Neuro-immune ChATing protects the heart

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-07-08 DOI:10.1016/j.immuni.2025.06.007

Teresa Gerhardt, Cameron S. McAlpine

引用次数: 0

Abstract

Autonomic imbalance is central to heart failure (HF), but the mechanistic impact of parasympathetic withdrawal has remained unclear. Li, Zhang, Li, et al. demonstrate that targeted optogenetic stimulation of choline acetyltransferase (ChAT)-expressing neurons in the dorsal vagal motor nucleus (DVMN) protects against HF by reprogramming inflammatory CCRL2⁺ cardiac macrophages through nicotinic acetylcholine receptor α7nAChR signaling.

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神经免疫欺骗保护心脏

自主神经失衡是心力衰竭（HF）的核心，但副交感神经戒断的机制影响尚不清楚。Li, Zhang， Li等人证明，通过烟碱乙酰胆碱受体α7nAChR信号重编程炎性CCRL2+心脏巨噬细胞，靶向光遗传刺激迷走背运动核（DVMN）中表达胆碱乙酰转移酶（ChAT）的神经元，可预防HF。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.