IL-9和ZBTB18是生发中心记忆制造者

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-04-08 DOI:10.1016/j.immuni.2025.03.010

Erica L. Stewart, Deborah L. Burnett

引用次数: 0

摘要

从生发中心（GCs）发育而来的长寿命记忆B细胞是保护性免疫的重要贡献者。在这一期的《免疫》杂志上，Luo等人报道，在初级反应中，T细胞来源的白细胞介素-9通过依赖于转录调节剂ZBTB18的方式，增强GC记忆前体向功能记忆B细胞的分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IL-9 and ZBTB18 are germinal center memory makers

Long-lived memory B cells developing from germinal centers (GCs) are important contributors to protective immunity. In this issue of Immunity, Luo et al. report that during primary responses, T cell-derived interleukin-9 potentiates differentiation of GC memory precursors into functional memory B cells in a manner dependent on the transcriptional regulator ZBTB18.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.