Immunity最新文献

Embracing macrophage complexity for research and translation. 研究和翻译巨噬细胞的复杂性。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-16 DOI: 10.1016/j.immuni.2026.09.015

Florent Ginhoux, Kevin Mulder, Sebastian Arcila-Barrera, Ido Amit

引用次数: 0

Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment 乳酸脱氢酶a依赖的氧化还原控制选择性mRNA翻译指导单核细胞命运承诺

IF 32.4 1区医学

Immunity Pub Date : 2026-10-15 DOI: 10.1016/j.immuni.2026.09.022

Ning Yang,Huixia He,Xin Liu

{"title":"Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment","authors":"Ning Yang,Huixia He,Xin Liu","doi":"10.1016/j.immuni.2026.09.022","DOIUrl":"https://doi.org/10.1016/j.immuni.2026.09.022","url":null,"abstract":"Monocyte-to-macrophage differentiation is a central process that shapes immune responses across diverse contexts, yet how inflammatory cues engage metabolism to instruct monocyte fate commitment remains unclear. Here, using a CRISPR-based metabolic screen combined with monocyte-specific perturbations in bacterial lung infection, we identified lactate dehydrogenase A (LDHA) as a key metabolic regulator of monocyte commitment to the nitric oxide synthase 2 (NOS2)+ macrophage fate in vivo. LDHA-dependent cytosolic nicotinamide adenine dinucleotide (NAD+) regeneration enabled selective hypoxia-inducible factor 1-alpha (HIF1α) translation through its 5′ untranslated region (UTR) and is associated with structural remodeling of this region. HIF1α then functioned as a downstream effector that promoted the NOS2+ macrophage fate. Granulocyte-macrophage colony-stimulating factor (GM-CSF) further acted as an upstream metabolic priming signal that enhanced LDHA-dependent HIF1α regulation and supported this differentiation process. Together, these findings suggest that metabolic redox state regulates monocyte fate commitment through selective mRNA translation coupled to RNA structural remodeling.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"15 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dan Kastner (1951–2026) 卡斯特纳(1951 - 2026)

IF 32.4 1区医学

Immunity Pub Date : 2026-10-15 DOI: 10.1016/j.immuni.2026.09.019

John J. O’Shea,Lindsey A. Criswell

引用次数: 0

The matrix remembers 矩阵记得

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.021

Agne Antanaviciute,Alison Simmons

引用次数: 0

Regulatory B cells: Induced, inspired, and ready to soothe neuroinflammation 调节性B细胞：诱导，激发，并准备缓解神经炎症

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.018

Rylee J. Beam,Douglas S. Prado,Rebecca A. Elsner

引用次数: 0

Astrocytes go into presenter mode 星形胶质细胞进入呈现模式

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.014

Lara Labarta-Bajo,Nicola J. Allen

引用次数: 0

The genesis of cutaneous neurogenic inflammation is a multi-step process requiring dendritic cell aggregation. 皮肤神经源性炎症的发生是一个多步骤的过程，需要树突状细胞聚集。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-13 Epub Date: 2026-08-11 DOI: 10.1016/j.immuni.2026.07.010

Chien-Sin Chen, Jacob E Gillis, Jonathan A Cohen, Alexandra R Glathar, Yijia Chen, Eric S Weiss, Lindsay M McKendrick, Caitlin O Bacon, Colton J Smith, Nick J Spencer, Isaac M Chiu, Brian M Davis, Tina L Sumpter, Anthony R Cillo, Amanda C Poholek, Daniel H Kaplan

{"title":"The genesis of cutaneous neurogenic inflammation is a multi-step process requiring dendritic cell aggregation.","authors":"Chien-Sin Chen, Jacob E Gillis, Jonathan A Cohen, Alexandra R Glathar, Yijia Chen, Eric S Weiss, Lindsay M McKendrick, Caitlin O Bacon, Colton J Smith, Nick J Spencer, Isaac M Chiu, Brian M Davis, Tina L Sumpter, Anthony R Cillo, Amanda C Poholek, Daniel H Kaplan","doi":"10.1016/j.immuni.2026.07.010","DOIUrl":"10.1016/j.immuni.2026.07.010","url":null,"abstract":"Cutaneous inflammation involving neuroimmune interactions can be initiated by both neurons and immune cells, making it complicated to parse the mechanisms of neurogenic inflammation. Optogenetic activation of Trpv1-expressing nociceptors drives type-17 inflammation in the absence of other inflammatory triggers. We found that two rounds of nociceptor activation were required for Il23a expression and maximal expression of Il1b and Il6, key drivers of type-17 inflammation. The first round of nociceptor activation triggered transient type 2 dendritic cell (DC2) aggregation that required substance P-Mrgprb2-dependent mast cell activation and mast cell-derived chemokine CCL2. Spatial transcriptomic analysis revealed that DC aggregation allowed the second nociceptor stimulation to efficiently activate DCs via the neuropeptide calcitonin gene-related peptide α (CGRPα). Thus, early neurogenic inflammation is a two-step process: substance P induces Mrgprb2-dependent mast cell activation and formation of DC aggregates that allow for efficient subsequent CGRPα-mediated DC activation. These data reveal a multi-cell, dynamic mechanism underlying neurogenic inflammation.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2707-2721.e7"},"PeriodicalIF":30.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation. 2组先天淋巴样细胞激活髓磷脂反应性T细胞，增强神经炎症。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-13 Epub Date: 2026-08-06 DOI: 10.1016/j.immuni.2026.07.011

Huachen Huang, Gaoyu Liu, Yali Han, Yuyang Miao, Zhibao Zhu, Ying Wang, Jianye Wang, Mengxuan Shi, Jinyi Li, Huaijin Yang, Tongxiao Xu, Caiyun Qi, Jinhao Yang, Wenjun Zhang, Zhaoli Han, Bingbing Wang, De-Cai Tian, Ying Fu, Jie Zhou, Qiang Liu

{"title":"Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation.","authors":"Huachen Huang, Gaoyu Liu, Yali Han, Yuyang Miao, Zhibao Zhu, Ying Wang, Jianye Wang, Mengxuan Shi, Jinyi Li, Huaijin Yang, Tongxiao Xu, Caiyun Qi, Jinhao Yang, Wenjun Zhang, Zhaoli Han, Bingbing Wang, De-Cai Tian, Ying Fu, Jie Zhou, Qiang Liu","doi":"10.1016/j.immuni.2026.07.011","DOIUrl":"10.1016/j.immuni.2026.07.011","url":null,"abstract":"The meninges are a gateway for pathogenic T cells to enter the central nervous system (CNS). They possess a diverse repertoire of immune cells that orchestrate CNS inflammation and autoimmunity, yet the underlying mechanisms are poorly understood. Here, we report that group 2 innate lymphoid cells (ILC2s) accumulated in the dura as experimental autoimmune encephalomyelitis (EAE) progressed. Single-cell RNA sequencing and flow cytometry analyses revealed distinct features of ILC2s, including expression of MHC class II. ILC2s acted as antigen-presenting cells to activate and expand myelin-reactive T cells in an MHC class II-dependent manner. ILC2-mediated expansion of myelin-reactive T cells increased expression of cytokines IFN-γ and IL-17A. Genetic ablation of ILC2s or of H2-Ab1 in ILC2s alleviated neuroinflammation and CNS demyelination during EAE. These findings revealed a role of ILC2s in neuroinflammation via instructing myelin-reactive T cells, implying targeting ILC2s may be an avenue to restrict CNS inflammation and autoimmunity.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2722-2737.e8"},"PeriodicalIF":30.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection. 在SARS-CoV-2感染中，一个独特的效应B细胞群驱动自身抗体的产生。

IF 30.6 1区医学

Immunity Pub Date : 2026-10-13 Epub Date: 2026-08-28 DOI: 10.1016/j.immuni.2026.08.002

Dan Yuan, Sarah Li, Rongyu Zhang, Rachel H Ng, Yapeng Su, Linda Lan, Mahasish Shome, Brett Smith, Pamela Troisch, Jingyi Xie, Jongchan Choi, Rick Edmark, Daniel Chen, Lee Rowen, Amy Nguyen, Rachel Liu, Vanessa Gutierrez, Conor Brennan, Michaela McKasson, Kim Murray, Julie A Wallick, Heather A Algren, Alexandria Duven, Brian Piening, Wendy Thomas, Hao Y Kueh, Andrew T Magis, Jennifer Hadlock, Michael Snyder, Jason D Goldman, James R Heath

{"title":"A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.","authors":"Dan Yuan, Sarah Li, Rongyu Zhang, Rachel H Ng, Yapeng Su, Linda Lan, Mahasish Shome, Brett Smith, Pamela Troisch, Jingyi Xie, Jongchan Choi, Rick Edmark, Daniel Chen, Lee Rowen, Amy Nguyen, Rachel Liu, Vanessa Gutierrez, Conor Brennan, Michaela McKasson, Kim Murray, Julie A Wallick, Heather A Algren, Alexandria Duven, Brian Piening, Wendy Thomas, Hao Y Kueh, Andrew T Magis, Jennifer Hadlock, Michael Snyder, Jason D Goldman, James R Heath","doi":"10.1016/j.immuni.2026.08.002","DOIUrl":"10.1016/j.immuni.2026.08.002","url":null,"abstract":"Autoantibodies (autoAbs) are linked to mortality and Long COVID, yet their cellular origins remain unclear. We analyzed the INCOV cohort and identified 12 age- and sex-matched participants with varying autoAb abundance and integrated single-cell RNA-seq and ATAC-seq data from B cells, plasma proteomics, proteome-wide autoAb profiling, clinical data, and in vitro assays. AutoAb abundance inversely correlated with neutralizing IgG and declined as infection resolved, paralleling the contraction of atypical memory B cells (AtMs). In vitro, AtMs preferentially differentiated into autoAb-producing antibody-secreting cells upon TLR7/8 stimulation. CD11c+ AtMs (double-negative 2, DN2s) in autoAb-high individuals exhibited increased TLR7 signaling, oxidative stress, and isotype switching, regulated by transcription factors T-bet and XBP1. Integrated genetic and genomic analyses showed that DN2s had the strongest enrichment for autoimmune trait heritability and inferred regulatory effects of autoimmune risk variants among B cell subsets. These findings identify DN2s as key precursors of autoAb-producing cells during SARS-CoV-2 infection.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2824-2841.e8"},"PeriodicalIF":30.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral deISGylation holds the key to the metabolic kingdom 病毒去isgyylation是进入代谢王国的关键

IF 32.4 1区医学

Immunity Pub Date : 2026-10-13 DOI: 10.1016/j.immuni.2026.09.017

Byron Shue,Sonja M. Best

引用次数: 0