Gerontology最新文献

{"title":"Study Protocol of the 10-Year Longitudinal Amersfoort Cohort Study on Functional Decline, Healthy Aging, and Frailty (AMCOHF) in a Community-Dwelling Older Population.","authors":"Dax Houtkamp, Sabrina Chettouf, Bart C Bongers, Albert Van de Wiel, Peter Van Roy, Patrick Schrama, David Beckwée, Willy H A M Smeets, Ivan Bautmans, Annelies L Pool-Goudzwaard","doi":"10.1159/000546943","DOIUrl":"10.1159/000546943","url":null,"abstract":"<p><strong>Introduction: </strong>Frailty, characterized by a reduction in intrinsic capacity across multiple physiological systems, is a key concern in healthy aging. Insight in the trajectory of an individual's functional ability and intrinsic reserve capacity in a relatively younger population of older adults is lacking. This study aims to investigate the early stages of frailty by tracking trajectories of physical indicators of intrinsic capacity before frailty becomes clinically evident.</p><p><strong>Methods: </strong>The AMersfoort COhort study on functional decline, Healthy aging and Frailty (AMCOHF) is a unique 10-year prospective cohort study evaluating the predictive value of longitudinal trajectories of physical parameters for frailty onset or robustness maintenance. An a-select community-dwelling robust population of Amersfoort (55-75 years) in the Netherlands will undergo baseline assessments for inclusion criteria and will be followed longitudinally every 2.5 years. Frailty status is assessed using the Fried phenotype, Rockwood frailty index, and Groningen frailty indicator. Testing procedures and questionnaire completion include physical performance tests in the domains: (1) musculoskeletal system, (2) articular system, (3) cardiorespiratory system, (4) sensory system, (5) immune system, and 6) uro-gynecological system. Study outcomes focus on intrinsic capacity, functional ability, explanatory data, and frailty. Statistical analyses evaluating the predictive capacity include logistic regression, confirmatory factor or latent class analysis, and structural equation modeling. Nonprobability convenience sampling recruits 2,078 robust participants, estimating a 1-year frailty incidence of 1.5%-6.0%. Ethical approval was obtained, and the trial is prospectively registered on Open Science Framework (DOI: 10.17605/OSF.IO/RMBQV).</p><p><strong>Conclusion: </strong>The AMCOHF study will contribute to knowledge about markers to predict an accelerated decline in intrinsic capacity in an early stage. This knowledge is important to deploy prevention strategies at an earlier stage in life then those currently undertaken, ultimately reducing healthcare costs and contributing to a healthy aging population.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Interventions for Reducing Loneliness in Elderly Patients in the Cardiac Intensive Care Unit: A Randomized Control Trial.","authors":"Daniel Minnes, Liza Grosman-Rimon, Yiffa Noylinger, Aida Nakhoul, Fadi Abu Shkara, Eran Keshet, Doron M Menachemi, Yulia Gendler, Jordan Rimon, Nathan Stall, Muhamd Atrash, Erez Kachel","doi":"10.1159/000547022","DOIUrl":"https://doi.org/10.1159/000547022","url":null,"abstract":"<p><p>Background Loneliness among the elderly population has been well-established as a risk factor for poor health outcomes, including increased morbidity and mortality. The study objective was to evaluate the feasibility of assessing and implementing patient-tailored interventions to reduce loneliness among elderly patients in the Cardiac Intensive Care Unit (CICU). Methods This randomized control trial conducted at the CICU included 58 patients, 28 patients were in control and 30 in the intervention groups. The University of California Los Angeles Loneliness Scale and the De Jong Gierveld Loneliness Scale were administered at the time of admission to the CICU and immediately before discharge. The intervention group was given an individualized questionnaire to determine their needs and preferences, which were used to create patient-tailored interventions provided by Cardiac Intensive Care Unit staff. The control group received standard care. Results The results of the study revealed that while there was no significant reduction in overall loneliness scores between the intervention and control groups, there was a significant difference in the reduction of loneliness scores for the item \"I miss having people around me\" (p = 0.02) in the intervention group compared to the control group. Additionally, a near significant difference in loneliness score reductions was observed for the item \"I feel left out\" (p = 0.05) in the intervention group. These results suggest that patient-tailored interventions focused on addressing patient-specific needs may lead to a reduction in certain aspects of loneliness. Conclusion This study demonstrates the feasibility of identifying loneliness in a critical care setting, as well as developing an intervention strategy tailored to the individual patient's needs. These findings highlight the importance of addressing loneliness in the setting of an Intensive Care Unit and provide support for the need to further explore and implement strategies to reduce loneliness in this population.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins and Hospitalizations from Recurrent Falls in the Elderly.","authors":"Zvi Shimoni, Erika Eva Kalaora, Vered Hermush, Paul Froom","doi":"10.1159/000548176","DOIUrl":"10.1159/000548176","url":null,"abstract":"<p><strong>Introduction: </strong>Statin-induced myopathy might increase the risk of falls in the elderly and change treatment decisions.</p><p><strong>Methods: </strong>In the following retrospective study, we selected 463 internal medicine patients aged ≥70 years old hospitalized after a fall during 2020-2021. We compared those with and without an admission for a previous fall in the last 12 months. The primary predictors were polypharmacy (≥5 drugs or ≥9 drugs), antidiabetic drugs, psychiatric drugs, drugs for hypertension, and statins (types and dose). Secondary predictors included age, female gender, admission serum creatinine, albumin, and hemoglobin concentrations, smoking at present, the Norton scale, and if the statin was given for primary prevention (no cardiovascular diseases), the patient's ambulatory status, where and when the patient fell, and what the patient was doing when the fall took place. We calculated the odds ratios and 95% confidence intervals for associations with recurrent versus single falls.</p><p><strong>Results: </strong>There were 463 patients hospitalized after a fall. Their age was 84 ± 7 years, and 47.7% (221/463) were female. There were 19.0% (88/463) who had recurrent falls, 116 patients treated with atorvastatin (25.1%) and 98 treated with other statins (21.2%). The secondary variables were not significantly different in those with and without recurrent falls. There was a significant increase in odds for recurrent falls in those treated with atorvastatin (1.68, 1.01-2.81) and insulin (2.46, 1.23-4.95). Individually, the drugs were not associated with recurrent falls, but the combination of both drugs was associated with a 5.2 (2.1-13.2) increased odds of a recurrent fall.</p><p><strong>Conclusions: </strong>The finding that the combined treatment with atorvastatin and insulin is associated with recurrent falls in elderly hospitalized patients is novel and warrants further research.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-5"},"PeriodicalIF":3.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Comprehensive Geriatric Assessment in Assessment, Management and Prognosis of Older Adult Patients with Sarcopenia: A Review of Research Progress and Practice.","authors":"Qiuran Jia, Yi Pan, Dan Pan, Yingying Xia, Junfan Wu","doi":"10.1159/000546715","DOIUrl":"10.1159/000546715","url":null,"abstract":"<p><strong>Background: </strong>With prevalence rising from 5 to 13% (60-70 years) to as high as 50% (>80 years), sarcopenia is associated with frailty, falls, and up to a 41% 3-year mortality in high-risk cohorts. Early recognition is hampered by variability in definitions and limited access to imaging in many regions.</p><p><strong>Summary: </strong>Comprehensive Geriatric Assessment (CGA) offers an integrated framework - spanning physical, functional, cognitive, psychological, and social domains - to improve the screening, diagnosis, and longitudinal monitoring of sarcopenia in older adults.</p><p><strong>Key messages: </strong>(1) CGA-guided care enables tailored interventions that combine protein-rich nutrition, progressive-resistance exercise and - in selected cases - emerging pharmacological agents. (2) Economic analyses indicate CGA can be cost-neutral or cost-saving when targeted to high-risk groups, but workforce requirements challenge its scalability outside well-resourced centers. (3) Evidence remains heterogeneous and drawn largely from urban, high-income settings; caution is required when generalizing outcomes to rural or low-resource environments. (4) Future research should standardize a muscle-specific CGA core set, test implementation in diverse health systems, and evaluate digital tools that reduce staff time without widening the digital divide.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in serial sarcomere number of five hindlimb muscles across adult aging in rats.","authors":"Avery Hinks, Geoffrey A Power","doi":"10.1159/000546887","DOIUrl":"https://doi.org/10.1159/000546887","url":null,"abstract":"<p><strong>Introduction: </strong>The age-associated loss of muscle mass is partly accounted for by a reduction in muscle fascicle length (FL). Studies on rodents have confirmed this reduced FL is driven by a loss of sarcomeres aligned in series (serial sarcomere number; SSN) along a muscle. However, studies on rodents have focused primarily on rat plantar flexor SSN at two aging timepoints, leaving an incomplete view of age-related changes in SSN. Hence, this study investigated SSN as a contributor to the age-related loss of muscle mass in five hindlimb muscles across four aging timepoints in rats.</p><p><strong>Methods: </strong>The soleus, medial gastrocnemius (MG), plantaris, tibialis anterior (TA), and vastus lateralis (VL) were obtained from 5 young (8 months), 5 middle-aged (20 months), 5 old (32 months), and 5 very old (36 months) male F344BN rats. After fixation of muscles in formalin and digestion in nitric acid, fascicles were teased out end-to-end to measure FL. SSN was determined by dividing FL by sarcomere length measured via laser diffraction. Muscle wet weight, anatomical cross-sectional area (ACSA), and physiological cross-sectional area (PCSA) were also determined for insight on age-related losses of whole-muscle mass and in-parallel muscle morphology.</p><p><strong>Results: </strong>Age-related SSN loss was apparent after middle age for all muscles, with the plantaris showing the smallest (8%) and the VL the greatest (21%) differences between age groups. The MG and VL appeared to plateau in their SSN loss by 32 months, while the soleus and TA demonstrated continued decline from 32 to 36 months. In all muscles, an age-related lower SSN evidently contributed in part to the smaller muscle mass, alongside less contractile tissue in parallel (indicated by ACSA and PCSA).</p><p><strong>Conclusion: </strong>As SSN is closely tied to biomechanical function, these findings present SSN as a distinct target for improving muscle performance in older adults.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-23"},"PeriodicalIF":3.1,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and osteoporosis.","authors":"Edoardo Mocini, Claudia Piciocchi, Giuseppe Defeudis, Silvia Migliaccio","doi":"10.1159/000546501","DOIUrl":"10.1159/000546501","url":null,"abstract":"<p><p>Sarcopenia and osteoporosis are common, interconnected conditions, in aging populations that lead to increased frailty, disability and a heightened risk of falls and fractures. Sarcopenia is the progressive loss of muscle mass, strength and function, that often coexists with osteoporosis, which is characterized by reduced bone strenght for a decreased bone mineral density (BMD) and altered bone quality. Together, these conditions form a clinical syndrome known as osteosarcopenia. Both disorders share common risk factors, including chronic inflammation, oxidative stress, and hormonal changes, which accelerate the deterioration of musculoskeletal health. This chapter discusses the overlapping pathophysiology and highlights the importance of early diagnosis and integrated therapeutic strategies. Nutritional approaches, such as ensuring adequate protein, vitamin D, and calcium intake, combined with resistance training, are essential to preserving muscle and bone health. Pharmacological treatments, including bisphosphonates for osteoporosis and emerging therapies like selective androgen receptor modulators (SARMs) and myostatin inhibitors for sarcopenia, offer promising avenues for comprehensive management. A multifaceted approach targeting both conditions can reduce the risk of falls and fractures, ultimately improving quality of life in older adults.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of virtual reality training on muscle strength of the elderly: A systematic review and meta-analysis.","authors":"Hamed Zarei, Ali Asghar Norasteh, Mohamad Mottaghitalab, Michael W Ertel, Ali Brian","doi":"10.1159/000546922","DOIUrl":"10.1159/000546922","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this systematic review is to examine the effects of virtual reality training (VRT) on the muscle strength of the elderly.</p><p><strong>Methods: </strong>Primary sources were obtained from 4 databases including PubMed, SCOPUS, CENTRAL, and Web of Science. The search period covered years from inception to February 1th, 2025. Standardized mean differences (SMDs), weighted mean differences, and 95% CIs were calculated using random or fixed-effect models for outcomes.</p><p><strong>Results: </strong>Following the screening process, 38 studies involving a total of 1280 participants were included in the systematic review. The results of the meta-analysis showed that VRT increased upper-body muscle strength (1.89 [95% CI: 0.65-3.13], p=0.003), lower-body muscle strength (0.68 [95% CI: 0.46-0.91], p=0.001) and handgrip (0.45 [95% CI: 0.26-0.63], p=0.001). Additionally, the results of the meta-analysis demonstrated that there was no significant difference between VRT and traditional training (TT) on lower-body muscle strength (0.04 [95% CI: -0.26-0.36), p=0.75) and handgrip (0.06 [95% CI: -0.11-0.24], p=0.48).</p><p><strong>Conclusion: </strong>The results meta-analysis demonstrated that VRT has a positive effect on the muscle strength of all three parts of the lower limb, upper limb, and HG. Also, comparing VRT with TT, no significant difference was observed between these two types of training.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-30"},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study on the Endorsement of Reporting Guidelines by Journals in Geriatrics and Gerontology.","authors":"Logan Corwin, Jacob Duncan, Shaelyn Ward, Caleb Smith, Danya Brewer, Griffin Hughes, Matt Vassar","doi":"10.1159/000546516","DOIUrl":"https://doi.org/10.1159/000546516","url":null,"abstract":"<p><strong>Introduction: </strong>The use of reporting guidelines and clinical trial registration policies by academic journals reduces bias and improves transparency in clinical research. It is unknown whether geriatric and gerontology journals mention, recommend, or require their use for the studies they may potentially publish. The purpose of this study is to assess the submission guidelines of the top geriatric and gerontology journals for their editorial recommendation or requirement of predetermined reporting guidelines and clinical trial registration.</p><p><strong>Methods: </strong>Using the 2021 Scopus CiteScore tool, we identified the top 100 journals in the \"Geriatrics and Gerontology\" subcategory. We reviewed each journal's \"Instructions to Authors\" for references to reporting guidelines commonly used for various study designs, categorizing them as \"Not Mentioned,\" \"Recommended,\" \"Does Not Require,\" or \"Required.\" Additionally, we assessed how each journal addressed clinical trial registration using the same classification system.</p><p><strong>Results: </strong>Among the 100 journals reviewed, none referenced the QUOROM statement. In contrast, the CONSORT statement was the most frequently mentioned, with 44 journals (44%) recommending or requiring its use. PRISMA guidelines were omitted by 57 journals (57%), while study registration was recommended or required by 92 journals (92%).</p><p><strong>Conclusion: </strong>The recommendation or requirement of reporting guidelines and clinical trial registration in the top 100 geriatric and gerontology journals is inconsistent. Journal editors should strongly recommend that authors follow reporting guidelines to reduce potential bias and improve transparency in the articles they publish.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Different Motor Learning Paradigms for Improving Balance Recovery Abilities Among Older Adults Random versus Block training: A Randomized Controlled Pilot Trial.","authors":"Hadas Nachmani, Inbal Paran, Moti Salti, Ilan Shelef, Noam Margalit, Michael Schwenk, Itshak Melzer","doi":"10.1159/000546907","DOIUrl":"https://doi.org/10.1159/000546907","url":null,"abstract":"<p><strong>Introduction: </strong>Older adults can reduce the risk of falls after participation in a Perturbation-Based Balance Training (PBBT). We aimed to compare two perturbation motor learning paradigms: random vs block practice.</p><p><strong>Methods: </strong>Twenty community-dwelling older adults were recruited and randomly allocated to a random PBBT group (n=8), participants were exposed to unannounced perturbations in multiple directions during each training session, or a block PBBT group (n=12) participants experienced perturbations from a single during every training session during treadmill walking. Both groups received eight training sessions over a four-weeks period that included a concurrent cognitive task during training. Primary outcome measures were parameters of reactive stepping i.e., step-thresholds in walking and kinematics of reactive stepping during walking; and secondary outcome measures were proactive balance, i.e. voluntary step test and cognitive performance. All outcomes were measured before and after PBBT.</p><p><strong>Results: </strong>Both PBBT groups improved their ability to cope with higher perturbations post training and a reduction in Center of Mass path displacement during the recovery after the perturbation in walking. No improvement was found in voluntary stepping post training, both groups, however, showed improvement in cognitive performance post-training.</p><p><strong>Discussion: </strong>Results show some improvements in reactive stepping performance but not in proactive voluntary stepping in both random and block PBBT methods, with no superiority of one training method over the other. Some improvements in cognitive performance in both groups suggest a transfer effect post training, regardless of training method. Given the small sample size, results are preliminary and should be interpreted with caution.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-23"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between living at moderate altitude and the loss of autonomy and independence in elderlies: a French longitudinal study.","authors":"Abdallah Ghaith, Mathieu Marillier, Mallory Cals, Patrice Flore, Sébastien Bailly, Samuel Verges","doi":"10.1159/000546945","DOIUrl":"https://doi.org/10.1159/000546945","url":null,"abstract":"<p><strong>Introduction: </strong>A loss of autonomy and independence are clearly identified for the majority of aging people, with a significant impact at the individual and society levels. Permanent residency at moderate altitude appears to be associated with beneficial health effects. This study aimed at determining changes in dependency and autonomy in elderlies depending on their altitude of residence in a French Alps area.</p><p><strong>Methods: </strong>We retrospectively analyzed longitudinal data from 9 863 elderlies initially residing at home, at <500m, 500-900m or >900m above sea level, and presenting with a mild reduction in autonomy and independence. Over a 5-year period, changes in GIR score (an index of autonomy and independence ranging from 6 to 1, the lower the score the more severe the loss of autonomy and independence) annually collected in elderlies by the local authority, and potential transfer to an institution, were analyzed.</p><p><strong>Results: </strong>After 5 years of follow-up, elderlies living at higher altitude showed a significantly larger GIR score reduction (p = 0.04). The time required to lose one GIR level tended to be shorter in elderlies living at moderate altitude. Elderlies residing at moderate altitude were institutionalized significantly later that those living at lower altitude (p < 0.01).</p><p><strong>Conclusion: </strong>These results do not support a positive effect of residing at moderate altitude on elderly autonomy and independence, the latter being likely influenced by a combination of environmental, behavioral and social factors.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}