Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-04-17 DOI:10.2217/fvl-2022-0174

Mostafa Salehi-Vaziri, Farzin Sadeghi, H. Haeri, F. Bokharaei-Salim, S. Monavari, F. Hashemi, S. Jalilvand, H. Keyvani

引用次数: 0

Abstract

Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer.

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伊朗妇女宫颈样本中人乳头瘤病毒16型的谱系和亚系

目的：本研究旨在分析人乳头瘤病毒16型（HPV16）的型内变异，并评估这些变异发展为癌症的风险。材料与方法：采用聚合酶链式反应直接测序法对58例女性HPV16变异株进行检测。结果：最常见的谱系是D（67.2%），其次是A（32.8%）。A谱系主要出现在正常（62.5%）和宫颈上皮内瘤样病变-1（CIN-1）（83.3%）中，而D谱系是癌症最常见的变体（100%）。结论：本研究揭示了伊朗HPV16变异的独特模式。根据我们的数据，主要的HPV16谱系是D，并且谱系D变异与宫颈癌症之间存在显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.