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Identification of host factors that bind to the 5′ end of the MERS-CoV RNA genome 鉴定与MERS-CoV RNA基因组5 '端结合的宿主因子
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-22 DOI: 10.2217/fvl-2023-0070
Bader Y. Alhatlani, Waleed Aljabr, F. Alhamlan, A. Almatroudi, M. Azam, M. Alsaleem, K. Allemailem
{"title":"Identification of host factors that bind to the 5′ end of the MERS-CoV RNA genome","authors":"Bader Y. Alhatlani, Waleed Aljabr, F. Alhamlan, A. Almatroudi, M. Azam, M. Alsaleem, K. Allemailem","doi":"10.2217/fvl-2023-0070","DOIUrl":"https://doi.org/10.2217/fvl-2023-0070","url":null,"abstract":"Aim: The aim of this study was to identify host factors that interact with the 5′ end of the MERS-CoV RNA genome. Materials & methods: RNA affinity chromatography followed by mass spectrometry analysis was used to identify the binding of host factors in Vero E6 cells. Results: A total of 59 host factors that bound the MERS-CoV RNA genome in non-infected Vero E6 cells were identified. Most of the identified cellular proteins were previously reported to interact with the genome of other RNA viruses. We validated our mass spectrometry results using western blotting. Conclusion: These data enhance our knowledge about the RNA–host interactions of coronaviruses, which could serve as targets for developing antiviral therapeutics against MERS-CoV.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48682635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short hairpin RNA-mediated matrix gene silencing of human respiratory syncytial virus as a potent antiviral strategy 短发夹RNA介导的人呼吸道合胞病毒基质基因沉默作为一种有效的抗病毒策略
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-16 DOI: 10.2217/fvl-2022-0207
Saeid Amiri Zadeh Fard, Haniyeh Abuei, A. Farhadi, Gholamreza Rafiei Dehbidi, F. Zare, Zahra Abbasfard, A. Behbahani
{"title":"Short hairpin RNA-mediated matrix gene silencing of human respiratory syncytial virus as a potent antiviral strategy","authors":"Saeid Amiri Zadeh Fard, Haniyeh Abuei, A. Farhadi, Gholamreza Rafiei Dehbidi, F. Zare, Zahra Abbasfard, A. Behbahani","doi":"10.2217/fvl-2022-0207","DOIUrl":"https://doi.org/10.2217/fvl-2022-0207","url":null,"abstract":"Aim: Human respiratory syncytial virus (HRSV) is a common cause of respiratory infections, particularly in infants and the elderly. Ribavirin is the only US FDA-approved antiviral drug for HRSV infection, but it has unwanted side effects. Methods: We engineered an shRNA targeting the HRSV- M gene to antagonize HRSV replication. Results: The results showed that shRNA had a similarly significant reduction in viral load (99.8%) as ribavirin. In addition, combined treatment with ribavirin and M-shRNA resulted in a significant reduction in viral load compared with ribavirin or M-shRNA alone. Conclusion: These results suggest that M-shRNA could be a potential new inhibitor of HRSV replication and could offer a safer and more effective treatment option for HRSV infection in the future.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42059459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kuwanon X from mulberry leaves exhibits antiviral activity against human adenoviruses 桑叶Kuwanon X对人腺病毒具有抗病毒活性
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-12 DOI: 10.2217/fvl-2023-0001
Chi Li, Jikui Deng, Lifeng Qi
{"title":"Kuwanon X from mulberry leaves exhibits antiviral activity against human adenoviruses","authors":"Chi Li, Jikui Deng, Lifeng Qi","doi":"10.2217/fvl-2023-0001","DOIUrl":"https://doi.org/10.2217/fvl-2023-0001","url":null,"abstract":"Aim: This study aimed to investigate the anti–adenoviral activity of stilbene derivatives from mulberry leaves. Materials & methods: The anti–adenoviral activity was tested against adenoviruses -3 and -7 on human airway epithelial cell models. Cytotoxicity was assessed by LDH assay. Adenoviral DNA was quantified by qPCR. Results: All five tested stilbene derivatives from mulberry leaves exhibited anti–adenoviral activity, with Kuwanon X showing the highest inhibitory effect. Kuwanon X showed no apparent cytotoxicity for a wide range of concentrations. The mechanistic study revealed that Kuwanon X did not affect viral entry and nuclear translocation of the adenoviral genome but reduced viral DNA production. Conclusion: Stilbene derivatives like Kuwanon X from mulberry leaves are good candidates for antiviral treatment against AdV.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42184298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of oxidative stress in the Epstein–Barr virus lifecycle and tumorigenicity 氧化应激在EB病毒生命周期和致瘤性中的作用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0007
Zixiu Zhao, Wen Liu, B. Luo
{"title":"Role of oxidative stress in the Epstein–Barr virus lifecycle and tumorigenicity","authors":"Zixiu Zhao, Wen Liu, B. Luo","doi":"10.2217/fvl-2023-0007","DOIUrl":"https://doi.org/10.2217/fvl-2023-0007","url":null,"abstract":"The Epstein–Barr virus (EBV) is an oncogenic virus with both latent and lytic states during its lifecycle. EBV employs a latency period as a strategy to avoid host immune surveillance and achieve lifelong persistent infection. However, the latent state may be interrupted and EBV may reactivate into a lytic replication cycle, exacerbating transmission and pathogenicity. The balance and transition between these two phases in the EBV lifecycle are complex, and reactive oxygen species play an important role. We reviewed the relationship between oxidative stress and lytic replication of EBV, and the role of oxidative stress in the development of EBV-related tumors. Further research is required to explore and develop tumor antioxidant therapy.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49489980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plant protease inhibitors against SARS-CoV-2 main protease: an in silico approach 抗严重急性呼吸系统综合征冠状病毒2型主要蛋白酶的植物蛋白酶抑制剂：一种计算机方法
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2022-0189
Adrianne M Lima, A. Á. de Souza, Jackson L. Amaral, V. N. Freire, Pedro F N Souza, H. D. de Oliveira
{"title":"Plant protease inhibitors against SARS-CoV-2 main protease: an in silico approach","authors":"Adrianne M Lima, A. Á. de Souza, Jackson L. Amaral, V. N. Freire, Pedro F N Souza, H. D. de Oliveira","doi":"10.2217/fvl-2022-0189","DOIUrl":"https://doi.org/10.2217/fvl-2022-0189","url":null,"abstract":"Aim: To evaluate using bioinformatics tools the interactions between plant protease inhibitors (PIs) and SARS-CoV-2 Mpro. Materials & methods: This was an in silico study based on molecular docking, molecular dynamics simulations and quantum biochemistry calculations. Results: The plant PIs pineapple cystatin and sesame cystatin interacted allosterically with Mpro, leading to significant structural alterations. These conformational changes lead to a reduction of the area and volume of the Mpro proteolytic site, likely affecting the protease activity and, consequently, reducing viral replication. Conclusion: This work highlights the therapeutic potential of plant PIs as candidates for future in vivo investigations into new therapeutics for COVID-19.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41614105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 post vaccination neuronal adverse events: probable mechanisms and treatment possibilities COVID-19疫苗接种后神经元不良事件:可能的机制和治疗可能性
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0042
A. Baig, Joachim Gerlach, Prakash Salunke, Rachel Jessey, Robin Rose
{"title":"COVID-19 post vaccination neuronal adverse events: probable mechanisms and treatment possibilities","authors":"A. Baig, Joachim Gerlach, Prakash Salunke, Rachel Jessey, Robin Rose","doi":"10.2217/fvl-2023-0042","DOIUrl":"https://doi.org/10.2217/fvl-2023-0042","url":null,"abstract":"","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42571140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cs-GRP78 recognition site on dengue virus envelope protein: in silico perspective 登革病毒包膜蛋白Cs-GRP78识别位点的计算机分析
4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2022-0192
Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany
{"title":"Cs-GRP78 recognition site on dengue virus envelope protein: <i>in silico</i> perspective","authors":"Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany","doi":"10.2217/fvl-2022-0192","DOIUrl":"https://doi.org/10.2217/fvl-2022-0192","url":null,"abstract":"Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials &amp; methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of quasi-enveloped hepatitis A virus in hepatitis A virus infection 准包膜甲型肝炎病毒在甲型肝炎病毒感染中的作用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 DOI: 10.2217/fvl-2023-0046
Yuxue Zhao, Yiwen Chen, Qiaoqiao Chen, Chenxuan Bao, Huayuan Xiang, Lingxiang Mao
{"title":"The role of quasi-enveloped hepatitis A virus in hepatitis A virus infection","authors":"Yuxue Zhao, Yiwen Chen, Qiaoqiao Chen, Chenxuan Bao, Huayuan Xiang, Lingxiang Mao","doi":"10.2217/fvl-2023-0046","DOIUrl":"https://doi.org/10.2217/fvl-2023-0046","url":null,"abstract":"Hepatitis A virus (HAV) infection affects the global population and is responsible for acute hepatitis. Although most acute HAV infections can resolve spontaneously, there are about 15,000–30,000 deaths occurring annually worldwide. Therefore, it is important to study the mechanism of HAV infection. Recent studies have shown that HAV can be cloaked in the host membrane and exit cells nonlytically. This unique form of HAV is called quasi-enveloped HAV (eHAV) and is infectious and resistant to neutralizing antibodies. eHAV makes HAV different from many picornaviruses and provides a new pathway to HAV infection. In this review, we briefly summarize the characteristics and functions of eHAV in HAV infection.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43284673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure-based virtual identification of natural inhibitors of SARS-CoV-2 and its Delta and Omicron variant proteins. 基于结构的SARS-CoV-2天然抑制剂及其Delta和Omicron变体蛋白的虚拟鉴定
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 Epub Date: 2023-06-01 DOI: 10.2217/fvl-2022-0184
Abdullah R Alanzi, Mohammad K Parvez, Mohammed S Al-Dosari
{"title":"Structure-based virtual identification of natural inhibitors of SARS-CoV-2 and its Delta and Omicron variant proteins.","authors":"Abdullah R Alanzi, Mohammad K Parvez, Mohammed S Al-Dosari","doi":"10.2217/fvl-2022-0184","DOIUrl":"10.2217/fvl-2022-0184","url":null,"abstract":"<p><strong>Aim: </strong>Structure-based identification of natural compounds against SARS-CoV-2, Delta and Omicron target proteins.</p><p><strong>Materials & methods: </strong>Several known antiviral natural compounds were subjected to molecular docking and MD simulation against SARS-CoV-2 Mpro, Helicase and Spike, including Delta and Omicron Spikes.</p><p><strong>Results: </strong>Of the docked ligands, 20 selected for each complex exhibited overall good binding affinities (-7.79 to -5.06 kcal/mol) with acceptable physiochemistry following Lipinski's rule. Finally, two best ligands from each complex upon simulation showed structural stability and compactness.</p><p><strong>Conclusion: </strong>Quercetin-3-acetyl-glucoside, Rutin, Kaempferol, Catechin, Orientin, Obetrioside and Neridienone A were identified as potential inhibitors of SARS-CoV-2 Mpro, Helicase and Spike, while Orientin and Obetrioside also showed good binding affinities with Omicron Spike. Catechin and Neridienone A formed stable complexes with Delta Spike.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42731052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CpG 684: an effective adjuvant for the inactivated COVID-19 vaccine in mice. CpG 684:小鼠COVID-19灭活疫苗的有效佐剂
IF 3.1 4区 医学
Future Virology Pub Date : 2023-05-01 Epub Date: 2023-06-01 DOI: 10.2217/fvl-2022-0172
Jiandong Liu, Tianle Cang, Congli Jiang, Kelei Li, Siyuan Liu, Haixin Wang, Meirong Wang, Yan Chen, Yan Shao, Jiankai Liu
{"title":"CpG 684: an effective adjuvant for the inactivated COVID-19 vaccine in mice.","authors":"Jiandong Liu, Tianle Cang, Congli Jiang, Kelei Li, Siyuan Liu, Haixin Wang, Meirong Wang, Yan Chen, Yan Shao, Jiankai Liu","doi":"10.2217/fvl-2022-0172","DOIUrl":"10.2217/fvl-2022-0172","url":null,"abstract":"<p><strong>Aim: </strong>This study used CpG 684 as adjuvant of inactivated COVID-19 vaccine to detect a humoral and cellular immune response in mice.</p><p><strong>Materials & methods: </strong>We used 10 and 20 µg CpG 684 as adjuvants of an inactivated COVID-19 vaccine to immunize mice. IgG, IgG1, IgG2a, IgG2b and IgM binding antibodies were detected in serum by ELISA. The IFN-γ cytokine was detected by ELISPOT.</p><p><strong>Results: </strong>CpG 684 improved spike-specific IgG and IgM subtype binding antibodies and increased the neutralizing antibody titer against prototype, Delta and Beta strains. CpG 684 also improved cellular immune response.</p><p><strong>Conclusion: </strong>CpG 684 is an effective adjuvant for inactivated COVID-19 vaccine.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48756097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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