trm样TIL的鉴别是谁

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-07-08 DOI:10.1016/j.immuni.2025.06.013

Artun Bülbül, Julian Hönninger, Veit R. Buchholz

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引用次数: 0

摘要

具有组织驻留记忆表型的肿瘤浸润性CD8+ T细胞已在小鼠和人类中被描述。在本期的《免疫》杂志中，Green等人详细分析了这些细胞在急性缓解和慢性病毒感染中与真正的组织驻留和耗尽的T细胞相关的转录和表观遗传调控。

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Who is who in differentiation of Trm-like TIL

Tumor-infiltrating CD8⁺ T cells with a tissue-resident memory phenotype have been described in both mice and humans. In this issue of Immunity, Green et al. provide a detailed analysis of the transcriptional and epigenetic regulation of these cells in relation to bona fide tissue-resident and exhausted T cells found in acutely resolving and chronic viral infections.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.