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Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-22 DOI: 10.1016/j.immuni.2024.12.012
Iñaki Robles-Vera, Aitor Jarit-Cabanillas, Paola Brandi, María Martínez-López, Sarai Martínez-Cano, Manuel Rodrigo-Tapias, Marcos Femenía-Muiña, Ana Redondo-Urzainqui, Vanesa Nuñez, Cristina González-Correa, Javier Moleón, Juan Duarte, Laura Conejero, Pablo Mata-Martínez, Carmen María Díez-Rivero, Marta Bergón-Gutiérrez, Iván Fernández-López, Manuel J. Gómez, Ana Quintas, Ana Dopazo, David Sancho
{"title":"Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow","authors":"Iñaki Robles-Vera, Aitor Jarit-Cabanillas, Paola Brandi, María Martínez-López, Sarai Martínez-Cano, Manuel Rodrigo-Tapias, Marcos Femenía-Muiña, Ana Redondo-Urzainqui, Vanesa Nuñez, Cristina González-Correa, Javier Moleón, Juan Duarte, Laura Conejero, Pablo Mata-Martínez, Carmen María Díez-Rivero, Marta Bergón-Gutiérrez, Iván Fernández-López, Manuel J. Gómez, Ana Quintas, Ana Dopazo, David Sancho","doi":"10.1016/j.immuni.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.012","url":null,"abstract":"Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a proinflammatory state in the host. Here, we investigated innate immune responses following increased gut permeability upon administration of dextran sulfate sodium (DSS) in mice. We found that <em>Enterococcus faecalis</em> translocated to the bone marrow following DSS treatment and induced trained immunity (TI) hallmarks in bone-marrow-derived mouse macrophages and human monocytes. DSS treatment or heat-killed <em>E. faecalis</em> reprogrammed bone marrow progenitors (BMPs), resulting in enhanced inflammatory responses <em>in vitro</em> and <em>in vivo</em> and protection against subsequent pathogen infections. The C-type lectin receptor Mincle (<em>Clec4e</em>) was essential for <em>E. faecalis</em>-induced TI in BMPs. <em>Clec4e</em><sup><em>−/−</em></sup> mice showed impaired TI upon <em>E. faecalis</em> administration and reduced pathology following DSS treatment. Thus, Mincle sensing of <em>E. faecalis</em> induces TI that may have long-term effects on pathologies associated with increased gut permeability.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"46 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-15 DOI: 10.1016/j.immuni.2025.01.001
Joshua D. Bromley, Sharie Keanne C. Ganchua, Sarah K. Nyquist, Pauline Maiello, Michael Chao, H. Jacob Borish, Mark Rodgers, Jaime Tomko, Kara Kracinovsky, Douaa Mugahid, Son Nguyen, Qianchang Dennis Wang, Jacob M. Rosenberg, Edwin C. Klein, Hannah P. Gideon, Roisin Floyd-O’Sullivan, Bonnie Berger, Charles A. Scanga, Philana Ling Lin, Sarah M. Fortune, JoAnne L. Flynn
{"title":"CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection","authors":"Joshua D. Bromley, Sharie Keanne C. Ganchua, Sarah K. Nyquist, Pauline Maiello, Michael Chao, H. Jacob Borish, Mark Rodgers, Jaime Tomko, Kara Kracinovsky, Douaa Mugahid, Son Nguyen, Qianchang Dennis Wang, Jacob M. Rosenberg, Edwin C. Klein, Hannah P. Gideon, Roisin Floyd-O’Sullivan, Bonnie Berger, Charles A. Scanga, Philana Ling Lin, Sarah M. Fortune, JoAnne L. Flynn","doi":"10.1016/j.immuni.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.immuni.2025.01.001","url":null,"abstract":"(Immunity <em>57</em>, 2380–2398.e1–e6; October 8, 2024)","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"24 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-15 DOI: 10.1016/j.immuni.2024.12.011
Clara Young, Mandeep Singh, Katherine J.L. Jackson, Matt A. Field, Timothy J. Peters, Stefano Angioletti-Uberti, Daan Frenkel, Shyamsundar Ravishankar, Money Gupta, Jing J. Wang, David Agapiou, Megan L. Faulks, Ghamdan Al-Eryani, Fabio Luciani, Tom P. Gordon, Joanne H. Reed, Mark Danta, Andrew Carr, Anthony D. Kelleher, Gregory J. Dore, Christopher C. Goodnow
{"title":"A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease","authors":"Clara Young, Mandeep Singh, Katherine J.L. Jackson, Matt A. Field, Timothy J. Peters, Stefano Angioletti-Uberti, Daan Frenkel, Shyamsundar Ravishankar, Money Gupta, Jing J. Wang, David Agapiou, Megan L. Faulks, Ghamdan Al-Eryani, Fabio Luciani, Tom P. Gordon, Joanne H. Reed, Mark Danta, Andrew Carr, Anthony D. Kelleher, Gregory J. Dore, Christopher C. Goodnow","doi":"10.1016/j.immuni.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.011","url":null,"abstract":"The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immunoglobulin G (IgG) but not viral E2 antigen. Whole-genome sequencing revealed thousands of somatic mutations, numerically comparable to chronic lymphocytic leukemia and normal memory B cells, but with 1–2 corresponding to driver mutations found recurrently in B cell leukemia and lymphoma. V(D)J hypermutation created autoantibodies with compromised solubility in complex with self-IgG. In this virus-induced autoimmune disease, infection promotes a catastrophic confluence of somatic mutagenesis in the descendants of a single B cell.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"118 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria and NLRP3: To die or inflame
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.007
Shuangshuang Yang, Guannan Huang, Jenny P.-Y. Ting
{"title":"Mitochondria and NLRP3: To die or inflame","authors":"Shuangshuang Yang, Guannan Huang, Jenny P.-Y. Ting","doi":"10.1016/j.immuni.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.007","url":null,"abstract":"Mitochondria play critical roles in intrinsic apoptosis and NLRP3 inflammasome activation, but how these processes are interconnected remains unclear. In this issue of <em>Immunity</em>, Saller et al. unveiled the complexity of NLRP3 activators, highlighting mitochondria’s roles in switching apoptosis to NLRP3 inflammasome activation.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"29 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut know-how: IL-22 from T cells boosts stress resilience
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.11.022
Ruodi Yang, Danyang He
{"title":"Gut know-how: IL-22 from T cells boosts stress resilience","authors":"Ruodi Yang, Danyang He","doi":"10.1016/j.immuni.2024.11.022","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.11.022","url":null,"abstract":"Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of <em>Immunity</em>, Xia, Lu, Lan et al.<span><span><sup>1</sup></span></span> uncover an anxiolytic function of intestinal IL-22 pathway, which protects against psychological stress.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"14 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-17 and fat: Timing is everything
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.005
Matthew C. Sinton, Olivia Shorthouse, Alice Costain, Juan F. Quintana
{"title":"Interleukin-17 and fat: Timing is everything","authors":"Matthew C. Sinton, Olivia Shorthouse, Alice Costain, Juan F. Quintana","doi":"10.1016/j.immuni.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.005","url":null,"abstract":"Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in <em>Nature</em>, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"16 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restimulation by macrophages exhausts T cells 巨噬细胞的再刺激会耗尽 T 细胞
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.010
Fernando Fernández-García, Barbara B. Maier
{"title":"Restimulation by macrophages exhausts T cells","authors":"Fernando Fernández-García, Barbara B. Maier","doi":"10.1016/j.immuni.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.010","url":null,"abstract":"Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of <em>Immunity</em>, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associated macrophages, not tumor cells, drives terminal T cell exhaustion in glioblastoma.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"75 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgG sialylation puts lung inflammation to REST IgG sialylation 使肺部炎症得到缓解
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.001
Lukasz Kedzierski, Katherine Kedzierska
{"title":"IgG sialylation puts lung inflammation to REST","authors":"Lukasz Kedzierski, Katherine Kedzierska","doi":"10.1016/j.immuni.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.001","url":null,"abstract":"The mechanisms underpinning susceptibility to influenza virus infection, resulting in life-threatening disease, are not well understood. In this issue of <em>Immunity</em>, Chakraborty et al. demonstrate that sialylated IgG suppresses NF-κB-driven inflammatory responses in the lungs by inducing repressor element-1 silencing transcription factor (REST) to prevent excessive inflammation without impacting viral replication.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"90 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunology of stroke and dementia 中风和痴呆症的免疫学
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.008
Costantino Iadecola, Josef Anrather
{"title":"The immunology of stroke and dementia","authors":"Costantino Iadecola, Josef Anrather","doi":"10.1016/j.immuni.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.008","url":null,"abstract":"Ischemic stroke and vascular cognitive impairment, caused by a sudden arterial occlusion or more subtle but protracted vascular insufficiency, respectively, are leading causes of morbidity and mortality worldwide with limited therapeutic options. Innate and adaptive immunity have long been implicated in neurovascular injury, but recent advances in methodology and new experimental approaches have shed new light on their contributions. A previously unappreciated dynamic interplay of brain-resident, meningeal, and systemic immune cells with the ischemic brain and its vasculature has emerged, and new insights into the frequent overlap between vascular and Alzheimer pathology have been provided. Here, we critically review these recent findings, place them in the context of current concepts on neurovascular pathologies and Alzheimer’s disease, and highlight their impact on recent stroke and Alzheimer therapies.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"115 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptations of neutrophils in cancer
IF 32.4 1区 医学
Immunity Pub Date : 2025-01-14 DOI: 10.1016/j.immuni.2024.12.009
Melissa Ng, Daniela Cerezo-Wallis, Lai Guan Ng, Andres Hidalgo
{"title":"Adaptations of neutrophils in cancer","authors":"Melissa Ng, Daniela Cerezo-Wallis, Lai Guan Ng, Andres Hidalgo","doi":"10.1016/j.immuni.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.12.009","url":null,"abstract":"There is a renewed interest in neutrophil biology, largely instigated by their prominence in cancer. From an immunologist’s perspective, a conceptual breakthrough is the realization that prototypical inflammatory, cytotoxic leukocytes can be tamed to promote the survival and growth of other cells. This has sparked interest in defining the biological principles and molecular mechanisms driving the adaptation of neutrophils to cancer. Yet, many questions remain: is this adaptation mediated by reprogramming mature neutrophils inside the tumoral mass, or rather by rewiring granulopoiesis in the bone marrow? Why, in some instances, are neutrophils beneficial and in others detrimental to cancer? How many different functional programs can be induced in neutrophils by tumors, and is this dependent on the type of tumor? This review summarizes what we know about these questions and discusses therapeutic strategies based on our incipient knowledge of how neutrophils adapt to cancer.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"76 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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