An inside job—CHIP infiltrates and promotes cancer

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-06-10 DOI:10.1016/j.immuni.2025.05.014

Brian Y. Soong, Nader Yatim, Miriam Merad

引用次数: 0

Abstract

Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on disease progression.

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一个内部的job-CHIP渗透并促进癌症

造血干细胞的体细胞突变可导致不确定潜能的克隆造血（CHIP），这是与许多与年龄相关的疾病（包括实体癌）相关的常见疾病。Pich等人在《新英格兰医学杂志》（New England Journal of Medicine）上报道，肿瘤浸润性CHIP与癌症预后和临床结果恶化相关，为免疫细胞突变对疾病进展的影响提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.