准包膜甲型肝炎病毒在甲型肝炎病毒感染中的作用

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-05-01 DOI:10.2217/fvl-2023-0046

Yuxue Zhao, Yiwen Chen, Qiaoqiao Chen, Chenxuan Bao, Huayuan Xiang, Lingxiang Mao

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引用次数: 0

摘要

甲型肝炎病毒(HAV)感染影响全球人口，并导致急性肝炎。虽然大多数急性甲肝感染可自行消退，但全世界每年仍有大约1.5万至3万人死亡。因此，研究HAV感染的机制具有重要意义。最近的研究表明，甲肝病毒可以隐藏在宿主膜内，非裂解性地离开细胞。这种独特形式的甲肝病毒被称为准包膜甲肝病毒(eHAV)，具有传染性，对中和抗体有抵抗力。eHAV使HAV不同于许多小核糖核酸病毒，为HAV感染提供了新的途径。本文就eHAV在HAV感染中的特点和作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of quasi-enveloped hepatitis A virus in hepatitis A virus infection

Hepatitis A virus (HAV) infection affects the global population and is responsible for acute hepatitis. Although most acute HAV infections can resolve spontaneously, there are about 15,000–30,000 deaths occurring annually worldwide. Therefore, it is important to study the mechanism of HAV infection. Recent studies have shown that HAV can be cloaked in the host membrane and exit cells nonlytically. This unique form of HAV is called quasi-enveloped HAV (eHAV) and is infectious and resistant to neutralizing antibodies. eHAV makes HAV different from many picornaviruses and provides a new pathway to HAV infection. In this review, we briefly summarize the characteristics and functions of eHAV in HAV infection.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.