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Short hairpin RNA-mediated matrix gene silencing of human respiratory syncytial virus as a potent antiviral strategy 短发夹RNA介导的人呼吸道合胞病毒基质基因沉默作为一种有效的抗病毒策略
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-16 DOI: 10.2217/fvl-2022-0207
Saeid Amiri Zadeh Fard, Haniyeh Abuei, A. Farhadi, Gholamreza Rafiei Dehbidi, F. Zare, Zahra Abbasfard, A. Behbahani
{"title":"Short hairpin RNA-mediated matrix gene silencing of human respiratory syncytial virus as a potent antiviral strategy","authors":"Saeid Amiri Zadeh Fard, Haniyeh Abuei, A. Farhadi, Gholamreza Rafiei Dehbidi, F. Zare, Zahra Abbasfard, A. Behbahani","doi":"10.2217/fvl-2022-0207","DOIUrl":"https://doi.org/10.2217/fvl-2022-0207","url":null,"abstract":"Aim: Human respiratory syncytial virus (HRSV) is a common cause of respiratory infections, particularly in infants and the elderly. Ribavirin is the only US FDA-approved antiviral drug for HRSV infection, but it has unwanted side effects. Methods: We engineered an shRNA targeting the HRSV- M gene to antagonize HRSV replication. Results: The results showed that shRNA had a similarly significant reduction in viral load (99.8%) as ribavirin. In addition, combined treatment with ribavirin and M-shRNA resulted in a significant reduction in viral load compared with ribavirin or M-shRNA alone. Conclusion: These results suggest that M-shRNA could be a potential new inhibitor of HRSV replication and could offer a safer and more effective treatment option for HRSV infection in the future.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42059459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kuwanon X from mulberry leaves exhibits antiviral activity against human adenoviruses 桑叶Kuwanon X对人腺病毒具有抗病毒活性
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-12 DOI: 10.2217/fvl-2023-0001
Chi Li, Jikui Deng, Lifeng Qi
{"title":"Kuwanon X from mulberry leaves exhibits antiviral activity against human adenoviruses","authors":"Chi Li, Jikui Deng, Lifeng Qi","doi":"10.2217/fvl-2023-0001","DOIUrl":"https://doi.org/10.2217/fvl-2023-0001","url":null,"abstract":"Aim: This study aimed to investigate the anti–adenoviral activity of stilbene derivatives from mulberry leaves. Materials & methods: The anti–adenoviral activity was tested against adenoviruses -3 and -7 on human airway epithelial cell models. Cytotoxicity was assessed by LDH assay. Adenoviral DNA was quantified by qPCR. Results: All five tested stilbene derivatives from mulberry leaves exhibited anti–adenoviral activity, with Kuwanon X showing the highest inhibitory effect. Kuwanon X showed no apparent cytotoxicity for a wide range of concentrations. The mechanistic study revealed that Kuwanon X did not affect viral entry and nuclear translocation of the adenoviral genome but reduced viral DNA production. Conclusion: Stilbene derivatives like Kuwanon X from mulberry leaves are good candidates for antiviral treatment against AdV.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42184298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant protease inhibitors against SARS-CoV-2 main protease: an in silico approach 抗严重急性呼吸系统综合征冠状病毒2型主要蛋白酶的植物蛋白酶抑制剂：一种计算机方法
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2022-0189
Adrianne M Lima, A. Á. de Souza, Jackson L. Amaral, V. N. Freire, Pedro F N Souza, H. D. de Oliveira
{"title":"Plant protease inhibitors against SARS-CoV-2 main protease: an in silico approach","authors":"Adrianne M Lima, A. Á. de Souza, Jackson L. Amaral, V. N. Freire, Pedro F N Souza, H. D. de Oliveira","doi":"10.2217/fvl-2022-0189","DOIUrl":"https://doi.org/10.2217/fvl-2022-0189","url":null,"abstract":"Aim: To evaluate using bioinformatics tools the interactions between plant protease inhibitors (PIs) and SARS-CoV-2 Mpro. Materials & methods: This was an in silico study based on molecular docking, molecular dynamics simulations and quantum biochemistry calculations. Results: The plant PIs pineapple cystatin and sesame cystatin interacted allosterically with Mpro, leading to significant structural alterations. These conformational changes lead to a reduction of the area and volume of the Mpro proteolytic site, likely affecting the protease activity and, consequently, reducing viral replication. Conclusion: This work highlights the therapeutic potential of plant PIs as candidates for future in vivo investigations into new therapeutics for COVID-19.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41614105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of oxidative stress in the Epstein–Barr virus lifecycle and tumorigenicity 氧化应激在EB病毒生命周期和致瘤性中的作用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0007
Zixiu Zhao, Wen Liu, B. Luo
{"title":"Role of oxidative stress in the Epstein–Barr virus lifecycle and tumorigenicity","authors":"Zixiu Zhao, Wen Liu, B. Luo","doi":"10.2217/fvl-2023-0007","DOIUrl":"https://doi.org/10.2217/fvl-2023-0007","url":null,"abstract":"The Epstein–Barr virus (EBV) is an oncogenic virus with both latent and lytic states during its lifecycle. EBV employs a latency period as a strategy to avoid host immune surveillance and achieve lifelong persistent infection. However, the latent state may be interrupted and EBV may reactivate into a lytic replication cycle, exacerbating transmission and pathogenicity. The balance and transition between these two phases in the EBV lifecycle are complex, and reactive oxygen species play an important role. We reviewed the relationship between oxidative stress and lytic replication of EBV, and the role of oxidative stress in the development of EBV-related tumors. Further research is required to explore and develop tumor antioxidant therapy.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49489980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
COVID-19 post vaccination neuronal adverse events: probable mechanisms and treatment possibilities COVID-19疫苗接种后神经元不良事件:可能的机制和治疗可能性
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0042
A. Baig, Joachim Gerlach, Prakash Salunke, Rachel Jessey, Robin Rose
{"title":"COVID-19 post vaccination neuronal adverse events: probable mechanisms and treatment possibilities","authors":"A. Baig, Joachim Gerlach, Prakash Salunke, Rachel Jessey, Robin Rose","doi":"10.2217/fvl-2023-0042","DOIUrl":"https://doi.org/10.2217/fvl-2023-0042","url":null,"abstract":"","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42571140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cs-GRP78 recognition site on dengue virus envelope protein: in silico perspective 登革病毒包膜蛋白Cs-GRP78识别位点的计算机分析
4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2022-0192
Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany
{"title":"Cs-GRP78 recognition site on dengue virus envelope protein: <i>in silico</i> perspective","authors":"Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany","doi":"10.2217/fvl-2022-0192","DOIUrl":"https://doi.org/10.2217/fvl-2022-0192","url":null,"abstract":"Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials &amp; methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of quasi-enveloped hepatitis A virus in hepatitis A virus infection 准包膜甲型肝炎病毒在甲型肝炎病毒感染中的作用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0046
Yuxue Zhao, Yiwen Chen, Qiaoqiao Chen, Chenxuan Bao, Huayuan Xiang, Lingxiang Mao
{"title":"The role of quasi-enveloped hepatitis A virus in hepatitis A virus infection","authors":"Yuxue Zhao, Yiwen Chen, Qiaoqiao Chen, Chenxuan Bao, Huayuan Xiang, Lingxiang Mao","doi":"10.2217/fvl-2023-0046","DOIUrl":"https://doi.org/10.2217/fvl-2023-0046","url":null,"abstract":"Hepatitis A virus (HAV) infection affects the global population and is responsible for acute hepatitis. Although most acute HAV infections can resolve spontaneously, there are about 15,000–30,000 deaths occurring annually worldwide. Therefore, it is important to study the mechanism of HAV infection. Recent studies have shown that HAV can be cloaked in the host membrane and exit cells nonlytically. This unique form of HAV is called quasi-enveloped HAV (eHAV) and is infectious and resistant to neutralizing antibodies. eHAV makes HAV different from many picornaviruses and provides a new pathway to HAV infection. In this review, we briefly summarize the characteristics and functions of eHAV in HAV infection.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43284673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women 伊朗妇女宫颈样本中人乳头瘤病毒16型的谱系和亚系
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-17 DOI: 10.2217/fvl-2022-0174
Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani
{"title":"Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women","authors":"Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani","doi":"10.2217/fvl-2022-0174","DOIUrl":"https://doi.org/10.2217/fvl-2022-0174","url":null,"abstract":"Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43820054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment NLRP3炎性体参与单纯疱疹病毒感染及治疗
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0031
Yuan Ding, Haifeng Yu, Liqiong Ding
{"title":"The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment","authors":"Yuan Ding, Haifeng Yu, Liqiong Ding","doi":"10.2217/fvl-2023-0031","DOIUrl":"https://doi.org/10.2217/fvl-2023-0031","url":null,"abstract":"Herpes simplex virus (HSV) can cause life-threatening diseases such as herpes simplex keratitis and herpes simplex encephalitis, with considerable tissue damage resulting from viral replication. The immune response that is activated in response to infection to control viral replication may become exaggerated and contribute to this damage. An overactive inflammatory response could be controlled using immunomodulatory strategies, an ideal target for which may be the multiple pattern recognition receptors that are involved in the innate immune response to HSV, including Toll-like receptors, RIG-I-like receptors, nucleotide oligomerization domain like receptors and cGAS-STING. Here, we summarize the role of the NLRP3 inflammasome in HSV infection and discuss the potential mechanism and therapeutic strategies of targeting the NLRP3 inflammasome for HSV-related diseases.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Higher viral load of BK polyomavirus in urothelial bladder tumors compared with nontumoral bladder tissues 与非肿瘤膀胱组织相比，尿路上皮膀胱肿瘤中BK多瘤病毒的病毒载量更高
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0025
H. Kamalinia, Talieh Mostaghimi, Mahdie Taheri, Moein Shirzad, A. A. Pasha, Y. Yahyapour, E. Moudi, Farzin Sadeghi
{"title":"Higher viral load of BK polyomavirus in urothelial bladder tumors compared with nontumoral bladder tissues","authors":"H. Kamalinia, Talieh Mostaghimi, Mahdie Taheri, Moein Shirzad, A. A. Pasha, Y. Yahyapour, E. Moudi, Farzin Sadeghi","doi":"10.2217/fvl-2023-0025","DOIUrl":"https://doi.org/10.2217/fvl-2023-0025","url":null,"abstract":"Aim: This study examined BK polyomavirus (BKPyV) genome and viral load in urothelial bladder carcinoma (UBC) and nontumoral bladder tissues. Materials & methods: Quantitative real-time PCR was used to measure viral LT-Ag copy number per cell in 114 fresh-frozen bladder biopsy samples (61 UBC and 53 nontumoral tissue samples). Results: Patients with UBC had a significantly higher mean BKPyV LT-Ag DNA load than those without UBC. In multivariate logistic regression analysis, BKPyV LT-Ag copies/cell and smoking/illicit use of drugs were associated with bladder cancer. Receiver operating characteristic curve analysis identified bladder cancer risk at 0.1 copies/cell. Conclusion: This study found high BKPyV LT-Ag DNA copy numbers in most UBC samples, supporting the hypothesis that BKPyV induces UBC tumorigenesis.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47806458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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