RORγt+ dendritic cells and regulatory T cells: A couple hiding in the shadows

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-07-08 DOI:10.1016/j.immuni.2025.06.012

Brian L. Kelsall

引用次数: 0

Abstract

The induction of CD4⁺Foxp3⁺ regulatory T cells (pTreg cells) in the intestine is important for preventing allergic and inflammatory disease, but which cells drive their differentiation is less clear. Three manuscripts in Nature, Cell, and Science conclude that one population of RORγt⁺ “dendritic cells” (DCs) is essential for both food- and microbe-specific pTreg cell responses in the intestine.

查看原文本刊更多论文

rorγ - T +树突状细胞和调节性T细胞：隐藏在阴影中的一对

在肠道中诱导CD4+Foxp3+调节性T细胞（pTreg细胞）对预防过敏性和炎症性疾病很重要，但哪些细胞驱动它们的分化尚不清楚。《自然》、《细胞》和《科学》杂志上的三篇论文得出结论，一群rorγ - t+“树突状细胞”（dc）对于肠道中食物和微生物特异性pTreg细胞反应都是必不可少的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.