Food Science & Nutrition最新文献

{"title":"Elderly Perception of Protein Products in Relation to Their Neophobic Attitude and Nutritional Protein Knowledge","authors":"Elizabeth Carrillo,&nbsp;Amparo Tárrega","doi":"10.1002/fsn3.70129","DOIUrl":"https://doi.org/10.1002/fsn3.70129","url":null,"abstract":"<p>This study examined the elderly response to protein-rich food measured in two contexts: Study 1, expected condition toward six commercial products; and Study 2, tasting the products (two protein breads) with special focus on the impact of individual food neophobia (FN) attitude and protein knowledge (PK). The initial study yielded findings indicating that the products were differentiated based on their similarity to the participants' usual dietary intake. Furthermore, differences were observed between participants with high and low levels of FN. In the first group, unfamiliar products were perceived as less healthy, less trustworthy, and more unusual than familiar products. Moreover, unfamiliar products elicited lower purchase intention. Similarly, low levels of PK also affected the perception of unfamiliar foods, albeit to a lesser extent. In Study 2, elderly individuals with a high level of FN also exhibited reduced purchase intention and a lower level of agreement that the product would be liked. Participants also perceived the products as less healthy, less satiating, and unsustainable for eating legumes. However, PK did not affect this response. These studies demonstrate the profound impact of FN on the aging process, influencing the rejection of protein-enriched products and impeding the ability to perceive the benefits of novel products.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypericum empetrifolium and H. lydium as Health Promoting Nutraceuticals: Assessing Their Role Combining In Vitro In Silico and Chemical Approaches","authors":"Stefania Sut,&nbsp;Stefano Dall'Acqua,&nbsp;Giancarlo Angeles Flores,&nbsp;Gaia Cusumano,&nbsp;İsmail Koyuncu,&nbsp;Ozgur Yuksekdag,&nbsp;Carla Emiliani,&nbsp;Roberto Venanzoni,&nbsp;Paola Angelini,&nbsp;Selami Selvi,&nbsp;Evren Yildiztugay,&nbsp;Adriano Mollica,&nbsp;Eleonora Procino,&nbsp;Gregorio Peron,&nbsp;Lorenza Marinaccio,&nbsp;Gokhan Zengin","doi":"10.1002/fsn3.70053","DOIUrl":"https://doi.org/10.1002/fsn3.70053","url":null,"abstract":"<p><i>Hypericum</i> species are known for their ability to produce multiple classes of secondary metabolite and in this article the possible health-promoting role of <i>H. empetrifolium</i> and <i>H. lydium</i> have been evaluated combining in vitro and in silico approaches. <i>H. empetrifolium</i> and <i>H. lydium</i> extracts were obtained using different solvents (ethyl acetate, aceton, aceton/water, and water) and the composition was compared using NMR and LC–MS based approaches. Myricetin-3-<i>O</i>-glucoside, Kaemempferol -3-<i>O</i>-glucoside, and hyperopliphylirrin were present only in <i>H. empetrifolium.</i> Rutin, quercetin-3-<i>O</i>-rhamnoside ant the triterpenoids oleanolic and ursolic acid were only detected in <i>H. lydium</i>. To establish a possible role against degenerative diseases antioxidant, antiradical activities of the extracts were studied and <i>H. empetrifolium</i> acetone/water and water extracts were the more active regarding these effects. The extracts were also evaluated for the inhibition of key-enzymes involved in degenerative diseases namely cholinesterase and tyrosinase for CNS-related pathologies and amylase for metabolic-related diseases. Significant inhibition of acetylcholinesterase was observed for the extracts obtained with lipophilic solvents. The extracts were also studied for their possible antiproliferative activity on cell lines including tumor (DU-145, A549, and MCF-7) and non-tumoral cells (HEK-293) revealing moderate activities. <i>H. lydium</i> ethyl acetate showed late apoptotic (17.5%) and necrotic (46.6%) effects in the Annexin V/PI assay. Molecular docking was used to establish possible interaction of identified compounds with target enzymes and a good interaction between rutin and tyrosinase, myricetin-7-<i>O</i>-glucoside and amylase, was reported. In conclusion, <i>Hypericum empetrifolium</i> and <i>H. lydium</i> thanks to their complex pattern of phytoconstituents and thanks to their significant antioxidant effects as well as with the ability to act on some key-target enzymes involved in degenerative diseases can be considered a good vegetal source for the preparation of nutraceuticals and food supplements useful as health-promoting products against oxidative stress-related diseases such as diabetes, cancer, and Alzheimer's disease.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umami Enhancing Properties of Enzymatically Hydrolyzed Mycelium of Flammulina velutipes Cultured on Potato Pulp","authors":"Katharina Happel,&nbsp;Lea Zeller,&nbsp;Andreas Klaus Hammer,&nbsp;Holger Zorn","doi":"10.1002/fsn3.70128","DOIUrl":"https://doi.org/10.1002/fsn3.70128","url":null,"abstract":"<p>The aim of this study was to hydrolyze cultivated fungal mycelium and to evaluate the effect on its taste. Potato pulp, a by-product of the potato starch industry, was therefore successfully utilized as a substrate for submerged cultivation of <i>Flammulina velutipes</i>, yielding a product with an estimated fungal content of 83% ± 3%. The fermentation increased the protein content from 5.3 ± 0.4 g/100 g DM to 13.9 ± 0.1 g/100 g DM with a biological protein value of 86. The fermentate was enzymatically hydrolyzed by Corolase APC-peptidase. After optimization of the hydrolysis conditions, a degree of hydrolysis (DH) of 75.1% ± 1.0% was achieved. The protein hydrolysis increased the contents of free glutamate more than 20-fold from 8.7 ± 0.1 mg/L to 188.7 ± 1.2 mg/L. Elevated glutamate levels led to an umami taste perception in aqueous solution and taste-enhancing properties in vegetable broth. Noteworthy, the fermentate itself exhibited an intrinsic peptidase activity. Without addition of auxiliary peptidases, mycelial enzymes caused a DH of 33.9% ± 0.7% and a free glutamate content of 99.1 ± 0.7 mg/L. For these samples, an increase in umami taste was only observed in vegetable broth, but not in water, indicating taste-enhancing properties but low umami taste. In addition to the nutritional and health benefits of fungi, their hydrolysates are of great interest for use as a protein booster with flavor-enhancing properties.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hybrid N-AHP-Based TOPSIS Decision Support Approach for Investigation of the Effect of Different Solvents on the Bioactive Properties, Anticancer, and Antimicrobial Activities of Aronia melanocarpa Extract","authors":"Gulsum Ucak Ozkaya","doi":"10.1002/fsn3.70122","DOIUrl":"https://doi.org/10.1002/fsn3.70122","url":null,"abstract":"<p>The aim of this study was to extract the bioactive components in <i>Aronia melanocarpa</i> L. fruit, commonly referred to as chokeberry, using various solvents (80% methanol + 1% formic acid, 80% ethanol, and 70% acetone) individually and to evaluate them through the Neutrosophic-Analytical Hierarchy Process (N-AHP)-based TOPSIS method. The ethanolic (EEA), methanolic (MEA), and acetone (AEA) extracts derived from Aronia fruit were analyzed for total phenolic, flavonoid, and anthocyanin contents, as well as antioxidant, antimicrobial, and cytotoxic activities. The EEA exhibited the highest overall anthocyanin content. The MEA exhibited the highest DPPH levels. The AEA exhibited the highest levels of total phenolic compounds, total flavonoid content, and CUPRAC values. The EEA, MEA, and AEA exhibited IC50 values of 11.65, 11.71, and 10.51 mg/mL against Caco-2 adenocarcinoma cells, respectively. EEA and MEA exhibited superior antimicrobial efficacy compared to AEA. According to the weights determined by N-AHP, the extraction with methanol was found to be the best extraction method according to the TOPSIS analysis results performed on real data. In other words, the extract with the lowest IC50 value and the highest antimicrobial activity was the one extracted with methanol. This study concluded that the N-AHP-based TOPSIS method is a significant multiple decision-making approach for evaluating plant extracts based on established criteria and is applicable to food and phytochemical sciences.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Porosity in Grain Compression Experiments Using Random Forest and Metaheuristic Optimization Algorithms","authors":"Jiahao Chen,&nbsp;Jiaxin Li,&nbsp;Deqian Zheng,&nbsp;Yan Zhang,&nbsp;Hang Jing,&nbsp;Jianjun Han,&nbsp;Manxing Wang,&nbsp;Runmei Zhao","doi":"10.1002/fsn3.70107","DOIUrl":"https://doi.org/10.1002/fsn3.70107","url":null,"abstract":"<p>Grain stored for long periods is highly susceptible to localized condensation, mold growth, and insect infestations, leading to significant storage losses. These issues are particularly acute in large-capacity bungalow warehouses, where food security concerns are even more pronounced. The porosity of grain piles is a critical parameter that influences heat and moisture transfer within the grain mass, as well as the ventilation of grain storage. To investigate the distribution pattern of bulk grain pile porosity in bungalow warehouses, this study employs machine learning (ML) techniques to predict grain pile porosity based on compression experiments. Four metaheuristic optimization algorithms—particle swarm optimization (PSO), gray wolf optimizer (GWO), sine cosine algorithm (SCA), and tunicate swarm algorithm (TSA)—were introduced to enhance the random forest (RF) algorithm, and five ML-based models (RF, PSO-RF, GWO-RF, SCA-RF, and TSA-RF) for predicting grain porosity were developed. The predictive performance of the five models was analyzed using error analysis, Taylor diagrams, evaluation metrics, and multi-criteria assessments to identify the optimal ML prediction model. The results indicate that the predictive performance of the four RF-based hybrid models surpasses that of the single RF model. Among these hybrid models, the TSA-RF model demonstrated the best predictive performance, achieving <i>R</i>² values of 0.9923 in the training set and 0.9723 in the test set. The TSA-RF model was employed to conduct a hierarchical prediction of bulk grain pile porosity in the bungalow warehouse. The results indicate that the porosity of the grain pile exhibits a pattern of being higher in the middle and smaller at the edges as the depth of the grain pile increases. The TSA-RF model developed in this study offers a novel and efficient method for predicting grain porosity, enabling rapid assessments of porosity in bulk grain piles within the bungalow warehouse.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotenoids Modulate FoxO-Induced Cell Cycle Awrrest in Human Cancer Cell Lines: A Scoping Review","authors":"Zi Xin Lee,&nbsp;Hanting Guo,&nbsp;Aaron Deming Looi,&nbsp;Saatheeyavaane Bhuvanendran,&nbsp;Kasthuri Bai Magalingam,&nbsp;Wai Leng Lee,&nbsp;Ammu Kutty Radhakrishnan","doi":"10.1002/fsn3.70100","DOIUrl":"https://doi.org/10.1002/fsn3.70100","url":null,"abstract":"<p>Carotenoids, a class of antioxidants, have shown great potential for cancer management. This scoping review aimed to elucidate the anticancer mechanisms of carotenoids by using a protein interactions and pathways approach. A literature search on five databases (Web of Science, PubMed, Ovid Medline, Ovid Embase and Scopus) was carried out, and studies investigating differential protein expression in cancer cell lines treated with carotenoids published in the last 10 years were included in the analysis. Sixty-three research articles were short-listed, and 17 carotenoids were used in these studies. The most studied carotenoids were fucoxanthin, astaxanthin, and crocin. The key cancer cell lines tested in these studies included breast, gastric, and lung cancers. Analysis of the proteins identified from these studies using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) revealed the upregulation of proteins belonging to the pro-apoptotic and FoxO signaling pathways. In contrast, several proteins in the PI3k/Akt and TNF signaling pathways and cell cycle regulation were downregulated, which can explain the observed anticancer effects. The findings from this scoping review suggest that the cell cycle arrest observed in carotenoid-treated cancer cells may work through activation of the FoxO signaling pathway in these cells, highlighting their role as potential anticancer agents. Nonetheless, the lack of evidence on the pharmacology, pharmacokinetics, and physiology of carotenoids necessitates more robust and well-designed clinical trials. Similarly, further investigations into the therapeutic effects of targeting the PI3K/Akt/FoxO axis to induce cell cycle arrest and its translational potential are required to ensure the successful development of effective treatments.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Utility of Prunus mahaleb Extracts as a Source of Natural Bioactive Compounds for Functional Applications","authors":"Bayram Atasagun,&nbsp;Ahmet Uysal,&nbsp;Noha Fathallah,&nbsp;Omayma Eldahshan,&nbsp;Abdel Nasser Singab,&nbsp;Mehmet Veyis Cetiz,&nbsp;Gokhan Zengin","doi":"10.1002/fsn3.70121","DOIUrl":"https://doi.org/10.1002/fsn3.70121","url":null,"abstract":"<p><i>Prunus mahaleb</i> has garnered attention as a potent medicinal agent and functional component. We aimed to detect the chemical composition and biological activities of several parts (fruit, leaves, and twigs) of <i>P. mahaleb</i>. Biological activities were assessed for antioxidant properties, enzyme inhibition, mutagenic/antimutagenic effects, and antibacterial efficacy. Antioxidant capabilities were evaluated using various assays, including DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating. The chemical constituents of the extracts were identified and quantified using the HPLC-ESI-MS/MS method. The effects of enzyme inhibition were examined on some enzymes, including AChE, BChE, tyrosinase, amylase, and glucosidase. The Ames test was used to evaluate the mutagenic and antimutagenic properties of the plant extracts. Furthermore, a broth microdilution assay was employed to evaluate the possible antibacterial effects of the extracts against microorganisms. The methanol extract of twigs showed superior antioxidant capabilities (DPPH: 388.39 mg TE/g; ABTS: 701.50 mg TE/g; CUPRAC: 459.05 mg TE/g; FRAP: 264.99 mg TE/g). The methanol extract of twigs demonstrated the highest tyrosinase inhibitory activity (61.91 mg KAE/g). A total of 40 metabolites, mainly flavonoids, were detected through HPLC-ESI-MS/MS analysis, revealing that ferulic acid, naringenin, and herniarin were the predominant compounds. In the Ames test, the tested extracts exhibited no mutagenic potential. The antimutagenicity assay demonstrated that methanol and ethyl acetate extracts from twigs and leaves were particularly efficient against frameshift and base pair substitution mutations induced by recognized mutagens. The metabolic activation system amplified these strong activities to inhibition rates ranging from 85% to 98%. The results from the antibacterial assay indicated antibacterial effectiveness at dosages between 6.25 and 0.195 mg/mL, particularly effective against <i>Sarcina lutea, Bacillus cereus, Candida albicans</i>, and <i>Staphylococcus aureus</i>. Our findings indicate that <i>P. mahaleb</i> can serve as a versatile raw material for the development of health-promoting applications, including medicines, cosmeceuticals, and nutraceuticals.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent Grading of Green Cardamom Using Data Fusion of Electronic Nose and Computer Vision Methods","authors":"Ehsan Godini,&nbsp;Hemad Zareiforoush,&nbsp;Adel Bakhshipour,&nbsp;Zahra Lorigooini,&nbsp;Sayed Hossain Payman","doi":"10.1002/fsn3.4645","DOIUrl":"https://doi.org/10.1002/fsn3.4645","url":null,"abstract":"<p>In this research, the intelligent quality grading of green cardamom was carried out using electronic nose (e-nose) and computer vision (CV) methods along with machine learning (ML) approaches. Cardamom samples were analyzed in three grades including Grade 1 (healthy and green), Grade 2 (healthy with yellow color), and Grade 3 (immature and shriveled) for capsules and Grade 1 (Black), Grade 2 (Brown), and Grade 3 (Yellow and red) for seeds. Three ML algorithms including Decision Tree (DT), Bayesian Network (BN), and Support Vector Machine (SVM) were used to classify the quality grades. Results showed that the correlation-based feature selection (CFS) algorithm decreased the number of input features and increased the classification performance. For classifying cardamom capsule samples based on the visual features, the CFS-BN model was the best classifier, with the root mean squared error (RMSE) and accuracy of 0.1408 and 96.67%, respectively. The RMSE and accuracy of this model for classifying cardamom seeds based on image features were 0.1220 and 96.67%, respectively. In classifying cardamom seeds using e-nose data, the CFS-DT model was the best classifier with RMSE and accuracy of 0.2093 and 93.33%, respectively. The CFS-BN model was the best for classifying cardamom capsules with an RMSE of 0.1126 and an accuracy of 96.67%. The fusion of e-nose and CV data increased the model performance compared to the separate use of e-nose and CV datasets. The accuracy of the CFS-BN model using the combination of CV and e-nose data was 100% during both the calibration and evaluation stages. It can be concluded that data fusion of e-nose and CV methods can be effectively used to develop an intelligent, accurate, reliable, fast, and non-destructive system for quality grading of cardamom capsules and seeds.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of Low-Fat Fish and Chicken Nuggets Fortified With Date Seed Powder and Quinoa Flour as Agricultural Dietary Fiber Sources","authors":"Shahab Naghdi,&nbsp;Masoud Rezaei,&nbsp;Mahboobeh Kashiri,&nbsp;Fatemeh Rezaei,&nbsp;Serva Naseri,&nbsp;Hossein Nourani,&nbsp;Zahra Khakpour","doi":"10.1002/fsn3.4749","DOIUrl":"https://doi.org/10.1002/fsn3.4749","url":null,"abstract":"<p>In recent years, high-oil-content fried products, such as nuggets, have posed a significant challenge and concern for consumers, leading to increased interest in fiber-enriched meat alternatives that offer specific functional properties and health benefits. This study investigated the incorporation of quinoa flour and date seed powder as fiber sources into chicken and fish paste formulations at a 6% concentration, with varying ratios of quinoa flour to date seed powder: 0:0 (T1), 100:0 (T2), 75:25 (T3), and 50:50 (T4). The results demonstrated that adding these ingredients markedly improved the dietary fiber content, water holding capacity, cooking yield, and pH levels of the nuggets (<i>p</i> &lt; 0.05). Notably, the T4 treatment exhibited the lowest oil absorption (3.82 g for chicken and 5.19 g for fish per 100 g of product) among all formulations (<i>p</i> &lt; 0.05). The fiber-enriched nuggets exhibited noticeable differences in texture and color. Additionally, the incorporation of quinoa flour and date seed powder positively influenced the sensory attributes of the nuggets, with T3 achieving the highest overall acceptance score. This formulation was identified as the most favorable option for both chicken and fish nuggets, owing to its optimal cooking yield, high acceptance, adequate fiber content, and minimal oil absorption.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Dietary Index for Gut Microbiota and Flavonoid Intake With Female Infertility in the United States","authors":"Di Xiao,&nbsp;Xiang Sun,&nbsp;Weidong Li,&nbsp;Zihao Wen,&nbsp;Wei-Hong Zhang,&nbsp;Li Yang","doi":"10.1002/fsn3.70098","DOIUrl":"https://doi.org/10.1002/fsn3.70098","url":null,"abstract":"<p>This study aimed to investigate the associations between a dietary index for gut microbiota (DI-GM), flavonoid intake, and female infertility, while exploring age-specific differences in these relationships to identify potential dietary strategies for female infertility prevention. This cross-sectional study focused on female participants aged 18–45 years, with data obtained from the 2017–2018 cycle of the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models were employed to examine the associations between DI-GM, flavonoid intake, and self-reported female infertility. Age-stratified analyses were performed to evaluate whether these associations varied across reproductive life stages. Higher DI-GM scores were significantly associated with reduced infertility risk (aOR = 0.30, 95% CI: 0.13–0.71, <i>p</i> = 0.006), with the strongest protective effects observed in women aged &lt; 35 years (Q3: aOR = 0.13, 95% CI: 0.03–0.58, <i>p</i> = 0.007; Q4: aOR = 0.27, 95% CI: 0.09–0.77, <i>p</i> = 0.015). Beneficial gut microbiota scores also showed a protective effect (aOR = 0.75, 95% CI: 0.57–0.98, <i>p</i> = 0.036). Among women aged ≥ 35 years, moderate flavonoid intake (Q2) showed a significant inverse association with female infertility risk (aOR = 0.19, 95% CI: 0.06–0.66, <i>p</i> = 0.009). Our findings reveal novel evidence that higher DI-GM scores and moderate flavonoid intake are significantly linked to a lower risk of female infertility, with age-specific patterns observed. Higher DI-GM scores showed significant protective effects in younger women (&lt; 35 years), while moderate flavonoid intake was protective in women aged ≥ 35 years. These findings underscore the potential of personalized dietary strategies targeting gut microbiota composition and flavonoid intake as cost-effective approaches for female infertility prevention and management across different reproductive life stages.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}