Immunity最新文献_第10页

Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria 自身抗体抑制恶性疟原虫的生长，并与临床疟疾的防护有关

IF 32.4 1区医学

Immunity Pub Date : 2024-06-19 DOI: 10.1016/j.immuni.2024.05.024

Kelly A. Hagadorn, Mary E. Peterson, Hemanta Kole, Bethany Scott, Jeff Skinner, Ababacar Diouf, Eizo Takashima, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabe, Shanping Li, Padmapriya Sekar, Mei Yan, Chengsong Zhu, Hikaru Nagaoka, Bernard N. Kanoi, Quan-Zhen Li, Carole Long, Eric O. Long, Kassoum Kayentao, Christine S. Hopp

{"title":"Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria","authors":"Kelly A. Hagadorn, Mary E. Peterson, Hemanta Kole, Bethany Scott, Jeff Skinner, Ababacar Diouf, Eizo Takashima, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabe, Shanping Li, Padmapriya Sekar, Mei Yan, Chengsong Zhu, Hikaru Nagaoka, Bernard N. Kanoi, Quan-Zhen Li, Carole Long, Eric O. Long, Kassoum Kayentao, Christine S. Hopp","doi":"10.1016/j.immuni.2024.05.024","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.05.024","url":null,"abstract":"Many infections, including malaria, are associated with an increase in autoantibodies (AAbs). Prior studies have reported an association between genetic markers of susceptibility to autoimmune disease and resistance to malaria, but the underlying mechanisms are unclear. Here, we performed a longitudinal study of children and adults (n = 602) in Mali and found that high levels of plasma AAbs before the malaria season independently predicted a reduced risk of clinical malaria in children during the ensuing malaria season. Baseline AAb seroprevalence increased with age and asymptomatic Plasmodium falciparum infection. We found that AAbs purified from the plasma of protected individuals inhibit the growth of blood-stage parasites and bind P. falciparum proteins that mediate parasite invasion. Protected individuals had higher plasma immunoglobulin G (IgG) reactivity against 33 of the 123 antigens assessed in an autoantigen microarray. This study provides evidence in support of the hypothesis that a propensity toward autoimmunity offers a survival advantage against malaria.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":null,"pages":null},"PeriodicalIF":32.4,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141425200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program 组织驻留调节性 T 细胞池是通过瞬时多组织迁移和保守的驻留程序形成的

IF 32.4 1区医学

Immunity Pub Date : 2024-06-18 DOI: 10.1016/j.immuni.2024.05.023

Oliver T. Burton, Orian Bricard, Samar Tareen, Vaclav Gergelits, Simon Andrews, Laura Biggins, Carlos P. Roca, Carly Whyte, Steffie Junius, Aleksandra Brajic, Emanuela Pasciuto, Magda Ali, Pierre Lemaitre, Susan M. Schlenner, Harumichi Ishigame, Brian D. Brown, James Dooley, Adrian Liston

{"title":"The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program","authors":"Oliver T. Burton, Orian Bricard, Samar Tareen, Vaclav Gergelits, Simon Andrews, Laura Biggins, Carlos P. Roca, Carly Whyte, Steffie Junius, Aleksandra Brajic, Emanuela Pasciuto, Magda Ali, Pierre Lemaitre, Susan M. Schlenner, Harumichi Ishigame, Brian D. Brown, James Dooley, Adrian Liston","doi":"10.1016/j.immuni.2024.05.023","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.05.023","url":null,"abstract":"The tissues are the site of many important immunological reactions, yet how the immune system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ regulatory T (Treg) cells in non-lymphoid tissues with unique characteristics compared with lymphoid Treg cells. However, tissue Treg cells have not been considered holistically across tissues. Here, we performed a systematic analysis of the Treg cell population residing in non-lymphoid organs throughout the body, revealing shared phenotypes, transient residency, and common molecular dependencies. Tissue Treg cells from different non-lymphoid organs shared T cell receptor (TCR) sequences, with functional capacity to drive multi-tissue Treg cell entry and were tissue-agnostic on tissue homing. Together, these results demonstrate that the tissue-resident Treg cell pool in most non-lymphoid organs, other than the gut, is largely constituted by broadly self-reactive Treg cells, characterized by transient multi-tissue migration. This work suggests common regulatory mechanisms may allow pan-tissue Treg cells to safeguard homeostasis across the body.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":null,"pages":null},"PeriodicalIF":32.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function 记忆性 B 细胞的高可召回性需要 ZFP318 对线粒体功能的转录调控

IF 32.4 1区医学

Immunity Pub Date : 2024-06-17 DOI: 10.1016/j.immuni.2024.05.022

Yifeng Wang, Wen Shao, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, Hai Qi

{"title":"High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function","authors":"Yifeng Wang, Wen Shao, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, Hai Qi","doi":"10.1016/j.immuni.2024.05.022","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.05.022","url":null,"abstract":"Expression of the transcriptional regulator ZFP318 is induced in germinal center (GC)-exiting memory B cell precursors and memory B cells (MBCs). Using a conditional ZFP318 fluorescence reporter that also enables ablation of ZFP318-expressing cells, we found that ZFP318-expressing MBCs were highly enriched with GC-derived cells. Although ZFP318-expressing MBCs constituted only a minority of the antigen-specific MBC compartment, their ablation severely impaired recall responses. Deletion of Zfp318 did not alter the magnitude of primary responses but markedly reduced MBC participation in recall. CD40 ligation promoted Zfp318 expression, whereas B cell receptor (BCR) signaling was inhibitory. Enforced ZFP318 expression enhanced recall performance of MBCs that otherwise responded poorly. ZFP318-deficient MBCs expressed less mitochondrial genes, had structurally compromised mitochondria, and were susceptible to reactivation-induced cell death. The abundance of ZFP318-expressing MBCs, instead of the number of antigen-specific MBCs, correlated with the potency of prime-boost vaccination. Therefore, ZFP318 controls the MBC recallability and represents a quality checkpoint of humoral immune memory.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":null,"pages":null},"PeriodicalIF":32.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies 对感染 RSV 的婴儿进行纵向体液分析，确定预先存在的 RSV 株系特异性 G 抗体和不断演变的交叉反应 F 抗体

IF 32.4 1区医学

Immunity Pub Date : 2024-06-13 DOI: 10.1016/j.immuni.2024.05.019

Nadège Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Boris Julg, Barney Graham, Octavio Ramilo, Asuncion Mejias, Galit Alter

{"title":"Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies","authors":"Nadège Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Boris Julg, Barney Graham, Octavio Ramilo, Asuncion Mejias, Galit Alter","doi":"10.1016/j.immuni.2024.05.019","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.05.019","url":null,"abstract":"Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory tract infection (LRTI) and hospitalization in infants. However, the mechanisms of immune control in infants remain incompletely understood. Antibody profiling against attachment (G) and fusion (F) proteins in children less than 2 years of age, with mild (outpatients) or severe (inpatients) RSV disease, indicated substantial age-dependent differences in RSV-specific immunity. Maternal antibodies were detectable for the first 3 months of life, followed by a long window of immune vulnerability between 3 and 6 months and a rapid evolution of FcγR-recruiting immunity after 6 months of age. Acutely ill hospitalized children exhibited lower G-specific antibodies compared with healthy controls. With disease resolution, RSV-infected infants generated broad functional RSV strain-specific G-responses and evolved cross-reactive F-responses, with minimal maternal imprinting. These data suggest an age-independent RSV G-specific functional humoral correlate of protection, and the evolution of RSV F-specific functional immunity with disease resolution.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":null,"pages":null},"PeriodicalIF":32.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation 微生物群决定 T 细胞克隆选择，从而增强干细胞移植后的移植物抗宿主疾病能力

IF 32.4 1区医学

Immunity Pub Date : 2024-06-13 DOI: 10.1016/j.immuni.2024.05.018

Albert C. Yeh, Motoko Koyama, Olivia G. Waltner, Simone A. Minnie, Julie R. Boiko, Tamer B. Shabaneh, Shuichiro Takahashi, Ping Zhang, Kathleen S. Ensbey, Christine R. Schmidt, Samuel R.W. Legg, Tomoko Sekiguchi, Ethan Nelson, Shruti S. Bhise, Andrew R. Stevens, Tracy Goodpaster, Saranya Chakka, Scott N. Furlan, Kate A. Markey, Marie E. Bleakley, Geoffrey R. Hill

{"title":"Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation","authors":"Albert C. Yeh, Motoko Koyama, Olivia G. Waltner, Simone A. Minnie, Julie R. Boiko, Tamer B. Shabaneh, Shuichiro Takahashi, Ping Zhang, Kathleen S. Ensbey, Christine R. Schmidt, Samuel R.W. Legg, Tomoko Sekiguchi, Ethan Nelson, Shruti S. Bhise, Andrew R. Stevens, Tracy Goodpaster, Saranya Chakka, Scott N. Furlan, Kate A. Markey, Marie E. Bleakley, Geoffrey R. Hill","doi":"10.1016/j.immuni.2024.05.018","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.05.018","url":null,"abstract":"Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by histocompatibility antigen disparities between donor and recipient. This paradigm represents a closed genetic system within which donor T cells interact with peptide-major histocompatibility complexes (MHCs), though clonal interrogation remains challenging due to the sparseness of the T cell repertoire. We developed a Bayesian model using donor and recipient T cell receptor (TCR) frequencies in murine stem cell transplant systems to define limited common expansion of T cell clones across genetically identical donor-recipient pairs. A subset of donor CD4+ T cell clonotypes differentially expanded in identical recipients and were microbiota dependent. Microbiota-specific T cells augmented GVHD lethality and could target microbial antigens presented by gastrointestinal epithelium during an alloreactive response. The microbiota serves as a source of cognate antigens that contribute to clonotypic T cell expansion and the induction of GVHD independent of donor-recipient genetics.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":null,"pages":null},"PeriodicalIF":32.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not so aDAMant after all: Plasticity of phagocytic microglia 毕竟不是那么无用吞噬型小胶质细胞的可塑性

IF 32.4 1区医学

Immunity Pub Date : 2024-06-11 DOI: 10.1016/j.immuni.2024.05.013

Aleksandra Deczkowska

引用次数: 0

AI and immunology 人工智能与免疫学

IF 32.4 1区医学

Immunity Pub Date : 2024-06-11 DOI: 10.1016/j.immuni.2024.05.016

Ronald N. Germain, Eliezer M. Van Allen, Gosia Trynka, John S. Tsang, Dominic Grün, Ashley L. Kiemen, Yigong Shi, Aimee Pugh Bernard, Garry P. Nolan

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Mast cells: The Janus of type 2 inflammation 肥大细胞2 型炎症的杰纳斯