Food Science & NutritionPub Date : 2026-04-16eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71734
Xi Liu, Cheng Wang, Ling Han, Yi'an Xiao, Hanchang Yu, Zhongxu Hu, Xiyun Fei, Min Peng, Jilin Zhou, Zhijun Zhong
{"title":"Xuming Zhusan Decoction Attenuates Post-Stroke via Modulating TLR4/MYD88/NF-κB Pathway in Mice.","authors":"Xi Liu, Cheng Wang, Ling Han, Yi'an Xiao, Hanchang Yu, Zhongxu Hu, Xiyun Fei, Min Peng, Jilin Zhou, Zhijun Zhong","doi":"10.1002/fsn3.71734","DOIUrl":"10.1002/fsn3.71734","url":null,"abstract":"<p><p>Ischemic stroke induces neuroinflammation that exacerbates neuronal damage. The Chinese Medicine Xuming Zhusan (XMZS) has shown promising efficacy in stroke treatment, but its mechanisms are unclear. This study aimed to explore the effect of XMZS on microglial-mediated neuroinflammation and explore its molecular targets. In vivo experiments were conducted using a mouse model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO), and in vitro studies were performed on primary microglia and cortical neurons with Oxygen-Glucose Deprivation/Reoxygenation (OGD/R) models. Behavioral assessments, histological analyses, Western blotting, co-immunoprecipitation, confocal microscopy, and enzyme-linked immunosorbent assay (ELISA) were employed to evaluate the neuroprotective effects of XMZS and its regulatory role in the TLR4/MYD88/NF-κB pathway. Results showed that high-dose (63 g/kg) XMZS improved neurological and cognitive functions, reduced infarct volume and brain edema in MCAO mice. Mechanistically, XMZS suppressed microglial activation, decreased the levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and downregulated the expression of TLR4, MYD88, and phosphorylated p65 in the TLR4/MYD88/NF-κB pathway. Additionally, cinditioned medium from XMZS-treated microglia enhanced the viability of primary neurons. In conclusion, XMZS exerts neuroprotective effects against cerebral ischemia-reperfusion injury by modulating the TLR4/MYD88/NF-κB pathway, thereby attenuating microglia-mediated neuroinflammation.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71734"},"PeriodicalIF":3.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71788
Xiaoyan Wang, Ting Yuan, Muhammad Asif Arain, Mohammed Al-Rasheed, Aftab Shaukat
{"title":"Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species-An In Silico Supported Review.","authors":"Xiaoyan Wang, Ting Yuan, Muhammad Asif Arain, Mohammed Al-Rasheed, Aftab Shaukat","doi":"10.1002/fsn3.71788","DOIUrl":"10.1002/fsn3.71788","url":null,"abstract":"<p><p>Heat stress (HS) remains a critical environmental constraint threatening the sustainability and productivity of global livestock and poultry production by including oxidative damage, compromising gut integrity, and disruption of immune homeostasis. The limited conventional nutritional strategies in conferring long-term thermotolerance underscore the urgent need for innovative and biologically effective interventions. In this context, phytobiotics, bioactive plant-derived compounds, have emerged as promising nutrigenomic modulators due to their potent antioxidant, anti-inflammatory, antimicrobial, and gut-protective properties, which collectively reinforce cellular defense mechanisms and enhance physiological adaptability under thermal challenge. This review provides a novel nutrigenomic perspective by elucidating how phytobiotics regulate the expression of key stress-responsive molecular pathways, including heat shock proteins (HSPs), nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), and mitogen-activated protein kinases (MAPKs), which govern oxidative balance, immune signaling, and apoptosis. Importantly, these mechanistic insights are reinforced by emerging in silico approaches, such as molecular docking and network pharmacology, which offer predictive validation of phytobiotic bioactivity, binding affinities, and target specificity against stress-related biomarkers, thereby accelerating the identification of high-potential candidates. By integrating experimental and computational evidence, this review consolidates current knowledge on the genomic and physiological roles of phytobiotics in mitigating HS and associated pathophysiological disturbances, and provides an effective scientific framework for the development of sustainable, phytobiotic-based nutritional strategies to enhance resilience and productivity in climate-vulnerable animal production systems.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71788"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71743
Şevval Şevgin Demirhan, Seval Andiç, Şehriban Oğuz
{"title":"Comparison of Physicochemical, Microbiological, and Sensory Properties of Yogurt Made From Cow, Goat, Sheep, and Buffalo Milk with and Without Probiotic Cultures.","authors":"Şevval Şevgin Demirhan, Seval Andiç, Şehriban Oğuz","doi":"10.1002/fsn3.71743","DOIUrl":"10.1002/fsn3.71743","url":null,"abstract":"<p><p>This study investigated the physicochemical, microbiological, textural, and sensory characteristics of yogurts produced from cow, goat, sheep, and buffalo milk, both with and without probiotic supplementation (<i>Lactobacillus acidophilus</i> LA-5 and <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BB-12), during 21 days of refrigerated storage. Results revealed that milk type markedly influenced compositional and structural attributes (<i>p</i> < 0.05). Sheep and buffalo milk yogurts exhibited higher dry matter, viscosity, and hardness, while goat milk yogurts showed the weakest water-holding capacity (WHC) and highest syneresis. The addition of probiotic cultures modified fermentation dynamics, leading to lower acidity and higher pH values, particularly in bifidobacteria-enriched samples. All probiotic yogurts maintained viable counts above 10<sup>6</sup> CFU/g throughout storage, confirming their probiotic status. Interestingly, goat milk provided the most favorable environment for <i>B. animalis</i> subsp. <i>lactis</i> BB-12 survival, likely due to its higher oligosaccharide content and buffering capacity. Sensory scores were highest for sheep and buffalo milk yogurts, reflecting their richer composition and superior texture. These findings highlight the strong influence of milk composition on the physicochemical behavior and probiotic viability of yogurt, suggesting that mixed-milk formulations could improve the sensory and functional quality of probiotic dairy products.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71743"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71774
Seong Chul Jin, You Yeon Choi, Batsukh Sosoburam, Hee Kyung Baek, Min Woo Song, Seungyob Yi, Ji Eun Park, Woong Mo Yang
{"title":"A Herbal Pair of <i>Taraxacum officinale</i> F.H.Wigg. and <i>Lonicera japonica</i> Thunb. Ameliorates Obesity and Modulates AMPK Signaling.","authors":"Seong Chul Jin, You Yeon Choi, Batsukh Sosoburam, Hee Kyung Baek, Min Woo Song, Seungyob Yi, Ji Eun Park, Woong Mo Yang","doi":"10.1002/fsn3.71774","DOIUrl":"10.1002/fsn3.71774","url":null,"abstract":"<p><p>Obesity is a complex metabolic disorder characterized by excessive fat accumulation and associated comorbidities. This study evaluated LIPO-700, a standardized herbal formulation combining <i>Lonicera japonica</i> Thunb. and <i>Taraxacum officinale</i> F.H.Wigg., for its anti-obesity effects and underlying mechanisms. Network pharmacology and KEGG enrichment analyses identified AMPK signaling, adipocytokine signaling, and regulation of lipolysis among the top enriched pathways associated with the predicted targets of LIPO-700. In vitro, LIPO-700 significantly reduced lipid accumulation in differentiated 3T3-L1 adipocytes (up to 19.11% at 100 μg/mL, <i>p</i> < 0.001) and free fatty acid-induced HepG2 hepatocytes (24.70%, <i>p</i> < 0.001), accompanied by increased phosphorylation of AMPK (3.49-fold, <i>p</i> < 0.001), restoration of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), and suppression of lipogenic and gluconeogenic markers including Sterol Regulatory Element-Binding Protein-1c (SREBP-1c), Fatty Acid Synthase, Phosphoenolpyruvate Carboxykinase, and Glucose-6-Phosphatase. In vivo, oral administration of LIPO-700 to high-fat diet-induced obese mice reduced body weight, fat mass, and adipocyte size in a dose-dependent manner without hepatotoxicity or nephrotoxicity. Western blot and gene expression analyses of epididymal white adipose tissue showed increased AMPK phosphorylation, together with downregulation of leptin and SREBP-1c, and upregulation of Lipoprotein Lipase, ATGL, and HSL. These findings demonstrate that LIPO-700 exerts multi-target anti-obesity effects through coordinated regulation of lipid metabolism, supporting its potential as a safe herbal intervention for obesity management.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71774"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Postharvest Oxalic Acid Treatments on Quality Properties and Biochemical Composition of Medlar (<i>Mespilus germanica</i> L.) Fruit.","authors":"Ayşen Melda Çolak, Özlem Gündoğdu, Erdal Aglar, Nevzat Sezgin, Erdal Orman, Muttalip Gundogdu","doi":"10.1002/fsn3.71362","DOIUrl":"https://doi.org/10.1002/fsn3.71362","url":null,"abstract":"<p><p>This study was conducted to investigate the effects of oxalic acid (OA) applications at different concentrations on the quality traits and biochemical components of medlar (<i>Mespilus germanica</i> L.) fruit. Fruits harvested in Bolu province in 2024 were subjected to control (0) and 0.5, 1.0, and 1.5 mM OA applications and stored at 4°C and 90% ± 5% relative humidity for 45 days. Samples were taken from the fruits at certain intervals (0, 15, 30, and 45 days) and analyzed. Specifically, 1.0 and 1.5 mM OA applications significantly reduced fruit weight loss and decay rates. OA also inhibited increases in fruit respiration rate and pH and slowed the decline in total acidity, soluble solids content (SSC), vitamin C, phenolic compounds, and organic acids. Malic, citric, succinic, tartaric, and fumaric acids, vitamin C, and important phenolic compounds (chlorogenic acid, gallic acid, quercetin, catechin) were protected by OA applications, and this protection was most pronounced at 1.5 mM OA dose. The correlation analyses revealed significant relationships between quality parameters and biochemical contents. The weight loss and decay rate were negatively correlated with bioactive compounds such as gallic acid and ascorbic acid, indicating that quality deterioration progressed in parallel with the decrease in nutrient content. A strong positive correlation was found between titratable acidity and malic and citric acids. In principal component analysis (PCA), malic and citric acids were prominent in the early storage period, while weight loss, decay, and increased respiration became dominant in the late storage period. Phenolic compounds decreased significantly with storage time, and antioxidant capacity decreased. Heat map analysis visually supported the increase in spoilage parameters with the decrease in ascorbic acid and phenolic compounds. OA applications maintained the quality of medlar fruit and increased biochemical stability, extending postharvest life. 1.5 mM OA, in particular, stands out as an effective postharvest preservation method. These results demonstrate that OA offers significant potential for increasing the commercial value of perishable fruits like medlar and for developing preservation technologies.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71362"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71780
Hayoung Kim, Hanbin Lee, Won Yeong Bang, Haeseong Park, Jin Seok Moon
{"title":"Comparison of Viable and Heat-Inactivated <i>Lacticaseibacillus rhamnosus</i>IDCC 3201: Anti-Pathogenic, Anti-Inflammatory, and Microbiota Modulating Effect.","authors":"Hayoung Kim, Hanbin Lee, Won Yeong Bang, Haeseong Park, Jin Seok Moon","doi":"10.1002/fsn3.71780","DOIUrl":"10.1002/fsn3.71780","url":null,"abstract":"<p><p><i>Lacticaseibacillus rhamnosus</i> is widely studied for strain-specific antimicrobial and immunomodulatory properties, but comparative data for viable and heat-inactivated preparations remain limited. This study compared the anti-pathogenic activity of live <i>L. rhamnosus</i> IDCC 3201 and its commercially prepared heat-inactivated formulation, RHT 3201, and examined their associated microbiota and metabolite profiles in a single-donor ex vivo fecal fermentation model. Transcript-level immunomodulatory activity was evaluated separately for RHT 3201 in LPS-stimulated RAW 264.7 cells. Both preparations inhibited key intestinal pathogens, including <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, and <i>Salmonella</i> Typhimurium, although live IDCC 3201 showed stronger inhibition against <i>E. faecalis</i> and <i>S. Typhimurium</i>. In LPS-stimulated RAW 264.7 cells, RHT 3201 reduced IL-1β, IL-6, COX-2, and TNF-α mRNA expression by approximately 39%, 23%, 17%, and 16%, respectively, at 10 × 10<sup>7</sup> CFU/mL. At the species level in the ex vivo fermentation model, RHT 3201 was associated with a higher relative abundance of <i>Bifidobacterium pseudocatenulatum</i> and <i>Lactobacillus ruminis</i>, whereas <i>L. rhamnosus</i> was detected only in the IDCC 3201 group during the 24-h culture period. Metabolite profiling also showed distinct product-associated signatures between the two preparations, with higher lactic acid detected in RHT 3201. Overall, the two preparations showed comparable activity against some pathogens but distinct microbiota- and metabolite-associated profiles in this single-donor ex vivo system, while anti-inflammatory activity was assessed only for RHT 3201 at the mRNA level. Additional multi-donor, protein-level, and in vivo studies are required to confirm the reproducibility and physiological relevance of these findings.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71780"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71719
Daniel Ramos Olcerenko, Bruna da Silva Miranda, Erica Vanessa Batista Dos Santos, Lucas Melo Neves, Patrícia Colombo-Souza
{"title":"Nutritional Status, School Time, and Eating Patterns in Children From 7 to 10 Years: Quantitative Evaluation of Macro and Micronutrients in the School Diet.","authors":"Daniel Ramos Olcerenko, Bruna da Silva Miranda, Erica Vanessa Batista Dos Santos, Lucas Melo Neves, Patrícia Colombo-Souza","doi":"10.1002/fsn3.71719","DOIUrl":"https://doi.org/10.1002/fsn3.71719","url":null,"abstract":"<p><p>To quantitatively evaluate the intake of key macronutrients and sodium in the diet of children aged 7-10 years and their relationship with nutritional status and school schedule, this cross-sectional study analyzed dietary data from guardian questionnaires using the Yazio, Food Converter, and Web Diet platforms. Nutrient intake was compared against guidelines, and statistical analyses included Chi‑squared, Mann-Whitney, and Kruskal-Wallis tests (<i>p</i> < 0.05). Data were collected from private schools in Cotia, São Paulo, Brazil, between January and August 2023. The sample comprised 60 children (27 girls, 33 boys; mean age 8.6 years), with 70% enrolled part‑time. Overall, 58.3% were eutrophic, while 41.7% had an altered nutritional status. Paradoxically, despite a high prevalence of overweight/obesity (26.7%), carbohydrate and fat intake were below recommendations for all children, suggesting poor diet quality. In contrast, 55% met water intake guidelines, while 48.3% exceeded sodium limits. Significant differences in intake were found across nutritional status categories (<i>p</i> < 0.001). Full‑time schooling was associated with higher carbohydrate intake (<i>p</i> = 0.018) and a trend toward higher sodium consumption (<i>p</i> = 0.073), but not with nutritional status (<i>p</i> = 0.298). The study reveals a double burden of poor diet quality, with full‑time schooling linked to higher intake of critical nutrients. This underscores the need for policies that regulate the school food environment, particularly in full‑time settings, and promote food education.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71719"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71733
Ewelina Węsierska, Małgorzata Pasternak, Katarzyna Niemczyńska-Wróbel, Jacek Słupski
{"title":"Selected Factors of Quality of Raw Salami-Type Sausage Made From Meat of Two Rare Native Cattle Breeds: Polish Red and White-Backed.","authors":"Ewelina Węsierska, Małgorzata Pasternak, Katarzyna Niemczyńska-Wróbel, Jacek Słupski","doi":"10.1002/fsn3.71733","DOIUrl":"https://doi.org/10.1002/fsn3.71733","url":null,"abstract":"<p><p>The aim of the study was to evaluate selected quality-related factors of salami-type sausages as nutritional and chemical composition, texture attributes, safety and microbiological status of dry-cured, salami-type sausage spontaneously fermented, produced from the meat of Polish Red (PR; <i>polska czerwona</i>) and White-Backed (WB; <i>białogrzbieta</i>) native cattle breeds. The work involved the evaluation of the following properties: chemical (basic chemical composition, biogenic amine content), physicochemical (pH, water activity a<sub>w</sub>, color and texture parameters) and microbiological (lactic acid bacteria LAB and coagulase-negative staphylococci CNS). Ripening time, pH and a<sub>w</sub> affected the populations of LAB and CNS and determined the redness and brightness of the final products. Sausages produced from PR and WB cattle meat did not differ in their basic chemical composition and therefore exhibited comparable energy values. Significant differences were observed between PR and WB sausages in color parameters, particularly redness and lightness as well as in the proportion of lactic acid bacteria. Despite comparable processing conditions, WB sausages showed a significantly higher histamine content, indicating differences in the metabolic activity of the bacteria. The use of black garlic significantly affected the color characteristics of the sausages, resulting in lower lightness, reduced color saturation, and greater overall color deviation. Sausages containing black garlic were characterized by higher hardness and shear force, but lower springiness, despite comparable water, protein, and fat contents. Increased salinity, reduced water activity, and low pH, regardless of garlic type, did not inhibit the growth of LAB but limited the development of CNS.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71733"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protective Effects of <i>Agrimonia pilosa</i> Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the FOXO Signaling Pathway.","authors":"Jian Chen, Zhixiang Wei, Jiaqi An, Dantong Li, Ying Gu, Yixin Zhang, Muqing Zhang","doi":"10.1002/fsn3.71778","DOIUrl":"https://doi.org/10.1002/fsn3.71778","url":null,"abstract":"<p><p><i>Agrimonia pilosa</i> Ledeb. (APL) is an edible and medicinal plant, which has a favorable cardioprotective effect. Myocardial fibrosis (MF) is a hallmark pathological feature of various cardiovascular diseases. This study aims to evaluate its protective effects against isoproterenol (ISO)-induced MF and investigate the underlying mechanisms. HPLC was employed to analyze the main active ingredients in APL. Network pharmacology methods, combined with experimental validation, elucidated the mechanism by which APL modulates mitophagy to alleviate MF. HPLC analysis showed that six ingredients were identified. We demonstrated that APL significantly attenuated myocardial injury, enhanced cardiac function, inhibited oxidative stress and apoptosis, and effectively ameliorated MF progression. Network pharmacological predictions and in vivo experimental validation demonstrated that APL exerts its therapeutic effects through regulation of the FOXO signaling pathway and suppression of excessive mitophagy. Furthermore, we artificially elevated FOXO1 expression in vitro, which reversed the effects of APL, as evidenced by increased expression of mitophagy and fibrosis-related proteins. Consistent results from both in vivo and in vitro experiments demonstrated that APL attenuates ISO-induced MF and suppresses mitophagy mediated by the FOXO signaling pathway.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71778"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food Science & NutritionPub Date : 2026-04-15eCollection Date: 2026-04-01DOI: 10.1002/fsn3.71758
{"title":"RETRACTION: Effective Innovative Technologies and One Health Strategies in Mitigating Aflatoxin Contamination in Peanut Oil: A Systematic Review and Meta-Analysis.","authors":"","doi":"10.1002/fsn3.71758","DOIUrl":"https://doi.org/10.1002/fsn3.71758","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1002/fsn3.70062.].</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 4","pages":"e71758"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}