Gerontology最新文献

{"title":"Baseline Blood Biochemical and Immunological Measures Correlate with Clinical Features and Treatment Responses in Late-Life Depression.","authors":"Irina Sergeevna Boksha, Olga Konstantinovna Savushkina, Tatyana Andreevna Prokhorova, Elena Borisovna Tereshkina, Liubov Vasilievna Androsova, Tatyana Petrovna Safarova, Olga Borisovna Yakovleva, Irina Nikolaevna Othman, Gulnur Shingojievna Burbaeva","doi":"10.1159/000548993","DOIUrl":"10.1159/000548993","url":null,"abstract":"<p><strong>Introduction: </strong>Heterogeneity of patients with late-life depression (LLD) makes it difficult to predict their responses to treatment.</p><p><strong>Methods: </strong>Hundred patients with LLD were stratified into clusters based on ten blood biochemical and immunological parameters measured at baseline. The treatment responses and clinical characteristics of the patients in the resulting clusters were compared.</p><p><strong>Results: </strong>The resulting 4 clusters of patients significantly differed in treatment responses and in a number of clinical traits.</p><p><strong>Conclusion: </strong>The study confirms the link between the activities of enzymes involved in energy, glutamate metabolism, and antioxidant and immune systems in patients with LLD and their response to therapy as well as their certain clinical characteristics.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"72-83"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of miR-28-5p in Ischemic Stroke and Its Neuroprotective Effect after Ischemia-Reperfusion Injury.","authors":"Zhu Li, Jianchang Mu, Hongfei Yang, Shuo Sun, Yuhao Zhang","doi":"10.1159/000551361","DOIUrl":"10.1159/000551361","url":null,"abstract":"<p><strong>Introduction: </strong>Ischemic stroke (IS) remains a leading cause of global morbidity and mortality, necessitating novel therapeutic targets. MicroRNAs show promise in modulating post-stroke pathology, yet the role of miR-28-5p in IS remains unexplored. This study aimed to investigate miR-28-5p expression in IS and its clinical and mechanistic significance.</p><p><strong>Methods: </strong>Serum miR-28-5p levels were quantified via qRT-PCR in 129 IS patients and 97 healthy controls. Kaplan-Meier (K-M) analysis and multivariate COX regression analysis evaluated the prognostic value of miR-28-5p in IS. In vitro, dual-luciferase assays validated the interaction between miR-28-5p and WNK3. Oxygen-glucose deprivation/reoxygenation (OGD/R)-treated HMC3 microglia were used to assess miR-28-5p/WNK3 axis in microglial polarization, oxidative stress, and inflammation.</p><p><strong>Results: </strong>Serum miR-28-5p was significantly downregulated in IS patients, associated with elevated triglycerides, low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol levels, and higher NIHSS scores. K-M analysis revealed a lower progression-free survival rate in IS patients with low miR-28-5p expression, and COX regression analysis confirmed miR-28-5p as an independent prognostic factor. In mechanism miR-28-5p directly targeted WNK3. Overexpression of miR-28-5p suppressed OGD/R-induced M1 polarization, oxidative stress (reduced malondialdehyde, elevated superoxide dismutase), and inflammatory cytokines (decreased TNF-α, IL-6, IL-1β, and increased IL-10), whereas WNK3 overexpression reversed these effects.</p><p><strong>Conclusion: </strong>MiR-28-5p served as a diagnostic biomarker and independent prognostic factor in IS. Its neuroprotection involved suppressing WNK3-mediated microglial M1 polarization, oxidative stress, and inflammation, highlighting its potential as a therapeutic target for IS.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"456-469"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-Level Variations in Hypertension Management and Cardiovascular Disease Risks in India: Public Spending on Health and Socioeconomic Inequalities.","authors":"Kanya Anindya, Yang Zhao, Sukumar Vellakkal, Arokiasamy Perianayagam, Sanghamitra Pati, Tiara Marthias, Mansi Malik, John Tayu Lee","doi":"10.1159/000549706","DOIUrl":"10.1159/000549706","url":null,"abstract":"<p><p><p>Introduction: This study aimed to assess the within- and between-states inequality in hypertension management and cardiovascular disease (CVD) risk across sociodemographic groups in India and the correlation between states/UTs expenditure on health, hypertension management, and CVD risk.</p><p><strong>Methods: </strong>This study utilized cross-sectional data from 2017/2018 Longitudinal Aging Study in India (LASI), with a total sample of 58,848 respondents aged ≥45 years. Hypertension management was assessed based on hypertension awareness, treatment, and control, while 10-year CVD risk was measured using the 2019 WHO CVD risk. We used multilevel logistic regression models to estimate the socioeconomic inequality in hypertension management and 10-year CVD risk, measured by the relative index of inequality (RII).</p><p><strong>Results: </strong>Rural areas had a substantially poorer coverage of hypertension awareness, treatment, and control compared with urban areas. Richest socioeconomic groups were more likely to be aware of their hypertensive status (RII 1.28, 95% CI: 1.16-1.42), receive antihypertensive treatment (RII 1.47, 95% CI: 1.28-1.69), have their blood pressure controlled (RII 1.60, 95% CI: 1.34-1.90), and have 10-year CVD risk <10% (1.06, 95% CI: 1.01-1.12) compared to the poorest. The variance partition coefficient ranged from 1.5% for 10-year CVD risk to 9.9% for hypertension control. There was no significant correlation between socioeconomic inequality in hypertension management, 10-year CVD risk, and the per capita public health expenditure of states/UTs.</p><p><strong>Conclusion: </strong>Differences in state-level health system capacity may disproportionately affect socioeconomically disadvantaged populations, underscoring the need for more equitable hypertension management and cardiovascular health strategies across India. </p>.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"95-109"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145603857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater Severity of Hearing Loss Is Associated with Worse Balance Performance, but Exercise May Improve Stability.","authors":"Liraz Arie, Maura Cosetti, Jennifer Kelly, Daphna Harel, Brittani Morris, Katherine Scigliano, Anat V Lubetzky","doi":"10.1159/000549842","DOIUrl":"10.1159/000549842","url":null,"abstract":"<p><p><p>Introduction: Understanding why bilateral sensorineural hearing loss (BHL) is associated with balance dysfunction can guide balance rehabilitation programs. We investigated whether adults with BHL demonstrated impaired standing balance and increased postural visual and somatosensory dependence as compared to those with normal hearing.</p><p><strong>Methods: </strong>This cross-sectional study assessed postural sway in 31 adults with BHL (mean age = 72.97) and 28 controls (mean age = 59.14), using the instrumented modified Clinical Test of Sensory Integration (mCTSIB). The mCTSIB has 4 tasks, each 30-s long: standing with eyes open/closed on floor/foam. Outcome measures, calculated from inertial measurement units, included overall stability (root-mean-square [RMS] sway, ms2) and smoothness of sway (anterior-posterior and mediolateral jerk, m2s5). Participants also self-reported whether they exercised on a regular basis.</p><p><strong>Results: </strong>Adjusting for age, both groups increased RMS and jerk significantly with task, with no significant differences between groups. Greater BHL severity moderately correlated with higher anterior-posterior jerk and RMS in foam eyes closed condition. Age showed no more than weak correlations with BHL severity, jerk, or RMS. As a post hoc analysis, we observed that people who reported exercising regularly exerted less effort to maintain stance and were significantly more stable on the most challenging tasks.</p><p><strong>Conclusions: </strong>Individuals with BHL did not show increased visual or somatosensory reliance and overall as a group showed similar balance performance to adults with normal hearing. Greater severity of hearing loss was associated with worse performance regardless of age. This study supports the role of regular exercise as protective against balance dysfunction in aging with or without hearing loss. </p>.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"142-153"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes-Related Balance Impairment in the Aging Population: A Combined NHANES and Mendelian Randomization Study.","authors":"Kai Cheng, Sodiq Fakorede, Olubodun M Lateef, Okikiola Samuel Fakorede, Deqiang Wang, Xia Liu, Dan Wang","doi":"10.1159/000552601","DOIUrl":"10.1159/000552601","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus contributes to motor control impairments that can compromise balance and increase fall risk, particularly in older adults. Given that both the prevalence of aging and diabetes are increasing globally, understanding this relationship is vital for targeted fall prevention. This study examined the association between diabetes status and balance performance in older adults and assessed potential causal relationships using Mendelian randomization.</p><p><strong>Methods: </strong>We analyzed 1,218 adults aged ≥60 years from the 2021-2023 National Health and Nutrition Examination Survey (NHANES). Participants were classified as nondiabetic (n = 248), prediabetic (n = 690), or diabetic (n = 280) on the basis of fasting glucose and HbA1c. Balance was evaluated via the modified Romberg test. Associations were examined via ordinal logistic regression, and causality was assessed via Mendelian randomization with diabetes-related genetic instruments.</p><p><strong>Results: </strong>In fully adjusted models, diabetes was strongly associated with impaired balance (β = -0.88; 95% CI: -1.33 to -0.44; p < 0.001). Prediabetes also demonstrated a significant association with balance impairment (β = -0.53; 95% CI: -0.85 to -0.22; p < 0.001). Mendelian randomization provided evidence that genetically predicted diabetes was associated with increased fall risk (OR = 4.75; 95% CI: 1.48-15.24; p = 0.009).</p><p><strong>Conclusions: </strong>Observational analyses link diabetes and prediabetes to poorer balance performance, and genetic evidence supports an association between diabetes liability and increased fall risk.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"591-602"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Multicenter External Validation of a Real-Time Artificial Intelligence Diagnostic System for Diabetic Peripheral Neuropathy Based on Wearable Devices.","authors":"Junlin Ran, Pengcheng Huang, Min He, Liling Deng, Qingqing Chen, Yiwen Qin, David G Armstrong, Bijan Najafi, Edward Jude, Yanzhong Wang, Wuquan Deng, Chenzhen Du","doi":"10.1159/000551704","DOIUrl":"10.1159/000551704","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic peripheral neuropathy (DPN) is a frequent diabetes complication, affecting over half of patients and causing pain, falls, ulcers, and amputations if undetected. Traditional methods like electromyography are resource-intensive and inaccessible. This study developed and validated STRIDE, a machine learning model using wearable gait and balance data for real-time DPN classification.</p><p><strong>Methods: </strong>In this study conducted across multiple centers, 206 participants from Chongqing hospitals were categorized as follows: healthy controls (n = 32), diabetics without DPN (n = 47), asymptomatic DPN (n = 48), and symptomatic DPN (n = 79). A separate group of 42 was used for validation. During a one-minute walk and modified balance test, LEG-Sys/BalanSens sensors produced 68 features. STRIDE used random forest and logistic regression with cross-validation. The metrics used were area under the receiver operating characteristic curve (AUROC), accuracy, sensitivity, specificity, F1-score, and SHAP for interpretability, with a scoring system allowing for real-time evaluation.</p><p><strong>Results: </strong>Random forest achieved AUROC 0.80 (95% CI: 0.64-0.92); logistic regression 0.79 (95% CI: 0.62-0.95). Key SHAP features: stride length variability (weight = 0.61) and double-support time. External validation: initial accuracy 78.6%, recall 86.5%, precision 88.9%; three of four false positives developed DPN within 1 year, yielding 89.3% adjusted concordance. STRIDE outperformed other parameters in mid-term prediction, unaffected by anemia for up to 4 years.</p><p><strong>Conclusion: </strong>STRIDE provides a scalable, interpretable tool for DPN classification, supporting early intervention and improved outcomes. Larger longitudinal studies are needed for clinical integration.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"500-516"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Aquatic Reactive Balance Training (AquaReBal) for Older Adults: Protocol for a Single-Arm Pre-Post Study.","authors":"Anna Ogonowska-Slodownik, Andresa Marinho-Buzelli, Cynthia Danells, Kristin E Musselman, Alison Bonnyman, Mohammad Alavinia, Avril Mansfield","doi":"10.1159/000550917","DOIUrl":"10.1159/000550917","url":null,"abstract":"<p><p><p>Introduction: Falls are a serious problem for older adults, and as the number of older adults increases rapidly, the burden of falls is expected to continue rising. Reactive balance training is an important component of balance and fall-prevention exercise programmes in older people at elevated fall risk. Despite its effectiveness for improving reactive balance control and preventing falls, land-based RBT programs can be associated with increased risk of adverse events, including joint pain, fear, and anxiety that results in participants withdrawing from the program. A water environment could minimize the barriers associated with land-based RBT. The aim of this research was to determine the feasibility and preliminary effectiveness of aquatic reactive balance training (AquaReBal). Methods: Older adults (n = 12-15) will be recruited and will complete twelve sessions of AquaReBal over 6 weeks. Feasibility outcomes (fidelity, acceptability, adherence, safety) will be assessed throughout the study. Interviews with participants will be conducted post-training to understand participants' experiences with the intervention. Secondary outcomes related to falls - physical activity, psychological consequences, generic health-related quality of life, and reactive balance control - will be assessed pre- and post-training; however, given the small sample size, these measures will be treated as exploratory and are not powered to detect change with precision. Falls in daily life will be recorded throughout the study until 6 months post-training. Conclusion: Findings from this study will inform the feasibility and design of AquaReBal, contributing to the development of aquatic interventions for fall prevention in older adults. </p>.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"375-383"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance on the Brain: Facilitators and Barriers of Intervention Implementation.","authors":"Jane Hopkins, Keith D Hill, Kathryn A Ellis, Elissa Burton","doi":"10.1159/000549641","DOIUrl":"10.1159/000549641","url":null,"abstract":"<p><p><p>Introduction: Balance on the Brain is a balance-focused multi-modal community-based exercise intervention aimed at reducing falls and improving health outcomes for people living with mild cognitive impairment (MCI). This study completed an important step when conducting randomised controlled trials (RCTs) by evaluating the barriers and facilitators of the program from the perspective of the intervention participants and the exercise providers delivering the intervention. This study also explored the perspective of the main informal support people (MISP) of intervention participants living with MCI.</p><p><strong>Methods: </strong>This was a qualitative study using face-to-face semi-structured interviews. Interviews were audio-recorded to enable verbatim transcriptions. Braun and Clarke's 6-step thematic analysis process was used to analyse the data.</p><p><strong>Results: </strong>A total of 26 RCT intervention participants, 4 physiotherapists, and 14 MISPs were interviewed at the end of the 6-month intervention. There was moderate diversity in the overall experiences; for example, what may have been a barrier for some was a facilitator for others. Overall, lack of motivation and other health issues were the most identified barriers across the Balance on the Brain intervention. Key facilitators for the intervention participant were the guidance provided by the physiotherapists delivering the program and the ease of adding the intervention into their daily routine. The MISPs had varying levels of involvement and support throughout the intervention; some completed the intervention exercises with the intervention participant, others were supportive and encouraged participation, and some had no input into the intervention participant's involvement in the Balance on the Brain intervention.</p><p><strong>Conclusion: </strong>The Balance on the Brain RCT was largely accepted by intervention participants, physiotherapists delivering the intervention, and the MISPs. Exercise interventions that can be tailored to each participant's needs are likely to be viewed more favourably. Future interventions for this population may be improved by adding opportunities for the MISPs to be more involved. </p>.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"171-190"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12803521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Cognitive-Motor Interference across Younger, Middle-Aged, and Older Adults during Dual-Task Walking.","authors":"Shatha Abdulaziz Aldraiwiesh, Robert S Gailey, James G Moore, Jennifer C Britton, Neva Jillaine Kirk-Sanchez","doi":"10.1159/000552128","DOIUrl":"10.1159/000552128","url":null,"abstract":"<p><strong>Introduction: </strong>Walking while listening or talking is a functionally relevant cognitive-motor dual-task (DT) activity that may challenge attentional capacity. DT activity alters gait and increases the risk of falls. The aging process may magnify challenges in DT performance. This study compared cognitive-motor interference (CMI) and DT performance across younger, middle-aged, and older adults during walking under varying memory task types.</p><p><strong>Methods: </strong>A cross-sectional sample of 32 younger (mean age = 25.2, range 22-32 years old), 18 middle-aged (mean age = 56.2, range 48-64 years old), and 19 older (mean age = 73.6, range 65-82 years old) healthy adults completed walking trials under single-task (ST) and four DT conditions with different memory-based tasks, two auditory encoding (story memory and list encoding), and two verbal retrieval (verbal fluency and list retrieval). Participants wore sensors that transmitted spatiotemporal walking data to a mobile iOS device. Gait parameters (speed [m/s], stride time [s], stride time variability [%CoV]) and memory performances were measured under ST and DT conditions. DT effects (DTEs) were calculated for all measures to quantify CMI, the percent change in performance under DT relative to ST. Statistical analyses included one-way ANOVAs with post hoc tests and correlations with age.</p><p><strong>Results: </strong>We found a decreasing trend in DTgait performance and worsening CMI across conditions with advancing age (e.g., DT verbal fluency gait speed: younger = 1.10 m/s, DTE = -15%; middle-aged = 0.98 m/s, DTE = -18%, older = 0.82 m/s, DTE = -24%). ANOVA showed differences between the 3 age groups in the DTE of all memory tasks on the gait measures (p < 0.05), with the DTE being consistently higher (worse) in older than younger adults. Middle-aged and older adults did not differ in DTE on speed or stride variability under memory retrieval tasks, but the latter had greater DTE on speed under memory encoding tasks. Middle-aged adults had similar DTE on gait measures to younger adults under encoding tasks, but greater on stride time and variability under retrieval tasks. Groups had similar DTE on memory tasks.</p><p><strong>Conclusion: </strong>Age-related differences in CMI were more prominent for gait than for secondary memory tasks. Findings support that DT performance incrementally declines with age. Middle-aged and older adults had similar gait destabilization in different DT walking demands, but older adults had higher interference with DT walking of auditory processing demands. Retrieval tasks during walking expose early deficits in middle-aged adults that differentiate them from younger adults. Results further suggest assessing DT walking of different demands and beginning from middle age to reduce fall risk and enhance DT ability early in life via education or cognitive-motor training.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"603-621"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.","authors":"Chi-Di Hung, Chia-Wei Chang, Hung-Pin Tu, Yi-Hsin Kung, Pei-Yun Tsai, Guan-Cheng Lin, Ya-Fen Liu, Hsiu-Shan Chen, Chen-Cheng Yang, Chun-Ying Lee, Hung-Yi Chuang, Chih-Hsing Hung","doi":"10.1159/000551103","DOIUrl":"10.1159/000551103","url":null,"abstract":"<p><strong>Introduction: </strong>In response to the rapidly growing elderly population, geriatric syndromes such as frailty, polypharmacy, and sarcopenia have gained significant attention due to their impact on aging-related health outcomes. To prevent functional decline, it is crucial to understand the relationship between physical performance and other potential confounding factors. This study aims to investigate how polypharmacy and other factors relate to physical performance.</p><p><strong>Methods: </strong>This cross-sectional study included 445 participants aged over 20, surveyed via questionnaire. Polypharmacy was defined as the daily use of 8 or more pills. Body composition was assessed using bioelectrical impedance analysis, and physical performance was measured via the Time-Up-and-Go (TUG) and five times Sit-to-Stand (5xSTS) tests.</p><p><strong>Results: </strong>The average age of participants was 64.22 years, with 11.0% on polypharmacy. The mean appendicular skeletal muscle mass index, TUG test, and 5xSTS test were 7.40 kg/m2, 8.29 seconds, and 9.33 seconds, respectively. Both physical performance tests correlated positively with age, low education, and polypharmacy and negatively with appendicular skeletal muscle mass index. Polypharmacy, low muscle mass, and lower educational levels were associated with poorer physical performance.</p><p><strong>Conclusion: </strong>These findings highlight the importance of early prevention strategies to address polypharmacy, muscle loss, and low education, all of which are potentially modifiable risk factors. Poorer physical performance was linked to polypharmacy, low muscle mass, and lower educational levels, suggesting a need for additional research into these contributing risk factors.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"354-362"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147304838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}