Immunity最新文献_第2页

Nasal immunity in respiratory viral infection, transmission, and protection. 鼻腔免疫在呼吸道病毒感染、传播和保护中的作用。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-13 Epub Date: 2026-07-13 DOI: 10.1016/j.immuni.2026.06.011

Samuel W Kazer, Jaclyn M L Walsh, Lillian J Juttukonda, Jose Ordovas-Montanes

引用次数: 0

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism. 病毒诱导的ISG15解偶联会失调先天免疫和细胞代谢。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-13 Epub Date: 2026-08-06 DOI: 10.1016/j.immuni.2026.07.007

Junji Zhu, GuanQun Liu, Jielin Xu, Zuberwasim Sayyad, Kun Li, Surajit Chakraborty, Christopher M Goins, Huaxu Yu, Yadi Zhou, Shanti Ross, Evangeline White, Jun Zhao, Oliver Fiehn, Shaun R Stauffer, Feixiong Cheng, Michaela U Gack

{"title":"Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.","authors":"Junji Zhu, GuanQun Liu, Jielin Xu, Zuberwasim Sayyad, Kun Li, Surajit Chakraborty, Christopher M Goins, Huaxu Yu, Yadi Zhou, Shanti Ross, Evangeline White, Jun Zhao, Oliver Fiehn, Shaun R Stauffer, Feixiong Cheng, Michaela U Gack","doi":"10.1016/j.immuni.2026.07.007","DOIUrl":"10.1016/j.immuni.2026.07.007","url":null,"abstract":"Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that regulates diverse cellular responses, including antiviral immunity, through its conjugation to proteins in a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the direct targets and physiological consequences of coronaviral deISGylation remain poorly defined. Here, we genetically ablated the deISGylating activity of the SARS-CoV-2-encoded papain-like protease (PLpro) and found that loss of deISGylation boosted innate immune activation, attenuated viral replication, and promoted viral clearance in human cells and mice. Metabolomics, ISGylome proteomics, and functional analyses revealed that PLpro deISGylation relieved metabolic restriction of virus infection by directly regulating the activity of key enzymes controlling glycolysis, the pentose phosphate pathway, and redox homeostasis. These findings provide fundamental insight into how reversible ISGylation regulates immunity and metabolic processes at the molecular level and highlight viral deISGylation as a major strategy to overcome host immunometabolic defenses.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2654-2670.e13"},"PeriodicalIF":30.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional view of immunotherapy 免疫治疗的多维视图

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.016

Jun Yu,Carlos-Filipe Pereira,Liangtao Zheng,Zemin Zhang,Georg Schett,Johann E. Gudjonsson,Kathryn Monroe,Teresa Lambe

引用次数: 0

The narrow path to CD8+ T cell recognition of mutant p53 CD8+ T细胞识别突变型p53的狭窄途径

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.020

Evan W. Newell

引用次数: 0

The nerve rings twice 神经循环两次

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.008

Kenji Kabashima

引用次数: 0

Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis 皮肤常驻CXCR6+记忆CD4+ T细胞和树突状细胞形成真皮血管周围中枢，驱动过敏性皮炎复发

IF 32.4 1区医学

Immunity Pub Date : 2026-10-12 DOI: 10.1016/j.immuni.2026.09.010

Ryota Asahina,Fuuka Minami,Satoshi Nakamizo,Toshiya Miyake,Satoru Yonekura,Toshiaki Kogame,Shuto Kanameishi,Kosuke Katsuo,Hiroyuki Irie,Saeko Nakajima,Takashi Nomura,Akihiko Kitoh,Gyohei Egawa,Kenji Kabashima

{"title":"Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis","authors":"Ryota Asahina,Fuuka Minami,Satoshi Nakamizo,Toshiya Miyake,Satoru Yonekura,Toshiaki Kogame,Shuto Kanameishi,Kosuke Katsuo,Hiroyuki Irie,Saeko Nakajima,Takashi Nomura,Akihiko Kitoh,Gyohei Egawa,Kenji Kabashima","doi":"10.1016/j.immuni.2026.09.010","DOIUrl":"https://doi.org/10.1016/j.immuni.2026.09.010","url":null,"abstract":"CD4+ tissue-resident memory T (TRM) cells are crucial for relapse in allergic skin conditions. However, the mechanisms underlying their maintenance and pathogenic potential remain poorly defined. Here, across multiple models of allergic dermatitis, we identified a C-X-C chemokine receptor 6 (CXCR6+) subpopulation within CD4+ TRM cells as a distinct pathogenic subset that rapidly induces relapse. This subset is supported by C-X-C chemokine ligand 16 (CXCL16)-dependent interactions with CD301b+ conventional type 2 dendritic cells (cDC2s) for in situ maintenance. Functional blockade of the CXCL16-CXCR6 signaling pathway impaired proliferation and maintenance of CXCR6+ CD4+ TRM cells. In human atopic dermatitis (AD), CXCR6+ CD4+ TRM cells co-localized with CD301+ cDC2s in perivascular clusters even after successful anti-IL-13 therapy. These findings point to CXCR6+ CD4+ TRM cells as a pathogenic reservoir sustaining chronic and recurrent inflammation and suggest the CXCL16-CXCR6 axis as a therapeutic target to prevent relapse in allergic skin diseases.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"45 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK⁺ to GZMB⁺ Tem cells to health trajectories. 全球队列的单细胞分析概述了免疫衰老的决定因素，并将GZMK+与GZMB+ Tem细胞的比例与健康轨迹联系起来。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-09 DOI: 10.1016/j.immuni.2026.09.012

Marina Terekhova, Maksim Kleverov, Thomas Francis, Dmitrii Usoltsev, Pavla Bohacova, Laura Arthur, Petr Tsurinov, Denis Kleverov, Luke Trinity, Kamila Husarcikova, Ivan Molotkov, Titas Grabauskas, Amir Fathi, Eloise Milbourn, Esme Newton, Leah Siegel, Adnaan Ghanchi, Urika Tse, Ross D Pollock, Niharika A Duggal, Janet M Lord, Norman R Lazarus, Ali H Ellebedy, Duygu Ucar, Stephen D R Harridge, Mykyta Artomov, Maxim N Artyomov

{"title":"Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories.","authors":"Marina Terekhova, Maksim Kleverov, Thomas Francis, Dmitrii Usoltsev, Pavla Bohacova, Laura Arthur, Petr Tsurinov, Denis Kleverov, Luke Trinity, Kamila Husarcikova, Ivan Molotkov, Titas Grabauskas, Amir Fathi, Eloise Milbourn, Esme Newton, Leah Siegel, Adnaan Ghanchi, Urika Tse, Ross D Pollock, Niharika A Duggal, Janet M Lord, Norman R Lazarus, Ali H Ellebedy, Duygu Ucar, Stephen D R Harridge, Mykyta Artomov, Maxim N Artyomov","doi":"10.1016/j.immuni.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.immuni.2026.09.012","url":null,"abstract":"Human immune aging is heterogeneous, with immune responses becoming increasingly variable over the lifespan. Here, we integrated seven large-scale public single-cell peripheral blood mononuclear cell (PBMC) datasets and a newly generated cohort, encompassing 2,609 ostensibly healthy individuals across diverse ages, ancestries, and biological sexes. We identified both conserved and cohort-associated age-associated remodeling across 59 immune populations, together with sex- and ancestry-dependent immune differences. CD8+ T cells emerged as major drivers of aging heterogeneity, with the GZMK+/GZMB+ effector memory ratio distinguishing healthy and pathology-associated aging trajectories. This ratio reflected immune remodeling driven by chronic viral exposure, including CMV, and disease-associated immune dysregulation, with the dominant driver varying across populations. Proteomic profiling across four cohorts revealed a Tem GZMB+ plasma signature associated with inflammaging, poor self-reported health, all-cause mortality, and increased risk of immune-related, metabolic, and cardiovascular diseases. Together, these findings define clinically relevant immune determinants for monitoring and guiding healthy aging interventions.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":""},"PeriodicalIF":30.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphatic constraint of germinal centers optimizes protective antibody responses. 生发中心的淋巴约束优化保护性抗体反应。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-09 DOI: 10.1016/j.immuni.2026.09.013

Tenny Mudianto, Gabrielle R Berman, Kimberly Zaldana, Marta Schips, Niklas Schwan, Luan Firmino-Cruz, Jana Bilanovic, Ochapa Ibrahim, Vanessa Cristaldi, William S Foster, Lina Fikri, Sabrina Solis, Han Chen, Dimitri Kakabadse-Schmidt, Michael Cammer, Ramin Sedaghat Herati, Sergei B Koralov, Andrew David Miller, Michael Meyer-Hermann, Carla R Nowosad, Amanda W Lund

{"title":"Lymphatic constraint of germinal centers optimizes protective antibody responses.","authors":"Tenny Mudianto, Gabrielle R Berman, Kimberly Zaldana, Marta Schips, Niklas Schwan, Luan Firmino-Cruz, Jana Bilanovic, Ochapa Ibrahim, Vanessa Cristaldi, William S Foster, Lina Fikri, Sabrina Solis, Han Chen, Dimitri Kakabadse-Schmidt, Michael Cammer, Ramin Sedaghat Herati, Sergei B Koralov, Andrew David Miller, Michael Meyer-Hermann, Carla R Nowosad, Amanda W Lund","doi":"10.1016/j.immuni.2026.09.013","DOIUrl":"10.1016/j.immuni.2026.09.013","url":null,"abstract":"Immunization strategies are central to pathogen control, where efficacy relies on antigen distribution and inflammatory context. Lymphatic vessels are necessary conduits for antigen transport that actively remodel in peripheral tissues and draining lymph nodes (LNs) in response to their inflammatory context. In this study, we found that inhibiting viral-induced lymphatic remodeling in skin and LNs prompted germinal center (GC) expansion but, paradoxically, decreased the protective antibody response. While GCs scaled proportionately, larger GCs failed to support proliferative bursts consistent with clonal selection due to impaired T-B cell interactions. Accordingly, follicle and GC size are evolutionarily conserved across diverse mammals despite increased LN size. Lymphatic vessels controlled GC size through two coordinated processes: lymphatic remodeling in infected skin limited viral transport to the LN, while the resulting permissive environment in the LN supported perifollicular lymphangiogenesis that constrained GC expansion.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":""},"PeriodicalIF":30.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse 小胶质细胞介导的细胞外基质破坏驱动酒精滥用后的神经元功能障碍、运动损伤和镇静

IF 32.4 1区医学

Immunity Pub Date : 2026-10-08 DOI: 10.1016/j.immuni.2026.09.011

Evi Paouri,Sarah Stanko,Nadia Gasmi,Gabriele Glusauskas,Valery Mao,Andrew Kwak,Stephanie Hsu,Sahar Sarmadi,Emily Huang,Aniruddha Das,Courtney Hershberger,Quinn Watercutter,Megan R. McMullen,Christopher Birck,Hope Burton,Hale Tobin,Anxhela Gjojdeshi,Julia Dziabis,Richa M. Hanamsagar,Daniel M. Rotroff,Richard A. Prayson,Staci D. Bilbo,Saba Valadkhan,Hod Dana,Laura E. Nagy,Dimitrios Davalos

{"title":"Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse","authors":"Evi Paouri,Sarah Stanko,Nadia Gasmi,Gabriele Glusauskas,Valery Mao,Andrew Kwak,Stephanie Hsu,Sahar Sarmadi,Emily Huang,Aniruddha Das,Courtney Hershberger,Quinn Watercutter,Megan R. McMullen,Christopher Birck,Hope Burton,Hale Tobin,Anxhela Gjojdeshi,Julia Dziabis,Richa M. Hanamsagar,Daniel M. Rotroff,Richard A. Prayson,Staci D. Bilbo,Saba Valadkhan,Hod Dana,Laura E. Nagy,Dimitrios Davalos","doi":"10.1016/j.immuni.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.immuni.2026.09.011","url":null,"abstract":"Alcohol abuse is the primary risk factor for alcohol use disorder (AUD), a leading cause of preventable morbidity and mortality worldwide. While direct effects of alcohol on neuronal function are well established, the role of microglia in acute and chronic neurological dysfunction in AUD remains underappreciated. Using mouse models of binge and high-intensity alcohol exposure and longitudinal in vivo imaging, we found that microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation. Ethanol also induced microglia-dependent extracellular matrix (ECM) disruption, synapse elimination, and reduced neuronal activity and density. Genetic deletion of microglial Myd88 protected against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing ECM disruption. Frontal cortex ECM was similarly disrupted in human brain tissue from individuals with AUD. These findings identify microglia as cellular drivers of brain dysfunction following alcohol abuse and MyD88 as a critical therapeutic target for AUD.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"10 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional evaluation of TCR-pMHC pairs at scale allows in silico TCR reactivity prediction TCR- pmhc对在规模上的功能评估允许在硅TCR反应性预测

IF 32.4 1区医学

Immunity Pub Date : 2026-10-01 DOI: 10.1016/j.immuni.2026.09.007

Marius Messemaker,Bjørn P.Y. Kwee,Živa Moravec,Sam de Paauw,Jos Urbanus,Daniel Álvarez-Salmoral,Jeroen Geerligs,Ren Xie,Rhianne Voogd,Ben Morris,Aurélie Guislain,Yaël Winkler,Connor A. Richterich,Maike Mussmann,Marijn Bakker,Maxime Steinmetz,Matyas Iras,Eric Marcus,Jonas Teuwen,Anastassis Perrakis,Roderick L. Beijersbergen,Wouter Scheper,Ton N. Schumacher

引用次数: 0