Seyda Bilgin, Veysel Suzan, Bahar Bektan Kanat, Gulru Ulugerger Avci, Suna Avci, Hakan Yavuzer, Ibrahim Murat Bolayırlı, Alper Doventas, Deniz Suna Erdincler
{"title":"探讨老年患者原发性肌肉减少症与肠屏障功能障碍之间的关系：来自SARC-F、血清DAO、Zonulin、LPS和I-FABP水平的见解","authors":"Seyda Bilgin, Veysel Suzan, Bahar Bektan Kanat, Gulru Ulugerger Avci, Suna Avci, Hakan Yavuzer, Ibrahim Murat Bolayırlı, Alper Doventas, Deniz Suna Erdincler","doi":"10.1159/000545939","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study is to assess the correlation between serum levels of DAO (Diamine oxidase), LPS (Lipopolysaccharide), I-FABP (Intestinal Fatty Acid Binding Protein), and Zonulin with primary sarcopenia in elderly patients, and to compare the diagnostic performance of these biomarkers with the SARC-F score.</p><p><strong>Methods: </strong>The study included 88 patients aged 65 and above. Comorbidities and geriatric syndromes were assessed, and those with secondary sarcopenia were excluded. The EWGSOP2 criteria were applied for diagnosing sarcopenia, while the SARC-F questionnaire was utilized to identify individuals at risk of sarcopenia. Serum levels of DAO, Zonulin, LPS, and I-FABP were measured using ELISA.</p><p><strong>Results: </strong>No significant differences were observed between the two groups regarding age and gender. SARC-F, serum DAO, and Zonulin concentrations were notably higher in the sarcopenia group than in the non-sarcopenia group (p<0.001). Statistically significant parameters were analyzed using stepwise multiple regression. In stepwise multivariate logistic regression analysis, both DAO and Zonulin scores were found to be associated with sarcopenia [Odds ratio (OR) 1.041, (95%) confidence interval (CI) 1.020-1.063, p<0.001; OR 1.108, (95%) CI 1.018-1.206, p=0.018, subsequently]. ROC curve analysis revealed that the area under the curve (AUC) for DAO, Zonulin, and SARC-F was 0.807 (p<0.001), 0.723 (p<0.001), and 0.943 (p<0.001), subsequently. The Spearman correlation test revealed a significant, low-correlation between serum Zonulin and the SARC-F score (r = 0.3583, p=0.0006), and a moderate-correlation between serum DAO and the SARC-F score (r = 0.4384, p<0.0001).</p><p><strong>Conclusion: </strong>This study is the first to show a connection between primary sarcopenia and intestinal barrier dysfunction. While the findings support the use of the SARC-F questionnaire in routine practice, serum levels of DAO and Zonulin could serve as an alternative when the SARC-F questionnaire is not applicable.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-17"},"PeriodicalIF":3.1000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Relationship Between Primary Sarcopenia and Intestinal Barrier Dysfunction in Geriatric Patients: Insights from SARC-F, Serum DAO, Zonulin, LPS, and I-FABP Levels.\",\"authors\":\"Seyda Bilgin, Veysel Suzan, Bahar Bektan Kanat, Gulru Ulugerger Avci, Suna Avci, Hakan Yavuzer, Ibrahim Murat Bolayırlı, Alper Doventas, Deniz Suna Erdincler\",\"doi\":\"10.1159/000545939\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The objective of this study is to assess the correlation between serum levels of DAO (Diamine oxidase), LPS (Lipopolysaccharide), I-FABP (Intestinal Fatty Acid Binding Protein), and Zonulin with primary sarcopenia in elderly patients, and to compare the diagnostic performance of these biomarkers with the SARC-F score.</p><p><strong>Methods: </strong>The study included 88 patients aged 65 and above. Comorbidities and geriatric syndromes were assessed, and those with secondary sarcopenia were excluded. The EWGSOP2 criteria were applied for diagnosing sarcopenia, while the SARC-F questionnaire was utilized to identify individuals at risk of sarcopenia. Serum levels of DAO, Zonulin, LPS, and I-FABP were measured using ELISA.</p><p><strong>Results: </strong>No significant differences were observed between the two groups regarding age and gender. SARC-F, serum DAO, and Zonulin concentrations were notably higher in the sarcopenia group than in the non-sarcopenia group (p<0.001). Statistically significant parameters were analyzed using stepwise multiple regression. In stepwise multivariate logistic regression analysis, both DAO and Zonulin scores were found to be associated with sarcopenia [Odds ratio (OR) 1.041, (95%) confidence interval (CI) 1.020-1.063, p<0.001; OR 1.108, (95%) CI 1.018-1.206, p=0.018, subsequently]. ROC curve analysis revealed that the area under the curve (AUC) for DAO, Zonulin, and SARC-F was 0.807 (p<0.001), 0.723 (p<0.001), and 0.943 (p<0.001), subsequently. The Spearman correlation test revealed a significant, low-correlation between serum Zonulin and the SARC-F score (r = 0.3583, p=0.0006), and a moderate-correlation between serum DAO and the SARC-F score (r = 0.4384, p<0.0001).</p><p><strong>Conclusion: </strong>This study is the first to show a connection between primary sarcopenia and intestinal barrier dysfunction. While the findings support the use of the SARC-F questionnaire in routine practice, serum levels of DAO and Zonulin could serve as an alternative when the SARC-F questionnaire is not applicable.</p>\",\"PeriodicalId\":12662,\"journal\":{\"name\":\"Gerontology\",\"volume\":\" \",\"pages\":\"1-17\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gerontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545939\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545939","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Exploring the Relationship Between Primary Sarcopenia and Intestinal Barrier Dysfunction in Geriatric Patients: Insights from SARC-F, Serum DAO, Zonulin, LPS, and I-FABP Levels.
Introduction: The objective of this study is to assess the correlation between serum levels of DAO (Diamine oxidase), LPS (Lipopolysaccharide), I-FABP (Intestinal Fatty Acid Binding Protein), and Zonulin with primary sarcopenia in elderly patients, and to compare the diagnostic performance of these biomarkers with the SARC-F score.
Methods: The study included 88 patients aged 65 and above. Comorbidities and geriatric syndromes were assessed, and those with secondary sarcopenia were excluded. The EWGSOP2 criteria were applied for diagnosing sarcopenia, while the SARC-F questionnaire was utilized to identify individuals at risk of sarcopenia. Serum levels of DAO, Zonulin, LPS, and I-FABP were measured using ELISA.
Results: No significant differences were observed between the two groups regarding age and gender. SARC-F, serum DAO, and Zonulin concentrations were notably higher in the sarcopenia group than in the non-sarcopenia group (p<0.001). Statistically significant parameters were analyzed using stepwise multiple regression. In stepwise multivariate logistic regression analysis, both DAO and Zonulin scores were found to be associated with sarcopenia [Odds ratio (OR) 1.041, (95%) confidence interval (CI) 1.020-1.063, p<0.001; OR 1.108, (95%) CI 1.018-1.206, p=0.018, subsequently]. ROC curve analysis revealed that the area under the curve (AUC) for DAO, Zonulin, and SARC-F was 0.807 (p<0.001), 0.723 (p<0.001), and 0.943 (p<0.001), subsequently. The Spearman correlation test revealed a significant, low-correlation between serum Zonulin and the SARC-F score (r = 0.3583, p=0.0006), and a moderate-correlation between serum DAO and the SARC-F score (r = 0.4384, p<0.0001).
Conclusion: This study is the first to show a connection between primary sarcopenia and intestinal barrier dysfunction. While the findings support the use of the SARC-F questionnaire in routine practice, serum levels of DAO and Zonulin could serve as an alternative when the SARC-F questionnaire is not applicable.
期刊介绍：
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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