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Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women 伊朗妇女宫颈样本中人乳头瘤病毒16型的谱系和亚系
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-17 DOI: 10.2217/fvl-2022-0174
Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani
{"title":"Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women","authors":"Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani","doi":"10.2217/fvl-2022-0174","DOIUrl":"https://doi.org/10.2217/fvl-2022-0174","url":null,"abstract":"Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43820054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment NLRP3炎性体参与单纯疱疹病毒感染及治疗
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0031
Yuan Ding, Haifeng Yu, Liqiong Ding
{"title":"The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment","authors":"Yuan Ding, Haifeng Yu, Liqiong Ding","doi":"10.2217/fvl-2023-0031","DOIUrl":"https://doi.org/10.2217/fvl-2023-0031","url":null,"abstract":"Herpes simplex virus (HSV) can cause life-threatening diseases such as herpes simplex keratitis and herpes simplex encephalitis, with considerable tissue damage resulting from viral replication. The immune response that is activated in response to infection to control viral replication may become exaggerated and contribute to this damage. An overactive inflammatory response could be controlled using immunomodulatory strategies, an ideal target for which may be the multiple pattern recognition receptors that are involved in the innate immune response to HSV, including Toll-like receptors, RIG-I-like receptors, nucleotide oligomerization domain like receptors and cGAS-STING. Here, we summarize the role of the NLRP3 inflammasome in HSV infection and discuss the potential mechanism and therapeutic strategies of targeting the NLRP3 inflammasome for HSV-related diseases.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Higher viral load of BK polyomavirus in urothelial bladder tumors compared with nontumoral bladder tissues 与非肿瘤膀胱组织相比，尿路上皮膀胱肿瘤中BK多瘤病毒的病毒载量更高
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-14 DOI: 10.2217/fvl-2023-0025
H. Kamalinia, Talieh Mostaghimi, Mahdie Taheri, Moein Shirzad, A. A. Pasha, Y. Yahyapour, E. Moudi, Farzin Sadeghi
{"title":"Higher viral load of BK polyomavirus in urothelial bladder tumors compared with nontumoral bladder tissues","authors":"H. Kamalinia, Talieh Mostaghimi, Mahdie Taheri, Moein Shirzad, A. A. Pasha, Y. Yahyapour, E. Moudi, Farzin Sadeghi","doi":"10.2217/fvl-2023-0025","DOIUrl":"https://doi.org/10.2217/fvl-2023-0025","url":null,"abstract":"Aim: This study examined BK polyomavirus (BKPyV) genome and viral load in urothelial bladder carcinoma (UBC) and nontumoral bladder tissues. Materials & methods: Quantitative real-time PCR was used to measure viral LT-Ag copy number per cell in 114 fresh-frozen bladder biopsy samples (61 UBC and 53 nontumoral tissue samples). Results: Patients with UBC had a significantly higher mean BKPyV LT-Ag DNA load than those without UBC. In multivariate logistic regression analysis, BKPyV LT-Ag copies/cell and smoking/illicit use of drugs were associated with bladder cancer. Receiver operating characteristic curve analysis identified bladder cancer risk at 0.1 copies/cell. Conclusion: This study found high BKPyV LT-Ag DNA copy numbers in most UBC samples, supporting the hypothesis that BKPyV induces UBC tumorigenesis.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47806458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico assessment of diterpenes as potential inhibitors of SARS-COV-2 main protease. 二萜作为SARS-COV-2主要蛋白酶潜在抑制剂的计算机模拟评估
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-01 Epub Date: 2023-05-22 DOI: 10.2217/fvl-2022-0163
Yousef A Abdelrady, Naeem Mahmood Ashraf, Arslan Hamid, Hayam S Thabet, Asmaa M Sayed, Shimaa H Salem, Emad Hm Hassanein, Ahmed M Sayed
{"title":"<i>In silico</i> assessment of diterpenes as potential inhibitors of SARS-COV-2 main protease.","authors":"Yousef A Abdelrady, Naeem Mahmood Ashraf, Arslan Hamid, Hayam S Thabet, Asmaa M Sayed, Shimaa H Salem, Emad Hm Hassanein, Ahmed M Sayed","doi":"10.2217/fvl-2022-0163","DOIUrl":"10.2217/fvl-2022-0163","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to investigate the potential inhibitory effects of diterpenes on SARS-CoV-2 main protease (Mpro).</p><p><strong>Materials & methods: </strong>We performed a virtual screening of diterpenoids against Mpro using molecular docking, molecular dynamics simulation and absorption, distribution, metabolism and excretion) analysis.</p><p><strong>Results: </strong>Some tested compounds followed Lipinski's rule and showed drug-like properties. Some diterpenoids possessed remarkable binding affinities with SARS-CoV-2 Mpro and drug-like pharmacokinetic properties. Three derivatives exhibited structural deviations lower than 1 Å.</p><p><strong>Conclusion: </strong>The findings of the study suggest that some of the diterpenes could be candidates as potential inhibitors for Mpro of SARS-CoV-2.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47570766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of COVID-19 and vaccination on the human immune system: cases of lymphopenia and autoimmunity 新冠肺炎和疫苗接种对人体免疫系统的影响：淋巴细胞减少和自身免疫病例
IF 3.1 4区 医学
Future Virology Pub Date : 2023-04-01 DOI: 10.2217/fvl-2022-0218
Joachim Gerlach, A. Baig
{"title":"Effects of COVID-19 and vaccination on the human immune system: cases of lymphopenia and autoimmunity","authors":"Joachim Gerlach, A. Baig","doi":"10.2217/fvl-2022-0218","DOIUrl":"https://doi.org/10.2217/fvl-2022-0218","url":null,"abstract":"","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43879156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conference proceedings from hybrid 25th Bangkok International Symposium on HIV Medicine 第25届曼谷艾滋病毒医学国际混合研讨会会议记录
IF 3.1 4区 医学
Future Virology Pub Date : 2023-03-28 DOI: 10.2217/fvl-2023-0019
P. Ohata, A. Avihingsanon, Siwat Thammapiwan, W. M. Han, Akarin Hiransuthikul, Hay Mar Su Lwin, S. Ubolyam, Jedsadakorn Boonrungsirisap, S. Kerr, S. Gatechompol, T. Puthanakit, O. Putcharoen, K. Ruxrungtham, P. Phanuphak
{"title":"Conference proceedings from hybrid 25th Bangkok International Symposium on HIV Medicine","authors":"P. Ohata, A. Avihingsanon, Siwat Thammapiwan, W. M. Han, Akarin Hiransuthikul, Hay Mar Su Lwin, S. Ubolyam, Jedsadakorn Boonrungsirisap, S. Kerr, S. Gatechompol, T. Puthanakit, O. Putcharoen, K. Ruxrungtham, P. Phanuphak","doi":"10.2217/fvl-2023-0019","DOIUrl":"https://doi.org/10.2217/fvl-2023-0019","url":null,"abstract":"The Bangkok International Symposium on HIV Medicine has commenced on the 3rd Wednesday in January since 1998. The Symposium aims to provide professional healthcare workers in Thailand and the region an opportunity to receive the most up-to-date information on HIV and its related conditions if they are unable to attend other HIV conferences abroad. This year’s hybrid symposium was held from 18 January to 20 January 2023. A total of six plenary sessions were held in the mornings, and four afternoon workshops held on Wednesday and Thursday. Expert speakers from Thailand, China, Malaysia, Singapore, India, Hong Kong, Philippines, Australia, UK, The Netherlands and the USA participated in the symposium.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43240772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RT-LAMP is a potential future molecular diagnostic tool for influenza A virus RT-LAMP是一种潜在的a型流感病毒分子诊断工具
IF 3.1 4区 医学
Future Virology Pub Date : 2023-03-15 DOI: 10.2217/fvl-2022-0136
Sanjit Boora, Anishkumar Khan, Vikrant Sharma, S. Kaushik, P. Mehta, S. Singh, S. Kaushik
{"title":"RT-LAMP is a potential future molecular diagnostic tool for influenza A virus","authors":"Sanjit Boora, Anishkumar Khan, Vikrant Sharma, S. Kaushik, P. Mehta, S. Singh, S. Kaushik","doi":"10.2217/fvl-2022-0136","DOIUrl":"https://doi.org/10.2217/fvl-2022-0136","url":null,"abstract":"Aim: Influenza A virus (IAV) causes serious illness and is responsible for significant morbidity and mortality. To diagnose IAV infection in its early stages, a quick, sensitive, precise detection method is needed for effective clinical management. Materials & methods: In-house hydroxylnaphthol blue (HNB)-based RT-LAMP assay for early detection of IAV using the HA gene was compared with RT-PCR/multiplex-RT-PCR. Results: For the reference strains of IAV, (H1N1 (A/Texas/50/2012) and H3N2 (A/Malaysia/2089302/2009)) RT-LAMP and RT-PCR/M-RT-PCR exhibited a limit of detection (LOD) of 10 and 100 fg/ml, respectively. Conclusion: HNB-based RT-LAMP is a rapid, sensitive, cost-effective diagnostic tool, and could be a point-of-care test for IAV patients during outbreaks.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47896372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Potential roles of core and core+1 proteins during the chronic phase of hepatitis C virus infection 核心蛋白和核心+1蛋白在丙型肝炎病毒感染慢性期的潜在作用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-03-14 DOI: 10.2217/fvl-2022-0117
Asra Malekshahi, A. Alamdary, Ali Safarzadeh, A. Khavandegar, H. R. Nikoo, Mahshid Safavi, Mobina Ajorloo, Atefeh Bahavar, Mehdi Ajorloo
{"title":"Potential roles of core and core+1 proteins during the chronic phase of hepatitis C virus infection","authors":"Asra Malekshahi, A. Alamdary, Ali Safarzadeh, A. Khavandegar, H. R. Nikoo, Mahshid Safavi, Mobina Ajorloo, Atefeh Bahavar, Mehdi Ajorloo","doi":"10.2217/fvl-2022-0117","DOIUrl":"https://doi.org/10.2217/fvl-2022-0117","url":null,"abstract":"The HCV Core protein is a multifunctional protein that interacts with many viral and cellular proteins. In addition to the encapsidation of the viral genome, it can disturb various cellular pathways and impede antiviral cellular responses such as interferon (IFN) production. The Core protein can also disrupt the functions of immune cells against HCV. The Core protein helps viral infection persistency by interfering with apoptosis. The Core+1 protein plays a significant role in inducing chronic HCV infection through diverse mechanisms. We review some of the mechanisms by which Core and Core+1 proteins facilitate HCV infection to chronic infection. These proteins could be considered for designing more sufficient treatments and effective vaccines against HCV.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46569306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanocarrier-based drug delivery system in herpes simplex virus treatment 纳米载体给药系统在单纯疱疹病毒治疗中的应用
IF 3.1 4区 医学
Future Virology Pub Date : 2023-03-09 DOI: 10.2217/fvl-2022-0171
W. Yin, Liqiong Ding
{"title":"Nanocarrier-based drug delivery system in herpes simplex virus treatment","authors":"W. Yin, Liqiong Ding","doi":"10.2217/fvl-2022-0171","DOIUrl":"https://doi.org/10.2217/fvl-2022-0171","url":null,"abstract":"Herpes simplex virus (HSV) is a highly contagious DNA virus that affects the majority of people worldwide. HSV establishes a latent infection in the ganglia, where it can reactivate, leading to recurrent disease. Currently, there are many experimental vaccines against HSV, but none have been used to treat herpes infections. At the same time, the therapeutic effect of existing anti-HSV drugs is limited. Nanocarriers, which deliver drugs to specific targets, have been used in different diseases, including viral infections. Nanocarriers could be designed to encapsulate drugs and directly target infected cells. This review will describe in detail the use of nanocarriers for targeted therapy of HSV infection.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42220984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological and clinical features of human rabies in Dazu District, Chongqing, China from 2014 to 2021 2014 - 2021年重庆市大足区人狂犬病流行病学及临床特征
IF 3.1 4区 医学
Future Virology Pub Date : 2023-03-06 DOI: 10.2217/fvl-2022-0149
Wan Shi-Gang, Liu He-Lei, Xia Hong, Wu Jing
{"title":"Epidemiological and clinical features of human rabies in Dazu District, Chongqing, China from 2014 to 2021","authors":"Wan Shi-Gang, Liu He-Lei, Xia Hong, Wu Jing","doi":"10.2217/fvl-2022-0149","DOIUrl":"https://doi.org/10.2217/fvl-2022-0149","url":null,"abstract":"The epidemiological and clinical data of human rabies cases in the Dazu District of Chongqing from 2014 to 2021 were analyzed retrospectively to determine the epidemiological and clinical features of human rabies cases in Chonqing, China. Nine cases were reported. All cases occurred in farmers from rural areas associated with lower rabies awareness, and eight cases had a definitive history of animal exposure, most commonly in the form of domestic dog bites. All nine patients presented as manic and died within 1–8 days from disease onset (mortality rate of 100%). Increased public awareness of rabies prevention and control is needed, especially among middle-aged and elderly populations in rural areas.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49236943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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