Immunity最新文献_第9页

Bacterial translocation promotes trained immunity 细菌的易位促进了训练有素的免疫力

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2025.01.011

Maria Francesca Viola, Elvira Mass

引用次数: 0

Nerve-racking worms 伤脑筋的蠕虫

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2025.01.014

Yisi Lu, Ruaidhrí Jackson

引用次数: 0

Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration 早期efferocytosis指导巨噬细胞花生四烯酸代谢组织再生

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2024.11.018

Connor Lantz, Amanda Becker, Matthew DeBerge, Mallory Filipp, Kristofor Glinton, Aparnaa Ananthakrishnan, Jessica Urbanczyk, Madeline Cetlin, Afnan Alzamroon, Ahmed Abdel-Latif, Matthew Spite, Zhi-Dong Ge, Edward B. Thorp

{"title":"Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration","authors":"Connor Lantz, Amanda Becker, Matthew DeBerge, Mallory Filipp, Kristofor Glinton, Aparnaa Ananthakrishnan, Jessica Urbanczyk, Madeline Cetlin, Afnan Alzamroon, Ahmed Abdel-Latif, Matthew Spite, Zhi-Dong Ge, Edward B. Thorp","doi":"10.1016/j.immuni.2024.11.018","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.11.018","url":null,"abstract":"In response to organ injury in adults, macrophages often promote scarring, yet during early life, they are required for tissue regeneration. To elucidate the mechanisms underlying age-associated regeneration, we compared the macrophage injury response in newborn versus adult hearts. Single-cell analysis revealed an accumulation of tissue-resident macrophages in neonates that were selectively polarized for apoptotic cell recognition and uptake (efferocytosis). Ablation of the apoptotic cell recognition receptor Mertk in newborns prevented cardiac regeneration. These findings could be attributed to reprogramming of macrophage gene expression that was required for biosynthesis of the eicosanoid thromboxane A2, which unexpectedly activated parenchymal cell proliferation. Markers of thromboxane A2 production were suppressed in adult macrophages after efferocytosis. Moreover, macrophage-neighboring neonatal cardiomyocytes expressed the thromboxane A2 receptor, whose activation induced a metabolic shift that supported cellular proliferation. Our data reveal a fundamental age-defined macrophage response in which lipid mitogens produced during efferocytosis support receptor-mediated tissue regeneration.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"16 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting to the chase: Pruning alloreactive T cells 切中要害：修剪同种异体反应性T细胞

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2025.01.005

Anita S. Chong, Marlena Habal

引用次数: 0

Everything everywhere all at once: Unraveling the waves of aging 所有的一切，所有的地方都在一起：解开衰老的波浪

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2025.01.015

Jose Ignacio Escrig-Larena, María Mittelbrunn

引用次数: 0

Next generation lysosome: Brought to you by cGAS-STING 下一代溶酶体：由cGAS-STING带来

IF 32.4 1区医学

Immunity Pub Date : 2025-02-11 DOI: 10.1016/j.immuni.2025.01.012

Lei Wang, Wen Zhou

引用次数: 0

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 利用进化的腺相关病毒变体Ark313在小鼠T细胞的体内工程

IF 32.4 1区医学

Immunity Pub Date : 2025-02-04 DOI: 10.1016/j.immuni.2025.01.009

William A. Nyberg, Charlotte H. Wang, Jonathan Ark, Chang Liu, Sylvanie Clouden, Anita Qualls, Sofia Caryotakis, Elina Wells, Katherine Simon, Celeste Garza, Pierre-Louis Bernard, Maya Lopez-Ichikawa, Zhongmei Li, Jin Seo, Gabriella R. Kimmerly, Joseph J. Muldoon, Peixin Amy Chen, Mingcheng Li, Hong-Erh Liang, Kelly Kersten, Justin Eyquem

{"title":"In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313","authors":"William A. Nyberg, Charlotte H. Wang, Jonathan Ark, Chang Liu, Sylvanie Clouden, Anita Qualls, Sofia Caryotakis, Elina Wells, Katherine Simon, Celeste Garza, Pierre-Louis Bernard, Maya Lopez-Ichikawa, Zhongmei Li, Jin Seo, Gabriella R. Kimmerly, Joseph J. Muldoon, Peixin Amy Chen, Mingcheng Li, Hong-Erh Liang, Kelly Kersten, Justin Eyquem","doi":"10.1016/j.immuni.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.immuni.2025.01.009","url":null,"abstract":"Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a transient transgene expression cassette was feasible using Ark313, and this serotype outperformed natural serotypes. A single intravenous injection of a Cre recombinase-expressing Ark313 in the Ai9 fluorescent reporter mouse model achieved permanent genetic modifications of T cells. Ark313 facilitated in vivo gene editing in both tissue-resident and splenic T cells and validation of immunotherapy targets in solid tumor models. Ark313 delivered large DNA donor templates to T cells in vivo and integrated transgenes in primary CD4+ and CD8+ T cells, including naive T cells. Ark313-mediated transgene delivery presents an efficient approach to target mouse T cells in vivo and a resource for the interrogation of T cell biology and for immunotherapy applications.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"39 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350 Epstein-Barr病毒gp350介导补体受体结合和病毒中和的结构基础

IF 32.4 1区医学

Immunity Pub Date : 2025-02-04 DOI: 10.1016/j.immuni.2025.01.010

M. Gordon Joyce, Wei Bu, Wei-Hung Chen, Rebecca A. Gillespie, Sarah F. Andrews, Adam K. Wheatley, Yaroslav Tsybovsky, Jaime L. Jensen, Tyler Stephens, Madhu Prabhakaran, Brian E. Fisher, Sandeep R. Narpala, Meghna Bagchi, Adrian B. McDermott, Gary J. Nabel, Peter D. Kwong, John R. Mascola, Jeffrey I. Cohen, Masaru Kanekiyo

{"title":"Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350","authors":"M. Gordon Joyce, Wei Bu, Wei-Hung Chen, Rebecca A. Gillespie, Sarah F. Andrews, Adam K. Wheatley, Yaroslav Tsybovsky, Jaime L. Jensen, Tyler Stephens, Madhu Prabhakaran, Brian E. Fisher, Sandeep R. Narpala, Meghna Bagchi, Adrian B. McDermott, Gary J. Nabel, Peter D. Kwong, John R. Mascola, Jeffrey I. Cohen, Masaru Kanekiyo","doi":"10.1016/j.immuni.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.immuni.2025.01.010","url":null,"abstract":"Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with malignancies in humans. Viral infection of B cells is initiated by the viral glycoprotein 350 (gp350) binding to complement receptor 2 (CR2). Despite decades of effort, no vaccines or curative agents have been developed, partly due to lack of atomic-level understanding of the virus-host interface. Here, we determined the 1.7 Å structure of gp350 in complex with CR2. CR2 binding of gp350 utilized the same set of Arg residues required for recognition of its natural ligand, complement C3d. We further determined the structures of gp350 in complex with three potently neutralizing antibodies (nAbs) obtained from vaccinated macaques and EBV-infected individuals. Like the CR2 interaction, these nAbs targeted the acidic pocket within the CR2-binding site on gp350 using Arg residues. Our results illustrate two axes of molecular mimicry—gp350 versus C3d and CR2 versus EBV nAbs—offering insights for EBV vaccines and therapeutics development.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"133 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143084095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated control of leukocyte compartments as a feature of adaptive physiology 作为适应性生理特征的白细胞区室的综合控制

IF 32.4 1区医学

Immunity Pub Date : 2025-02-04 DOI: 10.1016/j.immuni.2025.01.013

Nikolai P. Jaschke, Andrew Wang

引用次数: 0

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression nlrp3介导的谷氨酰胺溶解控制小胶质细胞吞噬促进阿尔茨海默病进展

IF 32.4 1区医学

Immunity Pub Date : 2025-02-03 DOI: 10.1016/j.immuni.2025.01.007

Róisín M. McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramón Perea, Johannes C.M. Schlachetzki, David S. Bouvier, Michelle-Amirah Khalil, Mario A. Lauterbach, Lea Heinemann, Titus Schlüter, Mehran Shaban Pour, Marta Lovotti, Rainer Stahl, Fraser Duthie, Juan F. Rodríguez-Alcázar, Susanne V. Schmidt, Jasper Spitzer, Peri Noori, Michael T. Heneka

{"title":"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression","authors":"Róisín M. McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramón Perea, Johannes C.M. Schlachetzki, David S. Bouvier, Michelle-Amirah Khalil, Mario A. Lauterbach, Lea Heinemann, Titus Schlüter, Mehran Shaban Pour, Marta Lovotti, Rainer Stahl, Fraser Duthie, Juan F. Rodríguez-Alcázar, Susanne V. Schmidt, Jasper Spitzer, Peri Noori, Michael T. Heneka","doi":"10.1016/j.immuni.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.immuni.2025.01.007","url":null,"abstract":"Activation of the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer’s disease (AD) via the release of IL-1β and ASC specks. However, whether NLRP3 is involved in pathways beyond this remained unknown. Here, we found that Aβ deposition in vivo directly triggered NLRP3 activation in APP/PS1 mice, which model many features of AD. Loss of NLRP3 increased glutamine- and glutamate-related metabolism and increased expression of microglial Slc1a3, which was associated with enhanced mitochondrial and metabolic activity. The generation of α-ketoglutarate during this process impacted cellular function, including increased clearance of Aβ peptides as well as epigenetic and gene transcription changes. This pathway was conserved between murine and human cells. Critically, we could mimic this effect pharmacologically using NLRP3-specific inhibitors, but only with chronic NLRP3 inhibition. Together, these data demonstrate an additional role for NLRP3, where it can modulate mitochondrial and metabolic function, with important downstream consequences for the progression of AD.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"52 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0