Gerontology最新文献

{"title":"Development and Multicenter External Validation of a Real-Time Artificial Intelligence Diagnostic System for Diabetic Peripheral Neuropathy Based on Wearable Devices.","authors":"Junlin Ran, Pengcheng Huang, Min He, Liling Deng, Qingqing Chen, Yiwen Qin, David G Armstrong, Bijan Najafi, Edward Jude, Yanzhong Wang, Wuquan Deng, Chenzhen Du","doi":"10.1159/000551704","DOIUrl":"https://doi.org/10.1159/000551704","url":null,"abstract":"<p><p>Diabetic peripheral neuropathy (DPN) ranks among the most common complications of diabetes worldwide, often leading to severe morbidity if undetected early. Traditional screening methods are time-intensive, require specialized personnel, and can be influenced by socioeconomic factors. This study aimed to develop and validate STRIDE (Sensor-based Tracking and Real-time Inference for Diabetic Peripheral Neuropathy Evaluation), an interpretable machine learning model utilizing gait and balance parameters from wearable devices to classify current DPN status. In this multicenter diagnostic study, we enrolled 206 participants from Chongqing hospitals, categorized as healthy controls (n=32), diabetics without DPN (n=47), asymptomatic DPN (n=48), and symptomatic DPN (n=79), with an independent cohort of 42 for external validation. Using LEG-Sys/BalanSens sensors, 68 features were extracted during one-minute walking and modified Clinical Test of Sensory Integration and Balance. The STRIDE model integrated random forest and logistic regression algorithms, demonstrating strong classification capability (random forest AUROC=0.80, 95% CI: 0.64-0.92; logistic regression AUROC=0.79, 95% CI: 0.62-0.95), with performance assessed via AUROC, accuracy, sensitivity, specificity, F1-score, and SHapley Additive exPlanations (SHAP) for interpretability. Key features identified included stride length variability (SHAP weight=0.61) and double-support time. External validation showed 89.3% concordance with electromyography, with three initial false positives developing DPN within one year. Additionally, STRIDE's real-time scoring demonstrates significant potential for scalable, resource-efficient DPN classification in diverse clinical and non-clinical settings, facilitating early intervention based on current biomechanical signatures.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Fitness and Physical Activity Levels One Year After Total Hip Arthroplasty in Older Hip Osteoarthritis Patients: A Longitudinal Observational Study.","authors":"Manne Godhe, Anders Stålman, Johnny Nilsson, Eva Andersson","doi":"10.1159/000551919","DOIUrl":"https://doi.org/10.1159/000551919","url":null,"abstract":"<p><strong>Background: </strong>Total hip arthroplasty (THA) effectively alleviates pain and improves quality of life in patients with severe hip osteoarthritis (OA). However, comprehensive longitudinal data regarding physical function and objectively measured physical activity patterns following THA are limited.</p><p><strong>Objective: </strong>To establish the test-retest reliability of physical fitness measures in hip OA patients and assess longitudinal changes in physical fitness and activity following THA.</p><p><strong>Methods: </strong>Seventy-eight OA patients (mean age 73.7 ± 4.2 years, 81% women) scheduled for THA underwent comprehensive physical fitness testing and accelerometry-based physical activity monitoring. Assessments were conducted at two preoperative time points and at 4-month (n = 57) and 1-year postoperative follow-up (n = 48). The test battery included measures of muscle strength, motor fitness, and cardiorespiratory fitness. Physical activity was objectively measured using hip-worn triaxial accelerometers. Self-reported Hip disability and Osteoarthritis Outcome Score (HOOS) were collected pre- and post-operatively.</p><p><strong>Results: </strong>Good to excellent test-retest reliability was demonstrated across 23 of 24 fitness parameters. At 1-year post-op, significant improvements were observed in 23 of 45 measured parameters, including functional mobility (Timed Up and Go: -29%), walking distance (Six-Minute Walk Test: +16%), trunk endurance-strength (+71-82%), shoulder-press (+32%), various leg strength tests (+13-42%), 4m max walking-speed (+42%), moderate-to vigorous-physical activity (+63%) and daily step count, from 6004 to 7558 steps/day, (+26%). Ipsilateral-to-contralateral step height asymmetry decreased from 27% pre-operatively to 8% at 1-year follow-up. VO₂peak demonstrated a modest but significant improvement from 22.7 to 23.6 mL/kg/min (+4%) one year postoperatively.</p><p><strong>Conclusions: </strong>This study revealed low fitness and activity levels in patients with severe hip osteoarthritis before surgery, with marked improvements in physical fitness and activity measurements one year after surgery. The high reliability of the comprehensive assessment battery supports its usefulness for both research and clinical practice. These findings contribute to the existing evidence on simple, field-based fitness tests for patients with hip osteoarthritis, while also offering methodological insights and recovery trajectories.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-25"},"PeriodicalIF":3.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Bunion Surgery on Fall Risk: A Nationwide Database Study of 127,990 Older Adults with Hallux Valgus.","authors":"Adam Fleischer, Rachel Albright, Zalak Bhatt, Neveen Abuali, Dyane Tower, Lowell Weil","doi":"10.1159/000551884","DOIUrl":"10.1159/000551884","url":null,"abstract":"<p><strong>Introduction: </strong>The presence of a bunion (hallux valgus) deformity is a recognized risk factor for falls among older adults; however, it is uncertain whether surgical correction of the foot deformity can help mitigate this risk.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of US adults aged 50 and over with hallux valgus using commercial, state, and federal healthcare claims obtained from a national database (PearlDiver, Inc.). Patients who underwent bunion surgery were compared to those treated nonoperatively for their bunion deformities from January 2011 to April 2022. Claims-based falls (all-cause) were tracked using diagnosis codes for up to 11 years. Group differences in fall risk were examined using both one-year and long-term adjusted hazard ratios (aHR) and corresponding absolute risks.</p><p><strong>Results: </strong>127,990 people were diagnosed with hallux valgus and 17,406 (13.6%) underwent surgery. The median follow-up time was 2905 and 2298 days for the surgery and non-surgery groups, respectively. A smaller proportion of people fell in the surgery versus non-surgery group (5 vs 8% at one year; 16 vs 21% over total follow-up). Furthermore, after controlling for important covariates, patients who underwent bunion surgery were 16% less likely to fall in the first year (aHR 0.84, 95% CI 0.76 to 0.92) and 42% less likely to fall over the 11-year follow-up (aHR 0.58, 95% CI 0.52 to 0.63) compared to those with uncorrected hallux valgus deformity.</p><p><strong>Conclusion: </strong>Among older adults in whom surgery is already indicated, a potential ancillary benefit may be a reduction in injurious falls over time.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Siah-1 is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of SKN-1.","authors":"Ferbian Milas Siswanto, Ana Lucia Ekowati, Susumu Imaoka","doi":"10.1159/000551680","DOIUrl":"https://doi.org/10.1159/000551680","url":null,"abstract":"<p><strong>Introduction: </strong>Hypoxia has been shown to extend lifespan in Caenorhabditis elegans through mechanisms involving HIF-1 and DAF-16, but the interplay with SKN-1/Nrf, a key regulator of oxidative stress responses, remains complex. Studies have shown that SKN-1 reduced lifespan when overexpressed in hypoxic environments. However, the mechanism behind SKN-1 regulation under hypoxia is largely unknown.</p><p><strong>Objective: </strong>This study aims to elucidate the hypoxic regulation of SKN-1, particularly by the E3 ubiquitin ligase Siah-1.</p><p><strong>Results: </strong>Under normoxia (O2= 21%), SKN-1 extended the lifespan of C. elegans and its stability was regulated by WDR-23. However, in hypoxic environment (O2= 1%), SKN-1 was detrimental to lifespan. Genetic and chemical inhibitions of Siah-1 revealed that SKN-1 stability in hypoxic environment was regulated by Siah-1. The results showed that the protein levels of Siah-1 were elevated under hypoxia. Under low oxygen conditions, Siah-1 attenuated the transcriptional activity of SKN-1, as shown by the reduced gcs-1, gss-1, and sod-3 mRNA expression and elevated reactive oxygen species levels. Mechanistic studies using kinase mutant worms revealed that PMK-1 was critical for this effect.</p><p><strong>Conclusion: </strong>The present study identifies Siah-1 as a novel mediator linking hypoxic signaling to SKN-1-dependent transcriptional programs, providing insights into conserved mechanisms of stress adaptation and aging. This work underscores the importance of ubiquitin-mediated regulatory nodes in coordinating longevity pathways under environmental stressors.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of miR-28-5p in ischemic stroke and its neuroprotective effect after ischemia-reperfusion injury.","authors":"Zhu Li, Jianchang Mu, Hongfei Yang, Shuo Sun, Yuhao Zhang","doi":"10.1159/000551361","DOIUrl":"https://doi.org/10.1159/000551361","url":null,"abstract":"<p><strong>Introduction: </strong>Ischemic stroke (IS) remains a leading cause of global morbidity and mortality, necessitating novel therapeutic targets. MicroRNAs (miRNAs) show promise in modulating post-stroke pathology, yet the role of miR-28-5p in IS remains unexplored. This study aimed to investigate miR-28-5p expression in IS and its clinical and mechanistic significance.</p><p><strong>Methods: </strong>Serum miR-28-5p levels were quantified via qRT-PCR in 129 IS patients and 97 healthy controls. Kaplan-Meier (K-M) analysis and multivariate COX regression analysis evaluated the prognostic value of miR-28-5p in IS. In vitro, dual-luciferase assays validated the interaction between miR-28-5p and WNK3. Oxygen-glucose deprivation/reoxygenation (OGD/R)-treated HMC3 microglia were used to assess miR-28-5p/WNK3 axis in microglial polarization, oxidative stress, and inflammation.</p><p><strong>Results: </strong>Serum miR-28-5p was significantly downregulated in IS patients, associated with elevated TG, LDL-C, reduced HDL-C levels, and higher NIHSS scores. K-M analysis revealed a lower progression-free survival (PFS) rate in IS patients with low miR-28-5p expression, and COX regression analysis confirmed miR-28-5p as an independent prognostic factor. In mechanism miR-28-5p directly targeted WNK3. Overexpression of miR-28-5p suppressed OGD/R-induced M1 polarization, oxidative stress (reduced MDA, elevated SOD), and inflammatory cytokines (decreased TNF-α, IL-6, IL-1β, and increased IL-10), whereas WNK3 overexpression reversed these effects.</p><p><strong>Conclusion: </strong>MiR-28-5p served as a diagnostic biomarker and independent prognostic factor in IS. Its neuroprotection involved suppressing WNK3-mediated microglial M1 polarization, oxidative stress, and inflammation, highlighting its potential as a therapeutic target for IS.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in Frailty Perceptions Between Patients and Physicians.","authors":"Teck Soon Seah, Yan Tong Chin, Johnathan Loh, Ru-San Tan, Louis L Y Teo, Jie Jun Wong, Angela S Koh","doi":"10.1159/000551199","DOIUrl":"https://doi.org/10.1159/000551199","url":null,"abstract":"<p><p>Background \"Frailty\" is frequently used by healthcare professionals, however, self-perception of frailty, also known as \"perceived frailty\" remains ambiguous and subjective. Such perceptions by physicians influence the design of treatment plans, alternatively, patients' self-perception also affects their acceptance of said plans. We performed a literature review to evaluate differences in perceived frailty between physicians and patients. Methods A no restriction, comprehensive literature search was conducted over 3 months in PubMed to identify relevant peer-reviewed studies, focusing on the concept of perceived frailty. Two independent reviewers screened the citations for inclusion. One reviewer then extracted and analyzed the data descriptively to map the available evidence. Quantitative and qualitative syntheses were performed. Results We examined papers written on the topic of frailty and excluded those that did not assess for perceived frailty among patients or physicians. 20 papers were included and data was extracted for N=27342 patients and physicians in aggregate. In the domain of physical frailty, more physicians perceived patients as frail (N=1262, 56.09%) compared to patient's self-perception (N=1004, 43.59%). Alternatively, more patients perceive themselves as socially frail (58.9%). Regarding ethnicity, most studies focused on Western cohorts(16 studies), followed by three Asian and one multi-ethnical Cohort. Among the eligible studies, more patients in Asia consider themselves frail (N=1542, 58.93%) compared to the Western population (N=1004, 43.59%). Conclusion We observed differences in frailty perception between patients, physicians and across different domains. It would be insightful when used as the foundation for future targeted models of educational and communication strategies across multi-faceted domains.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Optometrists' Practice Patterns in Falls Prevention Management.","authors":"Si Ye Lee, Khyber Alam, Jason Charng, Hamed Niyazmand, Jo-Aine Hang, Anne-Marie Hill","doi":"10.1159/000551621","DOIUrl":"https://doi.org/10.1159/000551621","url":null,"abstract":"<p><p>Introduction Optometrists, as primary eye care professionals working in the community, routinely provide consultations for older adults. Impaired vision significantly increases falls risk, positioning optometrists as important health service providers to address primary falls prevention. However, there is scarce evidence for how optometrists implement evidence-based falls prevention management. This study explored Australian community optometrists' understanding of falls prevention management and their perspectives on the barriers and enablers for implementing falls prevention management in their clinical practice. Methods The study employed a qualitative descriptive design, using purposeful sampling to recruit Western Australian optometrists across metropolitan and rural primary eye care settings. Focus group discussions explored participants' knowledge of falls prevention, implementation experiences, and educational opportunities to improve implementation. Data were analysed using inductive content analysis. Results Four focus groups were conducted (N = 23, females = 12 and males = 11). Participants were predominantly early career optometrists (52% with 1 - 5 years of experience), 87% were aged under 40 and primarily practicing in metropolitan areas. The main category identified a substantial evidence-to-practice gap in optometrists' falls prevention management for older adults within primary eye care settings. Four generic categories contributed; perceived low levels of knowledge and awareness about falls prevention, sporadic integration into clinical practice, the need for an improved approach to collaboration within multidisciplinary teams, and hesitancy to undertake falls prevention management. Conclusion Community optometrists had perceived low levels of knowledge about falls prevention and identified limited opportunities to implement falls prevention management. Suggestions to bridge this implementation gap included providing further education and promoting optometrists' engagement in multidisciplinary teams. Further research investigating how community optometrists can translate falls prevention evidence into practice is required.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-20"},"PeriodicalIF":3.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technology for finding misplaced objects in a home: Protocol for a scoping review.","authors":"Bing Ye, James McDonough, Cynthia Chui, Alex Mihailidis","doi":"10.1159/000551522","DOIUrl":"https://doi.org/10.1159/000551522","url":null,"abstract":"<p><strong>Background: </strong>As people age, it becomes more common for individuals to misplace household items, such as keys or phones. This could inevitably lead to disruption of daily routine and cause frustration. In recent years, many technologies have been rapidly developed to support older adults in maintaining their independent living and enhancing their quality of life. Among these, many have been designed as memory aids to help locate misplaced objects, reducing both the time spent searching and the stress it causes. However, to the best of our knowledge, no comprehensive review has mapped out the existing technologies for misplaced object retrieval.</p><p><strong>Objective: </strong>Therefore, this scoping review will serve to help understand the landscape of the current technologies, features, and challenges, including their ethical and usability concerns, in retrieving misplaced household items.</p><p><strong>Methods and analysis: </strong>An initial data search has been conducted by an information specialist targeting a set of databases to find studies that outline a technology aiding misplaced object retrieval in a home setting. Databases included MEDLINE, Embase, Web of Science, Compendex, Inspec, IEEE Xplore, and ACM Digital Library. Studies will be included if written in English, peer-reviewed, and depict a tested technology that aids in the specific retrieval of misplaced household objects. Screening will be done independently by two reviewers to ensure consistency and reduce bias. Reviewers will review decisions at the end of screening, and discrepancies will be solved through discussion between the two reviewers first or a third reviewer, if necessary. Both screening and extraction will be conducted on Covidence. Analysis of extracted data will be tabulated, and thematic analysis will be conducted through NVivo.</p><p><strong>Results: </strong>The initial search has generated 6556 records. The scoping review is expected to be completed by December 2025.</p><p><strong>Conclusions: </strong>This review will provide developers and researchers with a guide to the current landscape of the relevant technologies, along with their features, issues, and gaps. The review is intended to inspire innovation in future similar technologies. In addition, the review will explore the gap in technology translation and underscore the importance of an interdisciplinary approach that engages all relevant stakeholders to work in collaboration for better outcomes and successful technology design and adoption.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Aquatic Reactive Balance Training (AquaReBal) for Older Adults: Protocol for a Single-Arm Pre-Post Study.","authors":"Anna Ogonowska-Slodownik, Andresa Marinho-Buzelli, Cynthia Danells, Kristin E Musselman, Alison Bonnyman, Mohammad Alavinia, Avril Mansfield","doi":"10.1159/000550917","DOIUrl":"10.1159/000550917","url":null,"abstract":"<p><strong>Introduction: </strong>Falls are a serious problem for older adults, and as the number of older adults increases rapidly, the burden of falls is expected to continue rising. Reactive balance training is an important component of balance and fall-prevention exercise programmes in older people at elevated fall risk. Despite its effectiveness for improving reactive balance control and preventing falls, land-based RBT programs can be associated with increased risk of adverse events, including joint pain, fear, and anxiety that results in participants withdrawing from the program. A water environment could minimize the barriers associated with land-based RBT. The aim of this research was to determine the feasibility and preliminary effectiveness of aquatic reactive balance training (AquaReBal).</p><p><strong>Methods: </strong>Older adults (n = 12-15) will be recruited and will complete twelve sessions of AquaReBal over 6 weeks. Feasibility outcomes (fidelity, acceptability, adherence, safety) will be assessed throughout the study. Interviews with participants will be conducted post-training to understand participants' experiences with the intervention. Secondary outcomes related to falls - physical activity, psychological consequences, generic health-related quality of life, and reactive balance control - will be assessed pre- and post-training; however, given the small sample size, these measures will be treated as exploratory and are not powered to detect change with precision. Falls in daily life will be recorded throughout the study until 6 months post-training.</p><p><strong>Conclusion: </strong>Findings from this study will inform the feasibility and design of AquaReBal, contributing to the development of aquatic interventions for fall prevention in older adults.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.","authors":"Chi-Di Hung, Chia-Wei Chang, Hung-Pin Tu, Yi-Hsin Kung, Pei-Yun Tsai, Guan-Cheng Lin, Ya-Fen Liu, Hsiu-Shan Chen, Chen-Cheng Yang, Chun-Ying Lee, Hung-Yi Chuang, Chih-Hsing Hung","doi":"10.1159/000551103","DOIUrl":"10.1159/000551103","url":null,"abstract":"<p><strong>Introduction: </strong>In response to the rapidly growing elderly population, geriatric syndromes such as frailty, polypharmacy, and sarcopenia have gained significant attention due to their impact on aging-related health outcomes. To prevent functional decline, it is crucial to understand the relationship between physical performance and other potential confounding factors. This study aims to investigate how polypharmacy and other factors relate to physical performance.</p><p><strong>Methods: </strong>This cross-sectional study included 445 participants aged over 20, surveyed via questionnaire. Polypharmacy was defined as the daily use of 8 or more pills. Body composition was assessed using bioelectrical impedance analysis, and physical performance was measured via the Time-Up-and-Go (TUG) and five times Sit-to-Stand (5xSTS) tests.</p><p><strong>Results: </strong>The average age of participants was 64.22 years, with 11.0% on polypharmacy. The mean appendicular skeletal muscle mass index, TUG test, and 5xSTS test were 7.40 kg/m2, 8.29 seconds, and 9.33 seconds, respectively. Both physical performance tests correlated positively with age, low education, and polypharmacy and negatively with appendicular skeletal muscle mass index. Polypharmacy, low muscle mass, and lower educational levels were associated with poorer physical performance.</p><p><strong>Conclusion: </strong>These findings highlight the importance of early prevention strategies to address polypharmacy, muscle loss, and low education, all of which are potentially modifiable risk factors. Poorer physical performance was linked to polypharmacy, low muscle mass, and lower educational levels, suggesting a need for additional research into these contributing risk factors.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147304838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}