Food Science & Nutrition最新文献

{"title":"Nutritional Potential and Protective Effects of Colocassia esculenta Flowers Against 2,4-Dinitrophenyl Hydrazine (DNPH) Induced Anemia Wistar Strain Rats","authors":"Josée Rebecca Nombo,&nbsp;Armel Junior Mbock,&nbsp;Jules Christophe Koule Manz,&nbsp;Tene Stephano Tambo,&nbsp;Misse Jethro Roland Ngangue Ekwalla,&nbsp;Valery Jean François Nsoga,&nbsp;Mathieu Ndomou","doi":"10.1002/fsn3.70419","DOIUrl":"https://doi.org/10.1002/fsn3.70419","url":null,"abstract":"<p>This study aimed to assess the nutritional value and effect of <i>Colocasia esculenta</i> flowers on induced anemia in <i>Wistar</i> rats. Proximate composition and minerals analysis were performed using AOAC standard methods. Twenty-five rats were randomly divided into five groups. Rats in Group 1 were healthy and non-anemic. In Group 2, the rats were anemic and untreated. Anemic rats in Group 3 were given 5 mg/Kg of a reference drug (Apfer) against anemia. Rats in Groups 4 and 5 were anemic and fed with <i>C. esculenta</i> flower powder (5% substitution) harvested in Dschang and Yabassi. Anemia was induced in rats using 2,4-Dinitrophenyl hydrazine. After 23 days of treatment, some hematological and biochemical parameters as well as indicators of oxidative stress were evaluated. The results show that potassium, calcium, and phosphate were the main minerals present in <i>C. esculenta</i> flowers. Concerning proteins (21.29% ± 1.13%) and lipids content (8.99% ± 0.72%), flowers harvested in Dschang were the most nutritive. Calcium was more available in flowers harvested in Dschang. These flowers are the potential sources of carotenoids with around 2201.33 and 2535.04 mg/100 g, harvested in Dschang and Yabassi, respectively. The main metabolites identified were alkaloids, quinones, anthocyanins, triterpenes, and saponins, and this profile was not affected by the locality. <i>C. esculenta</i> flowers significantly (<i>p &lt;</i> 0.05) increased hematocrit, hemoglobin, and red blood cells in Groups 4 and 5 compared to Group 2. Supplementation of <i>C. esculenta</i> flower significantly (<i>p &lt;</i> 0.05) increased lipid profile in Groups 4 and 5 when compared to Groups 2 and 3. Also, the activity of superoxide dismutase (SOD) and catalase (CAT) significantly (<i>p</i> &lt; 0.05) increased in Groups 4 and 5 compared to Groups 2 and 3. Consumption of <i>C. esculenta</i> flowers could therefore help to prevent and fight against hemolytic anemia and oxidative stress.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Food Safety Practices and Microbiological Quality of Street Foods in Marrakech, Morocco","authors":"Morad Kaddouri,&nbsp;Omar Ait El Alia,&nbsp;Yassine Zine-eddine,&nbsp;Ali S. Alqahtani,&nbsp;Mohamed Bouhrim,&nbsp;Aziz Galman,&nbsp;Khalid Boutoial","doi":"10.1002/fsn3.70322","DOIUrl":"https://doi.org/10.1002/fsn3.70322","url":null,"abstract":"<p>This study investigates food safety practices and evaluates the microbiological quality of street foods marketed in Marrakech, Morocco. Data collection involved an observational checklist to systematically assess hygiene practices, environmental conditions, and the operational characteristics of street food vendors. Furthermore, microbiological analyses were conducted on 224 ready-to-eat food samples to determine their compliance with Moroccan food safety standards. The results revealed that 21% of the samples were non-compliant with these standards, with <i>Escherichia coli</i> (28%) and fecal coliforms (40%) identified as the predominant contaminants. Statistical analysis using chi-squared tests demonstrated significant associations between improved food safety practices—such as the use of gloves, hairnets, and appropriate utensil sanitation—and lower levels of microbial contamination. Additionally, environmental factors, particularly the cleanliness of vending sites, exhibited a strong correlation with elevated microbial loads. These findings highlight the pivotal role of hygienic practices and environmental conditions in mitigating foodborne risks. The study underscores the necessity for implementing robust food safety measures and reinforcing regulatory oversight within the street food sector to ensure public health protection.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Rheological, Microstructural, and Textural Properties of Set-Type Yogurts Fermented With Novel Streptococcus thermophilus Strains From Yogurts Produced Mountain Villages of Turkey With Those Produced With Commercial Cultures","authors":"Begüm Denktaş,&nbsp;Hale İnci Öztürk,&nbsp;Talha Demirci,&nbsp;Meryem Kübra Satılmış,&nbsp;Nihat Akın","doi":"10.1002/fsn3.70269","DOIUrl":"https://doi.org/10.1002/fsn3.70269","url":null,"abstract":"<p>In recent years, many consumers prefer artisanal cultures as they provide special characteristic taste and flavor compared to commercial ones. Therefore, it is important to preserve traditional cultures and use them in production to reduce dependence on commercial cultures and to develop consumer-pleasing products. This study aimed to evaluate the technological performance of <i>Streptococcus thermophilus</i> strains isolated from yogurts collected from villages in Konya province, and to assess their suitability for commercial yogurt production. Physicochemical, microbiological, textural, rheological, microstructural, and sensory properties of experimental samples were analyzed for 28 days. During the refrigerated time at 4°C<i>, S</i><i>. thermophilus</i> counts varied between 8.41 and 9.94 log CFU/g. The impact of different <i>S. thermophilus</i> isolates on textural properties was evident, with yogurt samples C, D, and B exhibiting the best performance across all textural parameters. The same situation was observed for microstructure; C, D, and E had the best microstructure images, supported by high water retention capacity and low syneresis degree. B yogurt received the highest general acceptability scores across all storage periods. The results suggested that the strains 10K1, 10K2, and 4K6 could be recommended as potential starter cultures for commercial yogurt production. Novel cultures do not always achieve the flavor and product-specific quality characteristics that consumers like. However, it is very promising that some <i>S. thermophilus</i> strains isolated in this study show better properties than commercial cultures.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Mixed Starter Culture on the Biogenic Amine Accumulation, Volatile Flavor, and Quality of Jinhua Dry-Cured Ham","authors":"Lin Chen,&nbsp;Lu Huang,&nbsp;QingYu Zhang,&nbsp;WuMei Yu","doi":"10.1002/fsn3.70324","DOIUrl":"https://doi.org/10.1002/fsn3.70324","url":null,"abstract":"<p>Jinhua ham is a traditional dry-cured product that favors an indigenous microflora, crucial for sensory characteristics. However, spontaneous fermentation may yield toxins such as biogenic amines. This study evaluates the impact of a mixed starter culture containing <i>Lactiplantibacillus plantarum, Lactilactobacillus sakei,</i> and <i>Staphylococcus xylosus</i> (<i>LLS</i>) on microbial diversity, biogenic amines accumulation, volatile flavor, quality, and sensory attributes of Jinhua dry-cured ham. Microbial profiling revealed that within the <i>LLS</i> starter culture, the <i>Lactobacillaceae</i> and <i>Staphylococcaceae</i> species predominated, with their relative abundances ranging from 15.2% to 42.3% and 3.5% to 35.6% throughout the fermentation process, respectively. The <i>LLS</i>-enriched ham demonstrated marked reductions in biogenic amines such as histamine, putrescine, tyramine, and cadaverine, accompanied by decreases in pH, water activity (<i>a</i>_<i>w</i>), and total volatile basic nitrogen (<i>p</i> &lt; 0.05) compared to the control. Using solid-phase microextraction coupled with gas chromatography–mass spectrometry, 56 volatile flavor compounds were detected in the Jinhua ham. The ham treated with <i>LLS</i> showed an increment of 11 volatile species compared to the control, enhancing the presence of desirable volatiles including 2,6-dimethylpyrazine, 2-ethyl-1-hexanol, and 1-octen-3-ol. These findings suggest that <i>LLS</i> starter cultures may serve as effective agents in Jinhua dry-cured ham production to mitigate BA formation while enhancing sensory properties.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials","authors":"Ali Jafari,&nbsp;Helia Mardani,&nbsp;Zahra Mirzaei Fashtali,&nbsp;Bahareh Arghavan","doi":"10.1002/fsn3.70423","DOIUrl":"https://doi.org/10.1002/fsn3.70423","url":null,"abstract":"<p>This study aimed to assess the impact of <i>Ganoderma lucidum</i> supplementation (200–11,200 mg/day, 1–24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals. A systematic review and meta-analysis were conducted using data from EMBASE, PubMed, Web of Science, and Scopus up to August 2024. Pooled analysis of 17 randomized controlled trials (RCTs) involving 971 participants revealed that <i>Ganoderma lucidum</i> supplementation demonstrated significant reductions in body mass index (BMI) (Weighted Mean Difference [WMD] = −0.43; 95% Confidence Interval [CI]: −0.77, −0.10; <i>p</i> = 0.011), creatinine (WMD = −0.14; 95% CI: −0.27, −0.02; <i>p</i> = 0.028), glutathione peroxidase (GPx) (WMD = 2.29; 95% CI: 1.67, 2.92; <i>p</i> &lt; 0.001), and heart rate (HR) (WMD = −3.92; 95% CI: −7.45, −0.40; <i>p</i> = 0.029). No significant effects were observed on body fat, waist circumference, blood pressure, fasting glucose, lipid profile, inflammatory markers, or liver enzymes. Subgroup analyses indicated effects varied by health condition, dosage, duration, and age. Subgroup analyses revealed variations in the effects of <i>Ganoderma</i> supplementation based on health conditions, dosage, intervention duration, age at intervention, country, sample size, and publication year. Significant improvements were observed in BMI, TC, creatinine, and MDA in specific subgroups, such as those receiving lower doses (&lt; 1400 mg/day) or those aged &lt; 50 years. The GRADE profile for <i>Ganoderma</i> supplementation evaluated the certainty of the outcomes and indicated that the quality of evidence was very low across all outcomes. <i>Ganoderma lucidum</i> supplementation may have modest effects on certain health indices, but the evidence is limited by very low quality.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Quercetin Intake Is Associated With a Lower Risk of Diabetic Nephropathy in US Adults: Data From NHANES 2007–2008, 2009–2010, and 2017–2018","authors":"Fang Liu,&nbsp;Binbin Zhao,&nbsp;Wei Wu,&nbsp;Fang Yang,&nbsp;Ming-gang Deng,&nbsp;Suqing Wang","doi":"10.1002/fsn3.70312","DOIUrl":"https://doi.org/10.1002/fsn3.70312","url":null,"abstract":"<p>The study aimed to investigate the association between dietary quercetin intake and the risk of diabetic nephropathy (DN) among US adults based on data from the National Health and Nutrition Examination Survey (NHANES) 2007–2008, 2009–2010, and 2017–2018. Dietary quercetin intake was estimated as the mean of two 24-h dietary recall surveys. DN was defined as a urine albumin-to-creatinine ratio greater than 30 mg/g in individuals with diabetes. Basic characteristics between DN and non-DN groups were compared using the Rao-Scott <i>χ</i>² test, <i>t</i>-test, and Wilcoxon rank-sum test. After adjusting for confounding factors, the relationship between dietary quercetin intake and the risk of DN was analyzed using weighted logistic regression. The dose–response relationship between dietary quercetin intake and the risk of DN was analyzed using restricted cubic splines (RCS). Among the 2279 diabetic patients in this study, 645 patients (25.20%) had concurrent DN. Weighted logistic regression analysis showed that, after adjusting for confounding factors, each unit increase in log-transformed dietary quercetin intake was associated with a 38.10% reduction in the risk of DN (OR: 0.619; 95% CI: 0.457–0.839). The RCS analysis indicated that, after adjusting for confounding factors, there was a linear negative correlation between dietary quercetin intake and the risk of DN (<i>p</i> for non-linearity = 0.059). When dietary quercetin intake was 22.4–65.2 mg/day, the reduction in DN risk was statistically significant. These findings highlighted the potential protective role of dietary quercetin against DN and underscored the importance of dietary interventions as a modifiable strategy for DN prevention among diabetic patients.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-Dried Instant Juice Powders From Guava, Amla, and Jamun: Evaluation of Physicochemical Properties, Bioactive Compounds, and Consumer Acceptance","authors":"Md. Rafiquzzaman,&nbsp;Md Akram Hossain,&nbsp;Rifat Rafique Dwip,&nbsp;Musfika Jahan,&nbsp;S. M. Kamrul Hasan","doi":"10.1002/fsn3.70374","DOIUrl":"https://doi.org/10.1002/fsn3.70374","url":null,"abstract":"<p>The nutritional enhancement and optimum physical properties in formulating instant fruit juice powder are challenging. This study explored the development and evaluation of freeze-dried instant fruit juice powders from three tropical fruits: Guava (<i>Psidium guajava</i>), Amla (<i>Phyllanthus emblica</i>), and Jamun/black plum (<i>Syzygium cumini</i>), aimed at offering health-promoting benefits and ensuring year-round supply. The freeze-drying method was chosen so that it helps in retaining the nutritional and sensory qualities of the fruits. Consequently, three types of juice powders were developed: Guava Juice Powder (GJP), Amla Juice Powder (AJP), and Jamun Juice Powder (JJP), through the mixing of dried fruit powders with other key ingredients. These juice powders were evaluated for their physical, chemical, and functional characteristics, as well as consumer appeal. The findings revealed that the powders successfully preserved the physical qualities essential for good storage and consumer use. They retained high levels of vitamin C (116.21–176.89 μM), carotenoids (5.09–8.03 μM β-carotene), phenolics (289.56–822.62 mg GAE/100 g), flavonoids (98.21–607.74 mg QE/100 g), and antioxidant activity (43.05–45.90 μM Trolox equivalents), highlighting their potential as functional food ingredients. Sensory evaluations showed high acceptability, particularly for JJP (8.29), with GJP (7.97) and AJP (7.74) also performing well. This research contributes to the functional foods market by offering a novel method for utilizing tropical fruits, thereby expanding consumer options, supporting health, and minimizing fruit waste.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Study of the Combined Effect of Gliding Arc Plasma and Zataria multiflora Essential Oil on Pathogens Inactivation and Quality Changes in Sliced Iranian White Cheese","authors":"Mahdieh Raoofi Asl Soofiani,&nbsp;Negin Noori,&nbsp;Afshin Akhondzadeh Basti,&nbsp;Hassan Gandomi,&nbsp;Hamed Ahari,&nbsp;Mohammadreza Khani","doi":"10.1002/fsn3.70320","DOIUrl":"https://doi.org/10.1002/fsn3.70320","url":null,"abstract":"<p>This study aimed to inactivate <i>Escherichia coli O</i>_<i>111</i>, <i>Listeria monocytogenes</i>, and <i>Aspergillus flavus</i> on sliced Iranian white cheese by using the combination of gliding arc nonthermal plasma (GAP) and <i>Zataria multiflora</i> essential oil (ZEO). The cheese samples were exposed to different levels of GAP (0, 2, and 5 min) and ZEO (0 and 100 ppm) and stored at 4°C for 60 days. The extraction yield of ZEO based on dry weight was 1.66%. Carvacrol (33.85%) was the most important compound in ZEO. During the storage period, <i>E. coli</i> and <i>L. monocytogenes</i> counts increased in all samples. However, the most effective inhibition of <i>E. coli</i> and <i>L. monocytogenes</i> was observed in samples treated with 100 ppm ZEO combined with 2 min of GAP, and 100 ppm ZEO combined with 5 min of GAP, respectively, resulting in increases of only 1.35 and 1.8 log CFU/g over the storage period. In terms of the growth inhibition percentage of <i>A. flavus</i>, the lowest inhibition was detected in the presence of essential oil alone, while the highest inhibitory effect resulted from 5 min of plasma treatment combined with essential oil. GAP treatment also reduced the pH value of the cheese while increasing thiobarbituric acid reactive substances (TBARS). The control sample showed the lowest pH and the highest TBARS during storage. The highest overall acceptance sensory properties score was observed in cheese samples treated with 2 min of GAP and 100 ppm ZEO. According to the results of microbial, chemical, and sensory tests, Iranian white cheese samples treated with 2 min of GAP and 100 ppm ZEO can be used as a novel technique for sterilization and extending the shelf life of white cheese.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Pilose Antler Extract and Hydroxytyrosol Enhances Bone Mineral Density in Both Animals and Postmenopausal Women","authors":"Xichi Ma,&nbsp;Yun Ma,&nbsp;Xilin Ma,&nbsp;Zubing Zhang,&nbsp;Yuan Li","doi":"10.1002/fsn3.70402","DOIUrl":"https://doi.org/10.1002/fsn3.70402","url":null,"abstract":"<p>Osteoporosis, characterized by reduced bone mineral density (BMD) and impaired bone microarchitecture, imposes a significant global health and economic burden, particularly on postmenopausal women. This study investigated the efficacy of a novel supplement that combines pilose antler extract and hydroxytyrosol (Ruiling capsule) in improving bone health in animal and human trials. In an osteoporotic rat model, Ruiling supplementation significantly increased BMD and bone calcium content, particularly at medium doses, surpassing untreated controls and restoring values to levels comparable with non-osteoporotic rats. In a parallel randomized, double-blind, placebo-controlled clinical trial, postmenopausal women who received Ruiling capsules for 32 weeks showed marked improvements in lumbar-spine and femoral-neck BMD, bone turnover markers, antioxidant enzyme activities, and reduced low back pain compared to the placebo group. No adverse effects were observed, suggesting that modulation of oxidative stress may underpin the bone-protective effects. These findings highlight the potential of combining pilose antler extract and hydroxytyrosol to address the multifactorial osteoporosis pathogenesis. The Ruiling capsule represents a safe, non-pharmacological intervention that offers both structural and functional benefits and could contribute to the long-term management of osteoporosis in aging populations.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide GTSFTTTAER From Rapana venosa Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation","authors":"Qifei Wang,&nbsp;Fenghua Xu,&nbsp;Yongna Cao,&nbsp;Bin Li,&nbsp;Shanshan Zhang,&nbsp;Yun Zhang","doi":"10.1002/fsn3.70427","DOIUrl":"https://doi.org/10.1002/fsn3.70427","url":null,"abstract":"<p>Inflammatory bowel disease (IBD) is a refractory chronic intestinal disease caused by immune dysfunction, with an unknown pathogenesis. In this study, the peptide GTSFTTTAER was isolated from <i>Rapana venosa</i> for treatment of IBD for the first time. We examined its protective effects on a zebrafish model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced IBD. The results indicate that the peptide GTSFTTTAER ameliorates intestinal inflammatory injury by reducing the number of immune cells at the intestinal site and increasing the frequency of intestinal peristalsis. Besides, in order to predict and verify the potential mechanism of the anti-inflammatory effects of peptide GTSFTTTAER, we performed transcriptome and reverse transcription-quantitative polymerase chain reaction analysis. The transcriptome analysis revealed that the key pathways for the potential protective effects of GTSFTTTAER were the Toll-like receptor signaling pathway and the necroptosis pathway. Lastly, molecular docking technology further confirmed the action target of peptide GTSFTTTAER. In conclusion, GTSFTTTAER has a beneficial effect on IBD in TNBS-induced zebrafish. Our study will provide a valuable reference for the utilization of peptide GTSFTTTAER from <i>Rapana venosa</i>, and it may also be helpful in developing therapeutic agents for IBD.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}