Cs-GRP78 recognition site on dengue virus envelope protein: in silico perspective

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-05-01 DOI:10.2217/fvl-2022-0192

Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany

引用次数: 0

Abstract

Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.

查看原文本刊更多论文

登革病毒包膜蛋白Cs-GRP78识别位点的计算机分析

目的:了解登革病毒(DENV)包膜与宿主细胞因子GRP78的结合。材料,方法:在本研究中，我们使用结构生物信息学工具模拟DENV包膜与GRP78的结合。结果:DENV包膜C3-C30和C302-C333区域与Pep42环肽序列相似，提示这些区域可能是GRP78的识别位点。C3-C30的大平均疏水性指数与Pep42相似，对GRP78的结合亲和力为负。结论:我们预测DENV包膜的C3-C30区域是GRP78的识别位点。进一步的实验验证对未来的研究很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.