NLRP3炎性体参与单纯疱疹病毒感染及治疗

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-04-14 DOI:10.2217/fvl-2023-0031

Yuan Ding, Haifeng Yu, Liqiong Ding

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引用次数: 0

摘要

单纯疱疹病毒（HSV）可导致危及生命的疾病，如单纯疱疹角膜炎和单纯疱疹脑炎，病毒复制会对组织造成相当大的损伤。在感染时被激活以控制病毒复制的免疫反应可能会被夸大，并导致这种损伤。过度活跃的炎症反应可以使用免疫调节策略来控制，其理想靶点可能是参与对HSV的先天免疫反应的多种模式识别受体，包括Toll样受体、RIG-I样受体、核苷酸寡聚结构域样受体和cGAS-STING。在此，我们总结了NLRP3炎症小体在HSV感染中的作用，并讨论了靶向NLRP3炎性小体治疗HSV相关疾病的潜在机制和治疗策略。

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The involvement of NLRP3 inflammasome in herpes simplex virus infection and treatment

Herpes simplex virus (HSV) can cause life-threatening diseases such as herpes simplex keratitis and herpes simplex encephalitis, with considerable tissue damage resulting from viral replication. The immune response that is activated in response to infection to control viral replication may become exaggerated and contribute to this damage. An overactive inflammatory response could be controlled using immunomodulatory strategies, an ideal target for which may be the multiple pattern recognition receptors that are involved in the innate immune response to HSV, including Toll-like receptors, RIG-I-like receptors, nucleotide oligomerization domain like receptors and cGAS-STING. Here, we summarize the role of the NLRP3 inflammasome in HSV infection and discuss the potential mechanism and therapeutic strategies of targeting the NLRP3 inflammasome for HSV-related diseases.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.