Food Science & Nutrition最新文献

{"title":"Antioxidant and Preservative Effects of Epilobium angustifolium Extract in Beef Burgers Products: Physicochemical Properties, Color Stability, Lipid Oxidation, and Molecular Docking Analyses","authors":"Nazik Meziyet Dilek,&nbsp;Abidin Gümrükçüoğlu,&nbsp;Gamze Demirel,&nbsp;Alper Durmaz,&nbsp;Emine Incilay Torunoğlu,&nbsp;Erdi Can Aytar,&nbsp;Kübra Ünal","doi":"10.1002/fsn3.70125","DOIUrl":"https://doi.org/10.1002/fsn3.70125","url":null,"abstract":"<p>Consumers are increasingly seeking natural alternatives to synthetic preservatives in meat products. This study evaluated the effects of willow <i>E. angustifolium</i> extract on beef burgers' physicochemical properties, color stability, and lipid oxidation during refrigerated storage. The extract demonstrated significant antioxidant activity, with a total phenolic content of 1263.48 mg GAE/L and a total flavonoid content of 278.43 mg <span>CE</span>/L. The pH values of the beef burgers decreased over time, with significant effects on Days 4 and 8 in the treated groups, except T1. The color properties, including lightness (<i>L</i>*), redness (<i>a</i>*), and yellowness (<i>b</i>*), were affected by the plant extract, with 1 g and 3 g concentrations leading to darker and redder hues. Moreover, adding 9 g extract led to discoloration due to increased <i>b</i>* values. Thiobarbituric acid-reactive substances analysis showed increased lipid oxidation, with the T3 group (9 g extract) exhibiting higher values, suggesting a prooxidant effect at higher concentrations. Gas chromatography–mass spectrometry analysis identified a range of phytochemicals, including α-pinene and β-thujone, which contributed to the complex, volatile profile of the extract. High-performance liquid chromatography analysis revealed the presence of significant phenolic compounds, such as ascorbic acid and gallic acid, with high antioxidant potential. Molecular docking studies indicated that gallic acid exhibited a moderate binding affinity with the target protein 9R-lipoxygenase (5EK8), followed by β-thujone and α-pinene, suggesting their potential as bioactive compounds in food preservation. The results provide insights into the functional potential of <i>E. angustifolium</i> extract as a natural antioxidant and preservative in meat products.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oleifera Extracts as Strategic Phyto-Therapy for Alzheimer's Disease","authors":"Rita Carrotta,&nbsp;Silvia Vilasi,&nbsp;Maria Assunta Costa,&nbsp;Fabio Librizzi,&nbsp;Vincenzo Martorana,&nbsp;Rosa Passantino,&nbsp;Carla Buzzanca,&nbsp;Vita di Stefano,&nbsp;Maria Grazia Ortore,&nbsp;Silvia Piccirillo,&nbsp;Alessandra Preziuso,&nbsp;Simona Magi,&nbsp;Maria Rosalia Mangione","doi":"10.1002/fsn3.70007","DOIUrl":"https://doi.org/10.1002/fsn3.70007","url":null,"abstract":"<p>In the last decades, plant extracts have received great attention. In particular, many studies pointed out the potential neuroprotective effect of polyphenols-rich extracts from plants. Evidence indeed highlights the action of polyphenols, both as antioxidants and as inhibitors in the formation of amyloid protein aggregates, known to be involved in neurodegenerative diseases. In this work, aqueous extracts obtained at high and room temperature from leaves of <i>Moringa oleifera</i> (MO) harvested in Sicily were characterized for polyphenolic content, anti-oxidative and free radical scavenging capacity. UHPLC-HESI-MS analysis shows that both water extracts are rich in terms of polyphenols. Then, MO aqueous extracts were tested as inhibitors in the amyloid aggregation process of Amyloid β-peptide 1–42 (Aβ_1-42). This peptide is strongly involved in Alzheimer's disease (AD), its overproduction and aggregated species being considered a hallmark of AD. Results show that MO extracts cause a strong inhibition on the amyloid process. Biophysical characterization of the extracts reveals the presence of stable polyphenol assemblies. Both free and aggregated polyphenols elicit an efficient inhibition mechanism held up by their ability to interact with metastable species, strongly hindering autocatalytic amyloid growth. Finally, the effects of the MO room temperature extract have been tested on an AD cell model, retinoic acid-differentiated SH-SY5Y cells challenged with glyceraldehyde (GA). Cell pretreatment with MO extract results in an improved cell viability in comparison with the control and furthermore in the reduction of both mitochondrial reactive oxygen species and GA-stimulated Aβ_1-42 production.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF-κB/MAPKs Signaling Pathway","authors":"Shizhan Deng,&nbsp;Dequan Zhong,&nbsp;Yonggan Dong,&nbsp;Yanan Qian,&nbsp;Biao Wang,&nbsp;Mengxue Hu,&nbsp;Meng Liu,&nbsp;Kemeng Tan,&nbsp;Chaojie Zhang,&nbsp;Heng Tang","doi":"10.1002/fsn3.70123","DOIUrl":"https://doi.org/10.1002/fsn3.70123","url":null,"abstract":"<p><i>Ganoderma lucidum</i> (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly in alleviating respiratory issues like cough and asthma. Recognized both as a therapeutic agent and an edible supplement, Lingzhi is celebrated for its health-promoting benefits. Despite its widespread use, the effectiveness of <i>G. lucidum</i> in treating pneumonia has not been extensively studied, highlighting the need for further research. This research aimed to evaluate the potential of <i>G. lucidum</i> in pneumonia treatment and to uncover the mechanisms behind its effects, specifically examining how its active constituents influence inflammatory pathways. The study utilized approaches such as network pharmacology, bioinformatics, molecular docking, and in vivo experiments. High-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC–MS) analyses revealed eight triterpenoids in <i>G. lucidum</i>, with ganodermanontriol being the most prominent. Molecular docking studies anticipated the interactions between these compounds and target proteins, while in vivo experiments on pneumonia-induced rat models assessed the efficacy of ganodermanontriol. Additionally, HPLC and LC–MS confirmed the presence of eight triterpenoids in the ethanol extract of <i>G. lucidum</i>, predominantly ganodermanontriol. Network pharmacology and molecular docking identified key genes—including TNF, EGFR, ESR1, HIF1A, HSP90AA1, and SRC—that played significant roles in the regulation of inflammatory pathways. In vivo results demonstrated that ganodermanontriol treatment mitigated lung tissue damage in rats with experimentally induced pneumonia by reducing the release of inflammatory mediators. Further mechanistic studies showed that ganodermanontriol downregulated TNF-α and inhibited the NF-κB/MAPKs signaling pathways. These findings suggested that ganodermanontriol holds promising potential as an anti-inflammatory agent for pneumonia by targeting the TNF/NF-κB/MAPKs signaling pathway, offering a novel therapeutic approach.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Potential and Bioactive Components of Wild Anatolian Sage (Salvia aethiopis L.)","authors":"Emine Bilginoğlu,&nbsp;Hamit Emre Kızıl,&nbsp;Hatice Öğütcü,&nbsp;Güleray Ağar,&nbsp;Yavuz Bağcı","doi":"10.1002/fsn3.70118","DOIUrl":"https://doi.org/10.1002/fsn3.70118","url":null,"abstract":"<p><i>Salvia aethiopis</i> L., a member of the Lamiaceae family, has gained attention due to its bioactive compounds with potential therapeutic applications. This study investigated the chemical composition and biological activities of <i>S. aethiopis</i> ethanol extract collected from Karaman province, Türkiye. The phenolic profile of the plant was characterized using LC–MS/MS analysis, which revealed substantial amounts of rosmarinic acid, ferulic acid, caffeic acid, and p-coumaric acid. The antimicrobial activity of the extracts was evaluated against various Gram-positive and Gram-negative bacteria, as well as fungal strains, using the agar well diffusion method. The results demonstrated potent antibacterial effects, particularly against <i>Staphylococcus aureus</i>, <i>Micrococcus luteus</i>, and <i>Klebsiella pneumoniae</i>. Furthermore, the cytotoxic potential of <i>S. aethiopis</i> was assessed on H-460 non-small cell lung cancer cells. The extract exhibited a dose-dependent cytotoxic effect, with a significant reduction in cell viability after 24 and 48 h of treatment, yielding IC₅₀ values of 80.08 and 56.19 μg/mL, respectively. These findings suggest that <i>S. aethiopis</i> possesses promising antimicrobial and anticancer properties, which could contribute to the development of novel therapeutic agents.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Thyme, Cumin, and Sumac Extracts on Apoptosis and Paraptosis in Hepatocellular Carcinoma: Synergistic, Antagonistic, or Additive Properties","authors":"Yagmur Yasar Firat,&nbsp;Betul Cicek,&nbsp;Ayca Kara,&nbsp;Nurefsan Konyaligil Ozturk,&nbsp;Selen Ilgun","doi":"10.1002/fsn3.70106","DOIUrl":"https://doi.org/10.1002/fsn3.70106","url":null,"abstract":"<p>This study evaluated the effect of single, double, and triple combined doses of sumac, thyme, and cumin extracts on apoptosis and paraptosis in the HepG2 cell line. The effect of thyme and cumin extracts was higher in proteins (mTOR, caspase-8, caspase-9, Bax and bcl-2) other than caspase-3 protein. The expression of caspase-3 protein was higher in the sumac extract-treated groups. The expression levels of GRP78/Bip and DDIT3/Chop proteins, which are indicators of paraptosis, did not exert a significant difference between the extracts. Even though their protein expression is different, according to MTT results, sumac and thyme extracts showed an additive effect, thyme and cumin extracts showed an antagonistic effect, sumac and cumin extracts showed a synergistic effect, and sumac, thyme, and cumin extracts showed a synergistic effect. Sumac, thyme, and cumin extracts induced cell death by causing apoptosis in HepG2 cells, and they may have a supportive impact on the treatment of hepatocellular carcinoma.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Process Optimization of Fluidized Bed Drying for Water Spinach: Evaluating the Effect of Blanching Through RSM and ANN Models","authors":"Mir Tuhin Billah,&nbsp;Noor E Zannat,&nbsp;Md Akram Hossain,&nbsp;Ishmam Haque Sachcha,&nbsp;Sabina Yasmin,&nbsp;Md. Sazzat Hossain Sarker","doi":"10.1002/fsn3.70114","DOIUrl":"https://doi.org/10.1002/fsn3.70114","url":null,"abstract":"<p>The quality of the dried leafy vegetables, such as water spinach (<i>Ipomoea aquatica</i>), has been found to be significantly affected by the drying process in terms of moisture content and retention of important nutrients, namely vitamin C and β-carotene. There is great potential for fluidized bed drying to be applied for leafy vegetables in optimizing process parameters for maximum nutrient retention since it has not been researched. This work investigated the effect of temperature, drying time, and bed thickness on the nutritional quality of blanched and unblanched water spinach samples. In the present study, the fluidized bed drying process has been designed and optimized using a Central Composite Design (CCD) and Response Surface Methodology (RSM). For this study, both RSM and artificial neural network (ANN) predictive models are developed for further comparison. Using a multiobjective desirability function, the best-optimized response was given from the experimental model for the responses of moisture content, vitamin C, and β-carotene retention. Appropriate statistical metrics are applied, for example, AARD (Absolute Average Relative Deviation), MRD (Mean Relative Deviation), MSE (Mean Squared Error), and <i>R</i>² (Coefficient of Determination), which helped in model comparison during the study. It was observed from the experiment that all the response variables are significantly affected by drying temperature, time, and bed thickness. Variation of bed thickness in the blanched samples affected &gt; 16% in moisture content attainment compared to unblanched samples, and vitamin C content exhibited a variation of more than 25% due to changes in bed thickness for blanched samples on the contrary. RSM has shown a better performance than ANN in its precision and prediction power. The optimized drying conditions came out to be 60°C as the drying temperature, 7.19 min as the drying time, and 5.12 cm as the bed thickness, which resulted in 2.95% of moisture content, 5.99 mg/100 g vitamin C, and 139.16 μg/g of β-carotene. The close alignment between predicted and experimental values confirms the suitability of the optimized conditions for industrial-scale drying of leafy vegetables.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Phenolic Signature of Psidium cattleianum Fruits and Leaves Modulates TRPV1 and TRPA1 Transient Receptor Potential Channels: A Metabolomics, In Vitro, and In Silico Study","authors":"Leilei Zhang,&nbsp;Fabio Arturo Iannotti,&nbsp;Fatema R. Saber,&nbsp;Reem K. Arafa,&nbsp;Aniello Schiano Moriello,&nbsp;Rasha A. Rasle,&nbsp;Anton Soria-Lopez,&nbsp;Sara G. Abd EL-Gawwad,&nbsp;Gabriele Rocchetti,&nbsp;Paz Otero,&nbsp;Łukasz Kulinowski,&nbsp;Krystyna Skalicka-Woźniak,&nbsp;Luigi Lucini,&nbsp;Jesus Simal-Gandara","doi":"10.1002/fsn3.70075","DOIUrl":"https://doi.org/10.1002/fsn3.70075","url":null,"abstract":"<p>Although <i>Psidium cattleianum</i> (strawberry guava, Myrtaceae) is known for its anti-inflammatory, antioxidant, antimicrobial, and antidiabetic properties, its phytochemical profile and associated bioactivities remain largely underexplored. This study employed UHPLC-QTOF-HRMS for untargeted phenolic profiling of leaf and fruit extracts from <i>P. cattleianum</i>, followed by semi-quantification of phenolic subclasses and multivariate data analysis. Four hundred sixty-nine metabolites, including various phenolic subclasses—predominantly flavonoids and phenolic acids were— identified and annotated. Using HEK-293 cells stably transfected with TRPA1 or TRPV1 cation channels, it was found that both leaf and fruit extracts activate and rapidly desensitize TRPA1 in a concentration-dependent manner (EC₅₀ 18 and 30 μg/mL; IC₅₀ 60 and 47 μg/mL, respectively). Additionally, molecular docking analysis provided deeper insights into the interactions between <i>P. cattleianum</i> phytochemicals and the TRPA1 cation channel, identifying theaflavin 3,3'-<i>O</i>-digallate as the phenolic compound with the highest affinity (S score of −9.27 Kcal/mol). Interestingly, except for theaflavin 3,3'-<i>O</i>-digallate, compounds enriched in the leaf extract exhibited weaker binding interactions and lower S scores (approximately −7 Kcal/mol) compared to those enriched in the fruit extract. Also, a 100 ns molecular dynamics study of theaflavin 3,3'-<i>O</i>-digallate with TRAP1 demonstrated high binding stability of the complex. Overall, this study offers valuable insights into the phytochemical characteristics of <i>P. cattleianum</i> extracts and reveals their mechanism of action through affinity for the TRPA1 cation channel-receptors.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Extraction Techniques on the Bioactive Characteristics of Dill (Anethum graveolens) Essential Oil","authors":"Ambreen Fatima,&nbsp;Muhammad Adnan Ayub,&nbsp;Nasrin Choobkar,&nbsp;Muhammad Zubair,&nbsp;Kim D. Thomspon,&nbsp;Amjad Hussain","doi":"10.1002/fsn3.70089","DOIUrl":"https://doi.org/10.1002/fsn3.70089","url":null,"abstract":"<p>This study explores the extraction of <i>Anethum graveolens</i> essential oil (EO) using advanced techniques, including Superheated Steam Extraction (SHSE), and compares them with traditional methods such as Hydro Distillation (HD), Steam Distillation (SD), and Supercritical Carbon Dioxide Extraction (SCF-CO₂). The novelty of this research lies in the comprehensive evaluation of SHSE, a relatively underexplored method, for its effectiveness in enhancing both yield and biological activities of the EO. This study provides a detailed comparative analysis of antioxidant and antimicrobial properties across different extraction methods. The SHSE method yielded essential oil with the highest antioxidant activity, including DPPH scavenging (87.48%) and total antioxidant capacity (measured by FRAP, 163.06 mg/L), outperforming traditional methods. The EO's high content of key components such as carvone, limonene, and dillapiole significantly contributes to its enhanced biological activities. These findings underscore the superior efficacy of SHSE in extracting essential oils, offering new insights into their potential applications in health and wellness, which set this study apart from previous work.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inulin Protects Caco-2 Cells Against Lipopolysaccharide-Induced Epithelial Barrier Dysfunction","authors":"A. Georgetta Skinner,&nbsp;Abdul Malik,&nbsp;M. Rizwan Siddiqui,&nbsp;Vineet Singh,&nbsp;Suhail Akhtar","doi":"10.1002/fsn3.70046","DOIUrl":"https://doi.org/10.1002/fsn3.70046","url":null,"abstract":"<p>Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, triggers inflammatory responses in intestinal epithelial cells. This activation leads to the production of pro-inflammatory cytokines which disrupt cellular homeostasis. LPS also impairs the integrity of the intestinal epithelial barrier by downregulating tight junction proteins, resulting in increased intestinal permeability. This compromised barrier function can allow further translocation of luminal antigens, perpetuating inflammation and contributing to gut-related disorders such as inflammatory bowel disease (IBD) and metabolic endotoxemia. This study investigated the therapeutic effects of inulin, a prebiotic dietary fiber, in attenuating LPS-induced intestinal epithelial barrier dysfunction. Caco-2 cells were treated with 100 ng/mL of LPS for 12 h, resulting in increased gene expression of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-18) and a significant downregulation of tight junction proteins claudin-1 and claudin-2, while occludin gene expression remained unaffected. Pretreatment with 2% inulin for 24 h before LPS exposure prevented the downregulation of claudin-1 and claudin-2 and significantly upregulated occludin gene expression. These molecular findings were supported by functional assays using transwell systems. LPS treatment increased paracellular permeability of the Caco-2 monolayer, indicating barrier dysfunction, while inulin pretreatment mitigated this effect. These results demonstrate that inulin can modulate tight junction protein expression and maintain gut barrier integrity under inflammatory conditions.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Antioxidant Capacity by Cooking Method of Apios (Apios americana Medicus) and Its Applicability as an Elder-Friendly Food","authors":"Dah-Sol Kim,&nbsp;Ju Hong Park","doi":"10.1002/fsn3.70102","DOIUrl":"https://doi.org/10.1002/fsn3.70102","url":null,"abstract":"<p>Considering the deteriorated chewing ability among the elderly people, this study aimed to develop elder-friendly foods that comply with the hardness standards set by Korean industrial standards (KS). First, we sought to establish an optimal cooking method by analyzing the antioxidant activity of Apios. Second, a gelling agent was incorporated into Apios cooked using the optimal method (sous-vide) to make a mousse that meets KS hardness requirements by controlling its rheological properties. Third, we aimed to develop an elder-friendly sous-vide Apios that considers gastronomic characteristics by utilizing 3D printing technology. As a result, the loss rate of antioxidant capacity in the sous-vide Apios was the lowest. A gelling agent was added to the sous-vide Apios to achieve the desired hardness for KS, leading to the derivation of the regression equations: “<i>Y</i> = 1837.2<i>X</i> + 2829.2” for gelatin and “<i>Y</i> = 2937.1<i>X</i> + 1445.2” for agar. After preparing a mousse-type sous-vide Apios with KS's second-level hardness based on these regression equations, optimal printing conditions were established to ensure stable output from the 3D printer. Considering these results, it is believed that the development of 3D-printed elder-friendly foods, which control rheological properties for easier chewing, will meet the diverse needs of elderly consumers. Furthermore, this innovation is expected to contribute to the growth of the elder-friendly food industry by utilizing domestic agricultural resources such as Apios.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}