noise caused by aperture narrowing. To assess the effectiveness of our method, we utilized standard image quality metrics, including Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), and Root Mean Squared Error (RMSE). Additionally, coherence factor (CF) and variance (Var) were employed to verify the method's ability to enhance signal coherence at the RF data level. The findings reveal that our approach greatly improves performance, achieving an average PSNR of 19.64 dB, an average SSIM of 0.71, and an average RMSE of 0.10, notably under conditions of sparse transmission. The conducted experimental analyses affirm the superior performance of our framework compared to alternative enhancement strategies, including adaptive beamforming methods and deep learning-based beamforming approaches.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-acoustic-wave-driven acoustic tweezing in a silicon microfluidic chip. 硅微流控芯片中表面声波驱动的声镊。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-20 DOI: 10.1109/TUFFC.2025.3581642

Shichao Jia, Hanmu Guo, Roderick Y H Lim, Soichiro Tsujino

{"title":"Surface-acoustic-wave-driven acoustic tweezing in a silicon microfluidic chip.","authors":"Shichao Jia, Hanmu Guo, Roderick Y H Lim, Soichiro Tsujino","doi":"10.1109/TUFFC.2025.3581642","DOIUrl":"10.1109/TUFFC.2025.3581642","url":null,"abstract":"Surface acoustic wave (SAW)-driven acoustic tweezers have been widely explored for high-resolution ultrasonic sample manipulation. Among these, hybrid acoustic tweezers comprising a reusable SAW chip and a disposable glass or silicon microfluidic chip as a superstrate offer advantages such as reduced experimental costs and minimized cross-contamination between experiments. However, maximizing the acoustic pressure within the microfluidic channel requires efficient acoustic coupling between the SAW and the microfluidic structure. In this work, we investigate the frequency-dependent characteristics of acoustophoresis of 50 MHz hybrid acoustic tweezers composed of a SAW chip and a silicon microfluidic chip. We elucidate the role of the bulk acoustic wave resonances in the silicon substrate in facilitating the formation of acoustic standing waves within the microfluidic channel. Experimental results demonstrate the generation of acoustic pressures up to 2.1 ± 0.5 MPa inside the channel. The fabricated device was successfully used to probe the transient viscoelastic deformation of HEK293T cells and to trap motile cells Tetrahymena. These findings highlight the potential of the propose hybrid acoustic tweezers as a platform for acoutsto-mechanical testing of soft matter and biological samples.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary Coded Multiplane Wave Sequences For SNR Increase in Ultrafast Power Doppler Ultrasound Imaging. 提高超快功率多普勒超声成像信噪比的互补编码多平面波序列。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-19 DOI: 10.1109/TUFFC.2025.3581350

Tamraoui Mohamed, Adeline Bernard, Roux Emannuel, Liebgott Herve

{"title":"Complementary Coded Multiplane Wave Sequences For SNR Increase in Ultrafast Power Doppler Ultrasound Imaging.","authors":"Tamraoui Mohamed, Adeline Bernard, Roux Emannuel, Liebgott Herve","doi":"10.1109/TUFFC.2025.3581350","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3581350","url":null,"abstract":"Power Doppler imaging is a commonly used technique for visualizing blood flow in ultrasound imaging. This technique measures flow amplitude rather than velocity, and it relies on detecting the power of Doppler signals, making it particularly useful for detecting weak blood flow. The emergence of coherent plane wave compounding has enabled significant progress in ultrafast power Doppler imaging. However, the lack of transmit focusing leads to low Signal-to-Noise Ratio (SNR) and contrast, thereby reducing the sensitivity to blood flow, particularly in deep tissue regions. We propose to increase the SNR and contrast of ultrafast power Doppler imaging by leveraging the ideal correlation properties of Complete Complementary Codes (CCC) for Multi-Plane Wave Imaging (MPWI). The MPWI-CCC method consists of transmitting quasi-simultaneously N tilted plane waves coded with a binary sequence of length L. Subsequently, the backscattered signals from each plane wave are individually recovered with high amplitude through decoding. We compared MPWI-CCC and Multi-plane Wave Imaging with Hadamard encoding (MPWI-HD) against Coherent Plane Wave Compounding (CPWC) in both simulations and experiments. When transmitting four plane waves on a commercial blood flow phantom, MPWI-CCC exhibited SNR and contrast gains of 13.02dB and 10.08dB, respectively, compared to CPWC. MPWI-HD, on the other hand, achieved gains of only 6.99dB and 4.29dB, respectively.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D Laser Induced Phased Arrays for Remote Volumetric Ultrasonic Imaging. 用于远程体积超声成像的二维激光诱导相控阵。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-16 DOI: 10.1109/TUFFC.2025.3580168

Peter Lukacs, Don Pieris, Geo Davis, Matthew W Riding, Theodosia Stratoudaki

{"title":"2D Laser Induced Phased Arrays for Remote Volumetric Ultrasonic Imaging.","authors":"Peter Lukacs, Don Pieris, Geo Davis, Matthew W Riding, Theodosia Stratoudaki","doi":"10.1109/TUFFC.2025.3580168","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3580168","url":null,"abstract":"Three dimensional (3D) modality is critical for ultrasonic imaging to provide a representative volumetric view within objects, for better evaluation of shape, size and orientation of internal features. Conventional ultrasonic transducers are still used for the majority of phased array ultrasonic measurements. However, transducer arrays have certain drawbacks and limitations: it is a contact technique, requiring couplant. They also have a considerable size/weight/footprint preventing use in places with restricted access and/or extreme environments. Laser generated and detected ultrasound presents a non-contact, remote, ultrasonic imaging method. Furthermore, laser induced phased arrays (LIPAs) have been developed for ultrasonic imaging. Data captured with LIPAs have already been used in conjunction with the delay-and-sum imaging algorithm, the Total Focusing Method (TFM), for high-quality, two-dimensional (2D) ultrasonic imaging. However, there have been very limited instances of 3D laser ultrasonic imaging in the literature and no realisation of TFM yet, even though the TFM is considered the gold standard for ultrasonic imaging. This paper presents a laser ultrasonic system capable of synthesising 2D LIPAs which acquire all-optical data for 3D TFM imaging. The potential and advantages of 2D LIPAs for volumetric imaging are demonstrated first by comparing the use of 1D and 2D arrays to image a crack-like defect. Following this, 3D TFM imaging using 2D LIPAs is evaluated by imaging a sample with 4 bottom-drilled holes. The results are compared to those using three other 3D laser ultrasonic techniques presented in the literature: Monostatic SAFT, Bistatic SAFT and a method called Fixed Detector.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Imaging of Local Degradations in Li-ion Batteries Using Sparsely Distributed Active Sensors. 基于稀疏分布有源传感器的锂离子电池局部退化空间成像。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-16 DOI: 10.1109/TUFFC.2025.3579871

Jaewon Lee, Xiaoning Jiang, Howuk Kim

{"title":"Spatial Imaging of Local Degradations in Li-ion Batteries Using Sparsely Distributed Active Sensors.","authors":"Jaewon Lee, Xiaoning Jiang, Howuk Kim","doi":"10.1109/TUFFC.2025.3579871","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3579871","url":null,"abstract":"This study investigates the integrity of lithium-ion batteries (LIBs) with the aid of guided ultrasonic waves (GUWs) generated by an active sensing network. Despite the expanding demands for secondary batteries in industrial fields, safety concerns remain with respect to LIBs in conventional battery management systems. In order to avoid such safety concerns including unpredictable explosions of LIBs, we developed a novel non-invasive imaging method to inspect the health status of LIBs with a relatively large spatial area using GUWs. We attached nine piezoelectric transducers on the surface of a LiFePO4 (LFP) battery by sectoring it into four spatial regions. The localized mechanical degradation of the LIB was simulated by attaching a weight that caused acoustic mismatch and wave interference. Numerical simulation results showed that acoustic signal changes caused by mechanical degradation in LIBs varied with the frequency and time domains. We investigated a status index based on the continuous wavelet transform for application to the probabilistic reconstruction algorithm. The method was then validated using an actual LFP battery with dimensions of approximately 210 × 300 × 12 mm3. The proposed method exhibited superior performance as compared with other existing indices, effectively capturing suspicious spatial regions with a high contrast-to-noise ratio of over 19%. The proposed Li-ion battery health status imaging method holds promise for inspecting and monitoring the integrity of specific spatial areas in LIBs.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nondestructive Ultrasound Molecular Imaging with Higher-Order Singular Value Decomposition. 基于高阶奇异值分解的无损超声分子成像。

IF 3 2区工程技术

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Pub Date : 2025-06-11 DOI: 10.1109/TUFFC.2025.3578895

Gonzalo Collado-Lara, Geraldi Wahyulaksana, Hendrik J Vos, Klazina Kooiman

{"title":"Nondestructive Ultrasound Molecular Imaging with Higher-Order Singular Value Decomposition.","authors":"Gonzalo Collado-Lara, Geraldi Wahyulaksana, Hendrik J Vos, Klazina Kooiman","doi":"10.1109/TUFFC.2025.3578895","DOIUrl":"https://doi.org/10.1109/TUFFC.2025.3578895","url":null,"abstract":"Ultrasound molecular imaging (UMI) uses targeted microbubbles (MBs) to detect disease-associated biomarkers. For UMI, distinguishing the acoustic signals produced by bound MBs from those by free MBs and tissue is critical. Currently, the main approach, known as differential Targeted Enhancement (DTE), is timeintensive and requires MB destruction. Here we introduce a novel, rapid, and non-destructive UMI technique utilizing higher-order singular value decomposition (HOSVD). HOSVD decomposes the signals of an acoustic contrast sequence, separating them owing to their nonlinear content and temporal coherence. The nonlinear separation enables distinction between tissue and MBs, while the temporal separation enables distinction between free and bound MBs. From the HOSVD output, we defined a bound MB indicator χ which indicates the presence of bound MBs. In our in vitro experiments, χ was lower for free MBs and tissue (0.04±0.03) compared to bound MBs (0.31±0.11 without free MBs, decreasing with concentration down to 0.11±0.07 at 20x103 free MBs/ml). In addition, the molecular signal determined from χ correlated well with a DTE ground truth acquisition. The method was compared to other nondestructive techniques such as low-pass filtering and normalized singular spectrum area, demonstrating an average molecular signal enhancement of 12 dB. Furthermore, when used as a binary classifier, our method achieved a detection of up to 1.81× more true positives while reducing false positives up to 1.78×. These findings suggest that HOSVD could pave the way to rapid, nondestructive UMI.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0