2-5A is an immunotransmitter that fuels RNase L immunity

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-04-08 DOI:10.1016/j.immuni.2025.03.007

Songnan Wang, Lingyin Li

引用次数: 0

Abstract

cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fide immunotransmitter.

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2-5A是一种促进RNase L免疫的免疫递质

cGAS-cGAMP-STING和OAS-2-5A-RNase L是进化趋同的先天性免疫途径。在本期《免疫》杂志上，Huai 等人绘制了 2-5A 在细胞间转移的图谱，将其确定为一种真正的免疫传递因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.