运动认知危险综合征的心电图指标。

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2025-04-01 Epub Date: 2025-02-13 DOI:10.1159/000544121

Joe Verghese, Sharika Sreeram, Vijin Joseph, Dristi Adhikari, Alben Sigamani, Helena M Blumen, V G Pradeep Kumar, Emmeline Ayers

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引用次数: 0

摘要

心血管疾病的存在与运动认知风险综合征（MCR）的患病率和发病率有关，MCR是一种以认知障碍和步态缓慢为特征的痴呆前期综合征。心电图（ECGs）可以提供一种成本效益高、无创、可靠的方法来检测MCR患者的心血管异常。这种方法不仅可以诊断心血管疾病，而且有助于及时干预，防止MCR病例进一步的认知能力下降。方法：我们在印度喀拉拉邦参加喀拉拉邦爱因斯坦研究（KES）的451名有心电图的老年人中检查了ECG异常与MCR流行的关系。采用调整年龄和性别的Logistic回归分析来检验相关性，并以95%置信区间（CI）的优势比（OR）报告。结果：191例（42.4%）参与者出现心电图异常。在43名被诊断为MCR的参与者中，23名（53.5%）有心电图异常。异常Q波（OR 5.1, 95% CI 1.7-14.9）和心脏传导阻滞（OR 6.0, 95% CI 2.1-17.4）在MCR患者中比对照组更常见。其他心电图异常发生率组间差异无统计学意义。结论：心电图异常在MCR患者中很常见，可作为MCR患者心血管疾病风险分层的依据。

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Electrocardiographic markers in Motoric Cognitive Risk syndrome.

Introduction: Presence of cardiovascular disease is linked to the prevalence and incidence of Motoric Cognitive Risk syndrome (MCR), a pre-dementia syndrome characterized by cognitive complaints and slow gait. Electrocardiograms (ECGs) may offer a cost-effective, non-invasive, and reliable method for detecting cardiovascular abnormalities in individuals with MCR. This approach can not only diagnose cardiovascular disease but also facilitate timely interventions to prevent further cognitive decline in MCR cases.

Methods: We examined the association of ECG abnormalities with prevalent MCR in 451 older adults with ECGs participating in the Kerala Einstein Study (KES), based in Indian state of Kerala. Logistic regression analysis adjusted for age and sex were used to examine associations, and reported as odds ratios (OR) with 95% confidence intervals (CI).

Results: ECG abnormalities were present in 191 (42.4%) participants. Of the 43 participants diagnosed with MCR, 23 (53.5%) had ECG abnormalities. Abnormal Q waves (OR 5.1, 95% CI 1.7-14.9) and heart block (OR 6.0, 95% CI 2.1-17.4) were more common in individuals with MCR compared to controls. There were no statistically significant group differences in the prevalence of other ECG abnormalities.

Conclusion: ECG abnormalities are common in MCR patients, and can be considered for cardiovascular disease risk-stratification in MCR cases.

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.