Food Science & Nutrition最新文献

{"title":"Date yogurt supplemented with Lactobacillus rhamnosus (ATCC 53103) encapsulated in wild sage (Salvia macrosiphon) mucilage and sodium alginate by extrusion: The survival and viability against the gastrointestinal condition, cold storage, heat, and salt with low pH","authors":"Mahsa Abbasi Saadi,&nbsp;Seyed Saeed Sekhavatizadeh,&nbsp;Hassan Barzegar,&nbsp;Behrooz Alizadeh Behbahani,&nbsp;Mohammad Amin Mehrnia","doi":"10.1002/fsn3.4304","DOIUrl":"10.1002/fsn3.4304","url":null,"abstract":"<p>The efficacy of probiotics in providing health benefits may be related to their ability to survive at a sufficient concentration of 10⁶ CFU/g during storage in food and colonization in the gastrointestinal tract. Microencapsulation is a viable method to improve the survivability of probiotics under harsh environmental conditions. In this research, microencapsulated <i>Lactobacillus rhamnosus</i> (MLR) was produced by a two-layer extrusion technique with sodium alginate and wild sage (<i>Salvia macrosiphon</i>) mucilage (SMM) in varying concentrations ranging from 0.2% to 0.8% as the first and second wall materials, respectively. The microencapsulation efficiency and second layer diameter of beads increased significantly with the increase in SMM concentrations. Microencapsulated <i>Lactobacillus rhamnosus</i> (LR) maintained its minimal concentration (6 log CFU/g) during 9 min at 72°C. The MLR-date yogurt (DY) sample had the lowest pH, highest acidity, and highest survival rate among the others at the end of storage. In simulated gastrointestinal conditions (SGC), the survival rates of free LR (FLR) and MLR were 45% and 47% on the 14th day of storage, respectively. In sensory properties, MLR had the highest score in odor and texture parameters but not in others. The MLR viscosity (666.3 mPa·s⁻¹) and SEM images show a relatively denser structure for MLR. In conclusion, this study emphasized the potential of using double-layered beads to protect probiotics, providing valuable inspiration for developing new functional foods with higher survival ability in harsh conditions.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights on the microbiology of Ethiopian fermented milk products: A review","authors":"Tiruha H. Karssa,&nbsp;Jamal B. Kussaga,&nbsp;Teresa Semedo-Lemsaddek,&nbsp;Jovin K. Mugula","doi":"10.1002/fsn3.4372","DOIUrl":"10.1002/fsn3.4372","url":null,"abstract":"<p>Fermented milk products play a vital role in the diets of Ethiopians. They are produced from either spontaneous fermentation or back-slopping methods at the household level, in which lactic acid bacteria (LAB) and yeasts predominate. As a result, the processing steps are not standardized and overall safety is still of public health relevance. Therefore, quality and safety improvement, standardization of traditional manufacturing practices, and commercialization of products to a wider market are important. Hence, this systematic review aimed to provide a comprehensive overview of the microbiology of traditional Ethiopian fermented milk products, including <i>ergo</i> (spontaneously fermented whole milk), <i>dhanaan</i> (fermented camel milk), <i>ititu</i> (concentrated sour milk or spontaneously fermented milk curd), <i>ayib</i> (traditional cottage cheese), <i>qibe</i> (traditional butter), <i>arrera</i> (defatted buttermilk), and <i>hazo</i> (spiced fermented buttermilk). We followed the Preferred Reporting Items for Systematic Reviews and searched relevant databases and search engines, including the Web of Science, Google Scholar, Scopus, PubMed, ScienceDirect, and ResearchGate. Furthermore, the pertinent literature was checked individually and identified. Dairy fermentation provides shelf-life extension and improves the organoleptic quality of products. Nonetheless, the aforementioned Ethiopian fermented foods may be contaminated with <i>Escherichia coli</i> 0157: H7, <i>Listeria monocytogenes</i>, <i>Salmonella</i> spp., or <i>Staphylococcus aureus</i> due to inadequate processing and handling practices. This systematic review also revealed that these traditional milk products lack consistent quality and safety due to poor hygienic preparation techniques, non-controlled fermentation, and limited knowledge or awareness of small-holder dairy farmers. Therefore, the use of suitable procedures including good hygienic practices and controlled fermentation is recommended.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-blind, randomized control trial to investigate the therapeutic potential of garlic scapes for high apoprotein E levels in a high-Fat diet-induced hypercholesteremic rat model","authors":"Nizwa Itrat,&nbsp;Mahr un Nisa,&nbsp;Fahad Al-Asmari,&nbsp;Mohamed Fawzy Ramadan,&nbsp;Eliasse Zongo","doi":"10.1002/fsn3.4331","DOIUrl":"10.1002/fsn3.4331","url":null,"abstract":"<p>Hypercholesteremia is the main contributor to metabolic diseases, including obesity, hypertension, and diabetes, which are the primary global sources of morbidity and death rates. Garlic scapes, a member of the <i>Allium sativum</i> family and a rich source of antioxidants, are utilized in various cuisine preparations due to their unique flavors and tastes. The current study examined garlic scape powder's effect on apoprotein E and its ability to decrease cholesterol. In an in vivo experiment, normal, healthy Wistar albino rats (weeks) were divided into a negative control group (NC, <i>n</i> = 10) and a high-fat diet-raised group (<i>n</i> = 50) until they achieved cholesterol ≥250 mg/dL. Hypercholesteremic rats were further divided randomly into five groups: positive control (PC), standard group (fenofibrate 20 mg/kg bwt), and treatment groups G1, G2, and G3 that were administered with garlic scape powder 400 mg, 800 mg, and 1200 mg/kg bwt orally, respectively, for 3 months. The blood samples were examined for cholesterol, triglycerides, high-density lipoproteins (HDLs), low-density lipoproteins, apoprotein E, albumin levels, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The liver tissues of the rats were subjected to histopathology. The lipid profile was assessed using serum kit techniques, whereas an ELISA kit was used to evaluate apoprotein E, and a serum kit was used to estimate ALT and AST. In comparison to all other groups except NC, the highest dose of 1200 mg/kg bwt of garlic scapes significantly (<i>p</i> ≤ .05) increased serum insulin (13.66 ± 0.72 μU/mL), apoprotein E levels (6.08 ± 0.10 mg/dL), HDL (42.1 ± 1.81 mg/dL), and reduce TG (88.7 ± 1.64 mg/dL) and decreased overall cholesterol levels (67.9 ± 1.17 mg/dL). Except for NC, all treatment groups had significantly (<i>p</i> ≤ .05) lower ALT and AST values than PC. To sum up, powdered garlic scapes may be a great way to avoid hyperlipidemia, which raises the risk of cardiovascular illnesses. ALT and AST levels were significantly (<i>p</i> ≤ .05) reduced in all treatment groups compared to PC, except for NC. In conclusion, garlic scape powder may be an excellent source to prevent hyperlipidemia, a risk factor for cardiovascular diseases. In addition, powdered garlic scapes supplementation at high doses may be used as an alternative natural source in functional foods to halt hyperlipidemia without liver toxicity in the long term.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141868995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the protective effect of Aronia melanocarpa extract on type 2 diabetes by regulating glucose and lipid metabolism through intestinal flora","authors":"Dan Song,&nbsp;Cheng Fang","doi":"10.1002/fsn3.4378","DOIUrl":"10.1002/fsn3.4378","url":null,"abstract":"<p><i>Aronia melanocarpa</i>, a plant rich in anthocyanins, has been studied for its potential to regulate blood sugar and blood lipids, although the specific mechanism is not yet understood. This research aims to identify the differential bacterial flora and elucidate the mechanism by which it improves glucose and lipid metabolism disorders through 16S rDNA gene sequencing. The study reveals the protective effect of <i>Aronia melanocarpa</i> extract (AME) on liver damage in type 2 diabetic rats. Experimental results demonstrate that AME can effectively modulate the abundance of intestinal flora, reduce colon tissue damage, enhance the weight of diabetic rats, and lower levels of fasting blood sugar, low-density lipoprotein (LDL), and triglycerides (TG). Additionally, liver morphology analysis shows that AME can effectively mitigate liver tissue structural damage in type 2 diabetic rats. In conclusion, AME regulates glucose and lipid metabolism by influencing intestinal flora, ultimately regulating glucose and lipid metabolism in type 2 diabetic rats.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141869156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and chemical properties and sensory evaluation of camel meat and new camel meat jerky","authors":"Jindi Wu,&nbsp;Xige He,&nbsp;Xueyan Yun,&nbsp;Mei Qi,&nbsp;Buren Menghe,&nbsp;Lu Chen,&nbsp;Yunfei Han,&nbsp;Yajuan Huang,&nbsp;Mingxu Wang,&nbsp;Rina Sha,&nbsp;Gerelt Borjigin","doi":"10.1002/fsn3.4310","DOIUrl":"10.1002/fsn3.4310","url":null,"abstract":"<p>Alxa Bactrian camel meat is an organic diet that provides balanced nutrition and is easy to digest and absorb. Despite its potential, it is currently underutilized. To develop a new type of camel jerky, this study utilized a single-factor design method to optimize the formula and fermentation process parameters of Alxa Bactrian camel jerky. Additionally, the physical and chemical composition, nutritional components, protein degradation, and microbial changes of the camel jerky were analyzed to evaluate the nutritional benefits of the new camel jerky created using modern fermentation technology. The results show that the optimal addition amounts of camel fermented jerky ingredients are 2.2% black pepper, 3% salt, 1.8% white sugar, and 9% cooking wine, whereas the optimal fermentation conditions by compound starter culture are 0.07% starter, 23 h of fermentation time, and a 30°C fermentation temperature. Compared to the single starter, the compound starter significantly increased the protein content, total amino acids, unsaturated fatty acids, trace elements, and <i>a</i>*, <i>L</i>*, and <i>e</i>-values of jerky; however, it also decreased the water activity (<i>a</i>_w), thiobarbituric acid, and pH values of jerky during storage. Compound starter strains can compensate for the shortage of single starters and improve the overall quality of meat products. These findings could provide new insights and serve as a reference for the development of camel meat products and hold significant importance for the growth of the camel industry.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects","authors":"Simona Sestito,&nbsp;Roberta Ibba,&nbsp;Federico Riu,&nbsp;Sara Carpi,&nbsp;Antonio Carta,&nbsp;Clementina Manera,&nbsp;Solomon Habtemariam,&nbsp;Balakyz Yeskaliyeva,&nbsp;Zainab M. Almarhoon,&nbsp;Javad Sharifi-Rad,&nbsp;Simona Rapposelli","doi":"10.1002/fsn3.4376","DOIUrl":"10.1002/fsn3.4376","url":null,"abstract":"<p>Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. <i>Angelica gigas</i> Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots – decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product-based drug discovery. This concise overview provides valuable insights into the potential of AGN-derived compounds in the field of natural product-based therapeutics.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The toxic effects of Helicobacter pylori and benzo(a)pyrene in inducing atrophic gastritis and gut microbiota dysbiosis in Mongolian gerbils","authors":"Yilun Huang,&nbsp;Yunxiang Chen,&nbsp;Lingfei Ma,&nbsp;Honggang Guo,&nbsp;Hao Chen,&nbsp;Bo Qiu,&nbsp;Mingfei Yao,&nbsp;Weixin Huang,&nbsp;Lian Zhu","doi":"10.1002/fsn3.4368","DOIUrl":"10.1002/fsn3.4368","url":null,"abstract":"<p>Food chemical and microbiological contamination are major global food safety issues. This study investigated the combined effects of the food-borne pathogen <i>Helicobacter pylori</i> (<i>H. pylori</i>) and the pollutant benzo(a)pyrene (Bap) on atrophic gastritis and gut microbiota in Mongolian gerbils. The results demonstrated that simultaneous administration of <i>H. pylori</i> and Bap caused more severe weight loss, DNA damage, and gastritis in Mongolian gerbils compared with those exposed to <i>H. pylori</i> or Bap alone. The combination also significantly increased the serum level of proinflammatory cytokines, including IL-1β (<i>p</i> &lt; .05), IL-6 (<i>p</i> &lt; .0001), and TNF-α (<i>p</i> &lt; .05). Additionally, the <i>H. pylori</i> and Bap combination altered the composition of gut microbiota in Mongolian gerbils: the relative abundance of <i>Lactobacillus</i> and <i>Ligilactobacillus</i> at the genus level (<i>p</i> &lt; .05) was significantly reduced while the relative abundance of <i>Allobaculum</i> and <i>Erysipelotrichaceae</i> enhanced (<i>p</i> &lt; .0001, <i>p</i> &lt; .05). Our study revealed that the synergy of <i>H. pylori</i> and Bap can boost the development of atrophic gastritis and lead to gut microbiota dysbiosis in Mongolian gerbils, which provides essential implications for preventing contaminated foods to sustain life and promote well-being.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141869047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunomodulator effect of Stevia rebaudiana Bertoni mediated by TNF-α and IL-1β in peripheral blood in diabetic rats","authors":"Erhan Cebeci,&nbsp;Ertan Katirci,&nbsp;Mustafa Karhan,&nbsp;Emin Turkay Korgun","doi":"10.1002/fsn3.4371","DOIUrl":"10.1002/fsn3.4371","url":null,"abstract":"<p><i>Stevia rebaudiana</i> Bertoni, which is a medicinal plant used in the treatment of diabetes, was the focus of this study aiming to investigate its immunomodulatory properties in diabetes. To form the diabetes group, rats were injected intraperitoneally with STZ and rats with blood glucose levels above 200 mg/dL 2 days after STZ injection were included in the diabetes group. To form the stevia and diabetes + stevia groups, stevia was administered daily by gavage to both healthy and diabetic rats for 28 days. At the end of 28 days, the levels of interleukin-1 beta and tumor necrosis factor-alpha in the blood were measured by ELISA. CD3, CD4, and CD8 protein levels in the blood were determined by flow cytometry. Rat body weight increased in the diabetes +25 mg/kg bW stevia group compared with the diabetes group. Blood glucose levels were significantly decreased in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**<i>p</i> &lt; .01). IL-1β cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**<i>p</i> &lt; .01). TNF-α cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**<i>p</i> &lt; .01). The amount of CD8 + T cells decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (*<i>p</i> &lt; .05). The stevia diet leads to a reduction in peripheral circulating cytotoxic T cells and proinflammatory cytokines interleukin-1 beta and tumor necrosis factor-alpha under hyperglycemic conditions.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141868997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-dyslipidemic effects of Pueraria lobata root and Glycine max (L.) Merrill extracts fermented with Lactiplantibacillus plantarum in ovariectomized mice","authors":"Hyo-Min Jang,&nbsp;Jimyeong Ha,&nbsp;Insuk Choi","doi":"10.1002/fsn3.4356","DOIUrl":"10.1002/fsn3.4356","url":null,"abstract":"<p><i>Pueraria lobata</i> root and <i>Glycine max</i> (<i>L.</i>) Merrill are rich in phytoestrogens. However, these bioactive ingredients have limited bioavailability due to their high molecular weight. In this study, we extracted two natural products and fermented with <i>Lactiplantibacillus plantarum</i> before mixing the fermented extracts (FPE-FGE). To understand whether FPE-FGE could alleviate menopause with dyslipidemia, we examined their effects on ovariectomy (OVX)-induced dyslipidemia in mice. Oral administration of the FPE-FGE (1:9, 3:7, and 9:1) did not affect safety-related biomarkers, such as uterus index (%), vagina index (%), aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine. Furthermore, FPE-FGE (1:9, 3:7, and 9:1) increased the levels of 17β-estradiol (E2) and expression of uterus estrogen receptor β (ERβ); there was little effect on the expression of uterus estrogen receptor α (ERα), and reduced the levels of gonadotropins, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, only the FPE-FGE (3:7) reduced the levels of blood lipids, including total cholesterol (TC) and LDL-cholesterol (LDL-C). Accordingly, FPE-FGE (3:7) upregulated endothelial nitric oxide synthase (eNOS), nitric oxide (NO), cyclic guanosine monophosphate (cGMP), and protein kinase G (PKG). In conclusion, FPE-FGE (3:7) attenuated the menopausal dyslipidemia by upregulating eNOS-NO-cGMP signaling pathway.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141869042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the anti-inflammatory and anti-glycemic properties of Royal Jelly and Tocotrienol-rich fraction in an experimental study: Does irisin mediate these effects?","authors":"Naimeh Mesri Alamdari,&nbsp;Pardis Irandoost,&nbsp;Neda Roshanravan,&nbsp;Farzad Najafipour,&nbsp;Mohammadreza Vafa,&nbsp;Farnaz Farsi,&nbsp;Majid Mobasseri,&nbsp;Amir Ali Mir Mazhari,&nbsp;Halimeh AmirAzad,&nbsp;Farzad Shidfar","doi":"10.1002/fsn3.4321","DOIUrl":"10.1002/fsn3.4321","url":null,"abstract":"<p>Irisin, a novel adipomyokine, has been proposed to be a therapeutic agent against obesity-related metabolic disease. Royal Jelly (RJ) and tocotrienol-rich fraction (TRF) are suggested to promote obesity and its related problems through potential mutual mechanistic pathways. This investigation intended to evaluate the glycemic and inflammation-promoting effects of RJ, TRF, and their combinations to evaluate their synergic effects through irisin action in obese rats induced by a high-fat diet (HFD) that underwent a calorie restriction diet (CRD). Fifty HFD-fed obese rats received the following interventions: RJ, TRF, or RJ + TRF in combination with a CRD for eight consecutive weeks. After the investigation, body weight, fasting blood sugar (FBS), irisin, insulin, C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), leptin, adiponectin, and insulin resistance (IR) were assessed. After 8 weeks of treatment, significant weight reduction was noticed in rats that received RJ and RJ + TRF related to the CRD rats (<i>p</i> &lt; .001), although this reduction was not considerable in TRF-treated rats. RJ and RJ + TRF supplementation markedly elevated irisin concentrations in CRD rats (<i>p</i> &lt; .05), but TRF did not. Glycemic indices, inflammatory indices including IL-1β and CRP levels, and leptin concentrations were significantly decreased after RJ, TRF, and their combinations were added to CRD (<i>p</i> &lt; .05). According to the mediational analysis results, irisin mediated the promoting effects of RJ on glycemic hemostasis. Based on the results of this investigation, RJ and TRF are novel nutrients that have the potential to improve obesity-related disorders. This research suggests that RJ exerts its beneficial glycemic regulatory effects through irisin.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}