登革病毒包膜蛋白Cs-GRP78识别位点的计算机分析

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-05-01 DOI:10.2217/fvl-2022-0192

Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany

{"title":"登革病毒包膜蛋白Cs-GRP78识别位点的计算机分析","authors":"Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany","doi":"10.2217/fvl-2022-0192","DOIUrl":null,"url":null,"abstract":"Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cs-GRP78 recognition site on dengue virus envelope protein: <i>in silico</i> perspective\",\"authors\":\"Abdo A Elfiky, Ahmed Amr, Amira Mosaad, Ahmed K Mubarak, Mohamed A Sayed, Kholoud K El-Halwany\",\"doi\":\"10.2217/fvl-2022-0192\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.\",\"PeriodicalId\":12505,\"journal\":{\"name\":\"Future Virology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Virology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2217/fvl-2022-0192\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Virology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/fvl-2022-0192","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的:了解登革病毒(DENV)包膜与宿主细胞因子GRP78的结合。材料,方法:在本研究中，我们使用结构生物信息学工具模拟DENV包膜与GRP78的结合。结果:DENV包膜C3-C30和C302-C333区域与Pep42环肽序列相似，提示这些区域可能是GRP78的识别位点。C3-C30的大平均疏水性指数与Pep42相似，对GRP78的结合亲和力为负。结论:我们预测DENV包膜的C3-C30区域是GRP78的识别位点。进一步的实验验证对未来的研究很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cs-GRP78 recognition site on dengue virus envelope protein: in silico perspective

Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.