Gerontology最新文献

{"title":"Impact of Living in a Mountain Environment on Health and Mortality: Insights from the Alpine Population in Northern Italy.","authors":"Essi Hantikainen, Nikola Dordevic, Daniel Neunhaeuserer, Peter P Pramstaller, Johannes Rainer, Hannes Gatterer","doi":"10.1159/000546975","DOIUrl":"https://doi.org/10.1159/000546975","url":null,"abstract":"<p><strong>Introduction: </strong>Residing at moderate altitudes has been associated with various health benefits also affecting mortality risk. This study investigates life expectancy and disease-specific mortality rates among populations in the Italian Alps and in northern Italian lowland regions. Additionally, cardiometabolic health and serum metabolite concentrations of residents in an Alpine province across three distinct elevation zones (<1,000 m, 1,000-1,500 m, and >1,500 m above sea level) are studied.</p><p><strong>Methods: </strong>Data on life expectancy and mortality rate (per ten thousand) were retrieved from the ISTAT database for 6 provinces located in the Italian Alps and 6 provinces at sea level near the Alps. Using cross-sectional data from a sub-sample of the Cooperative Health Research in South Tyrol (CHRIS) study (n=6,292), we fitted multivariable adjusted logistic regression models to investigate associations between altitude and cardiometabolic health, determined by the Cumulative Illness Rating Scale. Moreover, associations between altitude and 175 serum metabolites were evaluated through linear regression models (n=1,447).</p><p><strong>Results: </strong>Population size and sex distribution were similar between provinces (p>0.485). Life expectancy at 65 years differed between areas (20.8±0.4 vs 20.1±0.3, for Alps vs sea-level, respectively, p=0.026). Mortality rate for diseases of the circulatory system was lower in the Alps than at sea-level (35.3±5.7 vs. 44.5±6.8, respectively, p=0.026). No statistically significant differences were found for mortality (Alps vs. sea-level) from all causes (108.1±15.7 vs. 126.1±15.5, p=0.065), cerebrovascular diseases (8.4±2.5 vs. 12.6±3.1, p=0.065), endocrine, nutritional and metabolic diseases (3.6±1.0 vs. 5.0±1.0, p=0.065), neoplasms (31.1±4.7 vs. 34.3±2.4 p=0.394) and diseases of the respiratory system (8.3±1.7 vs. 8.8±1.7, p=0.589). In the CHRIS study sample, living at moderate vs. low altitude level was associated with lower odds of mild to severe conditions in the hypertension (OR:0.77; 95%CI: 0.62-0.96) and endocrine-metabolic domain (OR:0.77, 95%CI: 0.61-0.97). No differences in blood serum metabolic profiles were observed between people living at different altitude levels.</p><p><strong>Conclusions: </strong>Living in the Italian Alps seems to have a positive effect on life expectancy and mortality from certain diseases compared to living at sea level in northern Italy. Furthermore, living at moderate altitude conferred some cardiometabolic health benefits in the CHRIS study population, even after corrections for confounding factors. The metabolite profile in a sub-sample did, however, not reveal any significant differences between altitude levels.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-22"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between living at moderate altitude and the loss of autonomy and independence in elderlies: a French longitudinal study.","authors":"Abdallah Ghaith, Mathieu Marillier, Mallory Cals, Patrice Flore, Sébastien Bailly, Samuel Verges","doi":"10.1159/000546945","DOIUrl":"https://doi.org/10.1159/000546945","url":null,"abstract":"<p><strong>Introduction: </strong>A loss of autonomy and independence are clearly identified for the majority of aging people, with a significant impact at the individual and society levels. Permanent residency at moderate altitude appears to be associated with beneficial health effects. This study aimed at determining changes in dependency and autonomy in elderlies depending on their altitude of residence in a French Alps area.</p><p><strong>Methods: </strong>We retrospectively analyzed longitudinal data from 9 863 elderlies initially residing at home, at <500m, 500-900m or >900m above sea level, and presenting with a mild reduction in autonomy and independence. Over a 5-year period, changes in GIR score (an index of autonomy and independence ranging from 6 to 1, the lower the score the more severe the loss of autonomy and independence) annually collected in elderlies by the local authority, and potential transfer to an institution, were analyzed.</p><p><strong>Results: </strong>After 5 years of follow-up, elderlies living at higher altitude showed a significantly larger GIR score reduction (p = 0.04). The time required to lose one GIR level tended to be shorter in elderlies living at moderate altitude. Elderlies residing at moderate altitude were institutionalized significantly later that those living at lower altitude (p < 0.01).</p><p><strong>Conclusion: </strong>These results do not support a positive effect of residing at moderate altitude on elderly autonomy and independence, the latter being likely influenced by a combination of environmental, behavioral and social factors.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Mood Induction and Depression on Mind Wandering Tendencies in Older and Younger Adults.","authors":"Matthew Shake, Andrea Anderson","doi":"10.1159/000546773","DOIUrl":"https://doi.org/10.1159/000546773","url":null,"abstract":"<p><strong>Introduction: </strong>Mind wandering is a pervasive experience in which attention is focused on self-generated thoughts rather than an ongoing task. Prior research found that mind wandering decreases with age, but the reasons are unclear. The present study investigated the influence of mood induction on this phenomenon.</p><p><strong>Methods: </strong>We compared older and younger adults' mind wandering tendencies during a choice reaction time (CRT) task, after exposing them to one of three mood induction conditions (positive, negative, neutral). We measured participants' reaction times and accuracy during the CRT, as well as depression levels.</p><p><strong>Results: </strong>We found that older adults reported less mind wandering, and younger adults reported specifically more future-oriented mind wandering. Additionally, while both positive and negative mood inductions significantly shifted all participants' moods, we did not replicate a prior study of younger adults that found negative mood induction increased mind wandering. Mood induction also did not alter reaction times or accuracy on the CRT.</p><p><strong>Conclusion: </strong>These findings show an age-related reduction in mind wandering, but indicate that the causes of that reduction need further investigation. The results also suggest that prior mood induction studies warrant further careful replication attempts, and that the role of emotion in age differences in mind wandering needs further emphasis.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-19"},"PeriodicalIF":3.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Different Resistance Training Modalities on Muscle Strength in Community-Dwelling Older Adults: A Network Meta-Analysis.","authors":"Tim Wiedenmann, Steffen Held, Tobias Morat, Ludwig Rappelt, Eduard Isenmann, Elena Berndsen, Nils-Holger Hopp, Lars Donath","doi":"10.1159/000546346","DOIUrl":"10.1159/000546346","url":null,"abstract":"<p><strong>Introduction: </strong>Resistance training is widely recognized as a valuable method to enhance physical function, reduce the risk of falls, and improve overall health, independence and well-being in older adults. The training can be performed through various modalities of which the comparative effects have not yet been thoroughly elucidated. This network meta-analysis (NMA) therefore aims to compare and rank different resistance training modalities regarding their effects on strength outcomes in older adults.</p><p><strong>Methods: </strong>The studies included in this NMA were identified through a comprehensive search across three health-related and biomedical databases (PubMed, Web of Science, and SPORTDiscus). We included (randomized) controlled trials that assessed the effect of resistance training modes (including: free weight training, machine-based training, bodyweight training, elastic band training, and mixed training) in comparison to each other or to a control condition, focusing on traditional maximal strength outcomes in older individuals.</p><p><strong>Results: </strong>This NMA includes 102 trials involving 4,754 community-dwelling seniors with a mean age of 70 ± 4 years (range 63-87 years of age). All of the included resistance training modalities yield moderate to large positive effects on strength when compared to a \"no intervention\" control condition. Machine-based training {standardized mean difference (SMD) = 1.34 (95% confidence interval [CI]: 1.16; 1.52)} elicits the largest effects, followed by free weight (SMD = 1.15 [95% CI: 0.28; 2.03]), elastic band (SMD = 0.93 [95% CI: 0.49; 1.37]), mixed (SMD = 0.88 [95% CI: 0.51; 1.25]), and bodyweight training (SMD = 0.71 [95% CI: 0.16; 1.26]).</p><p><strong>Conclusion: </strong>Machine-based training elicits the largest effects with the smallest variance. However, our findings demonstrate that various resistance-training modalities can have large positive effects on strength development in older adults. We suggest that, with adequately chosen load criteria such as training intensity, volume and duration of the training period, the selection of the appropriate resistance training type might depend on individual preference, enjoyability, and practicability.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of mitochondria in age-related health benefits conferred by moderate hypoxia.","authors":"Johannes Burtscher, Kamilla Woznica Miskowiak, Katharina Hüfner, Hannelore Ehrenreich, Martin Kopp","doi":"10.1159/000546478","DOIUrl":"https://doi.org/10.1159/000546478","url":null,"abstract":"<p><p>Background Mitochondrial integrity and efficiency deteriorate with age and are linked to cellular senescence. Mitochondria are highly responsive to reduced oxygen availability (hypoxia), which for example occurs when exposed to altitude. We hypothesize that mitochondria are involved in the observed health benefits at moderate altitude. Because the experimental evidence on mitochondrial changes at moderate altitude is limited, we also evaluate dose-response associations of oxygen transport and mitochondrial functions derived from measurements at normoxia and severe hypoxia. Summary We summarize the effects of environmental oxygen availability and changes in cellular oxygen demand/supply on mitochondrial functions and assess, how this may influence aging. Hypotheses are presented how mild hypoxia at moderate altitude (1000 - 2500 m) could improve mitochondrial function and possibly explain the reported lower levels of mortality from several age-related diseases. Key messages It is unknown, whether continuous or intermittent types of hypoxia exposure are more effective in improving mitochondrial functions and promoting healthy aging. The combination of tissue-specific oxygen demand (for example during physical exercise) with mild reductions of ambient oxygen availability may enable the reported health benefits associated with moderate altitude residence.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-14"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological effects of mountainous environments over the life span and potential implications for healthy ageing: A narrative review.","authors":"Benedikt Hösl, Martin Niedermeier, Johannes Burtscher, Martin Kopp","doi":"10.1159/000546367","DOIUrl":"https://doi.org/10.1159/000546367","url":null,"abstract":"<p><strong>Background: </strong>Healthy ageing is defined as a process of preserving functional capacity to enable well-being in old age. This concept includes both a physical and a psychological component, which can be positively influenced by spending time in nature and being physically active. Mountainous areas offer diverse opportunities to be physically active in a natural environment. However, little research is available on the psychological effects of mountain environments and mountain sports, particularly in relation to healthy ageing.</p><p><strong>Summary: </strong>We analyze the extent to which the interactions of physical activity, nature exposure, and specific characteristics of mountainous regions including hypoxia may influence mental health, based on current research, and discuss the relevance of these factors individually and in combination for healthy ageing.</p><p><strong>Key messages: </strong>In general, the benefits reported from spending time in nature or physical activity seem to be transferable to mountainous regions and/or mountain sports. The available research primarily points to positive acute and longer-term psychological (and sometimes therapeutic) effects of exposure to mountainous regions and mountain sports performed in moderate altitude on various mental health parameters, such as well-being, anxiety, and depression, which could in turn promote healthy ageing. In contrast, staying at very high or extremely high altitudes seems to be associated with negative effects on mental health. Overall, further research is needed to draw more reliable conclusions.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal models for age-related osteoporosis.","authors":"Katharina Gelles, Maria Butylina, Peter Pietschmann","doi":"10.1159/000546107","DOIUrl":"https://doi.org/10.1159/000546107","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is a frequent age-related skeletal disorder, wielding an enormous influence on the quality of life of many women, but also men. Osteoporosis results from a shifted ratio between the activity of osteoblasts and osteoclasts resulting in an increased degradation of bone. This leads to a systemic impairment of bone mass and microarchitecture. Currently only a small number of patients with osteoporosis is treated adequately, making the disease an enormous economic burden. This implies the urgent need of developing new treatment strategies and application mechanisms. Therefore, animal models are of great importance for the investigation and treatment of bone diseases.</p><p><strong>Summary: </strong>In this narrative review we focus on animal models specially used for age-related osteoporosis including mice, fish and large animal models.</p><p><strong>Key message: </strong>With this manuscript we want to contribute to the identification of novel treatment strategies for the treatment of age-related osteoporosis.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-29"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms in Older People: Exploring Associations with Other Diseases, Functional Capacity and the Home Environment.","authors":"Abda Alicia Calheiros da Silva, João Araújo Barros-Neto, Laryssa Cristiane da Silva, Larissa de Lima Soares, Thaynara Maria Pontes Bulhões, Müller Ribeiro-Andrade, Andrey Ferreira da Silva, Ana Paula Grotti Clemente, Giovana Longo-Silva, Risia Cristina Egito de Menezes","doi":"10.1159/000545809","DOIUrl":"10.1159/000545809","url":null,"abstract":"<p><strong>Introduction: </strong>The presence of depressive symptoms in older people has become increasingly relevant in the context of global population aging. Although not a natural consequence of aging, such symptoms may be influenced by chronic conditions, functional limitations, and environmental factors. This study sought to assess the occurrence of depressive symptoms in older people from a region of Brazil and to investigate the related factors using a multilevel perspective.</p><p><strong>Methods: </strong>This is a cross-sectional, population-based study among individuals aged ≥60 years. Depressive symptoms (outcome) were measured using the GDS-15, with a score of five points or higher indicating the presence of depressive symptoms. Diseases were assessed through self-reports. Functional capacity was evaluated using (i) the Katz index; (ii) handgrip strength; and (iii) walking speed. The surrounding environment for physical activity was assessed based on participants' perceptions. Multilevel logistic regression models examined the odds of having depressive symptoms according to the variables analyzed.</p><p><strong>Results: </strong>The prevalence of depressive symptoms among older people was 36.6%, with a higher proportion among women (41.2%). Individuals diagnosed with diabetes mellitus (OR = 1.63; CI: 1.06-2.49), cataracts (OR = 1.76; CI: 1.17-2.66), those considered dependent for performing basic activities of daily living (OR = 6.70; CI: 1.21-37.14), with low handgrip strength (OR = 2.44; CI: 1.50-3.97), and those who reported heavy vehicle traffic as a barrier to physical activity (OR = 1.71; CI: 1.14-2.56) had higher chances of presenting depressive symptoms.</p><p><strong>Conclusion: </strong>Regardless of individual and municipal characteristics, the presence of depressive symptoms in older people was associated with chronic/degenerative diseases, functional capacity impairment, and the perception of the environment (heavy vehicle traffic) as a hindrance to physical activity around the home.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-11"},"PeriodicalIF":3.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 20-s Video-Based Assessment of Cognitive Frailty: Results from a Cohort Study within the Precision Aging Network.","authors":"Bijan Najafi, Myeounggon Lee, Mohammad Dehghan Rouzi, J Ray Runyon, Esther M Sternberg, Bonnie J LaFleur","doi":"10.1159/000546227","DOIUrl":"10.1159/000546227","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive frailty, the concurrent presence of mild cognitive impairment and physical frailty, poses a significant risk for adverse outcomes in older adults. Traditional assessments that rely on extensive walking tests or specialized equipment are impractical for routine or remote evaluations. This study evaluated a 20-s video-based Upper Frailty Meter (vFM) test, incorporating dual-task conditions, as a feasible tool for identifying cognitive frailty.</p><p><strong>Methods: </strong>Data from 413 participants aged 50-79 years in the Healthy Minds for Life cohort were analyzed across four sites: the University of Arizona, Johns Hopkins University, Emory University, and the University of Miami. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA), whereas frailty indices were derived from the vFM test. Participants performed repetitive elbow flexion extension under single-task (physical task only) and dual-task (physical task with concurrent cognitive exercise) conditions. Frailty phenotypes, including slowness, weakness, and exhaustion, were quantified using AI-based video kinematic analysis. Logistic regression and receiver operating characteristic (ROC) analyses evaluated the model's predictive accuracy for cognitive frailty.</p><p><strong>Results: </strong>Participants classified as cognitive frailty group (n = 53, 12.8%) demonstrated significantly higher frailty index scores compared to robust individuals (p < 0.001). Among all vFM-derived parameters, the dual-task slowness phenotype demonstrated the strongest correlation with MoCA scores (r = -0.282, p < 0.001) and emerged as the most predictive single marker for distinguishing the cognitive frailty group, demonstrating high clinical applicability (area under the curve [AUC] = 0.87). Combining single-task and dual-task metrics further enhanced predictive accuracy (AUC = 0.91), achieving sensitivity and specificity rates exceeding 85%. This combined approach significantly differentiated cognitive frailty from robust status, outperforming models based on age alone or single-task metrics.</p><p><strong>Conclusion: </strong>The 20-s vFM test offers a practical, noninvasive, easy-to-implement, and accessible solution for objectively evaluating cognitive frailty, demonstrating high predictive accuracy in distinguishing at-risk individuals. Its integration into telehealth platforms could enhance early detection and enable timely interventions, promoting healthier aging trajectories. Further longitudinal studies are recommended to validate its utility in tracking cognitive and physical decline over time.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Precision Aging: The Intersection of Cognitive Decline, Frailty, and Hormonal Biomarkers.","authors":"J Ray Runyon, Mohammad Dehghan Rouzi, Myeounggon Lee, Cole Babbitt, David W Tano, Diezel Cochenour, Esther M Sternberg, Terrill Yuhas, Lisa White, Bijan Najafi, Bonnie J LaFleur","doi":"10.1159/000546250","DOIUrl":"10.1159/000546250","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive frailty, characterized by the coexistence of cognitive impairment and physical frailty, is a significant predictor of cognitive decline. However, few studies integrate both cognitive and physical assessments alongside hormonal markers, such as cortisol, that may influence frailty and cognitive function. To address this gap, our study combines noninvasive physical, cognitive, and cortisol markers to assess frailty in aging adults.</p><p><strong>Methods: </strong>Data were collected from four sites as part of the Healthy Minds for Life (HML) longitudinal cohort, a project within the Precision Aging Network. Baseline data included cognitive evaluation using the Montreal Cognitive Assessment (MoCA); frailty assessment using a validated 20-s elbow flexion-extension test analyzed by AI under single-task (ST) and dual-task (DT) conditions; cortisol measurement in eccrine sweat samples via direct analysis in real-time mass spectrometry (DART-MS); and demographic information.</p><p><strong>Results: </strong>Of 202 participants completing all assessments, 60 were identified with mild cognitive impairment (MCI). The dual-task frailty index (FI) derived from the 20-s test significantly differentiated individuals with MCI from cognitively robust participants and correlated strongly with MoCA scores (p = 0.015). The dual-task FI showed superior model fit compared to the single-task FI when predicting cognitive function. A significant correlation between the dual-task FI and cortisol by age interaction was observed (p = 0.0042) highlighting the potential impact of cortisol to moderate the relationship between frailty and age in an otherwise healthy aging population. By contrast, no significant correlation was found between dual-task FI and aging outside of the presence of cortisol (p = 0.116) in this study.</p><p><strong>Conclusions: </strong>This study highlights practical and efficient methods for assessing frailty emphasizing the value of DT testing and cortisol measures in identifying individuals at higher risk for cognitive and physical decline. The findings underscore the importance of integrating hormonal markers with cognitive and physical assessments to enhance risk stratification and intervention planning in aging populations.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}