氧化应激在EB病毒生命周期和致瘤性中的作用

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-05-01 DOI:10.2217/fvl-2023-0007

Zixiu Zhao, Wen Liu, B. Luo

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引用次数: 1

摘要

EB病毒是一种致癌病毒，在其生命周期中具有潜伏状态和裂解状态。EBV采用潜伏期作为策略来避免宿主免疫监测并实现终身持续感染。然而，潜伏状态可能被中断，EBV可能重新激活进入裂解复制周期，加剧传播和致病性。EBV生命周期中这两个阶段之间的平衡和过渡是复杂的，活性氧物种发挥着重要作用。我们综述了氧化应激与EB病毒裂解复制之间的关系，以及氧化应激在EB病毒相关肿瘤发展中的作用。需要进一步的研究来探索和开发肿瘤抗氧化疗法。

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Role of oxidative stress in the Epstein–Barr virus lifecycle and tumorigenicity

The Epstein–Barr virus (EBV) is an oncogenic virus with both latent and lytic states during its lifecycle. EBV employs a latency period as a strategy to avoid host immune surveillance and achieve lifelong persistent infection. However, the latent state may be interrupted and EBV may reactivate into a lytic replication cycle, exacerbating transmission and pathogenicity. The balance and transition between these two phases in the EBV lifecycle are complex, and reactive oxygen species play an important role. We reviewed the relationship between oxidative stress and lytic replication of EBV, and the role of oxidative stress in the development of EBV-related tumors. Further research is required to explore and develop tumor antioxidant therapy.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.