Felipe Pantoja Mesquita, Pedro Filho Noronha Souza, Dyane Rocha Aragão, Expedito Maia Diógenes, Emerson Lucena da Silva, Jackson Lima Amaral, Valder Nogueira Freire, Débora de Souza Collares Maia Castelo-Branco, Raquel Carvalho Montenegro
{"title":"不同动物物种ACE2的计算机分析为SARS-CoV-2物种溢出提供了新的见解。","authors":"Felipe Pantoja Mesquita, Pedro Filho Noronha Souza, Dyane Rocha Aragão, Expedito Maia Diógenes, Emerson Lucena da Silva, Jackson Lima Amaral, Valder Nogueira Freire, Débora de Souza Collares Maia Castelo-Branco, Raquel Carvalho Montenegro","doi":"10.2217/fvl-2022-0187","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. <b>Materials & methods:</b> The phylogenetic construction and molecular interactions were assessed using computational models. <b>Results & conclusion:</b> Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD (<i>Chinchilla lanigera, Neovison vison</i>, <i>Rhinolophus sinicus, Emballonura alecto</i>, <i>Saccopteryx bilineata</i>, <i>Numida meleagris</i>). Among them, the avian <i>N. meleagris</i> was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.</p>","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096339/pdf/","citationCount":"1","resultStr":"{\"title\":\"<i>In silico</i> analysis of <i>ACE2</i> from different animal species provides new insights into SARS-CoV-2 species spillover.\",\"authors\":\"Felipe Pantoja Mesquita, Pedro Filho Noronha Souza, Dyane Rocha Aragão, Expedito Maia Diógenes, Emerson Lucena da Silva, Jackson Lima Amaral, Valder Nogueira Freire, Débora de Souza Collares Maia Castelo-Branco, Raquel Carvalho Montenegro\",\"doi\":\"10.2217/fvl-2022-0187\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. <b>Materials & methods:</b> The phylogenetic construction and molecular interactions were assessed using computational models. <b>Results & conclusion:</b> Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD (<i>Chinchilla lanigera, Neovison vison</i>, <i>Rhinolophus sinicus, Emballonura alecto</i>, <i>Saccopteryx bilineata</i>, <i>Numida meleagris</i>). Among them, the avian <i>N. meleagris</i> was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.</p>\",\"PeriodicalId\":12505,\"journal\":{\"name\":\"Future Virology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096339/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/fvl-2022-0187\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/fvl-2022-0187","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
In silico analysis of ACE2 from different animal species provides new insights into SARS-CoV-2 species spillover.
Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenetic construction and molecular interactions were assessed using computational models. Results & conclusion: Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD (Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris). Among them, the avian N. meleagris was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.
期刊介绍：
Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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