肿瘤中巨噬细胞极性的线粒体控制

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-07-08 DOI:10.1016/j.immuni.2025.06.008

Máté Kiss, Mikael J. Pittet

引用次数: 0

摘要

巨噬细胞可以培养促肿瘤或抗肿瘤的免疫环境。在这一期的《免疫》杂志上，Clark等人报道，改变线粒体电子传递链的组成将巨噬细胞重编程为CXCL9hiSPP1lo免疫刺激表型，从而增强抗肿瘤免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitochondrial control of macrophage polarity in tumors

Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9^hiSPP1^lo immunostimulatory phenotype, thus amplifying anti-tumor immunity.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.