The Three Graces of T cell receptor Vγ9Vδ2 chain activation

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-07-08 DOI:10.1016/j.immuni.2025.06.009

José Pedro Loureiro, Gennaro De Libero

引用次数: 0

Abstract

T cells expressing the T cell receptor (TCR) Vγ9Vδ2 chains recognize butyrophilins (BTNs) in the presence of phosphorylated antigens (pAgs). In this issue of Immunity, Zhang et al. and Zhu et al. illustrate the mechanism of TCR-BTN interaction using cryo-electron microscopy (cryo-EM). As pAgs accumulate, BTN heterotetramers assemble to bind to and activate the TCR Vγ9Vδ2.

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T细胞受体v - γ - 9v - δ2链活化的三种恩典

表达T细胞受体（TCR） Vγ9Vδ2链的T细胞在磷酸化抗原（pAgs）存在的情况下识别嗜丁酸蛋白（BTNs）。在本期《Immunity》中，Zhang等人和Zhu等人利用冷冻电镜（cryo-EM）阐述了TCR-BTN相互作用的机制。随着page的积累，BTN异四聚体聚集在一起，结合并激活TCR Vγ9Vδ2。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.