IEEE transactions on ultrasonics, ferroelectrics, and frequency control最新文献

{"title":"Ultrasonic Rough Crack Characterization Using Time-of-Flight Diffraction With Self-Attention Neural Network","authors":"Zhengjun Wang;Fan Shi;Junhao Ding;Xu Song","doi":"10.1109/TUFFC.2024.3459619","DOIUrl":"10.1109/TUFFC.2024.3459619","url":null,"abstract":"Time-of-flight diffraction (ToFD) is a widely used ultrasonic nondestructive evaluation (NDE) method for locating and characterizing rough defects, with high accuracy in sizing smooth cracks. However, naturally grown defects often have irregular surfaces, complicating the received tip diffraction waves and affecting the accuracy of defect characterization. This article proposes a self-attention (SA) deep learning method to interpret the ToFD A-scan signals for sizing rough defects. A high-fidelity finite-element (FE) simulation software Pogo is used to generate the synthetic datasets for training and testing the deep learning model. Besides, the transfer learning (TL) method is used to fine-tune the deep learning model trained by the Gaussian rough defects to boost the performance of characterizing realistic thermal fatigue rough defects. An ultrasonic experiment using 2-D rough crack samples made by additive manufacturing is conducted to validate the performance of the developed deep learning model. To demonstrate the accuracy of the proposed method, the crack characterization results are compared with those obtained using the conventional Hilbert peak-to-peak sizing method. The results indicate that the deep learning method achieves significantly reduced uncertainty and error in rough defect characterization, in comparison with traditional sizing approaches used in ToFD measurements.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1289-1301"},"PeriodicalIF":3.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial dual-mode ultrasound with a 3-mm MR-compatible catheter for image-guided HIFU and directional in-vitro tissue ablations.","authors":"Thomas Biscaldi, Romain L'Huillier, Laurent Milot, W Apoutou N'Djin","doi":"10.1109/TUFFC.2024.3458067","DOIUrl":"https://doi.org/10.1109/TUFFC.2024.3458067","url":null,"abstract":"<p><p>Current interstitial techniques of tumor ablation face challenges that ultrasound technologies could meet. The ablation radius and directionality of the ultrasound beam could improve the efficiency and precision. Here, a 9-gauge MR-compatible dual-mode ultrasound catheter prototype was experimentally evaluated for Ultrasound Image-guided High Intensity Focused Ultrasound (USgHIFU) conformal ablations. The prototype consisted of 64 piezocomposite linear array elements and was driven by an open research programmable dual-mode ultrasound platform. After verifying the US-image guidance capabilities of the prototype, the HIFU output performances (dynamic focusing and HIFU intensities) were quantitatively characterized, together with the associated 3D HIFU-induced thermal heating in tissue phantoms (using MR thermometry). Finally, the ability to produce robustly HIFU-induced thermal ablations in in-vitro liver was studied experimentally and compared to numerical modeling. Investigations of several HIFU dynamic focusing allowed overcoming the challenges of miniaturizing the device: mono-focal focusing maximized deep energy deposition, while multi-focal strategies eliminated grating lobes. The linear-array design of the prototype made it possible to produce interstitial ultrasound images of tissue and tumor mimics in situ. Multi-focal pressure fields were generated without grating lobes and transducer surface intensities reached up to Isapa = 14 W·cm^-2. Seventeen elementary thermal ablations were performed in vitro. Rotation of the catheter proved the directionality of ablation, sparing non-targeted tissue. This experimental proof of concept demonstrates the feasibility of treating volumes comparable to those of primary solid tumors with a miniaturized USgHIFU catheter whose dimensions are close to those of tools traditionally used in interventional radiology, while offering new functionalities.</p>","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Beam Acoustic Tweezers for Cell Biology: Molecular to In Vivo Level","authors":"Jinhee Yoo;Joongho Ahn;Honghyeon Ha;John Claud Jonas;Chulhong Kim;Hyung Ham Kim","doi":"10.1109/TUFFC.2024.3456083","DOIUrl":"10.1109/TUFFC.2024.3456083","url":null,"abstract":"Acoustic tweezers have attracted attention in various fields of cell biology, including in vitro single-cell and intercellular mechanics. Compared with other tweezing technologies such as optical and magnetic tweezers, acoustic tweezers possess stronger forces and are safer for use in biological systems. However, due to the limited spatial resolution or limited size of target objects, acoustic tweezers have primarily been used to manipulate cells in vitro. To extend the advantages of acoustic tweezers to other levels (e.g., molecular and in vivo levels), researchers have recently developed various types of acoustic tweezers such as single-beam acoustic tweezers (SBATs), surface acoustic wave (SAW) tweezers, and acoustic-streaming tweezers. Among these, SBATs utilize a single-focused beam, making the transducer and system simple, noninvasive, and capable of producing strong forces compared with other types of tweezers. Depending on the acoustic beam pattern, SBATs can be classified into Rayleigh regime, Mie regime, and acoustic vortex with different trapping dynamics and application levels. In this review, we provide an overview of the principles and configuration of each type of SBAT, their applications ranging from molecular to in vivo studies, and their limitations and prospects. Thus, this review demonstrates the significance and potential of SBAT technology in biophysics and biomedical engineering.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1269-1288"},"PeriodicalIF":3.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal Volume, Acoustic Radiation Force, and Strain in Two-Transducer Regimes","authors":"Kasra Naftchi-Ardebili;Mike D. Menz;Hossein Salahshoor;Gerald R. Popelka;Stephen A. Baccus;Kim Butts Pauly","doi":"10.1109/TUFFC.2024.3456048","DOIUrl":"10.1109/TUFFC.2024.3456048","url":null,"abstract":"Transcranial ultrasound stimulation (TUS) holds promise for noninvasive neural modulation in treating neurological disorders. Most clinically relevant targets are deep within the brain (near or at its geometric center), surrounded by other sensitive regions that need to be spared clinical intervention. However, in TUS, increasing frequency with the goal of improving spatial resolution reduces the effective penetration depth. We show that by using a pair of 1-MHz orthogonally arranged transducers, we improve the spatial resolution afforded by each of the transducers individually, by nearly 40 folds, achieving a subcubic millimeter target volume of \u0000<inline-formula> <tex-math>${0.24}~text {mm}^{{3}}$ </tex-math></inline-formula>\u0000. We show that orthogonally placed transducers generate highly localized standing waves with acoustic radiation force (ARF) arranged into periodic regions of compression and tension near the target. We further present an extended capability of the orthogonal setup, which is to impart selective pressures—either positive or negative, but not both—on the target. Finally, we share our preliminary findings that strain can arise from both particle motion (PM) and ARF with the former reaching its maximum value at the focus and the latter remaining null at the focus and reaching its maximum around the focus. As the field is investigating the mechanism of interaction in TUS by way of elucidating the mapping between ultrasound parameters and neural response, orthogonal transducers expand our toolbox by making it possible to conduct these investigations at much finer spatial resolutions, with localized and directed (compression versus tension) ARF and the capability of applying selective pressures at the target.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1199-1216"},"PeriodicalIF":3.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Ultrasound Spectroscopy Applied to the Differential Diagnosis of Pulmonary Diseases: An In Vivo Multicenter Clinical Study","authors":"Federico Mento;Mattia Perpenti;Giuliana Barcellona;Tiziano Perrone;Libertario Demi","doi":"10.1109/TUFFC.2024.3454956","DOIUrl":"10.1109/TUFFC.2024.3454956","url":null,"abstract":"Lung ultrasound (LUS) is an important imaging modality to assess the state of the lung surface. However, current LUS approaches are based on subjective interpretation of imaging artifacts, which results in poor specificity as quantitative evaluation lacks. The latter could be improved by adopting LUS spectroscopy of vertical artifacts. Indeed, parameterizing these artifacts with native frequency, bandwidth, and total intensity (\u0000<inline-formula> <tex-math>${I} {_{text {TOT}}}$ </tex-math></inline-formula>\u0000) already showed potentials in differentiating pulmonary fibrosis (PF). In this study, we acquired radio frequency (RF) data from 114 patients. These data (representing the largest LUS RF dataset worldwide) were acquired by utilizing a multifrequency approach, implemented with an ULtrasound Advanced Open Platform (ULA-OP). Convex (CA631) and linear (LA533) probes (Esaote, Florence, Italy) were utilized to acquire RF data at three (2, 3, and 4 MHz), and four (3, 4, 5, and 6 MHz) imaging frequencies. A multifrequency analysis was conducted on vertical artifacts detected in patients having cardiogenic pulmonary edema (CPE), pneumonia, or PF. These artifacts were characterized by the three abovementioned parameters, and their mean values were used to project each patient into a feature space having up to three dimensions. Binary classifiers were used to evaluate the performance of these three mean features in differentiating patients affected by CPE, pneumonia, and PF. Acquisitions of multifrequency data performed with linear probe lead to accuracies up to 85.43% in the differential diagnosis of these diseases (convex probes’ maximum accuracy was 74.51%). Moreover, the results showed high potentials of mean \u0000<inline-formula> <tex-math>${I} {_{text {TOT}}}$ </tex-math></inline-formula>\u0000 (by itself or combined with other features) in improving LUS specificity.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1217-1232"},"PeriodicalIF":3.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10666733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control Publication Information","authors":"","doi":"10.1109/TUFFC.2024.3446907","DOIUrl":"https://doi.org/10.1109/TUFFC.2024.3446907","url":null,"abstract":"","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 9","pages":"C2-C2"},"PeriodicalIF":3.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10665977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Voltage-Controlled Surface Acoustic Wave Oscillator Based on Lithium Niobate on Sapphire Low-Loss Acoustic Delay Line","authors":"Chin-Yu Chang;Ya-Ching Yu;Zhi-Qiang Lee;Ming-Huang Li","doi":"10.1109/TUFFC.2024.3453432","DOIUrl":"10.1109/TUFFC.2024.3453432","url":null,"abstract":"In this work, we investigate, for the first time, a low phase noise and wide tuning range voltage-controlled surface acoustic wave oscillator (VCSO) based on a lithium niobate on sapphire (LNOS) low-loss acoustic delay line (ADL). The thin-film LN/SiO2 bilayer acoustic waveguide, together with the single-phase unidirectional transducer (SPUDT) design, is key to attaining low insertion loss (IL) by enhancing energy confinement and directionality. Based on a high-performance ADL with an IL of only 5.2 dB, a fractional bandwidth (FBW) of 5.38%, and a group delay of 110 ns, the VCSO is implemented by commercially available circuit components using a series-resonant topology. The LNOS ADL oscillator operates at 888 MHz, showcasing a low phase noise of −94.1 dBc/Hz at 1-kHz offset and a root-mean-square (rms) jitter of only 30.26 fs (integrated from 12 kHz to 20 MHz) while only consuming 16 mA of supply current. Featuring a wide frequency tuning range of 6630 ppm, the proposed VCSO is a promising low-noise, low-power, and high-frequency timing device for emerging applications.Index Terms— Acoustic delay line (ADL), jitter, lithium niobate (LN), oscillator, phase noise, surface acoustic wave (SAW), thin film.skiptabldblfloatfix","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1314-1323"},"PeriodicalIF":3.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sound Out the Deep Clarity: Super-resolution Photoacoustic Imaging at Depths.","authors":"Nanchao Wang, Junjie Yao","doi":"10.1109/TUFFC.2024.3451986","DOIUrl":"https://doi.org/10.1109/TUFFC.2024.3451986","url":null,"abstract":"<p><p>Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a hybrid imaging modality that combines the rich contrast of optical imaging with the deep penetration of ultrasound imaging. Over the past decade, PAI has been increasingly utilized in biomedical studies, providing high-resolution high-contrast images of endogenous and exogenous chromophores in various fundamental and clinical research. However, PAI faces challenges in achieving high imaging resolution and deep tissue penetration simultaneously, limited by the optical and acoustic interactions with tissues. Overcoming these limitations is crucial for maximizing the potential of PAI for biomedical applications. Recent advances in super-resolution PAI have opened new possibilities for achieving high imaging resolution at greater depths. This review provides a comprehensive summary of these promising strategies, highlights their representative applications, envisions the potential future directions, and discusses the broader impact on biomedical imaging.</p>","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"PP ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Postactivation Behavioral Patterns of Intratumorally Injected Theranostic Nanodroplets: An Ultrasound-Only Extravascular Monitoring Technique","authors":"Anqi Huang;Ziyan Jia;Haitao Wu;Kangyi Feng;Chaonan Zhang;Mingxi Wan;Yujin Zong","doi":"10.1109/TUFFC.2024.3450885","DOIUrl":"10.1109/TUFFC.2024.3450885","url":null,"abstract":"Phase-change nanodroplets (PCNDs) are customizable and controllable theranostic agents of particular interest in extravascular therapies such as drug delivery and histotripsy. High-bulk-boiling-point (HBP) PCNDs are preferred for their enhanced thermal stability under physiological temperature to achieve on-demand therapeutic effects on target sites—mainly in tumor tissue. However, the behavioral patterns of high-concentration, heterogeneously distributed HBP PCNDs in vivo have rarely been explored—the foci of PCND-related therapies mostly fall on the final therapeutic effect rather than the detailed behaviors of PCNDs, which may hamper the development and improvement of in vivo treatments with PCNDs. To fill the gap, we demonstrate an ultrasound-only extravascular monitoring technique to analyze the underlying behavioral patterns of intratumorally injected HBP PCNDs. In our hypothesis, recondensation and coalescence are the two predominant patterns influencing the trend of the postactivation signal of PCNDs. A “blink map” method was, thus, proposed to separate the two parts of the signal by recognizing the unique signal pattern of stochastic recondensation, and four derivative metrics were calculated for further analysis. The results revealed the postactivation patterns of PCNDs at different activation-pulse durations and activation stages throughout the activation-imaging period, and several general trends were observed and explained by existing theories, suggesting the feasibility of our extravascular monitoring technique. Overall, this work enriches the knowledge of the characteristics of HBP PCNDs as extravascular theranostic agents, and the monitoring results have the potential to provide timely feedback on PCND-related treatments underway, which may help adjust the treatment strategy and improve the therapeutic efficacy.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1186-1198"},"PeriodicalIF":3.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Hologram-Assisted Bilateral Blood–Brain Barrier Opening in Non-Human Primates","authors":"Sergio Jiménez-Gambín;Sua Bae;Robin Ji;Fotios Tsitsos;Elisa E. Konofagou","doi":"10.1109/TUFFC.2024.3451289","DOIUrl":"10.1109/TUFFC.2024.3451289","url":null,"abstract":"Focused ultrasound (FUS) and microbubbles facilitate blood-brain barrier opening (BBBO) noninvasively, transiently, and safely for targeted drug delivery. Unlike state-of-the-art approaches, in this study, we demonstrate for the first time the simultaneous, bilateral BBBO in non-human primates (NHPs) using acoustic holograms at caudate and putamen structures. The simple and low-cost system with a single-element FUS transducer and 3-D printed acoustic hologram was guided by neuronavigation and a robotic arm. The advantages of holograms are transcranial aberration correction, simultaneous multifocus and high localization, and target-independent transducer positioning, defining a promising alternative for time- and cost-efficient FUS procedures. Holograms were designed with the k-space method by time-reversal techniques. T1-weighted MRI was used for treatment planning, while the computed tomography (CT) scan provided the head tissues acoustic properties. For the BBBO procedure, a robotic arm allowed transducer positioning errors below 0.1 mm and 0.1°. Following positioning, 0.5–0.6-MPa, 513-kHz microbubble-enhanced FUS was applied for 4 min. For BBBO assessment, Post-FUS T1-weighted MRI was acquired, and contrast enhancement indicated bilateral gadolinium extravasation at both caudate or putamen structures. The two BBBO locations were separated by 13.13 mm with a volume of 91.81 mm3 in the caudate, compared with 9.40 mm with a volume of 124.52 mm3 in simulation, while they were separated by 21.74 mm with a volume of 145.38 mm3 in the putamen and compared with 22.32 mm with a volume of 156.42 mm3 in simulation. No neurological damage was observed through T2-weighted and susceptibility-weighted imaging. This study demonstrates the feasibility and safety of hologram-assisted neuronavigation-guided-FUS for BBBO in NHP, providing thus an avenue for clinical translation.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"71 10","pages":"1172-1185"},"PeriodicalIF":3.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}