Food Science & Nutrition最新文献

{"title":"High-Fat and High-Sugar Diet Induces Murine Premature Ovarian Failure by Promoting Mitochondrial Oxidative Phosphorylation Response","authors":"Kai Li,&nbsp;Yichao Wen,&nbsp;Zeyu Cui,&nbsp;Lele Ling,&nbsp;Chunxia Wang,&nbsp;Bimeng Zhang,&nbsp;Te Liu","doi":"10.1002/fsn3.70973","DOIUrl":"https://doi.org/10.1002/fsn3.70973","url":null,"abstract":"<p>The causes of premature ovarian failure (POF) as a result of high-fat and high-sugar (HFHS) diets have not been studied systematically or in depth. In this study, we used single-cell RNA-seq (scRNA-seq) and molecular pathology experimental techniques to systematically analyze the ovarian landscape in HFHS diet-induced POF in mice. An HFHS diet decreased levels of AMH and E2 and induced a significant amount of follicular atresia in mice, according to the enzyme-linked immunosorbent assay (ELISA) and pathology results. The scRNA-seq results also showed that the number of Krt19 + epithelial cell, Csmd1 + cumulus cell, Mgarp + thecal cell, and mt-CO1 + granulosa cell clusters was much higher in the ovarian tissues of HFHS–POF mice than it was in the control group. According to the KEGG analysis, the differentially transcribed genes in these three cell clusters in different groups were chiefly involved in multiple signal transduction pathways, and their overlapping signaling pathways included oxidative phosphorylation. Immunofluorescence staining and qPCR showed that expression levels of the oxidative phosphorylation signaling pathway were significantly lower in the control group than they were in the thecal cell, epithelial cell, and stromal cell clusters of the HFHS–POF mice. To the best of our knowledge, this study is the first to report the application of scRNA-seq to analyze the ovarian landscape of HFHS-fed mice and to verify that the HFHS diet induced POF in mice by activating the oxidative phosphorylation signal transduction pathway in the thecal cell, granulosa cell, and cumulus cell clusters in mouse ovarian tissues.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Members of the Apple Sub-Family Maloideae Against Obesity and Metabolic Disorders: A Review","authors":"Zainab R. Abdelrahman,&nbsp;Mai S. Maaliah,&nbsp;Shtaywy S. Abdalla","doi":"10.1002/fsn3.70934","DOIUrl":"https://doi.org/10.1002/fsn3.70934","url":null,"abstract":"<p>Metabolic disorder, and obesity in particular, is a global epidemic among the world's population and is a complex multifactorial health problem. Obesity is associated with serious health risks like diabetes, coronary heart disease, non-alcoholic fatty liver disease, hyperlipidemia, and hyperglycemia disorders and has shown a steady increase in morbimortality indicators. Many drugs have been approved for effective treatment of metabolic disorders and their symptoms, but the cost on the health system and on the individual patient is extremely high. Therefore, an adjunctive treatment for managing obesity and metabolic disorder could be in the use of medicinal plants and functional foods, which could reduce the cost as well as reduce the side effects of these medications. Traditional herbal medicines and functional foods have become the subject of global importance, with both medical and economic implications. The apple subfamily Maloideae includes commercially and medicinally valuable fruits like apples, pears, loquat, quince, and hawthorn, and many other plants. This subfamily has a distinctive fruit, the pome, with characteristic antioxidant content. This review summarizes the recently published research, preclinical data, brief phytochemistry, and pharmacology on 5 Maloideae genera to underscore their potential as adjunctive therapy against obesity and metabolic disorder and future research opportunities.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caper Bush (Capparis spinosa L.) Minerals and Trace Elements Composition as Affected by Harsh Habitats in Gypsum and Non-Gypsum Drylands","authors":"Elham Yousefi,&nbsp;Mehdi Abedi,&nbsp;Tahereh A. Aghajanzadeh,&nbsp;Diego A. Moreno","doi":"10.1002/fsn3.70755","DOIUrl":"https://doi.org/10.1002/fsn3.70755","url":null,"abstract":"<p><i>Capparis spinosa</i> L. shrubs (Caper bush) are known for tolerating different ecological conditions. There is a lack of knowledge on the relations between the mineral nutrient composition of the Caper bush aerial plant parts according to the soil conditions where they have grown. Therefore, the aim is to study the mineral composition of soils, fruits, and leaves of <i>C. spinosa</i> species grown in two habitats. The samples (soils, leaves, and fruits) of the Caper bush were collected in Abkenar rangeland. Mineral nutrients and trace elements were determined in the samples of soils, fruits, and leaves, using the ICP-MS technique. The soil samples showed a significant increase in C, Ca, Mg, and S, and a notable decrease in P in the gypsum soils. However, there were no significant differences in the mineral nutrients of the leaves between the two sites, but among trace elements, gypsum-grown leaves had higher levels of Li, Se, Mo, Cr, and Sr. Apart from nitrogen, all other elements were within the normal range of sufficiency for the plant. For fruit elemental analysis, it was observed that the amount of S, Sr, and Mo was significantly higher and K significantly lower in gypsum habitats. As for fruit essential minerals, there was a slight deficiency in P, Ca, Mg, and Mn, while the levels of other elements were at the normal range. The biochemical adaptation of <i>C. spinosa</i> buffered or avoided the excessive accumulation of elements in the different soils. Also, the contents in the leaves and fruits were mainly in the normal range and not accumulating toxic elements.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70755","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Carbon Footprint, Water Footprint, Nutrient Profiles and Cost of Sustainable Menus Planned With Digital Modeling","authors":"Nida Nur Adiyan,&nbsp;Yasemin Beyhan,&nbsp;Taygun Dayi","doi":"10.1002/fsn3.70977","DOIUrl":"https://doi.org/10.1002/fsn3.70977","url":null,"abstract":"<p>This study aimed to evaluate the sustainability of digital program menus (DPMs) and compare them with the Turkish National Menu Planning Guide (TNMPG) and internet-accessible menus (IAM). A menu planning program was developed in Microsoft Excel, which also calculates the sustainability criteria (carbon footprint, water footprint, NRF 9.3, SAIN-LIM and cost) of the menus with the recommendations of the TNMPG. The digital menus were compared with the sustainability criteria of the TNMPG sample menus and menus accessed from the internet. DPM was found to be similar to the sample menus of the TNMPG in terms of sustainability features. All the meals on the menus were similar in terms of their carbon footprint (<i>p</i> &gt; 0.05), whereas the II-type meals of the kindergarten menu of DPM and the IV-type meals of the hospital menu of IAM were found to have greater water footprints (<i>p</i> &lt; 0.05). Some meals (II/III) in DPM had higher NRF-9.3 scores (<i>p</i> &lt; 0.05). The I-type meals of the kindergarten and prison menus of DPM and the II-type meals of the prison menu were found to have significantly higher costs (<i>p</i> &lt; 0.05). Digitalization could provide great benefits in service, as digital menus in food services can be prepared in a very short time, and sustainability criteria can be easily achieved.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakfast Skipping Increases the Risk of Coronary Heart Disease and Myocardial Infarction: Evidence From the Mendelian Randomization Study","authors":"Si Cao,&nbsp;Youjie Zeng,&nbsp;Gong Chen","doi":"10.1002/fsn3.70998","DOIUrl":"https://doi.org/10.1002/fsn3.70998","url":null,"abstract":"<p>Observational studies have suggested a potential association between breakfast skipping and the risk of coronary heart disease (CHD) and myocardial infarction (MI). Nevertheless, due to potential confounders and reverse causation, the causal relationship remains unclear. This study aims to comprehensively assess the causal effect of breakfast skipping on CHD and MI through a two-sample Mendelian randomization (MR) analysis. Genome-wide summary statistics of breakfast skipping, CHD, and MI were obtained from public databases. Instrument variables (IVs) proxying for breakfast skipping were screened based on strict (<i>p</i> &lt; 5e−8) and lenient (<i>p</i> &lt; 1e−5) thresholds. Quality control of IVs was performed using Cochran's <i>Q</i> test, MR-Egger intercept test, and MR PRESSO global test. Inverse variance weighted (IVW) served as the primary MR method for assessing causal associations, while MR-Egger, weighted median, and maximum likelihood were used as supplementary methods. The effect of breakfast skipping on CHD and MI in both CARDIoGRAMplusC4D and FinnGen cohorts was assessed, and the results were integrated using meta-analysis. Quality control tests showed no heterogeneity or horizontal pleiotropy in IVs. After conducting a meta-analysis of the MR results from the IVW method under strict IV screening thresholds, breakfast skipping significantly increases the risk of CHD [odds ratio (OR) = 1.358, <i>p</i> = 3.95E−02] and MI (OR = 1.449, <i>p</i> = 4.17E−02). Similarly, meta-analysis of the IVW results under lenient IV screening thresholds also demonstrated the detrimental effects of breakfast skipping on CHD (OR = 1.198, <i>p</i> = 5.55E−03) and MI (OR = 1.378, <i>p</i> = 4.08E−05). Three other MR methods showed parallel results to IVW (OR &gt; 1). Overall, the present study demonstrates that breakfast skipping significantly increases the risk of CHD and MI. Therefore, maintaining a high-quality breakfast intake can be considered an essential primary prevention measure for CHD and MI.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70998","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Effects of Inulin, Resistant Dextrin, and Stachyose on the Functional Properties and Digestibility of Corn Starch","authors":"Mengli Yao,&nbsp;Xiaofeng Han,&nbsp;Nick Pi,&nbsp;Ruoyong Wang,&nbsp;Zhong Han,&nbsp;Hua Dong,&nbsp;Zhiqiao Zhou,&nbsp;Jia Liu,&nbsp;Xue Wang,&nbsp;Shenglin Duan,&nbsp;Peng Yuan,&nbsp;Jie Liu","doi":"10.1002/fsn3.70165","DOIUrl":"https://doi.org/10.1002/fsn3.70165","url":null,"abstract":"<p>This study explores the effects of three soluble dietary fibers (SDFs)—inulin, resistant dextrin, and stachyose—on the in vitro digestion of corn starch. Incorporation of SDFs significantly influences starch physicochemical properties by reducing swelling power, solubility, pasting viscosity, and breakdown, while increasing pasting temperature and particle size (<i>p</i> &lt; 0.05). During in vitro digestion, the presence of SDFs significantly decreased the rapidly digestible starch (RDS) content and increased the resistant starch (RS) content (<i>p</i> &lt; 0.05). Microscopic observations reveal that SDFs alter the microstructure of starch gels, enhancing the stability of the gel matrix. Fourier-transform infrared (FT-IR) spectroscopy suggests the formation of hydrogen bonds between SDFs and starch. Furthermore, SDFs exhibit glucose adsorption capacity and α-amylase inhibitory activity, highlighting their multiple mechanisms in modulating starch digestion. The differential effects of SDFs depend on their molecular structure and physicochemical properties, such as chain length and hydroxyl group density. These findings offer new insights into the role of SDFs in modulating starch digestion and highlight their potential applications in designing low-glycemic and fiber-enriched functional foods.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Gamma Irradiation and Antioxidants on the Quality of Spicy Chicken Meat During Refrigerated Storage","authors":"Guolin Li,&nbsp;Ping Lin,&nbsp;Yangbo He,&nbsp;Zhihui Liu,&nbsp;Yongfu Li","doi":"10.1002/fsn3.70940","DOIUrl":"10.1002/fsn3.70940","url":null,"abstract":"<p>The effects of antioxidants on microbial quality, color, lipid oxidation, fatty acids, odor, and volatile compounds in irradiated spicy chicken were investigated. Chicken meat was treated with antioxidants (α-tocopherol, phytic acid, tea polyphenols, and tertiary butydroquinone) and 4 kGy gamma irradiation. The results showed that the total viable bacteria (TVB) and total coliform count (TCC) were significantly decreased after irradiation, and the combination of four kinds of antioxidants had no direct antibacterial effect. However, the antioxidants significantly inhibited the color fading of chili oil and repressed the increase in the peroxide value (POV) in irradiated samples. The contents of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) in irradiated meat with antioxidants were significantly higher than those in samples without antioxidants. The E-nose results indicate that the odor of the sample treated with irradiation and antioxidants was closer to that of the nonirradiated sample; in contrast, irradiated meat without antioxidants was distinguished from the others. Irradiation decreased the alcohols and esters, increased the alkenes, and induced the formation of 1,3-bis(1,1-dimethylethyl)-benzene. Alkenes were abundant in irradiated meat with antioxidants after storage for 60 days. These results suggest that 4 kGy gamma irradiation combined with antioxidants would be an alternative way to control the negative effects during spicy chicken irradiation processing.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme Technology in the Food Industry: Molecular Mechanisms, Applications, and Sustainable Innovations","authors":"Fahima Siddikey,&nbsp;Md Istiakh Jahan,&nbsp; Hormoni,&nbsp;Md Toufik Hasan,&nbsp;Nusrat Jerin Nishi,&nbsp;S. M. Kamrul Hasan,&nbsp;Nahidur Rahman,&nbsp;Md. Azmain Al Faik,&nbsp;Mohammad Afzal Hossain","doi":"10.1002/fsn3.70927","DOIUrl":"10.1002/fsn3.70927","url":null,"abstract":"<p>Enzymes are protein-based biocatalysts that speed up biochemical reactions without affecting equilibrium, with microbial sources being the most efficient and cost-effective for large-scale production. Their dual roles as processing aids and inhibitors of spoilage make understanding their structure, function, and specific activity vital for both in vitro applications and food product development. While the development of recombinant DNA technology and the advancements achieved by microbes in food applications are more economically and practically advantageous, certain of these enzymes are plentiful enough in their natural sources to allow for large-scale synthesis. Enzymes find extensive use across many domains, including but not limited to agriculture, environment, paper and pulp, leather tanning, chemicals and pharmaceuticals, detergents, food and drink, and so on. In this review, we have focused on the molecular mechanisms of enzyme activity and the enzyme manufacturing process within the food industry. We also dedicate a section to various enzymes used in this sector, including amylase, lipase, proteases, cellulase, lactase, glucose oxidase, glucose isomerase, invertase, catalase, and rennet. Additionally, we have presented case studies showcasing the successful implementation of sustainable enzyme practices across different food sectors, highlighting both practical benefits and challenges. The review concludes with an outlook on future trends and research directions aimed at achieving greater safety and sustainability in enzyme technology within the food industry.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Relationship Between Multiple Modifiable Risk Factors and Hallux Valgus: A Two-Sample Mendelian Randomization Study","authors":"Siyi Liu,&nbsp;Wanqin Zheng,&nbsp;Haitao Chen,&nbsp;Ming Tu,&nbsp;Yongkang Zhong,&nbsp;Yihan Lou,&nbsp;Yinxian Wen,&nbsp;Liaobin Chen","doi":"10.1002/fsn3.70965","DOIUrl":"10.1002/fsn3.70965","url":null,"abstract":"<p>This Mendelian randomization (MR) study aimed to investigate the potential causal associations between modifiable lifestyle/metabolic factors and the risk of hallux valgus (HV), a common foot deformity characterized by lateral deviation of the great toe. We selected independent genetic variants strongly associated with five lifestyle factors (lifetime smoking index, smoking initiation, alcohol consumption, coffee intake, and vigorous physical activity) and ten metabolic traits (body mass index (BMI), waist-hip ratio, type 2 diabetes, systolic/diastolic blood pressure, high/low-density lipoprotein, apolipoprotein A-1/B, and triglycerides) as instrumental variables through rigorous quality control (<i>R</i>² &lt; 0.001, <i>p</i> ≤ 5 × 10⁻⁸). Genetic association estimates were derived from large-scale genome-wide association studies (GWAS) in the UK Biobank, GSCAN consortium, and FinnGen cohorts. A two-sample MR approach was used to assess causal effects on HV risk. Genetically predicted smoking initiation (odds ratio (OR) 1.23, 95% confidence interval (CI) [1.06–1.43], <i>p</i> = 0.00784), lifetime smoking (OR 1.79, 95% CI [1.27–2.51] <i>p</i> = 0.000832), and higher BMI (OR 1.17, 95% CI [1.06–1.29] <i>p</i> = 0.00164) were significantly associated with increased HV risk. No significant associations were found for other tested factors. This study provides genetic evidence supporting a causal role of smoking and BMI in the development of HV. These findings highlight modifiable risk factors for targeted prevention strategies in HV management.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Iron Death by Lycium barbarum Polysaccharides Ameliorates Myocardial Injury in Sepsis: A Pharmacological Mechanism Study Based on the NRF2/HO-1 Pathway","authors":"Zesu Niu,&nbsp;Yi Hu,&nbsp;Long Yang,&nbsp;Xiaorui Meng,&nbsp;Mengfei Chen,&nbsp;Xue Bai,&nbsp;Ruxin Liu,&nbsp;Yujiao Tang,&nbsp;Liting Yang,&nbsp;Weiliang Xue","doi":"10.1002/fsn3.70835","DOIUrl":"10.1002/fsn3.70835","url":null,"abstract":"<p>Sepsis remains a leading global cause of mortality, with sepsis-induced myocardial injury (SIMI) being a critical determinant of clinical outcomes. <i>Lycium barbarum</i> L. (goji berry), a traditional Chinese herb, has demonstrated therapeutic potential in sepsis-related organ injuries through multiple pathways. However, its role and mechanisms in SIMI remain unexplored. A network pharmacology approach identified candidate targets of <i>Lycium barbarum</i> via TCMSP and SwissTargetPrediction, intersected with sepsis/myocardial injury-related targets from GeneCards. Protein–protein interaction (PPI) networks were constructed using STRING and analyzed via Cytoscape's cytoHubba plugin. Enriched pathways were explored through KEGG/GO analyses. Transcription factor prediction, molecular docking (AutoDock Vina), and molecular dynamics (MD) simulations (GROMACS) were performed for key targets. Experimental validation included in vivo LPS-induced sepsis models and in vitro H9C2 cardiomyocyte assays. This study reveals that <i>Lycium barbarum</i> alleviates SIMI by modulating the NRF2/HO-1 signaling pathway, positioning it as a novel therapeutic candidate for sepsis-associated cardiac complications.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}