Immunity最新文献_第3页

Antigen-presenting cells as specialized drivers of intestinal T cell functions 抗原递呈细胞是肠道 T 细胞功能的专门驱动力

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.011

Ranit Kedmi, Dan R. Littman

引用次数: 0

TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy TIL 终结：追踪采用细胞疗法期间 T 细胞克隆型的动态变化

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.012

Anthony C. Buzzai, Thomas Tüting

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Oligodendrocytes go with the flow: Meningeal lymphatics promote myelin integrity 少突胶质细胞随波逐流脑膜淋巴管促进髓鞘完整性

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.006

Eric D. Garcia, Jonah R. Chan

引用次数: 0

An autoreactive T cell’s perception of a land of plenty 自反应 T 细胞对富饶之地的感知

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.005

Thomas Korn

引用次数: 0

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. 使用经整理的流感血凝素抗体预测抗体特异性的可解释语言模型。

IF 25.5 1区医学

Immunity Pub Date : 2024-10-08 Epub Date: 2024-08-19 DOI: 10.1016/j.immuni.2024.07.022

Yiquan Wang, Huibin Lv, Qi Wen Teo, Ruipeng Lei, Akshita B Gopal, Wenhao O Ouyang, Yuen-Hei Yeung, Timothy J C Tan, Danbi Choi, Ivana R Shen, Xin Chen, Claire S Graham, Nicholas C Wu

{"title":"An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies.","authors":"Yiquan Wang, Huibin Lv, Qi Wen Teo, Ruipeng Lei, Akshita B Gopal, Wenhao O Ouyang, Yuen-Hei Yeung, Timothy J C Tan, Danbi Choi, Ivana R Shen, Xin Chen, Claire S Graham, Nicholas C Wu","doi":"10.1016/j.immuni.2024.07.022","DOIUrl":"10.1016/j.immuni.2024.07.022","url":null,"abstract":"Despite decades of antibody research, it remains challenging to predict the specificity of an antibody solely based on its sequence. Two major obstacles are the lack of appropriate models and the inaccessibility of datasets for model training. In this study, we curated >5,000 influenza hemagglutinin (HA) antibodies by mining research publications and patents, which revealed many distinct sequence features between antibodies to HA head and stem domains. We then leveraged this dataset to develop a lightweight memory B cell language model (mBLM) for sequence-based antibody specificity prediction. Model explainability analysis showed that mBLM could identify key sequence features of HA stem antibodies. Additionally, by applying mBLM to HA antibodies with unknown epitopes, we discovered and experimentally validated many HA stem antibodies. Overall, this study not only advances our molecular understanding of the antibody response to the influenza virus but also provides a valuable resource for applying deep learning to antibody research.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2453-2465.e7"},"PeriodicalIF":25.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAGging behind no more: PD-1 has a new immunotherapy partner 不再落后PD-1 有了新的免疫疗法伙伴

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.010

Andrew J. Gunderson

引用次数: 0

Superficial ice and deep blaze: A defense strategy of the skin 表层结冰和深层灼伤：皮肤的防御策略

IF 32.4 1区医学

Immunity Pub Date : 2024-10-08 DOI: 10.1016/j.immuni.2024.09.008

Zhuoqiong Qiu, Wei Li

引用次数: 0

Type I IFN drives unconventional IL-1β secretion in lupus monocytes I 型 IFN 驱动狼疮单核细胞分泌非常规 IL-1β

IF 32.4 1区医学

Immunity Pub Date : 2024-10-07 DOI: 10.1016/j.immuni.2024.09.004

Simone Caielli, Preetha Balasubramanian, Juan Rodriguez-Alcazar, Uthra Balaji, Lauren Robinson, Zurong Wan, Jeanine Baisch, Cynthia Smitherman, Lynnette Walters, Paola Sparagana, Djamel Nehar-Belaid, Radu Marches, Lorien Nassi, Katie Stewart, Julie Fuller, Jacques F. Banchereau, Jinghua Gu, Tracey Wright, Virginia Pascual

{"title":"Type I IFN drives unconventional IL-1β secretion in lupus monocytes","authors":"Simone Caielli, Preetha Balasubramanian, Juan Rodriguez-Alcazar, Uthra Balaji, Lauren Robinson, Zurong Wan, Jeanine Baisch, Cynthia Smitherman, Lynnette Walters, Paola Sparagana, Djamel Nehar-Belaid, Radu Marches, Lorien Nassi, Katie Stewart, Julie Fuller, Jacques F. Banchereau, Jinghua Gu, Tracey Wright, Virginia Pascual","doi":"10.1016/j.immuni.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.09.004","url":null,"abstract":"Opsonization of red blood cells that retain mitochondria (Mito+ RBCs), a feature of systemic lupus erythematosus (SLE), triggers type I interferon (IFN) production in macrophages. We report that monocytes (Mos) co-produce IFN and mature interleukin-1β (mIL-1β) upon Mito+ RBC opsonization. IFN expression depended on cyclic GMP-AMP synthase (cGAS) and RIG-I-like receptors’ (RLRs) sensing of Mito+ RBC-derived mitochondrial DNA (mtDNA) and mtRNA, respectively. Interleukin-1β (IL-1β) production was initiated by the RLR antiviral signaling adaptor (MAVS) pathway recognition of Mito+ RBC-derived mtRNA. This led to the cytosolic release of Mo mtDNA, which activated the inflammasome. Importantly, mIL-1β secretion was independent of gasdermin D (GSDMD) and pyroptosis but relied on IFN-inducible myxovirus-resistant protein 1 (MxA), which facilitated the incorporation of mIL-1β into a trans-Golgi network (TGN)-mediated secretory pathway. RBC internalization identified a subset of blood Mo expressing IFN-stimulated genes (ISGs) that released mIL-1β and expanded in SLE patients with active disease.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"52 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels 黑色素瘤脑肿瘤的 T 淋巴细胞募集依赖于独特的静脉血管

IF 32.4 1区医学

Immunity Pub Date : 2024-10-04 DOI: 10.1016/j.immuni.2024.09.003

Julia M. Messmer, Calvin Thommek, Manuel Piechutta, Varun Venkataramani, Rebekka Wehner, Dana Westphal, Marc Schubert, Chanté D. Mayer, Maike Effern, Anna S. Berghoff, Daniel Hinze, Iris Helfrich, Dirk Schadendorf, Wolfgang Wick, Michael Hölzel, Matthia A. Karreman, Frank Winkler

{"title":"T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels","authors":"Julia M. Messmer, Calvin Thommek, Manuel Piechutta, Varun Venkataramani, Rebekka Wehner, Dana Westphal, Marc Schubert, Chanté D. Mayer, Maike Effern, Anna S. Berghoff, Daniel Hinze, Iris Helfrich, Dirk Schadendorf, Wolfgang Wick, Michael Hölzel, Matthia A. Karreman, Frank Winkler","doi":"10.1016/j.immuni.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.09.003","url":null,"abstract":"To improve immunotherapy for brain tumors, it is important to determine the principal intracranial site of T cell recruitment from the bloodstream and their intracranial route to brain tumors. Using intravital microscopy in mouse models of intracranial melanoma, we discovered that circulating T cells preferably adhered and extravasated at a distinct type of venous blood vessel in the tumor vicinity, peritumoral venous vessels (PVVs). Other vascular structures were excluded as alternative T cell routes to intracranial melanomas. Anti-PD-1/CTLA-4 immune checkpoint inhibitors increased intracranial T cell motility, facilitating migration from PVVs to the tumor and subsequently inhibiting intracranial tumor growth. The endothelial adhesion molecule ICAM-1 was particularly expressed on PVVs, and, in samples of human brain metastases, ICAM-1 positivity of PVV-like vessels correlated with intratumoral T cell infiltration. These findings uncover a distinct mechanism by which the immune system can access and control brain tumors and potentially influence other brain pathologies.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"63 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation 在 2 型炎症期间，含有 Alarmin 的细胞外脂滴可诱导气道中性粒细胞浸润

IF 32.4 1区医学

Immunity Pub Date : 2024-10-03 DOI: 10.1016/j.immuni.2024.09.001

Zebing Rao, Shaorui Liu, Zhicheng Li, Qiuying Wang, Feng Gao, Han Peng, Deshan Ren, Yang Zang, Hui Li, Yan Li, Qi Hu, Danyang He, Heping Xu

{"title":"Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation","authors":"Zebing Rao, Shaorui Liu, Zhicheng Li, Qiuying Wang, Feng Gao, Han Peng, Deshan Ren, Yang Zang, Hui Li, Yan Li, Qi Hu, Danyang He, Heping Xu","doi":"10.1016/j.immuni.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.09.001","url":null,"abstract":"Group 2 innate lymphoid cells (ILC2s) play a crucial role in allergic diseases by coordinating a complex network of various effector cell lineages involved in type 2 inflammation. However, their function in regulating airway neutrophil infiltration, a deleterious symptom of severe asthma, remains unknown. Here, we observed ILC2-dependent neutrophil accumulation in the bronchoalveolar lavage fluid (BALF) of allergic mouse models. Chromatography followed by proteomics analysis identified the alarmin high mobility group box-1 (HMGB1) in the supernatant of lung ILC2s initiated neutrophil chemotaxis. Genetic perturbation of Hmgb1 in ILC2s reduced BALF neutrophil numbers and alleviated airway inflammation. HMGB1 was loaded onto the membrane of lipid droplets (LDs) released from activated lung ILC2s. Genetic inhibition of LD accumulation in ILC2s significantly decreased extracellular HMGB1 abundance and BALF neutrophil infiltration. These findings unveil a previously uncharacterized extracellular LD-mediated immune signaling delivery pathway by which ILC2s regulate airway neutrophil infiltration during allergic inflammation.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"54 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142369159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0